Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis.

abstract：PURPOSE:To investigate the expression pattern of claudins in human corneal endothelium, and to evaluate the functional role of the claudin-10b subtype. METHODS:Corneal endothelium with Descemet's membrane and the corneal epithelium were stripped from donor human corneal stroma. Reverse transcription-polymerase chain r...

journal_title：Investigative ophthalmology & visual science

authors： Inagaki E,Hatou S,Yoshida S,Miyashita H,Tsubota K,Shimmura S

更新日期：2013-11-08 00:00:00

abstract：PURPOSE:To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity. METHODS:Retinal detachments were created in mice deficient for GFAP and vimentin (GFAP(-/-)vim(-/-)) and age-matched wild-type (wt) mice. The reactivity of the retina was studied by immunofluorescence and e...

journal_title：Investigative ophthalmology & visual science

authors： Verardo MR,Lewis GP,Takeda M,Linberg KA,Byun J,Luna G,Wilhelmsson U,Pekny M,Chen DF,Fisher SK

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:Experiments in chickens have implicated the transcription factor ZENK (also known as Egr-1, NGFI-A, zif268, tis8, cef5, and Krox24) in the feedback mechanisms for visual control of axial eye growth and myopia development. ZENK is upregulated in retinal glucagon amacrine cells when axial eye growth is inhibited ...

journal_title：Investigative ophthalmology & visual science

authors： Schippert R,Burkhardt E,Feldkaemper M,Schaeffel F

更新日期：2007-01-01 00:00:00

abstract：:We examined the sources of artifacts of vitreous fluorophotometry (VF), a technique used to assess the permeability of the blood-retinal barrier. By performing in vitro measurements in a model eye and in vivo readings in humans, we investigated the influence of various concentrations of fluorescein in the anterior cha...

journal_title：Investigative ophthalmology & visual science

authors： Zeimer RC,Cunha-Vaz JG,Johnson ME

更新日期：1982-05-01 00:00:00

abstract：:The ocular toxicity of liposome-intercalated amphotericin B and commercial amphotericin B were compared after intravitreal injection in healthy pigmented rabbits. Ophthalmoscopic observations over 5 weeks following a single intravitreal injection showed vitreal band formation and focal retinal damage after doses of co...

journal_title：Investigative ophthalmology & visual science

authors： Tremblay C,Barza M,Szoka F,Lahav M,Baum J

更新日期：1985-05-01 00:00:00

abstract：:In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Foley KM,Rismondo V

更新日期：1986-08-01 00:00:00

abstract：Purpose:The activation of the urokinase-type plasminogen activator and its receptor system is associated with retinal diseases. Among peptide inhibitors of this system, UPARANT acts by preventing the onset of pathologic signs of neovascular ocular diseases. We investigated whether systemic UPARANT may act in a therapeu...

journal_title：Investigative ophthalmology & visual science

authors： Cammalleri M,Locri F,Marsili S,Dal Monte M,Pisano C,Mancinelli A,Lista L,Rusciano D,De Rosa M,Pavone V,Bagnoli P

更新日期：2017-06-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:Refraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia ...

journal_title：Investigative ophthalmology & visual science

authors： Klein AP,Duggal P,Lee KE,Cheng CY,Klein R,Bailey-Wilson JE,Klein BE

更新日期：2011-07-13 00:00:00

abstract：PURPOSE:To investigate both the effect of diabetic macular edema (DME) on measured peripapillary retinal nerve fiber layer (RNFL) thickness and the effect of intravitreal bevacizumab injection on RNFL thickness using spectral-domain optical coherence tomography (SD-OCT) in patients with diabetic retinopathy. METHODS:W...

journal_title：Investigative ophthalmology & visual science

authors： Hwang DJ,Lee EJ,Lee SY,Park KH,Woo SJ

更新日期：2014-05-15 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test in detecting visual acuity (VA) of >20/200. METHODS:This was a combined retrospective and prospective, noninterventional study. In phase I of the study, data from 168 eyes of 154 subjects who underwent the computerized objective VA tes...

