Effect of glial cell line-derived neurotrophic factor on retinal function after experimental branch retinal vein occlusion.

abstract：:Interocular differences in apparent size (aniseikonia) are typically associated with interocular differences in refractive error (anisometropia). Aniseikonia is generally thought to reflect disparities in retinal image size that often accompany anisometropia. This assumption was examined with seven highly anisometropi...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Rabin J,Freeman RD

更新日期：1983-04-01 00:00:00

abstract：:Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably accor...

journal_title：Investigative ophthalmology & visual science

authors： Sirigu P,Shen RL,Pinto da Silva P

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:Adhesion molecules play a critical role in leukocyte emigration to wound sites, but differences are evident in different vascular beds. In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated. METHODS:Re-epithelialization, neut...

journal_title：Investigative ophthalmology & visual science

authors： Li Z,Rumbaut RE,Burns AR,Smith CW

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To characterize the interleukin (IL)-4 receptor (IL-4R) complex in human corneal fibroblasts. METHODS:The presence of IL-4R subunit mRNAs and proteins in cultured human corneal fibroblasts was examined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. The interaction of 125I-...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Fujitsu Y,Kumagai N,Nishida T

更新日期：2002-01-01 00:00:00

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:To evaluate the consequences of altering retinal sterol metabolism and composition on the development, histologic organization, and electrophysiological function of the retina, under conditions that mimic the biochemical hallmarks of the Smith-Lemli-Opitz (SLO) syndrome. METHODS:Pregnant Sprague-Dawley rats we...

journal_title：Investigative ophthalmology & visual science

authors： Fliesler SJ,Richards MJ,Miller C,Peachey NS

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:The Rd4/+ mouse inherits an autosomal dominant retinal degeneration that cosegregates with a large inversion spanning nearly all of mouse chromosome 4 (Chr 4). This inversion is homozygous lethal. The hypothesis for the study was that disruption of a gene at one of the two breakpoints in the Rd4 chromosome is r...

journal_title：Investigative ophthalmology & visual science

authors： Kitamura E,Danciger M,Yamashita C,Rao NP,Nusinowitz S,Chang B,Farber DB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To investigate the responses of retinal ganglion cells (RGCs) to electrical stimulation, using electrodes comparable in size to those used in human studies investigating the feasibility of an electronic retinal prosthesis. METHODS:Rabbit retinas were stimulated in vitro with current pulses applied to the inner...

journal_title：Investigative ophthalmology & visual science

authors： Jensen RJ,Ziv OR,Rizzo JF 3rd

更新日期：2005-04-01 00:00:00

abstract：:Experimental detachments were made in Dutch rabbit eyes by injecting autologous serum or Hanks' solution into the subretinal space through a glass micropipette. The serum was resorbed at a rate of 0.064 +/- 0.023 microliter/mm2/hr, which is approximately half as fast as Hanks' solution. Both cyclic GMP and dibutyryl c...

journal_title：Investigative ophthalmology & visual science

authors： Kawano S,Marmor MF

更新日期：1988-08-01 00:00:00

abstract：Purpose:The purpose of this study was to study the effect of minocycline and several neurotrophic factors, alone or in combination, on photoreceptor survival and macro/microglial reactivity in two rat models of retinal degeneration. Methods:P23H-1 (rhodopsin mutation), Royal College of Surgeon (RCS, pigment epithelium...

journal_title：Investigative ophthalmology & visual science

authors： Di Pierdomenico J,Scholz R,Valiente-Soriano FJ,Sánchez-Migallón MC,Vidal-Sanz M,Langmann T,Agudo-Barriuso M,García-Ayuso D,Villegas-Pérez MP

更新日期：2018-09-04 00:00:00

abstract：Purpose:Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis...

journal_title：Investigative ophthalmology & visual science

authors： Denniston AK,Keane PA,Srivastava SK

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Activation of complement has been implicated as one of the major causes of age-related macular degeneration (AMD). Evidence is accumulating for a role of complement in other retinal diseases, such as diabetic retinopathy and proliferative vitreoretinopathy. Because of the paucity of animal models that directly ...

journal_title：Investigative ophthalmology & visual science

authors： Cashman SM,Desai A,Ramo K,Kumar-Singh R

更新日期：2011-05-18 00:00:00

abstract：Purpose:To examine the association between intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in high myopia. Methods:The hospital-based observational study consisted of patients treated in the Tokyo High Myopia Clinics and for whom fundus photographs and IOP readings were available. ...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nagaoka N,Fang YX,Weber P,Ohno-Matsui K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:To study the effects of nipradilol, a nonselective beta-blocker with alpha 1-blocking activity and nitroglycerin-like activity, on aqueous humor dynamics and optic nerve head (ONH) circulation in albino rabbits. METHODS:Experiments were carried out during the dark phase, in conscious rabbits conditioned to a s...

