Differential distribution of CaM kinases and induction of c-fos expression by flashing and sustained light in rat retinal cells.

abstract：PURPOSE:To assess dynamic interactions of eye and head movements during return-sweep saccades (RSS) when reading with single-vision (SVL) versus progressive-addition (PAL) lenses in a simulated computer-based business environment. METHODS:Horizontal eye and head movements were recorded objectively and simultaneously a...

journal_title：Investigative ophthalmology & visual science

authors： Han Y,Ciuffreda KJ,Selenow A,Ali SR

更新日期：2003-04-01 00:00:00

abstract：:The purpose of this study was to determine whether unilateral gonadectomy caused any change in intraocular pressure. Repeated measurements in 22 male and nine female rabbits after unilateral gonadectomy were made by three different methods of determining intraocular pressure. We were unable to find a decrease in intra...

journal_title：Investigative ophthalmology & visual science

authors： van den Pol A,Maul E,Sears M

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:The aim of the present study was to use an in vivo model of retinal excitotoxicity to investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. METHODS:Adult Sprague-Dawley rats (weight range, 250-300 g) intravitreally received (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyd...

journal_title：Investigative ophthalmology & visual science

authors： Kiagiadaki F,Thermos K

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS:We measure...

journal_title：Investigative ophthalmology & visual science

authors： Jia Y,Hu DN,Zhu D,Zhang L,Gu P,Fan X,Zhou J

更新日期：2014-05-29 00:00:00

abstract：PURPOSE:To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHOD...

journal_title：Investigative ophthalmology & visual science

authors： van den Berg TJ

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:Varicella zoster virus (VZV) is a common cause of infectious uveitis associated with an intraocular inflammatory response involving virus-specific T cells. In the current study, the functional characteristics and the antigen specificity of VZV-reactive T cells recovered from intraocular fluid (IOF) samples of f...

journal_title：Investigative ophthalmology & visual science

authors： Milikan JC,Kinchington PR,Baarsma GS,Kuijpers RW,Osterhaus AD,Verjans GM

更新日期：2007-08-01 00:00:00

abstract：Purpose:Diabetes leads to the downregulation of the retinal Kir4.1 channels and Müller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Müller cells. Circadian rhythms play an integral role in normal physiology; however, diabetes leads to a circadian dysrhythmia...

journal_title：Investigative ophthalmology & visual science

authors： Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb. METHODS:Thirty-seven patients (43 eyes) who had recently (<2 years) undergone ...

journal_title：Investigative ophthalmology & visual science

authors： Pfenninger L,Schneider F,Funk J

更新日期：2011-04-14 00:00:00

abstract：PURPOSE:To map the gene for autosomal dominant cataracts (ADC) in an American white family of European descent. METHODS:Ophthalmic examinations and linkage analyses using a variety of polymorphisms were performed; two-point lod scores calculated. RESULTS:Affected individuals (14 studied) exhibited variable expressivi...

journal_title：Investigative ophthalmology & visual science

authors： Bateman JB,Johannes M,Flodman P,Geyer DD,Clancy KP,Heinzmann C,Kojis T,Berry R,Sparkes RS,Spence MA

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To identify risk factors for the development of high-risk proliferative diabetic retinopathy (PDR) and for the development of severe visual loss or vitrectomy (SVLV) in eyes assigned to deferral of photocoagulation in the Early Treatment Diabetic Retinopathy Study (ETDRS). METHODS:Multivariable Cox models were...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Fisher MR,Gangnon RE,Barton F,Aiello LM,Chew EY,Ferris FL 3rd,Knatterud GL

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To reveal the effects of minocycline, an anti-inflammatory and neuroprotective agent, on the viability and physiological properties of retinal pigment epithelial (RPE) cells and to compare the effects with those of triamcinolone acetonide. METHODS:The proliferation of human RPE cells in vitro was investigated ...

journal_title：Investigative ophthalmology & visual science

authors： Hollborn M,Wiedemann P,Bringmann A,Kohen L

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：Purpose:To investigate transepidermal water loss (TEWL) from the ocular area in dry eye disease (DED) and evaluate the correlation between ocular TEWL and other DED parameters. Methods:Transepidermal water loss from the ocular area in 56 eyes with DED and 38 healthy eyes was measured using a Tewameter TM300 that was e...

journal_title：Investigative ophthalmology & visual science

authors： Jeon HS,Youn SW,Jeon HE,Kim JH,Hyon JY

更新日期：2016-09-01 00:00:00

abstract：Purpose:To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods:In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained tw...

