Microkeratome-assisted preparation of ultrathin grafts for descemet stripping automated endothelial keratoplasty.

abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...

journal_title：Investigative ophthalmology & visual science

authors： Zhou X,Robinson CM,Rajaiya J,Dehghan S,Seto D,Jones MS,Dyer DW,Chodosh J

更新日期：2012-05-14 00:00:00

abstract：Purpose:Treatment success in clinical trials for AMD would ideally be aligned to measurable performance in visual tasks rather than imperceptible changes on clinical charts. We test the hypothesis that patients with dry AMD perform worse than visually healthy peers on computer-based surrogates of "real-world" visual se...

journal_title：Investigative ophthalmology & visual science

authors： Taylor DJ,Smith ND,Crabb DP

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To investigate the biometric characteristics of eyes with idiopathic central serous chorioretinopathy (CSC). METHODS:Medical records of 52 consecutive patients with unilateral CSC were reviewed. Central serous chorioretinopathy was diagnosed using spectral-domain optical coherence tomography (SD-OCT) and fluor...

journal_title：Investigative ophthalmology & visual science

authors： Oh JH,Oh J,Togloom A,Kim SW,Huh K

更新日期：2014-03-13 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：Purpose:Mutations in the retinitis pigmentosa-1-like-1 (RP1L1) gene are the major cause of autosomal dominant occult macular dystrophy (OCMD), while recessive mutations have been linked to autosomal recessive retinitis pigmentosa (arRP). We present the clinical phenotype of a large German OCMD cohort, as well as four R...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Zobor G,Hipp S,Baumann B,Weisschuh N,Biskup S,Sliesoraityte I,Zrenner E,Kohl S

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To investigate the relationship between long-term glycemic control and photopic negative response (PhNR) changes in the blue flash ERG in adolescents with type 1 diabetes (T1D) without diabetic retinopathy (DR). METHODS:After light adaptation, ERG responses to 1.60 cd·s/m(2) blue (420 nm) flashes (blue flash E...

journal_title：Investigative ophthalmology & visual science

authors： McFarlane M,Wright T,Stephens D,Nilsson J,Westall CA

更新日期：2012-02-13 00:00:00

abstract：:Scanning electron microscopic (SEM) observations of the rabbit retinal pigment epithelium (RPE) are reported both for normal tissue and for tissue subjected to laser radiation. In normal RPE, cells were observed to be closely packed and to have the characteristic hexagonal shape. The microvilli were abundant and of tw...

journal_title：Investigative ophthalmology & visual science

authors： Borwein B,Sanwal M,Medeiros JA,McGowan JW

更新日期：1977-08-01 00:00:00

abstract：PURPOSE:To investigate the potential use of amniotic membrane transplantation (AMT) in the construction of glaucoma filtering blebs. METHODS:Twenty-four albino rabbits underwent glaucoma filtration surgery in one eye. In alternate cases, the conjunctival flap was replaced with AMT. Postoperative examination data were ...

journal_title：Investigative ophthalmology & visual science

authors： Barton K,Budenz DL,Khaw PT,Tseng SC

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:Corneas with scars and certain chronic pathologic conditions contain highly sulfated dermatan sulfate, but little is known of the core proteins that carry these atypical glycosaminoglycans. In this study the proteoglycan proteins attached to dermatan sulfate in normal and pathologic human corneas were examined ...

journal_title：Investigative ophthalmology & visual science

authors： Funderburgh JL,Hevelone ND,Roth MR,Funderburgh ML,Rodrigues MR,Nirankari VS,Conrad GW

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To compare local functional measures, the multifocal electroretinogram (mfERG) and visual field sensitivity, with a local structural measure, spectral domain (SD) optical coherence tomography (OCT), of receptor damage in patients with retinitis pigmentosa (RP). METHODS:MfERGs, visual fields, and SD-OCT scans w...

journal_title：Investigative ophthalmology & visual science

authors： Wen Y,Klein M,Hood DC,Birch DG

更新日期：2012-02-21 00:00:00

abstract：PURPOSE:It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can...

journal_title：Investigative ophthalmology & visual science

authors： Wang S,Lu B,Girman S,Holmes T,Bischoff N,Lund RD

更新日期：2008-01-01 00:00:00

abstract：Purpose:To evaluate the relationship between refractive error, circadian phase, and melatonin with consideration of prior light exposure, physical activity, and sleep. Methods:Healthy young myopic (spherical equivalent refraction [SER] ≤-0.50DS) and emmetropic adults underwent noncycloplegic autorefraction and axial l...

journal_title：Investigative ophthalmology & visual science

authors： Flanagan SC,Cobice D,Richardson P,Sittlington JJ,Saunders KJ

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To improve the 30-year-old "trypsin digestion" procedure for isolation of the complete retinal vasculature, which, in its time, was a revolutionary advance that allowed important discoveries about diabetic retinopathy; to provide a method that will yield more consistent results when applied to retinas represent...

journal_title：Investigative ophthalmology & visual science

authors： Laver NM,Robison WG Jr,Pfeffer BA

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:In Program K, a new automated kinetic algorithm that we developed, the frequency distributions of the number of patients' response points were obtained for external angles to distinguish normal and abnormal isopters. We also assessed the agreement between the results of Program K and Goldmann manual kinetic per...

journal_title：Investigative ophthalmology & visual science

authors： Hashimoto S,Matsumoto C,Okuyama S,Takada S,Arimura-Koike E,Shimomura Y

更新日期：2015-03-05 00:00:00

abstract：PURPOSE:Varicella zoster virus (VZV) is a common cause of infectious uveitis associated with an intraocular inflammatory response involving virus-specific T cells. In the current study, the functional characteristics and the antigen specificity of VZV-reactive T cells recovered from intraocular fluid (IOF) samples of f...

