Riboflavin Concentrations at the Endothelium During Corneal Cross-Linking in Humans.

abstract：PURPOSE:Optical coherence tomography (OCT) can monitor for glaucoma by measuring dimensions of the optic nerve head (ONH) cup and disc. Multiple clinical studies have shown that different OCT devices yield different estimates of retinal dimensions. We developed phantoms mimicking ONH morphology as a new way to compare ...

journal_title：Investigative ophthalmology & visual science

authors： Agrawal A,Baxi J,Calhoun W,Chen CL,Ishikawa H,Schuman JS,Wollstein G,Hammer DX

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Sildenafil increases ocular blood flow. Thus, the authors investigated if it also increases anterior chamber (AC) refilling after paracentesis. METHODS:Corriedale sheep and albino rabbits were used as animal models. Intraocular pressure (IOP) was measured, paracentesis performed on one eye, and AC refilling fo...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Alvarez LJ,Candia OA

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Animal studies suggest that the periphery of the eye plays a major role in emmetropization. It is also known that human myopes tend to have relative peripheral hyperopia compared to the foveal refraction. This study investigated peripheral sensitivity to defocus in human subjects, specifically whether myopes ar...

journal_title：Investigative ophthalmology & visual science

authors： Rosén R,Lundström L,Unsbo P

更新日期：2012-10-17 00:00:00

abstract：:The immunolabeling patterns for vimentin and glial fibrillary acidic protein (GFAP) were studied in five rhesus monkeys that had undergone retinal detachment or detachment and reattachment. Anti-vimentin and anti-GFAP labeling intensity increased in Müller cells after 2 days of detachment. Weak anti-vimentin labeling ...

journal_title：Investigative ophthalmology & visual science

authors： Guérin CJ,Anderson DH,Fisher SK

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:We investigated the response of retinal vessel diameters and oxygen saturation to flicker light stimulation of neuronal activity in patients with diabetic retinopathy. METHODS:We included 18 patients with nonproliferative diabetic retinopathy (mean age 62.2 ± 8.3 years, diabetes type 1 in 4 patients and type 2...

journal_title：Investigative ophthalmology & visual science

authors： Hammer M,Heller T,Jentsch S,Dawczynski J,Schweitzer D,Peters S,Schmidtke KU,Müller UA

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the sh1 alleles examined hav...

journal_title：Investigative ophthalmology & visual science

authors： Libby RT,Steel KP

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Intraocular pressure (IOP) is dynamic and can be influenced by the use of tonometers. The authors developed a technique to implant a telemetric pressure transducer to measure IOP continuously in unrestrained rabbits. METHODS:A commercial telemetric pressure transducer was implanted subcutaneously on the dorsal...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF,FitzSimon JS

更新日期：1996-05-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS:TM specimens were collected from 146 patie...

journal_title：Investigative ophthalmology & visual science

authors： Fernández-Durango R,Fernández-Martínez A,García-Feijoo J,Castillo A,de la Casa JM,García-Bueno B,Pérez-Nievas BG,Fernández-Cruz A,Leza JC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Adult salamander photoreceptors retract existing axons and extend new neuritic processes in vitro. In mammalian retina, similar forms of structural plasticity occur in injury and disease. The authors asked whether RhoA is present in photoreceptor axon terminals and whether activity in the RhoA-ROCK pathway cont...

journal_title：Investigative ophthalmology & visual science

authors： Fontainhas AM,Townes-Anderson E

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:This study was conducted to explore the association of autophagy-related genes (ATGs) single nucleotide polymorphisms (SNPs) with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS:A two-stage association study was carried out in 940 BD, 1061 VKH, and 2007 health...

journal_title：Investigative ophthalmology & visual science

authors： Zheng M,Yu H,Zhang L,Li H,Liu Y,Kijlstra A,Yang P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG). METHODS:Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork....

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Burgoyne CF,Cull G,Thompson S,Fortune B

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Multidrug resistance protein 4 (MRP4) effluxes a wide variety of endogenous compounds, including cyclic adenosine monophosphate (cAMP), and is exclusively expressed in vascular endothelial cells (ECs) of the retina. This study aimed to investigate the role of MRP4 in retinal vascular development. METHODS:The r...

journal_title：Investigative ophthalmology & visual science

authors： Matsumiya W,Kusuhara S,Hayashibe K,Maruyama K,Kusuhara H,Tagami M,Schuetz JD,Negi A

更新日期：2012-12-07 00:00:00

abstract：:In recent years, there has been great interest in recording the pattern electroretinogram (PERG) in glaucomatous and diabetic populations. The Dawson, Trick, and Litzkow thread electrode (DTLTE) and the gold foil electrode (GFE), commonly used for recording PERGs, were compared for variations in amplitude of response,...

