A method for preparing a viable corneal endothelial layer, completely denuded of overlying stroma.

abstract：PURPOSE:To investigate whether signaling pathways that incorporate protein tyrosine kinases and phosphatases regulate PKC-sensitive, volume-sensitive Cl(-) currents (I(Cl,vol)) in cultured rabbit nonpigmented ciliary epithelial cells. METHODS:Activation of I(Cl,vol) in response to hyposmotic stimulation was recorded w...

journal_title：Investigative ophthalmology & visual science

authors： Shi C,Barnes S,Coca-Prados M,Kelly ME

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Vitamin D3 is a secosteroid mainly synthesized from the conversion of the skin precursor 7-dehydrocholesterol (7DHC) to vitamin D3 by ultraviolet (UV) B sunlight. Extrarenal synthesis of vitamin D3 has been reported in many tissues and cells, including barrier sites. This study characterizes the expression of c...

journal_title：Investigative ophthalmology & visual science

authors： Alsalem JA,Patel D,Susarla R,Coca-Prados M,Bland R,Walker EA,Rauz S,Wallace GR

更新日期：2014-04-07 00:00:00

abstract：:Bovine corneal endothelial cells in culture synthesize predominantly type III collagen, unlike rabbit corneal endothelial cultures which synthesize type IV collagen. In an attempt to document whether this type III collagen synthesis by bovine cells is a tissue culture-specific phenomenon, collagens synthesized by orga...

journal_title：Investigative ophthalmology & visual science

authors： Kay EP,Oh S

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting oxidative stress-induced damage to RPE...

journal_title：Investigative ophthalmology & visual science

authors： He Y,Leung KW,Ren Y,Pei J,Ge J,Tombran-Tink J

更新日期：2014-09-11 00:00:00

abstract：PURPOSE:To describe refractive status in children and young adults with cerebral palsy (CP) and relate refractive error to standardized measures of type and severity of CP impairment and to ocular dimensions. METHODS:A population-based sample of 118 participants aged 4 to 23 years with CP (mean 11.64 +/- 4.06) and an ...

journal_title：Investigative ophthalmology & visual science

authors： Saunders KJ,Little JA,McClelland JF,Jackson AJ

更新日期：2010-06-01 00:00:00

abstract：Purpose:To discover novel therapies that lower IOP by increasing aqueous humor outflow facility, ex vivo ocular perfusion systems provide a valuable tool. However, currently available designs are limited by their throughput. Here we report the development of a compact, scalable perfusion system with improved throughput...

journal_title：Investigative ophthalmology & visual science

authors： Zhou EH,Paolucci M,Dryja TP,Manley T,Xiang C,Rice DS,Prasanna G,Chen A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To evaluate the refractive status and optical components in school age children born prematurely and to examine the risk factors associated with refractive errors. METHODS:The participants were a cohort of children aged 7 to 9 years with gestational age less than 35 weeks or birth weight less than 1500 g. The ...

journal_title：Investigative ophthalmology & visual science

authors： Chen TC,Tsai TH,Shih YF,Yeh PT,Yang CH,Hu FC,Lin LL,Yang CM

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Neovascular age-related macular degeneration (AMD) resulting in decreased central vision severely impairs affected individuals. Current standard treatment is an intravitreal anti-VEGF therapy (ranibizumab), but responses to treatment show large variability. Genetic factors that influence AMD and that affect the...

journal_title：Investigative ophthalmology & visual science

authors： Kloeckener-Gruissem B,Barthelmes D,Labs S,Schindler C,Kurz-Levin M,Michels S,Fleischhauer J,Berger W,Sutter F,Menghini M

更新日期：2011-07-01 00:00:00

abstract：:Intravitreal membranes from patients with proliferative vitreoretinopathy (PVR) consist partly of retinal glial (RG) and retinal pigment epithelial (RPE) cells surrounded by varying amounts of extracellular matrix (ECM). The contribution of the ECM to the growth of PVR membranes is unknown. This study was undertaken t...

journal_title：Investigative ophthalmology & visual science

authors： Williams DF,Burke JM

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:To compare the Swedish interactive thresholding algorithm (SITA) with the full-threshold (FT) strategy for short-wavelength automated perimetry (SWAP). METHODS:One eye of 286 patients with glaucomatous optic neuropathy (GON) and 289 age-matched participants without GON from the Diagnostic Innovations in Glauco...

