Nonoptical determinants of aniseikonia.

abstract：:The autofluorescence of reduced pyridine nucleotides (NADH and NADPH) and oxidized flavoproteins within the rabbit cornea were noninvasively measured as a function of depth. This was accomplished by combining a corneal specular microscope with a time-shared spectrofluorometer. When either 8 mM sodium pentobarbital or ...

journal_title：Investigative ophthalmology & visual science

authors： Laing RA,Fischbarg J,Chance B

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:To investigate immediate and long-term changes in static ocular alignment with acute acquired superior oblique palsy (SOP) in monkeys. METHODS:The trochlear nerve was severed intracranially in two rhesus monkeys. After the surgery, the paretic eye was patched for 6 to 9 days, and then binocular viewing was all...

journal_title：Investigative ophthalmology & visual science

authors： Shan X,Tian J,Ying HS,Quaia C,Optican LM,Walker MF,Tamargo RJ,Zee DS

更新日期：2007-06-01 00:00:00

abstract：:Parallel studies of the ionic balance and membrane permeability characteristics of normal human lenses were carried out in three countries (USA, England and Italy). Similar age-related changes were found in each laboratory. The lens membrane potential and resistance declined markedly with age while internal Na+ and fr...

journal_title：Investigative ophthalmology & visual science

authors： Duncan G,Hightower KR,Gandolfi SA,Tomlinson J,Maraini G

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To determine the impact of substratum compliance and latrunculin-B (Lat-B), both alone and together, on fundamental human trabecular meshwork (HTM) cell behavior. Lat-B is a reversible actin cytoskeleton disruptor that decreases resistance to aqueous humor outflow and decreases intraocular pressure. METHODS:HT...

journal_title：Investigative ophthalmology & visual science

authors： Wood JA,McKee CT,Thomasy SM,Fischer ME,Shah NM,Murphy CJ,Russell P

更新日期：2011-12-02 00:00:00

abstract：PURPOSE:The association of age and blood pressure (BP) with retinal vessel change is widely reported, with inverse relationships between retinal arteriolar and venular diameter and increasing age and elevated BP. No previous studies have dissected the separate effects of age and BP on the diameter of retinal vessels. ...

journal_title：Investigative ophthalmology & visual science

authors： Kaushik S,Kifley A,Mitchell P,Wang JJ

更新日期：2007-02-01 00:00:00

abstract：Purpose:Sjögren syndrome (SS) is an autoimmune disease characterized by the inflammatory destruction of salivary and lacrimal glands (LG). Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy. The purpose of the study is to investigate the effect of CQ on the development of dry eye ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HJ,Shin S,Yoon SG,Cheon EJ,Chung SH

更新日期：2019-09-03 00:00:00

abstract：:Glaucoma has been known to be associated with a loss of retinal ganglion cells and their axons throughout the fundus and a decreased count of photoreceptors and retinal pigment epithelial (RPE) cells in the parapapillary region. This study investigated whether glaucomatous changes of the deep retinal layer occur outsi...

journal_title：Investigative ophthalmology & visual science

authors： Panda S,Jonas JB

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:We compared the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. METHODS:The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits recei...

journal_title：Investigative ophthalmology & visual science

authors： Min J,Lukowski ZL,Levine MA,Meyers CA,Beattie AR,Schultz GS,Samuelson DA,Sherwood MB

更新日期：2012-11-19 00:00:00

abstract：PURPOSE:To detect the expression of cell adhesion molecules (CAMs), including beta integrins, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1, leukocyte-endothelial cell adhesion molecule-2, E-cadherin, and CD44, in cultured lens epithelial cells (LECs) of human cataracts. To show that LEC...

journal_title：Investigative ophthalmology & visual science

authors： Nishi O,Nishi K,Akaishi T,Shirasawa E

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT). METHODS:Laser photocoagulation was applied to the mouse fundus using a 532-nm diode laser (100, 150, and 200 mW; 100-μm diameter, 0.1-second duration). SD-O...

journal_title：Investigative ophthalmology & visual science

authors： Giani A,Thanos A,Roh MI,Connolly E,Trichonas G,Kim I,Gragoudas E,Vavvas D,Miller JW

更新日期：2011-06-01 00:00:00

abstract：Purpose:To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods:In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Ret...

journal_title：Investigative ophthalmology & visual science

authors： Lei J,Yi E,Suo Y,Chen C,Xu X,Ding W,Abdelfattah NS,Fan X,Lu H

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:The accessory lacrimal glands are assumed to contribute to the production of tear fluid, but little is known about their function. The goal of this study was to conduct an analysis of gene expression by glands of Wolfring that would provide a more complete picture of the function of these glands. METHODS:Gland...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Gipson IK,Spurr-Michaud SJ,Tisdale AS,Van Dyken RE,Hatton MP

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：:Prostaglandins and other eicosanoids in the trabecular meshwork may play important physiological and pharmacological roles in the aqueous outflow pathway. In the present studies, we employed [14C]-arachidonic acid to explore potentially important pathways for the production of eicosanoids in cultured human trabecular ...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Polansky JR,Alvarado JA,Mitchell MD

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts. METHODS:The GJA8 gene was directly sequenced. Formation of functional channels was assessed by the two-microelectrode voltage-clamp METHOD:Connexin protein levels and distribu...

journal_title：Investigative ophthalmology & visual science

authors： Minogue PJ,Tong JJ,Arora A,Russell-Eggitt I,Hunt DM,Moore AT,Ebihara L,Beyer EC,Berthoud VM

