Essential fatty acid deficiency and photoreceptor membrane renewal--a reappraisal.

abstract：PURPOSE:To determine the disease course of retinal dystrophy caused by recessive variants in the DRAM2 (damage-regulated autophagy modulator 2) gene. METHODS:Sixteen individuals with DRAM2-retinopathy were examined (six families; age range, 19-56 years, includes one pre-symptomatic case). The change in visual acuity o...

journal_title：Investigative ophthalmology & visual science

authors： Sergouniotis PI,McKibbin M,Robson AG,Bolz HJ,De Baere E,Müller PL,Heller R,El-Asrag ME,Van Schil K,Plagnol V,Toomes C,Uk Inherited Retinal Disease Consortium.,Ali M,Holder GE,Charbel Issa P,Leroy BP,Inglehearn CF,Webste

更新日期：2015-12-01 00:00:00

abstract：:PURPOSE. To investigate morphologic photoreceptor layer abnormalities and their correlation with visual function in occult macular dystrophy (OMD), by using spectral-domain optical coherence tomography (SD-OCT). METHODS. This observational case series included 18 eyes of 9 patients with OMD. All patients underwent an ...

journal_title：Investigative ophthalmology & visual science

authors： Park SJ,Woo SJ,Park KH,Hwang JM,Chung H

更新日期：2010-07-01 00:00:00

abstract：:Adaptation of saccadic magnitude and vestibulo-ocular reflex gain (VOR) was examined in six monkeys that had undergone a tenectomy of the medial and lateral recti of one eye. After the tenectomy, when the normal eye was patched, a conjugate increase in saccadic magnitude and VOR was observed in both eyes. Subsequent u...

journal_title：Investigative ophthalmology & visual science

authors： Snow R,Hore J,Vilis T

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response in Behçet's disease (BD) patients and the possible mechanisms involved. METHODS:Naive CD4(+) T cells from active BD patients and norm...

journal_title：Investigative ophthalmology & visual science

authors： Tian Y,Wang C,Ye Z,Xiao X,Kijlstra A,Yang P

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:The phenotype of specialized cells arises, in part, from their characteristic gene expression patterns. Retinal ganglion cells (RGCs) are of wide interest in neuroscience and die in glaucoma and other optic neuropathies. In this study the genes expressed by RGCs were profiled by expressed sequence tag (EST) ana...

journal_title：Investigative ophthalmology & visual science

authors： Farkas RH,Qian J,Goldberg JL,Quigley HA,Zack DJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC, OMIM 116150). METHODS:CCMC families were recruited from a national database on hereditary eye diseases; DNA was procured from a national gene bank on hereditary eye diseases and by blood samp...

journal_title：Investigative ophthalmology & visual science

authors： Hansen L,Yao W,Eiberg H,Kjaer KW,Baggesen K,Hejtmancik JF,Rosenberg T

更新日期：2007-09-01 00:00:00

abstract：:In 150 retinoblastomas the authors found a uniform thickness of the cuff of viable retinoblastoma cells that surrounds blood vessels. The mean thickness was 98.7 microns with a standard deviation of 11.9 microns. The cross-sectional area of the cuff was negatively correlated with the mitotic activity in the cuff and p...

journal_title：Investigative ophthalmology & visual science

authors： Burnier MN,McLean IW,Zimmerman LE,Rosenberg SH

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To assess the mutation spectrum in the ABCR gene and clinical phenotypes in Italian families with autosomal recessive Stargardt disease (STGD1) and fundus flavimaculatus (FFM). METHODS:Eleven families from southern Italy, including 18 patients with diagnoses of STGD1, were clinically examined. Ophthalmologic e...

journal_title：Investigative ophthalmology & visual science

authors： Simonelli F,Testa F,de Crecchio G,Rinaldi E,Hutchinson A,Atkinson A,Dean M,D'Urso M,Allikmets R

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell-mediated immune response is generated in the lymphoid compartment and to characterize the functional phenotype of the T c...

journal_title：Investigative ophthalmology & visual science

authors： El Annan J,Chauhan SK,Ecoiffier T,Zhang Q,Saban DR,Dana R

更新日期：2009-08-01 00:00:00

abstract：:In order to determine the importance of lens actin filament configuration to lens accommodation, the pattern of actin filaments in the epithelium was studied in human lenses from different decades of life spanning the accommodative and non-accommodative years. Polygonal arrays of microfilaments were demonstrated in wh...

journal_title：Investigative ophthalmology & visual science

authors： Yeh S,Scholz DL,Liou W,Rafferty NS

更新日期：1986-10-01 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To investigate the regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation (EMT). METHODS:Corneal endothelial cells (CECs) treated with FGF-2 from the primary culture to the third passage were transformed and designated as fibroblastic CECs (fCECs). Steady state lev...