journal_title：Investigative ophthalmology & visual science

authors： Ng M,Racette L,Pascual JP,Liebmann JM,Girkin CA,Lovell SL,Zangwill LM,Weinreb RN,Sample PA

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Juvenile neuronal ceroid lipofuscinosis (JNCL or Batten Disease) is one of the most common progressive neurodegenerative disorders of childhood, resulting from autosomal recessive inheritance of mutations in the CLN3 gene. Pathologically, Batten disease is characterized by lysosomal storage of autofluorescent m...

journal_title：Investigative ophthalmology & visual science

authors： Chattopadhyay S,Kingsley E,Serour A,Curran TM,Brooks AI,Pearce DA

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aim...

journal_title：Investigative ophthalmology & visual science

authors： Ng SK,Burdon KP,Fitzgerald JT,Zhou T,Fogarty R,Souzeau E,Landers J,Mills RA,Casson RJ,Ridge B,Graham SL,Hewitt AW,Mackey DA,Healey PR,Wang JJ,Mitchell P,MacGregor S,Craig JE

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, and endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Exercise and posture changes can be used to manipulate blood pressure, ocular perfusion pressure (OPP), or both. It was hypothes...

journal_title：Investigative ophthalmology & visual science

authors： Khayi H,Pepin JL,Geiser MH,Tonini M,Tamisier R,Renard E,Baguet JP,Levy P,Romanet JP,Chiquet C

更新日期：2011-12-16 00:00:00

abstract：PURPOSE:This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. METHODS:Control and streptozotocin (STZ)-diabetic rats were treated with or without the PARP inhibitors 1,5-isoquinolinediol (ISO; 3 mg kg(-1) d(-1) intraperitoneally) and 10-(4-...

journal_title：Investigative ophthalmology & visual science

authors： Drel VR,Xu W,Zhang J,Kador PF,Ali TK,Shin J,Julius U,Slusher B,El-Remessy AB,Obrosova IG

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To evaluate the structure-function relationship between ganglion cell-inner plexiform layer (GCIPL) thickness at the macula and 10-2 standard automated perimetry (SAP) in glaucoma and to evaluate the relationship using a recently proposed linear model. METHODS:In a cross-sectional analysis, structure-function ...

journal_title：Investigative ophthalmology & visual science

authors： Rao HL,Qasim M,Hussain RS,Januwada M,Pillutla LN,Begum VU,Chaitanya A,Senthil S,Garudadri CS

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To determine the distribution of perceived visual ability for functional vision performance among persons with low vision in the Indian state of Andhra Pradesh. METHODS:As part of a population-based epidemiologic study, the Andhra Pradesh Eye Disease Study (APEDS), a 16-item visual function questionnaire was d...

journal_title：Investigative ophthalmology & visual science

authors： Nutheti R,Shamanna BR,Krishnaiah S,Gothwal VK,Thomas R,Rao GN

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To investigate the effect of high glucose on the proliferation of human retinal endothelial cells (HRECs) and to elucidate the possible mechanisms of antiangiogenic activity of curcumin, a diferuloylmethane. METHODS:Human retinal endothelial cells were isolated from the retinal tissue obtained from human donor...

journal_title：Investigative ophthalmology & visual science

authors： Premanand C,Rema M,Sameer MZ,Sujatha M,Balasubramanyam M

更新日期：2006-05-01 00:00:00

abstract：:In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Foley KM,Rismondo V

更新日期：1986-08-01 00:00:00

abstract：Purpose:We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods:MPOD was measured using the two-wavelength autofluorescence method with a modif...

journal_title：Investigative ophthalmology & visual science

authors： Ajana S,Weber D,Helmer C,Merle BM,Stuetz W,Dartigues JF,Rougier MB,Korobelnik JF,Grune T,Delcourt C,Féart C

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Fluorescein and rose bengal are dyes used routinely in the examination of the ocular surface. As part of an ongoing search for a superior ophthalmic dye with optimal specificity and sensitivity and a lack of interference with subsequent viral cultures, and as part of studies that use chemical dyes to understand...