更新日期：2009-12-01 00:00:00

abstract：Purpose:To determine the riboflavin concentration in the posterior corneal stroma, Descemet's membrane, and endothelium prior to UV irradiation in corneal cross-linking (CXL) in humans. Methods:Five human deepithelialized cadaver corneas were mounted into artificial anterior chambers. After the establishment of stable...

journal_title：Investigative ophthalmology & visual science

authors： Seiler TG,Batista A,Frueh BE,Koenig K

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00

abstract：:Increased vascular permeability, one of the characteristic features of immediate hypersensitivity (Type I), is mediated through a variety of compounds, including histamine and platelet-activating factor (PAF), a phospholipid inflammatory mediator. The effects on vascular permeability of histamine, PAF, and ethanol, th...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Roth SI,Kim ED,Walsh MK,Thamman R

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Peroxynitrite generated during the early phase of experimental autoimmune uveoretinitis (EAU) causes peroxidation of docosahexaenoic acid (22:6), a principal unsaturated fatty acid of the photoreceptor membrane, to its hydroperoxide (22:6HP). During this phase, microglia migrate to the site of photoreceptors. T...

journal_title：Investigative ophthalmology & visual science

authors： Saraswathy S,Wu G,Rao NA

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Genetic modification of cells before transplantation may allow the delivery of neuroprotective and other functional molecules to patients with neurodegenerative diseases. To avoid complications associated with virally transfected cells, we have explored the use of nonviral methods to insert genetic material int...

journal_title：Investigative ophthalmology & visual science

authors： Johnen S,Kazanskaya O,Armogan N,Stickelmann C,Stöcker M,Walter P,Thumann G

更新日期：2011-07-23 00:00:00

abstract：PURPOSE:Adeno-associated viral (AAV) vectors have been used to express several different proteins in the eye. The purpose of this study was to determine whether AAV-mediated intraocular gene transfer of pigment epithelium-derived factor (PEDF) inhibits the development of choroidal neovascularization (CNV) in a murine m...

journal_title：Investigative ophthalmology & visual science

authors： Mori K,Gehlbach P,Yamamoto S,Duh E,Zack DJ,Li Q,Berns KI,Raisler BJ,Hauswirth WW,Campochiaro PA

更新日期：2002-06-01 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:To investigate thickness profile changes of the corneal epithelium and Bowman's layer at the vertical and horizontal meridians with overnight myopia orthokeratology (OK) lenses. METHODS:Twenty subjects (age range: 19-33 years) wore reverse-geometry rigid gas-permeable OK lenses in both eyes for 30 days. Before...

journal_title：Investigative ophthalmology & visual science

authors： Lian Y,Shen M,Jiang J,Mao X,Lu P,Zhu D,Chen Q,Wang J,Lu F

更新日期：2013-01-23 00:00:00

abstract：PURPOSE:To optimize a nonviral gene transfection system targeting the corneal limbal stem/progenitor cells. METHODS:A plasmid containing LacZ gene coding for beta-galactosidase (beta-gal) was transfected into human corneal epithelial cells (HCECs) and multilineage progenitor cells (MLPCs) with different transfection r...

journal_title：Investigative ophthalmology & visual science

authors： Zhao B,Allinson SL,Ma A,Bentley AJ,Martin FL,Fullwood NJ

更新日期：2008-08-01 00:00:00

abstract：:In cell culture, azelaic acid (C9) has been shown to have an antiproliferative and cytotoxic effect on human and murine malignant cutaneous melanocytes. Normal melanocytes are unaffected, as are normal choroidal melanocytes. Here, effects on cell kinetics and ultrastructure of cells of a human choroidal melanoma line ...

journal_title：Investigative ophthalmology & visual science

authors： Breathnach AS,Robins EJ,Pätzold HC,Bhasin YP,Ethridge LB,Garner A,Nazzaro-Porro M

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:Keratoconus is characterized by thinning and scarring of the central region of the cornea. Previous research showed that, in corneas obtained from patients with keratoconus, lysosomal enzyme activities are elevated, whereas levels of protease inhibitors such as alpha1-proteinase inhibitor are reduced. This stud...

journal_title：Investigative ophthalmology & visual science

authors： Zhou L,Sawaguchi S,Twining SS,Sugar J,Feder RS,Yue BY

更新日期：1998-06-01 00:00:00

abstract：Purpose:Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis...

journal_title：Investigative ophthalmology & visual science

authors： Denniston AK,Keane PA,Srivastava SK

更新日期：2017-05-01 00:00:00

abstract：Purpose:To ascertain cellular constituents within islands of preserved retina in choroideremia (CHM) by multimodal imaging. Methods:CHM probands (16) and female carriers (9) of CHM were studied. Near-infrared autofluorescence (NIR-AF; 787-nm excitation; emission, >830 nm), short-wavelength autofluorescence (SW-AF; 488...

journal_title：Investigative ophthalmology & visual science

authors： Paavo M,Carvalho JRL Jr,Lee W,Sengillo JD,Tsang SH,Sparrow JR

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To develop a sensitive and reproducible technique for measuring the adherence of blood lymphocytes to vessel walls exposed in sections of human retina and for examining the role of lymphocyte and vascular adhesion molecules in these events. METHODS:Cryostat sections of human retina were overlaid with blood lym...

journal_title：Investigative ophthalmology & visual science

authors： Hill TA,Stanford MR,Graham EM,Dumonde DC,Brown KA

更新日期：1997-11-01 00:00:00

abstract：:PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu. METHODS. Primary RPE cell cultures were established from human donor eyes and screened f...

journal_title：Investigative ophthalmology & visual science

authors： An E,Sen S,Park SK,Gordish-Dressman H,Hathout Y

更新日期：2010-07-01 00:00:00