Abstract：
PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield loss (n = 136) and normal controls (n = 99) were analyzed. Disc ovality index and torsion degree were measured on retinal photographs. Imaging of optic disc was obtained using Heidelberg retinal tomography (HRT) III and Cirrus spectral-domain optical coherence tomography (OCT). The degree of temporal disc tilt was assessed using horizontal topographic images and vertical (upward or downward) disc tilt using vertical topographic images, respectively. RESULTS:In all subjects, disc ovality was significantly associated with HRT- and OCT-measured temporal disc tilt and axial length (AL) (all P < 0.001), whereas disc torsion degree was associated with HRT- and OCT-measured vertical disc tilt and AL (all P < 0.05). Association of AL with disc ovality and torsion became more evident as the mean deviation increased. When data on glaucoma patients with superior and inferior hemifield defects were compared, the vertical disc tilt (HRT- and OCT-assessed, P < 0.001 and 0.030, respectively) and the torsion degree (P = 0.002) differed significantly. Upon multivariate logistic regression analysis, the HRT-measured vertical disc tilt was an independent factor determining initial location of the VF defect (P = 0.012). CONCLUSIONS:Measurement of vertical disc tilt may give valuable information about the superior versus inferior regional susceptibilities of glaucoma.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Choi JA,Park HY,Shin HY,Park CKdoi
10.1167/iovs.14-14663subject
Has Abstractpub_date
2014-07-01 00:00:00pages
4991-8issue
8eissn
0146-0404issn
1552-5783pii
iovs.14-14663journal_volume
55pub_type
杂志文章abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...
journal_title：Investigative ophthalmology & visual science
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abstract：PURPOSE:The main purpose of this study was to develop a cell culture model of immortalized epithelium from the human cornea for drug permeability testing. METHODS:Immortalized human corneal epithelial (HCE) cells were grown on filters, with various filter materials and coating procedures. In the optimal case, HCE cell...
journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2001-11-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章,评审
doi：10.1167/iovs.14-14605
更新日期：2014-05-27 00:00:00
abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章,随机对照试验
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journal_title：Investigative ophthalmology & visual science
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更新日期：2014-07-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.08-2697
更新日期：2009-09-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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更新日期：2015-01-15 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.14-14568
更新日期：2014-06-26 00:00:00
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journal_title：Investigative ophthalmology & visual science
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更新日期：1988-04-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章,多中心研究
doi：10.1167/iovs.14-14479
更新日期：2014-06-12 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2002-02-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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更新日期：2015-07-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.10-5657
更新日期：2011-02-16 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2002-03-01 00:00:00
abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.14-14261
更新日期：2014-09-02 00:00:00
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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更新日期：1999-11-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：1991-08-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
更新日期：2001-07-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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更新日期：2011-08-22 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：Purpose:We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function ...
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