Retinol secretion by the lacrimal gland.

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:To examine the expression pattern and roles of Sonic hedgehog (Shh) in healing corneal epithelium. METHODS:Immunofluorescent staining and Western blot analysis were used to detect Shh, patched 1 (Ptc 1) receptors, and Gli transcription factors in corneal epithelium of Wistar rats (n = 44) at various intervals ...

journal_title：Investigative ophthalmology & visual science

authors： Saika S,Muragaki Y,Okada Y,Miyamoto T,Ohnishi Y,Ooshima A,Kao WW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:Ca(2+) is a major regulator of cell function. In the retinal pigment epithelium (RPE), intracellular free Ca(2+) concentration ([Ca(2+)](i)) is essential for the maintenance of normal retinal function. Therefore, accurate control of [Ca(2+)](i) is vital in these cells. Because Ca(2+) is permanently extruded fro...

journal_title：Investigative ophthalmology & visual science

authors： Wimmers S,Strauss O

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

journal_title：Investigative ophthalmology & visual science

authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

更新日期：1999-12-01 00:00:00

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional [3D]) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with postoperative lamina cribrosa (LC) and prelaminar neural tissue (PLT) chang...

journal_title：Investigative ophthalmology & visual science

authors： Yoshikawa M,Akagi T,Hangai M,Ohashi-Ikeda H,Takayama K,Morooka S,Kimura Y,Nakano N,Yoshimura N

更新日期：2014-01-23 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods:Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight su...

journal_title：Investigative ophthalmology & visual science

authors： Kim DY,Song J,Kim JY,Choi K,Hyung S,Chae JB

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-1 (TGF beta-1) can modulate inflammation. Endotoxin-induced uveitis (EIU) is characterized by acute ocular inflammation related to the release of cytokines, including interleukin (IL)-6. The authors investigated the effect of TGF beta-1 on EIU in mice. METHODS:Three independent ...

journal_title：Investigative ophthalmology & visual science

authors： Peng B,Li Q,Roberge FG,Chan CC

更新日期：1997-01-01 00:00:00

abstract：:We describe an instrument called a scanning ocular spectrofluorophotometer (SOSF) that measures fluorescence in a two-dimensional cross-section through the anterior chamber and cornea and provides the ability to change excitation and emission wavelengths rapidly. The output of a xenon arc lamp is filtered by a diffrac...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:To evaluate the efficiency, cell specificity, stability, and toxicity of recombinant adeno-associated virus (rAAV)-mediated retinal transduction in vivo in the adult immunocompetent mouse. To assess the usefulness of green fluorescent protein (GFP) for real-time, noninvasive monitoring of retinal transgene expr...

journal_title：Investigative ophthalmology & visual science

authors： Bennett J,Duan D,Engelhardt JF,Maguire AM

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the retinal structure and expression of molecula...

journal_title：Investigative ophthalmology & visual science

authors： Hernández M,Pearce-Kelling SE,Rodriguez FD,Aguirre GD,Vecino E

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：Purpose:To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods:An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochem...

journal_title：Investigative ophthalmology & visual science

authors： Vujosevic S,Simó R

更新日期：2017-05-01 00:00:00

abstract：:Angiotensin II (A2) is a vasoconstrictor generated by the renin-angiotensin system. A2 appears to act also as an angiogenic factor. Recent evidence suggests that renin is synthesized at many tissue sites and may generate A2 locally. Local A2 may have important functions in the normal and diseased eye. We examined eigh...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Day RP,Ehrlich EN

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:To examine the expression of c-fos proto-oncogene and phosphorylation of cAMP responsive element binding (CREB) protein in the rat retina after changes in the light-dark condition. METHODS:Rats were exposed to both steady light and flashing light and were killed at the end of light exposure. The retinas were a...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Imaki J,Fujisawa H,Harada T,Ohki K,Matsuda H,Hagiwara M

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Advanced glycation end products (AGEs) form irreversible cross-links with many macromolecules and have been shown to accumulate in tissues at an accelerated rate in diabetes. In the present study, AGE formation in vitreous was examined in patients of various ages and in patients with diabetes. Ex vivo investiga...

journal_title：Investigative ophthalmology & visual science

authors： Stitt AW,Moore JE,Sharkey JA,Murphy G,Simpson DA,Bucala R,Vlassara H,Archer DB

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:Identification of causative mutations for retinal blinding disorders is often limited by restricted understanding of gene expression and underlying molecular mechanisms that trigger degenerative processes. This study was conducted to develop a catalog of canine retina-expressed genes that would provide a unique...