journal_title：Investigative ophthalmology & visual science

authors： Milikan JC,Kinchington PR,Baarsma GS,Kuijpers RW,Osterhaus AD,Verjans GM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Previous in vitro studies with transgenic and gene-knockout mice have shown that lenses with elevated levels of glutathione peroxidase (GPX)-1 activity are able to resist the cytotoxic effect of H(2)O(2), compared with normal lenses and lenses from GPX-1-deficient animals. The purpose of this study was to inves...

journal_title：Investigative ophthalmology & visual science

authors： Reddy VN,Giblin FJ,Lin LR,Dang L,Unakar NJ,Musch DC,Boyle DL,Takemoto LJ,Ho YS,Knoernschild T,Juenemann A,Lütjen-Drecoll E

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:To characterize the phagocytosis of extracellular matrix components by retinal pigment epithelial cells and to determine which receptors and signal transduction pathways are involved. METHODS:Fluorescent latex beads were coated with fibronectin (FN), collagen type I or IV, or thrombospondin and incubated with ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao MW,Jin ML,He S,Spee C,Ryan SJ,Hinton DR

更新日期：1999-10-01 00:00:00

abstract：:The mitotic rate and goblet cell content of conjunctival epithelium following total or central corneal epithelial removal using n-heptanol was measured to determine how the conjunctival epithelium responds to injury and whether conjuctiva responds to central corneal epithelial loss. One day following a wound that remo...

journal_title：Investigative ophthalmology & visual science

authors： Danjo S,Friend J,Thoft RA

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:The goal of this study was to functionally evaluate three previously uncharacterized heat shock factor protein 4 (HSF4) mutations (c.595_599delGGGCC, c.1213C>T, c.1327+4A>G) encoding mutant HSF4 proteins (G199EfsX15, R405X, and M419GfsX29) with missing C-terminal ends. These HSF4 mutations were previously ident...

journal_title：Investigative ophthalmology & visual science

authors： Merath K,Ronchetti A,Sidjanin DJ

更新日期：2013-10-11 00:00:00

abstract：PURPOSE:To define the phenotypes of retinal degenerations associated with mutations in the gene encoding CRX (cone-rod homeobox), a photoreceptor-specific transcription factor. METHODS:Heterozygotes with the E168 [delta1 bp], E168 [delta2 bp], or G217 [delta1 bp] CRXgene mutation were studied clinically, with visual f...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Huang Y,Hanna DB,Freund CL,Affatigato LM,Carr RE,Zack DJ,Stone EM,McInnes RR

更新日期：1998-11-01 00:00:00

abstract：Purpose:To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods:In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of sy...

journal_title：Investigative ophthalmology & visual science

authors： Augstburger E,Zéboulon P,Keilani C,Baudouin C,Labbé A

更新日期：2018-02-01 00:00:00

abstract：:Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the ...

journal_title：Investigative ophthalmology & visual science

authors： She SC,Steahly LP,Moticka EJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To evaluate the visual and refractive outcome for four wavefront-guided surface ablation (WGSA) techniques (LASEK, LASEK flap-off [LASEK FO], Epi-LASIK, and Epi-LASIK flap-off [Epi-LASIK FO]) in a large myopic population. METHODS:This retrospective review included 1000 myopic eyes (spherical equivalent [SE] -1...

journal_title：Investigative ophthalmology & visual science

authors： Kulkarni SV,AlMahmoud T,Priest D,Taylor SE,Mintsioulis G,Jackson WB

更新日期：2013-01-21 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00

abstract：PURPOSE:Best disease is a monogenic macular degeneration caused mainly by heterozygous mutations in the BEST1 gene. The objective was to characterize the molecular and clinical features of patients with the classical form of Best disease that is inherited in an autosomal recessive mode. METHODS:Clinical evaluation inc...

journal_title：Investigative ophthalmology & visual science

authors： Bitner H,Mizrahi-Meissonnier L,Griefner G,Erdinest I,Sharon D,Banin E

更新日期：2011-07-18 00:00:00

abstract：Purpose:Most of the inflammation in murine herpes simplex virus type 1 (HSV-1)-induced stromal keratitis (HSK) is due to exposure stress resulting from loss of corneal nerves and blink reflex. Corneal grafts often fail when placed on corneal beds with a history of HSK. We asked if corneal exposure contributes to the se...

journal_title：Investigative ophthalmology & visual science

authors： Rowe AM,Yun H,Hendricks RL

更新日期：2017-01-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of genetic deletion of NOS3 in CAV1-/- mice on aqueous humor outflow function using a mouse genetic double knockout model (DKO, NOS3-/- CAV1-/-). Methods:IOP was measured in DKO, NOS3 KO, CAV1 KO, and wild-type (WT) mice by rebound tonometry. Outflow faci...

journal_title：Investigative ophthalmology & visual science

authors： Song M,Wu J,Lei Y,Sun X

更新日期：2017-10-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:Müller glia have multiple functions in the retina, including synthesis of neurotrophic factors, uptake and metabolism of neurotransmitters, spatial buffering of ions, maintenance of the blood-retinal barrier, and response to injury. A population of Müller glia has some stem cell-like characteristics both in viv...

journal_title：Investigative ophthalmology & visual science

authors： Otteson DC,Phillips MJ

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To investigate whether mucosal immune responses directed against the ubiquitous parasite Toxoplasma gondii can be detected in tears of healthy humans. METHODS:Nonstimulated tears and blood were obtained from 62 healthy humans (mean age, 35 +/- 10 [SD] years). Serum anti-T. gondii immunoglobulin titers were det...

journal_title：Investigative ophthalmology & visual science

authors： Meek B,Klaren VN,van Haeringen NJ,Kijlstra A,Peek R

更新日期：2000-08-01 00:00:00