Safety profile of topical VEGF neutralization at the cornea.

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00

abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

journal_title：Investigative ophthalmology & visual science

authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

更新日期：2020-08-03 00:00:00

abstract：Purpose:Melanopsin expressing intrinsically photosensitive retinal ganglion cells (ipRGC) input to multiple brain regions including those for pupil control, circadian rhythms, sleep and mood regulation. Here we measured ipRGC function and its relationship to sleep quality and depression in patients with advanced AMD. ...

journal_title：Investigative ophthalmology & visual science

authors： Maynard ML,Zele AJ,Kwan AS,Feigl B

更新日期：2017-02-01 00:00:00

abstract：Purpose:To determine the effect of voluntary exercise on choroidal neovascularization (CNV) in mice. Methods:Age-matched wild-type C57BL/6J mice were housed in cages equipped with or without running wheels. After four weeks of voluntary running or sedentariness, mice were subjected to laser injury to induce CNV. After...

journal_title：Investigative ophthalmology & visual science

authors： Makin RD,Argyle D,Hirahara S,Nagasaka Y,Zhang M,Yan Z,Kerur N,Ambati J,Gelfand BD

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Accommodative effort during nearwork is thought to be a causative factor in the development of myopia. It has been proposed that an anomaly in autonomic control may be a precursor to the development of myopia. In the present study the closed-loop accommodation response after variations in fixation period was in...

journal_title：Investigative ophthalmology & visual science

authors： Culhane HM,Winn B

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has be...

journal_title：Investigative ophthalmology & visual science

authors： Dieckow J,Brandt W,Hattermann K,Schob S,Schulze U,Mentlein R,Ackermann P,Sel S,Paulsen FP

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To determine the cellular origin and the vascular endothelial growth factor (VEGF) immunoreactivity of the nonvascular stromal cells in surgically excised age-related macular degeneration (ARMD)-associated choroidal neovascular membranes (CNVMs). METHODS:Immunohistochemical analysis was performed on frozen sec...

journal_title：Investigative ophthalmology & visual science

authors： Lopez PF,Sippy BD,Lambert HM,Thach AB,Hinton DR

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:To analyze the roles of vitreal macrophages and circulating leukocytes in retinal vascular growth. METHODS:Bone marrow (BM) cells from green fluorescent protein (GFP) transgenic mice were transplanted into postnatal day (P)1 mice after irradiation. The mice were exposed to 76% to 78% oxygen (P7-P12), to initia...

journal_title：Investigative ophthalmology & visual science

authors： Kataoka K,Nishiguchi KM,Kaneko H,van Rooijen N,Kachi S,Terasaki H

更新日期：2011-03-14 00:00:00

abstract：PURPOSE:The loss of attentional visual field (AVF) has been linked to poor mobility and car crashes. We investigated the risk factors associated with a decrease in AVF over time among participants in the Salisbury Eye Evaluation Driving Study (SEEDS). METHODS:In a longitudinal cohort of 968 individuals ages 67 to 87, ...

journal_title：Investigative ophthalmology & visual science

authors： Rao P,Munoz B,Turano K,Munro C,West SK

更新日期：2013-03-13 00:00:00

abstract：PURPOSE:This study investigated the role of sterile alpha/Armadillo/Toll-Interleukin receptor homology domain 1 protein (SARM1) in Wallerian-like degeneration of retinal ganglion cells (RGCs) and their axons after inducing excitotoxicity. METHODS:To induce excitotoxicity, kainic acid (KA) was injected into the vitreou...

journal_title：Investigative ophthalmology & visual science

authors： Massoll C,Mando W,Chintala SK

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:Transforming growth factor beta-1 (TGF beta-1) can modulate inflammation. Endotoxin-induced uveitis (EIU) is characterized by acute ocular inflammation related to the release of cytokines, including interleukin (IL)-6. The authors investigated the effect of TGF beta-1 on EIU in mice. METHODS:Three independent ...

journal_title：Investigative ophthalmology & visual science

authors： Peng B,Li Q,Roberge FG,Chan CC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To characterize reticular pseudodrusen (RPD) by using a point-to-point comparison of the reticular pattern on infrared reflectance (IR), autofluorescence (AF), and red-free (RF) images registered with en face sections of the choroid from spectral domain optical coherence tomography (SD-OCT) scans. METHODS:A cr...

journal_title：Investigative ophthalmology & visual science

authors： Sohrab MA,Smith RT,Salehi-Had H,Sadda SR,Fawzi AA

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:Lymphatic research has progressed rapidly in recent years. Lymphatic dysfunction has been found in myriad disorders from cancer metastasis to transplant rejection; however, effective treatment for lymphatic disorders is still limited. This study investigates the role of angiopoietin-2 (Ang-2) in corneal inflamm...

journal_title：Investigative ophthalmology & visual science

authors： Yuen D,Grimaldo S,Sessa R,Ecoiffier T,Truong T,Huang E,Bernas M,Daley S,Witte M,Chen L

更新日期：2014-04-29 00:00:00

abstract：PURPOSE:To determine the relationship between changes in contrast sensitivity, if any, after glaucoma therapy and the test-retest reliability of the CSV-1000 contrast sensitivity test. METHODS:Patients with primary open angle glaucoma (N = 16) were retrospectively evaluated to determine changes in visual function, as ...

