Abstract:
PURPOSE:Recent studies on ocular shape have raised increased interest in the peripheral characteristics of the eye, as it potentially triggers changes in the central vision. Current techniques are, however, not capable of accurately measuring the three-dimensional shape of the retina. We describe a new magnetic resonance imaging (MRI)-based method to obtain the retinal shape with high precision and use it to assess if differences in retinal shape could explain previously described trends in peripheral refraction. METHODS:Twenty-one healthy subjects were examined using high-field ocular MRI. The resulting data were automatically segmented and processed to calculate the retinal topographic map. We validated the method against partial coherence interferometry and assessed the reproducibility for four subjects. RESULTS:The retinal topographic maps describe the retinal shape with subpixel reproducibility (SD between sessions = 0.11 mm). Comparison with partial coherence interferometry showed a mean difference of 0.08 mm, 95% confidence interval -0.39 to 0.55 mm, with a standard deviation of 0.23 mm. The data give a possible geometric explanation for the previously described trend in myopic eyes toward relatively hyperopic refraction in the periphery, with full three-dimensional information. The retinal maps furthermore show small, submillimeter, irregularities that could have an important influence on the subjects' peripheral vision. CONCLUSIONS:The possibility to quantitatively characterize the full three-dimensional retinal shape by MRI offers new ophthalmologic possibilities, such as quantitative geometric description of staphyloma. It could in addition be used as a validation technique, independent of standard optical methods, to measure the peripheral retinal shape.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Beenakker JW,Shamonin DP,Webb AG,Luyten GP,Stoel BCdoi
10.1167/iovs.14-15161subject
Has Abstractpub_date
2015-01-15 00:00:00pages
1033-9issue
2eissn
0146-0404issn
1552-5783pii
iovs.14-15161journal_volume
56pub_type
杂志文章abstract:PURPOSE:Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability. METHODS:(1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired. RESULTS:Compared with meibum fr...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.11-8341
更新日期:2012-01-31 00:00:00
abstract:PURPOSE:To gain better understanding of the relationship between abnormalities detected by the multifocal VEP (mfVEP) compared with those detected by static achromatic, automated perimetry in patients with glaucoma. METHODS:Fifty patients were studied who had open-angle glaucoma that met the following criteria: (1) a ...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.03-0602
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abstract:PURPOSE:Retinopathy of prematurity (ROP) is a major problem among very preterm survivors of neonatal intensive care. Neovascularization of the retina is prominent in the proliferative stages of ROP and is under the control of several factors such as vascular endothelial growth factor (VEGF). This study was undertaken o...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.03-1303
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To determine whether resolvin E1 (RvE1), an endogenous oxygenation product of eicosapentaenoic acid (EPA), induces increases in migration in human corneal epithelial cells (HCECs) and to identify signal pathways mediating this response. METHODS:Migration was measured with the scratch wound assay. Western blot ...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.14-15268
更新日期:2015-01-08 00:00:00
abstract::A simple method for the culture of human retinal capillary endothelial cells in vitro is described in this report. Through a process of gentle mechanical disruption and sieving, a sufficient yield of retinal microvessels was obtained from one or two human eyes to allow the culture of endothelial cells in abundance. Th...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:One of the critical difficulties in design of a high-resolution retinal implant is the proximity of stimulating electrodes to the target cells. This is a report of a phenomenon of retinal cellular migration into a perforated membrane that may help to address this problem. METHODS:Mylar membranes with an array ...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2012-08-07 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS:A total of 660 men and women born in Sheffield, United Kingdom, between 1922 and 1930 and whose size at birth was available were traced and invited to take part...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxidative stress damage. To date, the roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any mam...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.05-0018
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:To test a newly developed tear evaporimetry system that detects real-time changes in tear evaporation rates and shows the tear film stability in patients with obstructive meibomian gland dysfunction (MGD). METHODS:A ventilated chamber system with high-sensitivity microbalance sensor was used to evaluate tear e...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.02-0170
更新日期:2003-02-01 00:00:00
abstract::The cornea of one eye was opacified in two young macaque monkeys by multiple stromal injections of a suspension of polystyrene particles (latex). Ultrasound measurements showed that the eye with opaque cornea grew at a faster rate, so that after 1 year it was more than 1 mm longer than the normal eye. This difference ...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract:PURPOSE:The lipid layer of the tear film forms a barrier to evaporation. Evaporation is a major cause of tear thinning between blinks and tear breakup. The purpose of this study was to investigate the relation between tear film thinning and lipid layer thickness before and after instillation of an emulsion eye drop. M...
journal_title:Investigative ophthalmology & visual science
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更新日期:2010-05-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2010-09-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-28 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2008-08-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2019-10-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2014-12-02 00:00:00
abstract:PURPOSE:To examine the reliability and usefulness of a video-based Hirschberg test under clinical conditions. METHODS:The authors estimated ocular deviation in 87 patients with strabismus through automated analysis of corneal reflex displacement using a video refractor. The reproducibility of measurement, the comparis...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.04-0043
更新日期:2005-03-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2013-08-07 00:00:00