journal_title：Investigative ophthalmology & visual science

authors： Ko MK,Kay EP

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:To assess the impact of glaucoma-related vision loss on measures of out-loud reading, including time to say individual words, interval time between consecutive words, lexical errors, skipped words, and repetitions. METHODS:Glaucoma subjects (n = 63) with bilateral visual field loss and glaucoma suspect control...

journal_title：Investigative ophthalmology & visual science

authors： Mathews PM,Rubin GS,McCloskey M,Salek S,Ramulu PY

更新日期：2015-03-03 00:00:00

abstract：PURPOSE:Angiotensin II (AII) has been shown to play a role in many vascular diseases. In the study described, the effect of AII on vascular endothelial growth factor (VEGF) expression and related intracellular signaling mechanism was investigated in bovine retinal microcapillary pericytes. METHODS:Cultured bovine reti...

journal_title：Investigative ophthalmology & visual science

authors： Otani A,Takagi H,Oh H,Suzuma K,Matsumura M,Ikeda E,Honda Y

更新日期：2000-04-01 00:00:00

abstract：:Flicker contrast sensitivity was tested in the "good" eyes of 13 patients with monocular exudative age-related maculopathy (ARM). The stimulus was a foveal, long-wavelength, low spatial frequency 2.8 degrees circle in an equiluminant (photopic) surround. Two of these ARM-risk eyes have since developed exudative ARM. C...

journal_title：Investigative ophthalmology & visual science

authors： Mayer MJ,Spiegler SJ,Ward B,Glucs A,Kim CB

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:The objective of the study was to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on the multifocal electroretinogram (mfERG) following an induced branch retinal vein occlusion (BRVO) in pigs. METHODS:Electrophysiological examination of the retina was performed in 20 pigs with stan...

journal_title：Investigative ophthalmology & visual science

authors： Ejstrup R,Cour Ml,Kyhn MV,Heegaard S,Kiilgaard JF

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

更新日期：2012-06-20 00:00:00

abstract：:Various noninvasive test procedures were used to evaluate retinal function in a patient who had become night blind following vincristine chemotherapy. The results obtained were strikingly similar to those reported previously in subjects with recessively inherited stationary night blindness; the dark-adaptation curve w...

journal_title：Investigative ophthalmology & visual science

authors： Ripps H,Carr RE,Siegel IM,Greenstein VC

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:The chaperone proteins, α-crystallins, also possess antiapoptotic properties. The purpose of the present study was to investigate whether 19 to 20-mer α-crystallin-derived mini-chaperone peptides (α-crystallin mini-chaperone) are antiapoptotic, and to identify their putative transporters in human fetal RPE (hfR...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Chothe P,Sharma KK,Baid R,Kompella U,Spee C,Kannan N,Manh C,Ryan SJ,Ganapathy V,Kannan R,Hinton DR

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

journal_title：Investigative ophthalmology & visual science

authors： Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsilateral and contralateral ophthalmic arteries ...

journal_title：Investigative ophthalmology & visual science

authors： Morén H,Gesslein B,Undrén P,Andreasson S,Malmsjö M

更新日期：2013-09-09 00:00:00

abstract：PURPOSE:Histone lysine methylation (HKM) is an important epigenetic mechanism that establishes cell-specific gene expression and functions in development. However, epigenetic control of retinal development is poorly understood. To study the roles of HKM in retinogenesis, the authors examined the dynamic changes of thre...

journal_title：Investigative ophthalmology & visual science

authors： Rao RC,Tchedre KT,Malik MT,Coleman N,Fang Y,Marquez VE,Chen DF

更新日期：2010-12-01 00:00:00

abstract：Purpose:Ocular lens fiber cell elongation, differentiation, and compaction are associated with extensive reorganization of cell adhesive interactions and cytoskeleton; however, our knowledge of proteins critical to these events is still evolving. This study characterizes the distribution pattern of neuronal-specific α-...

journal_title：Investigative ophthalmology & visual science

authors： Maddala R,Rao PV

更新日期：2017-07-01 00:00:00

abstract：:The scleral spur and trabecular mesh of the human eye contain approximately 5% elastic tissue. Elastic tissue forms less than 2% of the sclera. ...

journal_title：Investigative ophthalmology & visual science

authors： Moses RA,Grodzki WJ Jr,Starcher BC,Galione MJ

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS:C57BL/6(B6), FasL (CD95L)-deficient B6-...

journal_title：Investigative ophthalmology & visual science

authors： Stuart PM,Pan F,Plambeck S,Ferguson TA

更新日期：2003-01-01 00:00:00