journal_title：Investigative ophthalmology & visual science

authors： Prager TC,Saad N,Schweitzer FC,Garcia CA,Arden GB

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). METHODS:We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who underwent both fluorescein angiography (FA) and volu...

journal_title：Investigative ophthalmology & visual science

authors： Hariri A,Heussen FM,Nittala MG,Sadda SR

更新日期：2013-12-09 00:00:00

abstract：:The free epsilon-amino groups and 5-hydroxymethylfurfural (5-HMF) contents were determined in soluble and insoluble proteins of clear human lenses and diabetic and nondiabetic senile cataractous lenses. The free epsilon-amino group content of soluble proteins in diabetic cataracts was decreased by 37% (P less than 0.0...

journal_title：Investigative ophthalmology & visual science

authors： Rao GN,Cotlier E

更新日期：1986-01-01 00:00:00

abstract：Purpose:To assess the phenotypic variability and natural course of inherited retinal diseases (IRDs) caused by EYS mutations. Methods:Multiethnic cohort study (N = 30) with biallelic EYS variants from a clinical IRD database (retinitis pigmentosa [RP], N = 27; cone-rod dystrophy [CRD], N = 1; and macular dystrophy, N ...

journal_title：Investigative ophthalmology & visual science

authors： Pierrache LHM,Messchaert M,Thiadens AAHJ,Haer-Wigman L,de Jong-Hesse Y,van Zelst-Stams WAG,Collin RWJ,Klaver CCW,van den Born LI

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:BetaIG-H3 is a TGF-beta-induced cell adhesion molecule, the mutations of which are responsible for a group of 5q31-linked corneal dystrophies. The characteristic findings in these diseases are accumulation of protein deposits of different ultrastructures. To understand the mechanisms of protein deposits in 5q31...

journal_title：Investigative ophthalmology & visual science

authors： Kim JE,Park RW,Choi JY,Bae YC,Kim KS,Joo CK,Kim IS

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delinea...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2014-03-28 00:00:00

abstract：PURPOSE:Visibility of low-spatial frequency stimuli improves when their contrast is modulated at 5 to 10 Hz compared with stationary stimuli. Therefore, temporal modulations of visual objects could enhance the performance of low vision patients who primarily perceive images of low-spatial frequency content. We investig...

journal_title：Investigative ophthalmology & visual science

authors： Watson LM,Strang NC,Scobie F,Love GD,Seidel D,Manahilov V

更新日期：2012-09-06 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:To design a contrast sensitivity perimetry (CSP) protocol that decreases variability in glaucomatous defects while maintaining good sensitivity to glaucomatous loss. METHODS:Twenty patients with glaucoma and 20 control subjects were tested with a CSP protocol implemented on a monitor-based testing station. In ...

journal_title：Investigative ophthalmology & visual science

authors： Hot A,Dul MW,Swanson WH

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The hypothesis in the study was that androgens control meibomian gland function, regulate the quality and/or quantity of lipids produced by this tissue, and promote the formation of the tear film's lipid layer. To test this hypothesis, a study was conducted to determine whether androgen receptor protein exists ...

journal_title：Investigative ophthalmology & visual science

authors： Sullivan DA,Sullivan BD,Ullman MD,Rocha EM,Krenzer KL,Cermak JM,Toda I,Doane MG,Evans JE,Wickham LA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：PURPOSE:To determine a time window in the rhodopsin knockout (Rho(-/-)) mouse during which retinal function is already sufficiently developed but cone degeneration is not yet substantial, thus representing an all-cone retina. METHODS:Electroretinograms (ERGs) were obtained from 14 homozygous Rho(-/-) mice and eight C5...

journal_title：Investigative ophthalmology & visual science

authors： Jaissle GB,May CA,Reinhard J,Kohler K,Fauser S,Lütjen-Drecoll E,Zrenner E,Seeliger MW

更新日期：2001-02-01 00:00:00

abstract：:The therapeutic effect of citrate on alkali-burned eyes is thought to be the result of inhibition of PMN activities while ascorbate apparently stimulates the production of new collagen by scorbutic fibroblasts. Attachment of PMNs to the vascular endothelium is the initial PMN response to mediators and must occur befor...

journal_title：Investigative ophthalmology & visual science

authors： Pfister RR,Haddox JL,Snyder TL

更新日期：1988-06-01 00:00:00

abstract：PURPOSE:Looping patterns rich in laminin are present in tissue samples of primary aggressive human uveal melanomas and their metastases. Because these extravascular patterns connect to blood vessels and transmit fluid in vitro and in vivo, the three-dimensional configuration of these patterns has been the subject of co...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Ai Z,Rasmussen M,Bajcsy P,Auvil L,Welge M,Leach L,Vangveeravong S,Maniotis AJ,Folberg R

更新日期：2003-07-01 00:00:00