journal_title：Investigative ophthalmology & visual science

authors： Kanno M,Araie M,Tomita K,Sawanobori K

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). METHODS:We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who underwent both fluorescein angiography (FA) and volu...

journal_title：Investigative ophthalmology & visual science

authors： Hariri A,Heussen FM,Nittala MG,Sadda SR

更新日期：2013-12-09 00:00:00

abstract：PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

journal_title：Investigative ophthalmology & visual science

authors： Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Juvenile open-angle glaucoma (JOAG) differs from primary open-angle glaucoma in that it is usually a more severe phenotype and has an earlier age of onset. Optineurin was recently associated with a variant of POAG that is characterized by intraocular pressure within normal limits: normal-tension glaucoma. The p...

journal_title：Investigative ophthalmology & visual science

authors： Willoughby CE,Chan LL,Herd S,Billingsley G,Noordeh N,Levin AV,Buys Y,Trope G,Sarfarazi M,Héon E

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD). METHODS:Twenty-two EMZL and 16 RLH tissues were examined in this study. Paraformaldeh...

journal_title：Investigative ophthalmology & visual science

authors： Kinoshita S,Kase S,Ando R,Dong Z,Fukuhara J,Dong Y,Inafuku S,Noda K,Noda M,Kanda A,Ishida S

更新日期：2014-05-13 00:00:00

abstract：PURPOSE:Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mito...

journal_title：Investigative ophthalmology & visual science

authors： Joyce NC,Harris DL,Mello DM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Tissues derived from immune-privileged sites sometimes possess special characteristics that promote their own survival when transplanted to a nonprivileged site. This study was undertaken to evaluate whether retinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly....

journal_title：Investigative ophthalmology & visual science

authors： Wenkel H,Streilein JW

更新日期：2000-10-01 00:00:00

abstract：:Postmitochondrial supernatant, cytosol, and microsomes were exposed to near-ultraviolet light and assayed for incorporation of (3H)leucine. The results indicate that near-ultraviolet light decreased the incorporation of radioactivity into the aminoacyl-tRNA fraction and into proteins. This effect depended on the wavel...

journal_title：Investigative ophthalmology & visual science

authors： Matuk Y,Lou P,Parker JA

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:To investigate the foveal changes after repair of macula-off rhegmatogenous retinal detachment (RRD). METHODS:Prospective comparative case series. Twenty-four eyes of 24 patients with macula-off/fovea-on detachment (n = 9) and fovea-off detachment (n = 15) were studied. Serial optical coherence tomography (OCT...

journal_title：Investigative ophthalmology & visual science

authors： dell'Omo R,Viggiano D,Giorgio D,Filippelli M,Di Iorio R,Calo' R,Cardone M,Rinaldi M,dell'Omo E,Costagliola C

更新日期：2015-01-22 00:00:00

abstract：PURPOSE:Lens epithelial cells transdifferentiate to myofibroblasts during the formation of anterior subcapsular cataracts and secondary cataracts. One of the defining characteristics of myofibroblasts is the expression of alpha-smooth muscle actin (alpha-SMA). This study investigated some of the factors that influence ...

journal_title：Investigative ophthalmology & visual science

authors： Nagamoto T,Eguchi G,Beebe DC

更新日期：2000-04-01 00:00:00

abstract：Purpose:Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). Methods:Expression of postulated s...

journal_title：Investigative ophthalmology & visual science

authors： Doherty RE,Sisley K,Hammond DW,Rennie IG,Cross NA

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Research to restore some degree of vision to patients suffering from retinal degeneration is becoming increasingly more promising. Several groups have chosen electrical stimulation of the remaining network of a degenerate retina as a means to generate discrete light percepts (phosphenes). Approaches vary signif...

journal_title：Investigative ophthalmology & visual science

authors： Matteucci PB,Chen SC,Tsai D,Dodds CW,Dokos S,Morley JW,Lovell NH,Suaning GJ

更新日期：2013-06-21 00:00:00

abstract：PURPOSE:To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. METHODS:A rat cornea micropocket assay was used to initiate IL-6- and VEGF-mediated angiogenesis. The ability of TA or neutralizing VE...

journal_title：Investigative ophthalmology & visual science

authors： Ebrahem Q,Minamoto A,Hoppe G,Anand-Apte B,Sears JE

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS:Anterior chamber inoculation of the right ey...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen QD,Uy HS,Merchant A,Medina CA,Baltatzis S,Zhao T,Zhao ZS,Cantor H,Foster CS

更新日期：2001-10-01 00:00:00