Unilateral gonadectomy does not alter contralateral intraocular pressure in rabbit eyes.

abstract：PURPOSE:To examine the expression of five prostaglandin (PG) receptors, EP(1), EP(2), EP(3), EP(4), and FP and their corresponding mRNA transcripts in human sclera and cultured human scleral fibroblasts (HSFs). METHODS:Primary cultures of HSFs were established from donor eyes. Also, sclera from human donor eyes was sn...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Aihara M,Weinreb RN

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:The link between nasal-temporal motion asymmetries and anomalous binocular sensory function in infantile esotropia (ET) has led to the idea that visual evoked potential responses to horizontal motion (mVE) is an alternative measure of sensory binocularity to stereopsis. A second hypothesis is that the mVEP resp...

journal_title：Investigative ophthalmology & visual science

authors： Fawcett SL,Birch EE

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

journal_title：Investigative ophthalmology & visual science

authors： Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular gl...

journal_title：Investigative ophthalmology & visual science

authors： Vorwerk CK,Naskar R,Schuettauf F,Quinto K,Zurakowski D,Gochenauer G,Robinson MB,Mackler SA,Dreyer EB

更新日期：2000-10-01 00:00:00

abstract：:The visual effects of carbon disulfide exposure were studied in macaque monkeys with measurements of visual thresholds, fluorescein angiography and fundus photography. Five monkeys were exposed by inhalation for 6 hr a day, 5 days a week to 256 ppm carbon disulfide (CS2). The motor dysfunction observed in these monkey...

journal_title：Investigative ophthalmology & visual science

authors： Merigan WH,Wood RW,Zehl D,Eskin TA

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS:Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The ex...

journal_title：Investigative ophthalmology & visual science

authors： Morand S,Buchillier V,Maurer F,Bonny C,Arsenijevic Y,Munier FL,Schorderet DF

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To gain better understanding of the relationship between abnormalities detected by the multifocal VEP (mfVEP) compared with those detected by static achromatic, automated perimetry in patients with glaucoma. METHODS:Fifty patients were studied who had open-angle glaucoma that met the following criteria: (1) a ...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Thienprasiddhi P,Greenstein VC,Winn BJ,Ohri N,Liebmann JM,Ritch R

更新日期：2004-02-01 00:00:00

abstract：Purpose:Individuals with developmental dyslexia suffer not only from reading problems as more general motor deficits can also be observed in this patient group. Both psychometric clinical tests and objective eyetracking methods suggest that unstable binocular fixation may contribute to reading problems. Because binocul...

journal_title：Investigative ophthalmology & visual science

authors： Przekoracka-Krawczyk A,Brenk-Krakowska A,Nawrot P,Rusiak P,Naskrecki R

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To determine whether corneal acidosis, which occurs during contact lens wear, alters corneal O2 consumption (QO2) and if so, whether increased ion transport activity could contribute to altered QO2 during acidosis. METHODS:PO2 was measured, using the phosphorescence quenching of Pd-meso-tetra-(4-carboxyphenyl)...

journal_title：Investigative ophthalmology & visual science

authors： Harvitt DM,Bonanno JA

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:The presence of eosinophilic granulocytes in ocular tissue is a hallmark of the host response to environmental and parasite allergens. Using a mouse model of Onchocerca volvulus-mediated keratitis (river blindness), the present study examined the role of the cytokines interleukin (IL)-4 and IL-13 in regulating ...

journal_title：Investigative ophthalmology & visual science

authors： Berger RB,Blackwell NM,Lass JH,Diaconu E,Pearlman E

更新日期：2002-09-01 00:00:00

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:To describe the variation in ocular biometry and its association with refraction in adult Mongolians. METHODS:The study included 1800 subjects, aged 40 years or more, who were selected in two Mongolian provinces-Hövsgöl and Omnögobi-to participate in this population survey. Axial length (AL) and its componen...

journal_title：Investigative ophthalmology & visual science

authors： Wickremasinghe S,Foster PJ,Uranchimeg D,Lee PS,Devereux JG,Alsbirk PH,Machin D,Johnson GJ,Baasanhu J

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield ...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Shin HY,Park CK

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Many retinal imaging instruments use infrared wavelengths to reduce the risk of light damage. However, we have discovered that exposure to infrared illumination causes a long-lasting reduction in infrared autofluorescence (IRAF). We have characterized the dependence of this effect on radiant exposure and invest...

journal_title：Investigative ophthalmology & visual science

authors： Masella BD,Williams DR,Fischer WS,Rossi EA,Hunter JJ

更新日期：2014-05-20 00:00:00

abstract：PURPOSE:Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin coh...

