Conjunctival epithelium in healing of corneal epithelial wounds.

abstract：PURPOSE:To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dual-wavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS:Forty-three patients were divided into groups 1 (contro...

journal_title：Investigative ophthalmology & visual science

authors： Lima VC,Rosen RB,Maia M,Prata TS,Dorairaj S,Farah ME,Sallum J

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To characterize the signaling pathways used by hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) in human corneal epithelial cells. METHODS:Cultures of SV40 large T antigen-transfected human corneal epithelial cells were treated with recombinant human HGF or KGF at 50 ng/ml to 100 ng/ml for 5...

journal_title：Investigative ophthalmology & visual science

authors： Liang Q,Mohan RR,Chen L,Wilson SE

更新日期：1998-07-01 00:00:00

abstract：:Purpose. Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina. The thera...

journal_title：Investigative ophthalmology & visual science

authors： Iwata D,Kitaichi N,Miyazaki A,Iwabuchi K,Yoshida K,Namba K,Ozaki M,Ohno S,Umezawa K,Yamashita K,Todo S,Ishida S,Onoé K

更新日期：2010-04-01 00:00:00

abstract：:Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively u...

journal_title：Investigative ophthalmology & visual science

authors： Peng H,Park JK,Lavker RM

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Vitreoretinal disorders are frequently characterized by increased vitreous levels of cellular mediators, including cytokines, chemokines, and growth factors. The study was conducted to investigate whether multiplex bead analysis could identify disease-specific profiles of these mediators in a variety of vitreor...

journal_title：Investigative ophthalmology & visual science

authors： Banerjee S,Savant V,Scott RA,Curnow SJ,Wallace GR,Murray PI

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To prepare binary transgenic mouse lines that overexpress reporter genes in a corneal-epithelium-specific manner when induced by doxycycline. METHODS:A gene-targeting construct containing an internal ribosomal entry site-reverse tetracycline transcription activator (IRES-rtTA) cassette was inserted into the Kr...

journal_title：Investigative ophthalmology & visual science

authors： Chikama T,Hayashi Y,Liu CY,Terai N,Terai K,Kao CW,Wang L,Hayashi M,Nishida T,Sanford P,Doestchman T,Kao WW

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:To characterize the spatial and temporal expression of key structural and phototransduction cascade proteins in the monkey cone outer segment (OS). METHODS:Retinas from Macaca monkeys from ages fetal day (Fd) 89 through adulthood were double labeled using immunofluorescence for short (S) or long/medium (L/M) w...

journal_title：Investigative ophthalmology & visual science

authors： Sears S,Erickson A,Hendrickson A

更新日期：2000-04-01 00:00:00

abstract：Purpose:To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods:Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG me...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Mecham RP,Trackman PC,Roy S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：Purpose:To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the dystrophies associated with SLC4A11 mutations, congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Frausto R,Chung DD,Griffis CG,Kao L,Chen A,Azimov R,Sampath AP,Kurtz I,Aldave AJ

更新日期：2020-07-01 00:00:00

abstract：Purpose:This study evaluates the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the PARL-ABCC5-HTR3D-HTR3C region with primary angle closure glaucoma (PACG), with a view to identify the responsible SNP in this region. Methods:Thirty SNPs from the PARL-ABCC5-HTR3D-HTR3C region were genotype...

journal_title：Investigative ophthalmology & visual science

authors： Tang FY,Ma L,Tam POS,Pang CP,Tham CC,Chen LJ

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS:Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of ste...

journal_title：Investigative ophthalmology & visual science

authors： Healey PR,Mitchell P,Gilbert CE,Lee AJ,Ge D,Snieder H,Spector TD,Hammond CJ

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To characterize the response of cultured human retinal pigment epithelial (RPE) cells to lowered environmental oxygen. METHODS:The response of cultured RPE cells to lowered oxygen environments was compared to that of cell types of presumed high (Madin-Darby canine kidney [MDCK] cells, an epithelial cell line) ...

journal_title：Investigative ophthalmology & visual science

authors： Nash RW,McKay BS,Burke JM

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To examine the expression of Angiotensin II (Ang II) and its type I, and type II receptors (AT1R, AT2R) in rabbit Tenon's capsule fibroblasts after trabeculectomy, and to investigate the effects of Ang II on cultured human Tenon's capsule fibroblasts (HTFs) proliferation, migration, phenotype transition, and ex...

journal_title：Investigative ophthalmology & visual science

authors： Shi H,Zhang Y,Fu S,Lu Z,Ye W,Xiao Y

更新日期：2015-01-06 00:00:00

abstract：UNLABELLED:PURPOSE. Test the hypothesis that the developmental increases in rod photoreceptor sensitivity and rod-mediated visual sensitivity at 10 degrees, 20 degrees , and 30 degrees eccentric are concurrent. It is known that maturation of the parafoveal (10 degrees eccentric) rod outer segments and visual sensitivit...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Hansen RM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:We compared the reproducibility and mutual agreement of the subfoveal choroidal thickness measurements by expert raters and an automated algorithm in enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes with nonneovascular age-related macular degeneration (AMD). METHODS:We recruited 44 ...

journal_title：Investigative ophthalmology & visual science

authors： Lee S,Fallah N,Forooghian F,Ko A,Pakzad-Vaezi K,Merkur AB,Kirker AW,Albiani DA,Young M,Sarunic MV,Beg MF

更新日期：2013-04-23 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：Purpose:To determine whether high glucose (HG) or diabetes alters mitochondrial morphology and promotes mitochondrial fragmentation in retinal vascular cells and thereby triggers apoptosis associated with diabetic retinopathy. Methods:To assess whether diabetes promotes mitochondrial fragmentation and thereby triggers...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Roy S

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

journal_title：Investigative ophthalmology & visual science

authors： Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

更新日期：2015-06-01 00:00:00

abstract：Purpose:We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina of rats with T1D. Methods:Retinas from T1D (n = 7), T2D (n = 13)...

journal_title：Investigative ophthalmology & visual science

authors： Hu P,Hunt NH,Arfuso F,Shaw LC,Uddin MN,Zhu M,Devasahayam R,Adamson SJ,Benson VL,Chan-Ling T,Grant MB

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：:In 150 retinoblastomas the authors found a uniform thickness of the cuff of viable retinoblastoma cells that surrounds blood vessels. The mean thickness was 98.7 microns with a standard deviation of 11.9 microns. The cross-sectional area of the cuff was negatively correlated with the mitotic activity in the cuff and p...

journal_title：Investigative ophthalmology & visual science

authors： Burnier MN,McLean IW,Zimmerman LE,Rosenberg SH

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The phenoxyacetic acid, ethacrynic acid (ECA), has potential use in glaucoma therapy because it acts to increase aqueous outflow in vivo and in vitro. In human trabecular meshwork (HTM) cell culture, ECA acts to change cell shape and attachment, effects that have been correlated with microtubule (MT) alteration...

journal_title：Investigative ophthalmology & visual science

authors： Epstein DL,Roberts BC,Skinner LL

更新日期：1997-07-01 00:00:00

abstract：:After viewing red vertical stripes and green horizontal stripes, the eye subsequently views white vertical stripes as greenish and white horizontal stripes as pinkish. It has been theorized that this phenomenon, known as the McCollough effect, is related to long-tern adaptation of cells tuned for both color and orient...

journal_title：Investigative ophthalmology & visual science

authors： Maguire WM,Meyer GE,Baizer JS

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00