A Compact Whole-Eye Perfusion System to Evaluate Pharmacologic Responses of Outflow Facility.

abstract：PURPOSE:To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. METHODS:In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared refl...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Ayton LN,Makeyeva G,Guymer RH,Luu CD

更新日期：2015-03-03 00:00:00

abstract：:PURPOSE. To investigate the anti-inflammatory effect of aminoimidazole carboxamide ribonucleotide (AICAR), an analog of adenosine monophosphate (AMP), in endotoxin-induced uveitis (EIU). METHODS. EIU was induced by subcutaneous injection of lipopolysaccharide (LPS) (200 μg) in Lewis rats. AICAR (50 mg/kg, intraperiton...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki J,Manola A,Murakami Y,Morizane Y,Takeuchi K,Kayama M,Miller JW,Sobrin L,Vavvas DG

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:To investigate the role of angiopoietin-1 (Ang1) in choroidal neovascularization (CNV) and vascular leakage. METHODS:We generated laser-induced CNV in mice and measured the size of CNV and vascular leakage after intravitreal administration of Ang1. The expressions and distributions of endothelial junctional pr...

journal_title：Investigative ophthalmology & visual science

authors： Lee J,Park DY,Park DY,Park I,Chang W,Nakaoka Y,Komuro I,Yoo OJ,Koh GY

更新日期：2014-04-07 00:00:00

abstract：Purpose:To investigate whether rapamycin protects tear production and the ocular surface during endoplasmic reticulum (ER) stress-induced dry eye syndrome in mice. Methods:Tunicamycin was injected intraperitoneally in BALB/c mice without or with rapamycin (TM or RM5 group). Peritoneal injection of PBS performed in veh...

journal_title：Investigative ophthalmology & visual science

authors： Cho BJ,Hwang JS,Shin YJ,Kim JW,Chung TY,Hyon JY

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:We measured the aqueous humor levels of matrix metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP) TIMP-1, TIMP-2, and TIMP-3 in patients with myopia or cataract, and investigated the relationship between their levels and axial length (AL). METHODS:We measure...

journal_title：Investigative ophthalmology & visual science

authors： Jia Y,Hu DN,Zhu D,Zhang L,Gu P,Fan X,Zhou J

更新日期：2014-05-29 00:00:00

abstract：PURPOSE:Classic studies have demonstrated that corneal epithelial cell density in culture can alter the balance of stimulatory and inhibitory cytokines controlling the elaboration of collagenolytic activity by co-cultured stromal cells. The current study attempts to bring the understanding of this mechanism to a molecu...

journal_title：Investigative ophthalmology & visual science

authors： Strissel KJ,Rinehart WB,Fini ME

更新日期：1997-02-01 00:00:00

abstract：Purpose:To improve the transparency of the acellular dermal matrix (ADM) and investigate the optical, mechanical and histologic properties and biocompatibility of transparent ADM (TADM) in lamellar keratoplasty. Methods:A stepwise sectioning strategy was applied to determine the transparency distribution of the ADM, a...

journal_title：Investigative ophthalmology & visual science

authors： Wang Y,Ma J,Jiang X,Liu Z,Yang J,Li X

更新日期：2020-01-23 00:00:00

abstract：PURPOSE:To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. METHODS:The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) prolife...

journal_title：Investigative ophthalmology & visual science

authors： Hos D,Regenfuss B,Bock F,Onderka J,Cursiefen C

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

journal_title：Investigative ophthalmology & visual science

authors： Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

更新日期：2015-06-01 00:00:00

abstract：:The role of heterozygous galactokinase deficiency in the development of presenile cataracts is presently undetermined. Erythrocyte galactokinase activity was measured from 95 normal Caucasian subjects and from 39 Caucasian patients who had developed idiopathic bilateral cataracts between ages 20 and 55. The diagnosis ...

journal_title：Investigative ophthalmology & visual science

authors： Stambolian D,Scarpino-Myers V,Eagle RC Jr,Hodes B,Harris H

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. METHODS:Temporal, rather than spatial, resolution was investigated in pa...

journal_title：Investigative ophthalmology & visual science

authors： Spang K,Fahle M

更新日期：2009-11-01 00:00:00

abstract：Purpose:Purpose The role of endothelial Yes-associated protein 1 (YAP) in the pathogenesis of retinal angiogenesis and the astrocyte network in the mouse oxygen-induced retinopathy (OIR) model is unknown. Methods:For in vivo studies, OIR was induced in conditional endothelial YAP knockout mice and their wild-type litt...

journal_title：Investigative ophthalmology & visual science

authors： Ai LQ,Zhu JY,Chen X,Li X,Luo LL,Hu QM,Lin S,Ye J

更新日期：2020-04-09 00:00:00

abstract：PURPOSE:To determine some of the mechanisms by which substance P (SP) induces contraction in the isolated rat iris. METHODS:Rings of rat iris were mounted in a 5-ml organ chamber containing Krebs solution at 37 degrees C under basal tension of 75 mg, and isometric tension was recorded. RESULTS:Substance P produced gr...

journal_title：Investigative ophthalmology & visual science

authors： Grumann-Júnior A,Dias MA,Alves RV,Boteon JE,Calixto JB

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:The authors compared the efficacy of two different forms of flicker perimetry: temporal modulation perimetry (TMP), which measures contrast thresholds for a fixed temporal frequency, and critical flicker frequency (CFF), which measures the highest frequency for which flicker is detected at a fixed contrast. ME...