journal_title：Investigative ophthalmology & visual science

authors： Pomerance GN,Evans DW

更新日期：1994-08-01 00:00:00

abstract：:Chinese hamster ovarian (CHO) cells in culture were used to evaluate the relative antiproliferative potential of drugs. These agents have been used to improve the clinical response after glaucoma filtering surgery. The following drugs were evaluated: 5-fluorouracil (5-FU) as the benchmark, 5-fluorouridine (FUR), 5-flu...

journal_title：Investigative ophthalmology & visual science

authors： Senderoff RI,Weber PA,Smith DR,Sokoloski TD

更新日期：1990-12-01 00:00:00

abstract：:Angiotensin II (A2) is a vasoconstrictor generated by the renin-angiotensin system. A2 appears to act also as an angiogenic factor. Recent evidence suggests that renin is synthesized at many tissue sites and may generate A2 locally. Local A2 may have important functions in the normal and diseased eye. We examined eigh...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Day RP,Ehrlich EN

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells are known to express ionotropic P2X(7) receptors for ATP. Stimulation of these receptors in other cells can elevate Ca(2+) and sometimes lead to cell death. This study asked whether P2X(7) receptor stimulation alters the Ca(2+) levels and viability of retinal ganglion cells. METHODS:P2X(...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Zhang M,Laties AM,Mitchell CH

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:To investigate the effect of nerve growth factor (NGF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a rabbit model after PRK and correlate the findings with functional tear test. METHODS:Unilateral PRK was performed on 21 New Zealand albino rabbits. Three groups, each consist...

journal_title：Investigative ophthalmology & visual science

authors： Esquenazi S,Bazan HE,Bui V,He J,Kim DB,Bazan NG

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on the photoreceptors, and whether it slows the rate of decrease of the electroretinogram (ERG) in rhodopsin P347L transgenic (Tg) rabbits. METHODS:Six-week-old Tg rabbits received TES through a contact lens electrode on...

journal_title：Investigative ophthalmology & visual science

authors： Morimoto T,Kanda H,Kondo M,Terasaki H,Nishida K,Fujikado T

更新日期：2012-06-28 00:00:00

abstract：PURPOSE:Methylenetetrahydrofolate reductase (Mthfr) is a key enzyme in homocysteine-methionine metabolism. We investigated Mthfr expression in retina and asked whether mild hyperhomocysteinemia, due to Mthfr deficiency, alters retinal neurovascular structure and function. METHODS:Expression of Mthfr was investigated a...

journal_title：Investigative ophthalmology & visual science

authors： Markand S,Saul A,Roon P,Prasad P,Martin P,Rozen R,Ganapathy V,Smith SB

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To determine whether the uniform field and pattern ERGs that are reduced in macaque eyes with experimental glaucoma have the same inner-retinal origins. METHODS:ERGs were recorded from 14 anesthetized adult macaques using DTL electrodes. Six monkeys had laser-induced experimental glaucoma, and two others recei...

journal_title：Investigative ophthalmology & visual science

authors： Viswanathan S,Frishman LJ,Robson JG

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To determine whether there is rod system dysfunction in the central retina of patients with age-related macular degeneration (AMD). METHODS:Dark-adapted sensitivity (500-nm stimulus) and light-adapted sensitivity (600 nm) were measured psychophysically at 52 loci in the central 38 degrees (diameter) of retina ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,Jackson GR,Cideciyan AV,Huang Y,Fine SL,Ho AC,Maguire MG,Lolley V,Jacobson SG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Photodynamic therapy (PDT) and the administration of compounds acting against vascular endothelial growth factor (anti-VEGF) are approved for the treatment of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Experimental evidence that the combined use of both treatment opt...

journal_title：Investigative ophthalmology & visual science

authors： Zuluaga MF,Mailhos C,Robinson G,Shima DT,Gurny R,Lange N

更新日期：2007-04-01 00:00:00

abstract：Purpose:Ocular lens fiber cell elongation, differentiation, and compaction are associated with extensive reorganization of cell adhesive interactions and cytoskeleton; however, our knowledge of proteins critical to these events is still evolving. This study characterizes the distribution pattern of neuronal-specific α-...

journal_title：Investigative ophthalmology & visual science

authors： Maddala R,Rao PV

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:This study focuses on the identification of regulatory elements that contribute to lens-specific expression of the human CP49 gene within the 5'-flanking DNA sequences. METHODS:The DNA sequence upstream of the human CP49 coding region was subcloned as a set of 5' and 3' deletion series. The constructs were tra...

journal_title：Investigative ophthalmology & visual science

authors： DePianto DJ,Hess JF,Blankenship TN,FitzGerald PG

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Primary open angle glaucoma-associated mutations in myocilin (MYOC) cause protein "nonsecretion," rendering secreted MYOC difficult to detect using conventional techniques. This study focused on developing and using an assay that can quickly and easily detect mutant MYOC secretion. METHODS:We fused Gaussia luc...

journal_title：Investigative ophthalmology & visual science

authors： Zadoo S,Nguyen A,Zode G,Hulleman JD

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population. METHODS:Participants aged 40 years and older (N = 6130) from the Los Angeles Latino Eye Study (LALES), a large, population-based study of self-ident...

journal_title：Investigative ophthalmology & visual science

authors： Memarzadeh F,Ying-Lai M,Chung J,Azen SP,Varma R,Los Angeles Latino Eye Study Group.

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00