journal_title：Investigative ophthalmology & visual science

authors： Schäche M,Richardson AJ,Pertile KK,Dirani M,Scurrah K,Baird PN

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Placental growth factor (PlGF) has been implicated as a contributor to resistance against anti-VEGF therapy. The purpose of the present study was to analyze the systemic levels of PlGF, VEGF-A, and VEGF-B in patients with neovascular age-related macular degeneration (AMD) after treatment with aflibercept, ranib...

journal_title：Investigative ophthalmology & visual science

authors： Zehetner C,Bechrakis NE,Stattin M,Kirchmair R,Ulmer H,Kralinger MT,Kieselbach GF

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To determine whether integrin-linked kinase (ILK) controls the organization of the actin cytoskeleton in the trabecular meshwork (TM) by regulating integrin co-signaling. METHODS:The cell binding domain and the Heparin II (Hep II) domain of fibronectin were used to activate α5β1 and α4β1 integrin signaling, re...

journal_title：Investigative ophthalmology & visual science

authors： Faralli JA,Newman JR,Sheibani N,Dedhar S,Peters DM

更新日期：2011-03-25 00:00:00

abstract：PURPOSE:To evaluate diurnal intraocular pressure (DIOP) among individuals with primary angle closure (PAC) or primary angle-closure suspect (PACS). Additionally, the hypothesis that greater DIOP fluctuation is related to smaller angle parameters was investigated. METHODS:Forty Caucasian newly referred untreated patien...

journal_title：Investigative ophthalmology & visual science

authors： Sanchez-Parra L,Pardhan S,Buckley RJ,Parker M,Bourne RR

更新日期：2015-05-01 00:00:00

abstract：:In previous studies we found that a mild thermal burn of the vitamin A-deficient rat cornea caused collagenase release into the medium of corneas placed in culture media 72 hr after applying the burn. Collagenase was released only on day 1 of culture and was not released from identically burned corneas of control rats...

journal_title：Investigative ophthalmology & visual science

authors： Seng WL,Kenyon KR,Wolf G

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:meso-Zeaxanthin is a carotenoid that is rarely encountered in nature outside of the vertebrate eye. It is not a constituent of a normal human diet, yet this carotenoid comprises one-third of the primate macular pigment. In the current study, we undertook a systematic approach to biochemically characterize the p...

journal_title：Investigative ophthalmology & visual science

authors： Gorusupudi A,Shyam R,Li B,Vachali P,Subhani YK,Nelson K,Bernstein PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Recent studies demonstrated that short peptides derived from activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotective protein (ADNP) are neuroprotective at femtomolar concentrations. We evaluated these findings in cultures of purified rat retinal ganglion cells (RGCs) using two such ...

journal_title：Investigative ophthalmology & visual science

authors： Lagrèze WA,Pielen A,Steingart R,Schlunck G,Hofmann HD,Gozes I,Kirsch M

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To investigate regional differences in Ca(2+) mobilization kinetics in the intact human lens produced by exposure to agonists of tyrosine-kinase and G-protein-coupled receptors and to characterize the major receptor subtypes involved in Ca(2+) signaling in the different regions. METHODS:Whole human lenses were...

journal_title：Investigative ophthalmology & visual science

authors： Collison DJ,Duncan G

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:Adaptive optics scanning laser ophthalmoscopy (AOSLO) under optimized wavefront correction allows for routine imaging of foveal cone photoreceptors. The intersubject variability of foveal cone density was measured and its relation to eye length evaluated. METHODS:AOSLO was used to image 18 healthy eyes with ax...

journal_title：Investigative ophthalmology & visual science

authors： Li KY,Tiruveedhula P,Roorda A

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：:Newborn stump-tail monkeys were continuously exposed to 400 f-c of cool, white, fluorescent light for periods varying from 12 hr to 7 days. The right eye of each monkey was occluded by a patch of black velour material to serve as a control. The protected eyes retained normal ultrastructure; the exposed eyes showed pro...

journal_title：Investigative ophthalmology & visual science

authors： Messner KH,Maisels MJ,Leure-DuPree AE

更新日期：1978-02-01 00:00:00

abstract：PURPOSE:To determine if limited proteolysis of beta-crystallins is associated with insolubilization of proteins in rats lens during maturation and to test if the protease, calpain II, is involved. METHODS:Soluble and insoluble lens proteins from 4-day-old to 4-month-old rat lens cortexes and nuclei were separated by t...

journal_title：Investigative ophthalmology & visual science

authors： David LL,Azuma M,Shearer TR

更新日期：1994-03-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00