Degradation of Visual Performance With Increasing Levels of Retinal Stray Light.

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To examine the expression of c-fos proto-oncogene and phosphorylation of cAMP responsive element binding (CREB) protein in the rat retina after changes in the light-dark condition. METHODS:Rats were exposed to both steady light and flashing light and were killed at the end of light exposure. The retinas were a...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Imaki J,Fujisawa H,Harada T,Ohki K,Matsuda H,Hagiwara M

更新日期：1996-01-01 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

journal_title：Investigative ophthalmology & visual science

authors： Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To evaluate the visual and refractive outcome for four wavefront-guided surface ablation (WGSA) techniques (LASEK, LASEK flap-off [LASEK FO], Epi-LASIK, and Epi-LASIK flap-off [Epi-LASIK FO]) in a large myopic population. METHODS:This retrospective review included 1000 myopic eyes (spherical equivalent [SE] -1...

journal_title：Investigative ophthalmology & visual science

authors： Kulkarni SV,AlMahmoud T,Priest D,Taylor SE,Mintsioulis G,Jackson WB

更新日期：2013-01-21 00:00:00

abstract：PURPOSE:To develop a method to isolate human iris microvascular endothelial cells (HIECs) for exploring their constitutive and inflammatory agent-modulated expression of intercellular adhesion molecules (ICAM)-1 and -2, vascular cell adhesion molecule (VCAM)-1, and E-selectin. METHODS:Endothelial cells from collagenas...

journal_title：Investigative ophthalmology & visual science

authors： Silverman MD,Zamora DO,Pan Y,Texeira PV,Planck SR,Rosenbaum JT

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To identify if whole-body hydration plays an important role in dry eye (DE). We hypothesized that individuals classified as DE have higher plasma osmolality (Posm), indicating suboptimal hydration, compared with those classified as non-DE. METHODS:Using a hospital-based observational cross-sectional design, as...

journal_title：Investigative ophthalmology & visual science

authors： Walsh NP,Fortes MB,Raymond-Barker P,Bishop C,Owen J,Tye E,Esmaeelpour M,Purslow C,Elghenzai S

更新日期：2012-09-25 00:00:00

abstract：PURPOSE:To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS:Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of ...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Siemers E,Abel LA,Yee RD

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To evaluate quantitatively the relationship between the displacement of anterior visual pathway structures by pituitary tumors and visual field damage with the goal of improving diagnosis and management. METHODS:Subjects had pituitary macroadenomas and both magnetic resonance imaging (MRI) and static perimetry...

journal_title：Investigative ophthalmology & visual science

authors： Boland MV,Lee IH,Zan E,Yousem DM,Miller NR

更新日期：2016-07-01 00:00:00

abstract：:Cataracts removed intracapsularly by cryoprobe technique from human diabetics were analyzed for sugars and polyols by gas liquid chromatography. The contents of sorbitol and fructose of lenses followed blood glucose levels at least up to 250 mg/dl. Studies indicate that human lens is capable of synthesizing substantia...

journal_title：Investigative ophthalmology & visual science

authors： Varma SD,Schocket SS,Richards RD

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS:The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patient...

journal_title：Investigative ophthalmology & visual science

authors： Nishiguchi KM,Sokal I,Yang L,Roychowdhury N,Palczewski K,Berson EL,Dryja TP,Baehr W

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

journal_title：Investigative ophthalmology & visual science

authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

更新日期：2011-10-31 00:00:00

abstract：PURPOSE:To investigate the effects of mitomycin C (MMC) on the number of keratocytes and the proliferation of fibroblasts after photorefractive keratectomy (PRK) and exposure to ultraviolet B (UV-B) irradiation. METHODS:The right eyes of New Zealand White rabbits in Groups 1, 2, and 3 (n = 18 each) underwent PRK to co...

journal_title：Investigative ophthalmology & visual science

authors： Kim TI,Pak JH,Lee SY,Tchah H

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. METHODS:Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies t...