journal_title：Investigative ophthalmology & visual science

authors： Han SB,Yang HK,Hyon JY,Seo JM,Lee JH,Lee IB,Hwang JM

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00

abstract：:Analysis of cell populations in the cornea may be performed rapidly and accurately employing the technique of enzymatic disaggregation. To illustrate this method normal rat corneas and corneas infected 24 and 48 hours previously with Staphylococcus aureus were disaggregated in a solution containing pancreatin and coll...

journal_title：Investigative ophthalmology & visual science

authors： Badenoch PR,Finlay-Jones JJ,Coster DJ

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:To determine if there is endothelin-mediated regulation of cell signaling and proliferation in rabbit corneal epithelium. METHODS:Endothelin-1 (ET-1) gene and protein expression by the rabbit corneal epithelial (RCE) cells were analyzed by polymerase chain reaction, sequence analysis, and enzyme immunoassay. D...

journal_title：Investigative ophthalmology & visual science

authors： Takagi H,Reinach PS,Tachado SD,Yoshimura N

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：:Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the ...

journal_title：Investigative ophthalmology & visual science

authors： She SC,Steahly LP,Moticka EJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：:Selenium toxicity was investigated in cultured rabbit lenses to provide further information about the role of Ca++ in Se cataract. At a dose of 0.1 mM for 20 hr, Se induces a 10% change in Na levels within 6 hr, a 30% increase after 20 hr, and a three-fold increase within 48 hr of subsequent culture after removal of S...

journal_title：Investigative ophthalmology & visual science

authors： Hightower KR,McCready JP

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To determine whether blur adaptation influences blur sensitivity and blur discrimination thresholds in young adult myopes and emmetropes. In addition, to determine whether there is a differential effect of blur adaptation on blur sensitivity and discrimination between refractive error groups. METHODS:Proximal ...

journal_title：Investigative ophthalmology & visual science

authors： Cufflin MP,Mankowska A,Mallen EA

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To relate the oxygen environment of the retina to photoreceptor stability, protection, and function in the P23H rat. METHODS:Heterozygote P23H-3 (Line 3) rats were studied. Photoreceptor death rates were assessed with the TUNEL technique for detection of fragmenting DNA, in a developmental series from postnata...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Cringle S,Valter K,Walsh N,Lee D,Stone J

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To determine the accommodative accuracy of infants and young children before they had had any form of clinical intervention or treatment, in an attempt to determine the difference between 'normal' and 'abnormal' visual experience for these individuals. METHODS:Nott retinoscopy was performed on 111 subjects in ...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Gray KH,Hohenbary CC,Lyon DW

更新日期：2012-01-17 00:00:00

abstract：PURPOSE:The objective of this study was to determine whether alteration in mucins could be detected in patients with dry eye symptoms by using the monoclonal antibody H185, which recognizes carbohydrate epitopes on mucin molecules. METHODS:Immunohistochemistry and immunoelectron microscopy was used to examine binding ...

journal_title：Investigative ophthalmology & visual science

authors： Danjo Y,Watanabe H,Tisdale AS,George M,Tsumura T,Abelson MB,Gipson IK

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were obse...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DM

更新日期：2011-06-22 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00

abstract：PURPOSE:Orbital magnetic resonance imaging (MRI) was used to investigate the structural basis of motility abnormalities in congenital fibrosis of the extraocular muscles type 3 (CFEOM3), a disorder resulting from missense mutations in TUBB3, which encodes neuron-specific beta-tubulin isotype III. METHODS:Ophthalmic ex...

journal_title：Investigative ophthalmology & visual science

authors： Demer JL,Clark RA,Tischfield MA,Engle EC

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：:Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. ...

journal_title：Investigative ophthalmology & visual science

authors： Lee DA,Lee TC,Cortes AE,Kitada S

更新日期：1990-10-01 00:00:00

abstract：:The rate of aqueous humor flow of 19 normal subjects was measured by a fluorescein clearance technique during the day, during sleep (at night) and during sleep deprivation (at night). Subjects engaged in routine activities during the daytime measurements and slept in comfortable quarters during the nighttime measureme...

journal_title：Investigative ophthalmology & visual science

authors： Reiss GR,Lee DA,Topper JE,Brubaker RF

更新日期：1984-06-01 00:00:00