journal_title：Investigative ophthalmology & visual science

authors： Yoshiyama KK,Johnson CA

更新日期：1997-10-01 00:00:00

abstract：:In orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. The density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794...

journal_title：Investigative ophthalmology & visual science

authors： Allansmith MR,Baird RS,Kashima K,Bloch KJ

更新日期：1979-08-01 00:00:00

abstract：PURPOSE:To determine the possible antiangiogenic effect of metalloproteinase (MMP) 14 cleavage of vascular endothelial growth factor receptor 1 (VEGFR1) in the cornea. METHODS:Recombinant mouse (rm) VEGFR1 was incubated with various concentrations of recombinant MMP14 to examine proteolysis in vitro. The reaction mixt...

journal_title：Investigative ophthalmology & visual science

authors： Han KY,Dugas-Ford J,Lee H,Chang JH,Azar DT

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:This study was designed to investigate the suppressive effects of antithrombin (AT)III on inflammatory reactions during endotoxin-induced uveitis (EIU) in rats by studying leukocyte-endothelium interactions. METHODS:EIU was induced in Lewis rats by footpad injection of lipopolysaccharide (LPS). ATIII was admin...

journal_title：Investigative ophthalmology & visual science

authors： Yamashiro K,Kiryu J,Tsujikawa A,Honjo M,Nonaka A,Miyamoto K,Honda Y,Tanihara H,Ogura Y

更新日期：2001-06-01 00:00:00

abstract：Purpose:To quantify the effect of induced stray light on halo size, luminance threshold, and contrast sensitivity. Methods:Retinal stray light was induced in five healthy subjects using different photographic filters. The stray light induced ranged from levels observed in intraocular lenses (IOLs) with glistenings (lo...

journal_title：Investigative ophthalmology & visual science

authors： van der Mooren M,Rosén R,Franssen L,Lundström L,Piers P

更新日期：2016-10-01 00:00:00

abstract：:Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave im...

journal_title：Investigative ophthalmology & visual science

authors： Witzel DA,Smith EL,Wilson RD,Aguirre GD

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:To determine whether adenovirus vectors are capable of transferring a foreign active protein to the perfused anterior segment of the human eye. METHODS:Primary cultures from the human trabecular meshwork tissue were exposed to replication-deficient adenovirus Av1LacZ4 carrying the reporter beta-galactosidase g...

journal_title：Investigative ophthalmology & visual science

authors： Borrás T,Matsumoto Y,Epstein DL,Johnson DH

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Our study aimed to explore the heritability of retinal vascular caliber among Singapore Chinese families. METHODS:In the Strabismus, Amblyopia, and Refractive Error Study in Singaporean Chinese Preschoolers (STARS) family study conducted from 2008 to 2010, a total of 727 participants (304 parent-child pairs, 8...

journal_title：Investigative ophthalmology & visual science

authors： Li LJ,Liao J,Fan Q,Cheung CY,Ikram MK,Cheng CY,Saw SM,Wong TY

更新日期：2013-08-19 00:00:00

abstract：PURPOSE:To determine whether nonglaucomatous optic disc cupping in children violates the ISNT rule (which states that for normal optic discs the neuroretinal rim width is greatest in the order inferior >or= superior >or= nasal >or= temporal). METHODS:Digital ocular fundus photographs from a random cohort of children w...

journal_title：Investigative ophthalmology & visual science

authors： Pogrebniak AE,Wehrung B,Pogrebniak KL,Shetty RK,Crawford P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether clinical signs of infectious keratitis can be used to identify the causative organism. METHODS:Eighty photographs of eyes with culture-proven bacterial keratitis or smear-proven fungal keratitis were randomly selected from 2 clinical trials. Fifteen cornea spe...

journal_title：Investigative ophthalmology & visual science

authors： Dalmon C,Porco TC,Lietman TM,Prajna NV,Prajna L,Das MR,Kumar JA,Mascarenhas J,Margolis TP,Whitcher JP,Jeng BH,Keenan JD,Chan MF,McLeod SD,Acharya NR

更新日期：2012-04-02 00:00:00

abstract：PURPOSE:Somatostatin (SST) analogues have been used to treat proliferative diabetic retinopathy, pseudotumor cerebri, thyroid orbitopathy, and cystoid macular edema. There is a paucity of published data in regards to cell-specific distribution of SST receptors (SSTR) in normal human eye tissues. Gene expression for all...

journal_title：Investigative ophthalmology & visual science

authors： Klisovic DD,O'Dorisio MS,Katz SE,Sall JW,Balster D,O'Dorisio TM,Craig E,Lubow M

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles o...

journal_title：Investigative ophthalmology & visual science

authors： Radu RA,Yuan Q,Hu J,Peng JH,Lloyd M,Nusinowitz S,Bok D,Travis GH

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To determine whether the lipid peroxidation inhibitor tirilazad mesylate can block the death of retinal ganglion cells induced by the inhibition of oxidative phosphorylation and glycolysis. METHODS:Rat retinal ganglion cells were labeled retrogradely with the fluorescent tracer DiI, and mixed cultures were pre...

journal_title：Investigative ophthalmology & visual science

authors： Levin LA,Clark JA,Johns LK

更新日期：1996-12-01 00:00:00

abstract：:One hypothesized cause of low-tension glaucoma is chronic or intermittent ischemia of the optic nerve. Since the optic nerve and brain are both parts of the central nervous system and share a common blood supply, the authors wondered if patients with low-tension glaucoma might also have clinical or radiographic eviden...

journal_title：Investigative ophthalmology & visual science

authors： Corbett JJ,Phelps CD,Eslinger P,Montague PR

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00