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Variation of the axial location of Bruch's membrane opening with age, choroidal thickness, and race.

Abstract：

PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delineated within 24 axial slices to develop point clouds for Bruch's membrane and anterior scleral surfaces. A BMO-independent reference plane was generated based on the peripapillary sclera to measure BMO position. General estimating equations were used to determine the relationship of the axial position of BMO (BMO height) with choroidal thickness, age, and race (African Descent [AD] versus European Descent [ED]) controlling for variations in axial length. RESULTS:The peripapillary choroid was thinner with increasing axial length (-14.9 μm/mm, P = 0.0096), advancing age (-1.1 μm/y, P = 0.00091), and in the ED group (20.2 μm, P = 0.019) in a multivariable model. Choroidal thickness was also strongly related to BMO height (P < 0.00001) independent of all covariates. Bruch's membrane opening position was more posterior relative to the sclera in older subjects (1.3 μm/y, P = 0.00017), independent of axial length and race. However, when choroidal thickness was included in the model, this association was lost (P = 0.225). There was no significant difference in BMO height between racial groups after adjustment for age and axial length. CONCLUSIONS:Bruch's membrane opening is more posteriorly located in older individuals. These differences are largely due to differences in choroidal thickness and suggest that BMO migrates posteriorly with age due to age-related choroidal thinning. However, additional studies in longitudinal datasets are needed to validate these findings.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

doi

10.1167/iovs.13-12937

subject

Has Abstract

pub_date

2014-03-28 00:00:00

pages

2004-9

issue

eissn

0146-0404

issn

1552-5783

pii

iovs.13-12937

journal_volume

pub_type

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Variation of the axial location of Bruch's membrane opening with age, choroidal thickness, and race.