journal_title：Investigative ophthalmology & visual science

authors： Tan R,Guymer RH,Luu CD

更新日期：2018-08-01 00:00:00

abstract：:PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histo...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Lai-Cheong J,Borthwick GM,He L,Taylor GA,Greaves LC,Taylor RW,Griffiths PG,Turnbull DM

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Activity in regions of the visual cortex corresponding to central scotomas in subjects with macular degeneration (MD) is considered evidence for functional reorganization in the brain. Three unresolved issues related to cortical activity in subjects with MD were addressed: Is the cortical response to stimuli pr...

journal_title：Investigative ophthalmology & visual science

authors： Liu T,Cheung SH,Schuchard RA,Glielmi CB,Hu X,He S,Legge GE

更新日期：2010-12-01 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS:Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography....

journal_title：Investigative ophthalmology & visual science

authors： Arvind H,George R,Raju P,Ve RS,Mani B,Kannan P,Vijaya L

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To investigate corneal nerve damage and its subsequent regeneration after excimer laser photokeratectomy in rabbit eyes. METHODS:Corneal photokeratectomy was performed on the right eyes of 34 pigmented rabbits, while the left eyes were used as a control. A Summit UV 200 excimer laser (Summit Technology, Waltha...

journal_title：Investigative ophthalmology & visual science

authors： Trabucchi G,Brancato R,Verdi M,Carones F,Sala C

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS:ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analys...

journal_title：Investigative ophthalmology & visual science

authors： Ruether K,Grosse J,Matthiessen E,Hoffmann K,Hartmann C

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：Purpose:We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT). Methods:Diabetic participants underwent VA testing and AO...

journal_title：Investigative ophthalmology & visual science

authors： Lammer J,Karst SG,Lin MM,Cheney M,Silva PS,Burns SA,Aiello LP,Sun JK

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To study factors associated with choroidal thickness (CT) and to compare CT in angle closure (AC), open angle (OA), and normal eyes. METHODS:Forty controls, 106 OA, and 79 AC subjects underwent measurements of posterior CT by spectral domain-optical coherence tomography, and of intraocular pressure (IOP), bloo...

journal_title：Investigative ophthalmology & visual science

authors： Arora KS,Jefferys JL,Maul EA,Quigley HA

更新日期：2012-11-27 00:00:00

abstract：Purpose:Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. Methods:Nine patients (...

journal_title：Investigative ophthalmology & visual science

authors： Gao TY,Ledgeway T,Lie AL,Anstice N,Black J,McGraw PV,Thompson B

更新日期：2018-11-01 00:00:00

abstract：:The unscarified corneas of rabbits were inoculated with 50 microliter of 2-4 X 10(6) PFU/ml of herpes simplex virus, type 1 (HSV-1), McKrae strain in 10 separate experiments over a 12-month period. Sixty of 104 (57.7%) rabbits survived to postinoculation (PI) day 20. These sixty rabbits were swabbed with dacron-tipped...

journal_title：Investigative ophthalmology & visual science

authors： Berman EJ,Hill JM

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:To compare directly the robustness of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), frequency-doubling perimetry (FDP), and grating-resolution perimetry (GRP) stimuli to different degrees of intraocular stray light induced by commercially available opacity-containing filters. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RS,Redmond T,McDowell DR,Breslin KM,Zlatkova MB

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To investigate the effect of ABCA4 mutation status on lipofuscin-related quantitative autofluorescence (qAF) in humans and on bisretinoid accumulation in mice. METHODS:Genotyped parents (n = 26; age 37-64 years) of patients with biallelic ABCA4-related retinopathy underwent in-depth retinal phenotyping includi...

journal_title：Investigative ophthalmology & visual science

authors： Müller PL,Gliem M,Mangold E,Bolz HJ,Finger RP,McGuinness M,Betz C,Jiang Z,Weber BH,MacLaren RE,Holz FG,Radu RA,Charbel Issa P

更新日期：2015-12-01 00:00:00

abstract：:Voluntary vertical saccades were recorded in five normal human subjects with electro-oculography (EOG), an infrared, limbus tracking system (IR), and a magnetic scleral search coil method. The peak velocity-amplitude relationships of up and down saccades were measured during refixations across the center of the orbit ...

journal_title：Investigative ophthalmology & visual science

authors： Yee RD,Schiller VL,Lim V,Baloh FG,Baloh RW,Honrubia V

更新日期：1985-07-01 00:00:00