journal_title：Investigative ophthalmology & visual science

authors： Chodosh J,Dix RD,Howell RC,Stroop WG,Tseng SC

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

journal_title：Investigative ophthalmology & visual science

authors： Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

更新日期：2001-05-01 00:00:00

abstract：:Voluntary vertical saccades were recorded in five normal human subjects with electro-oculography (EOG), an infrared, limbus tracking system (IR), and a magnetic scleral search coil method. The peak velocity-amplitude relationships of up and down saccades were measured during refixations across the center of the orbit ...

journal_title：Investigative ophthalmology & visual science

authors： Yee RD,Schiller VL,Lim V,Baloh FG,Baloh RW,Honrubia V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To investigate the pharmacologic effect of tetramethylpyrazine (TMP) on human Tenon's fibroblasts (HTFs), the cells implicated in scarring after filtration surgery. METHODS:Transforming growth factor-β2 (TGF-β2) was used to stimulate a fibrotic phenotype in primary HTFs, and the influence of TMP on the fibroti...

journal_title：Investigative ophthalmology & visual science

authors： Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To characterize the phagocytosis of extracellular matrix components by retinal pigment epithelial cells and to determine which receptors and signal transduction pathways are involved. METHODS:Fluorescent latex beads were coated with fibronectin (FN), collagen type I or IV, or thrombospondin and incubated with ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao MW,Jin ML,He S,Spee C,Ryan SJ,Hinton DR

更新日期：1999-10-01 00:00:00

abstract：Purpose:To investigate diurnal variation in the length of mouse rod outer segments in vivo. Methods:The lengths of rod inner and outer segments (RIS, ROS) of dark-adapted albino mice maintained on a 12-hour dark:12-hour light cycle with light onset 7 AM were measured at prescribed times (6:30 AM, 11 AM, 3:30 PM) durin...

journal_title：Investigative ophthalmology & visual science

authors： Zhang P,Shibata B,Peinado G,Zawadzki RJ,FitzGerald P,Pugh EN Jr

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To investigate in vitro the cell toxicity and antioxidant effects of two major tear substitutes, hyaluronic acid and a widely used carbomer, with and without preservative. METHODS:Chang conjunctival cells were treated with different concentrations of unpreserved or preserved carbomer 934P (0.03% and 0.3%), unp...

journal_title：Investigative ophthalmology & visual science

authors： Debbasch C,De La Salle SB,Brignole F,Rat P,Warnet JM,Baudouin C

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:This study explores the order of assembly of the lens fiber cell plasma membrane. Because the lens must synthesize most of its membrane components, our approach was to map directly the spatial distribution of cholesterol, fatty acid (reflecting phospholipid), and the main intrinsic protein, MP26, synthesis in t...

journal_title：Investigative ophthalmology & visual science

authors： Cenedella RJ

更新日期：1993-06-01 00:00:00

abstract：Purpose:To evaluate the corneal endothelial characteristics across the primary angle closure (PAC) disease spectrum amongst patients diagnosed as PAC suspects (PACS), PAC, PAC glaucoma (PACG), and previous acute PAC (APAC). Methods:We analyzed a total of 529 subjects (51 PACS, 170 PAC, 234 PACG, and 74 with previous A...

journal_title：Investigative ophthalmology & visual science

authors： Verma S,Nongpiur ME,Husain R,Wong TT,Boey PY,Quek D,Perera SA,Aung T

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:To determine the impact of repetitive nonlethal oxidant injury with hydroquinone (HQ) on regulation of cell membrane blebbing and molecules, which are essential in extracellular matrix turnover (ECM) maintenance, especially matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-2, and type IV collagen...

journal_title：Investigative ophthalmology & visual science

authors： Marin-Castaño ME,Striker GE,Alcazar O,Catanuto P,Espinosa-Heidmann DG,Cousins SW

更新日期：2006-09-01 00:00:00

abstract：:A method of analysing fluorescein angiograms that yields a parameter of intraocular blood flow designated as the fluorescein appearance rate is presented. The appearance rate was decreased in those eyes in which intraocular pressure (Pi) was found to be increased. The appearance rate was also decreased in the two case...

journal_title：Investigative ophthalmology & visual science

authors： Moses RA

更新日期：1983-03-01 00:00:00