journal_title：Investigative ophthalmology & visual science

authors： Zangerl B,Sun Q,Pillardy J,Johnson JL,Schweitzer PA,Hernandez AG,Liu L,Acland GM,Aguirre GD

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS:DNA was prepared from whole blood of 126 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Wallace GR,Vaughan RW,Kondeatis E,Mathew R,Chen Y,Graham EM,Stanford MR

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

journal_title：Investigative ophthalmology & visual science

authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

更新日期：2011-10-31 00:00:00

abstract：PURPOSE:Fundus autofluorescence (FAF), as an index of lipofuscin accumulation in the retinal pigment epithelium (RPE), provides indirect information on the level of metabolic activity of the RPE and thus the integrity of the RPE/photoreceptor complex. To investigate whether the photoreceptor/RPE complex is still viable...

journal_title：Investigative ophthalmology & visual science

authors： Scholl HP,Chong NH,Robson AG,Holder GE,Moore AT,Bird AC

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To test the hypothesis that longitudinal differences between retinal nerve fiber layer (RNFL) birefringence, measured by scanning laser polarimetry (SLP), and RNFL thickness, measured by optical coherence tomography (OCT), are informative about the state of axonal degeneration. METHODS:Colchicine was injected ...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Wang L,Cull G,Cioffi GA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:CD40 antigen is a membrane receptor that plays a role in the regulation of immune reactions. The expressions of CD40 and CD40 ligand (CD40L) were investigated ex vivo and in vitro in conjunctival epithelial cells, in correlation with HLA DR class H antigen, previously shown to be upregulated in conjunctival inf...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,De Saint-Jean M,Brignole F,Goguel A,Baudouin C

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Migration of retinal pigment epithelial (RPE) cells can be triggered by disruption of the RPE monolayer or injury to the neural retina. Migrating cells may re-establish a confluent monolayer, or they may invade the neural retina and disrupt visual function. The purpose of this study was to examine the role of e...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DA,Fields C,Fallon A,Fitzgerald ME,Viar MJ,Johnson LR

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:To investigate the intracellular mechanisms that induce amyloid beta (Abeta) accumulation and angiogenesis in the human retinal pigment epithelial cell line ARPE19. METHODS:The authors used two endoplasmic reticulum (ER) stress-inducing reagents, thapsigargin (TG), which inhibits the sarcoplasmic/endoplasmic c...

journal_title：Investigative ophthalmology & visual science

authors： Koyama Y,Matsuzaki S,Gomi F,Yamada K,Katayama T,Sato K,Kumada T,Fukuda A,Matsuda S,Tano Y,Tohyama M

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Protein kinase C α (PKCα) is abundantly expressed in rod bipolar cells (RBCs) in the retina, yet the physiological function of PKCα in these cells is not well understood. To elucidate the role of PKCα in visual processing in the eye, we examined the effect of genetic deletion of PKCα on the ERG and on RBC light...

journal_title：Investigative ophthalmology & visual science

authors： Xiong WH,Pang JJ,Pennesi ME,Duvoisin RM,Wu SM,Morgans CW

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) has been used to investigate papilledema in single-site, mostly retrospective studies. We investigated whether spectral-domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve head and retina, could reliably demonstrate structural changes due t...

journal_title：Investigative ophthalmology & visual science

authors： OCT Sub-Study Committee for NORDIC Idiopathic Intracranial Hypertension Study Group.,Auinger P,Durbin M,Feldon S,Garvin M,Kardon R,Keltner J,Kupersmith M,Sibony P,Plumb K,Wang JK,Werner JS

更新日期：2014-11-04 00:00:00

abstract：PURPOSE:Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA and p75 receptors. Clinically relevant use of NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine the mechanis...

journal_title：Investigative ophthalmology & visual science

authors： Blanco-Mezquita T,Martinez-Garcia C,Proença R,Zieske JD,Bonini S,Lambiase A,Merayo-Lloves J

更新日期：2013-06-04 00:00:00

abstract：PURPOSE:To compare the prophylactic effects of intravenous moxifloxacin and vancomycin for Staphylococcus epidermidis endophthalmitis in a rabbit model. METHODS:Albino rabbits (n = 60) were divided into three groups. Intravenous moxifloxacin was injected into 20 animals (group 1), and intravenous vancomycin was inject...

journal_title：Investigative ophthalmology & visual science

authors： Kim JY,Kim SY

更新日期：2011-03-25 00:00:00