journal_title：Investigative ophthalmology & visual science

authors： Hirst LW,Bancroft J,Yamauchi K,Green WR

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:In a group of humans with strabismic amblyopia, the relationship was examined between the structure and function of different brain regions. Three question were addressed: (1) Is the lateral geniculate nucleus (LGN) in humans with amblyopia structurally as well as functionally abnormal? (2) Do structural anomal...

journal_title：Investigative ophthalmology & visual science

authors： Barnes GR,Li X,Thompson B,Singh KD,Dumoulin SO,Hess RF

更新日期：2010-03-01 00:00:00

abstract：:Quantitative autoradiography was used to study the incorporation of 3H-thymidine into the retina of albino rats following in vivo exposure to 300-nm radiation. Relative to background labeling in unexposed eyes, there was 8-20 times as much label per unit area in the outer nuclear layer, inner nuclear layer, and gangli...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Jose JG,Pitts DG

更新日期：1985-03-01 00:00:00

abstract：:Extracellular matrix (ECM) turnover and remodeling are initiated, at least in part, by the regulated secretion of members of a family of matrix metalloproteinases. Human and bovine trabecular mesh-work in culture secrete interstitial collagenase, both the 72- and the 92-kD forms of type IV collagenase (gelatinases) an...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Samples JR,Van Buskirk EM,Acott TS

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The influences of diurnal rhythms involving a variety of ocular parameters are implicated in the development of myopia. The purpose of this study was to determine the expression of the melatonin receptor subtype proteins in chick ocular tissues and to examine the role of the circadian signaling molecule melaton...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Wiechmann AF

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Achieving good vision in infants born with a unilateral cataract is believed to require early surgery and consistent occlusion of the fellow eye. This article examines the relationship between adherence to patching and grating acuity. METHODS:Data came from the Infant Aphakia Treatment Study, a randomized clin...

journal_title：Investigative ophthalmology & visual science

authors： Drews-Botsch CD,Celano M,Kruger S,Hartmann EE,Infant Aphakia Treatment Study.

更新日期：2012-06-05 00:00:00

abstract：PURPOSE:To investigate thickness profile changes of the corneal epithelium and Bowman's layer at the vertical and horizontal meridians with overnight myopia orthokeratology (OK) lenses. METHODS:Twenty subjects (age range: 19-33 years) wore reverse-geometry rigid gas-permeable OK lenses in both eyes for 30 days. Before...

journal_title：Investigative ophthalmology & visual science

authors： Lian Y,Shen M,Jiang J,Mao X,Lu P,Zhu D,Chen Q,Wang J,Lu F

更新日期：2013-01-23 00:00:00

abstract：Purpose:Although normal function of the lacrimal gland is essential for vision (and thus for human well-being), the lacrimal gland remains rather poorly understood at a molecular level. The purpose of this study was to identify new genes and signaling cascades involved in lacrimal gland development. Methods:To identif...

journal_title：Investigative ophthalmology & visual science

authors： Dvoriantchikova G,Tao W,Pappas S,Gaidosh G,Tse DT,Ivanov D,Pelaez D

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Th2 lymphocytes may play a key role in the development of allergic diseases such as vernal keratoconjunctivitis (VKC). Cytokine flow cytometry of tear samples was used to identify the phenotypical and functional properties of lymphocytes at the actual site of the allergic reaction. METHODS:Tear and blood sampl...

journal_title：Investigative ophthalmology & visual science

authors： Leonardi A,DeFranchis G,Zancanaro F,Crivellari G,De Paoli M,Plebani M,Secchi AG

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human beta-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localization of HBD9 protein in different OS regions and to determine the ro...

journal_title：Investigative ophthalmology & visual science

authors： Mohammed I,Suleman H,Otri AM,Kulkarni BB,Chen P,Hopkinson A,Dua HS

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cells are known to play important roles in maintaining the homeostasis of the retina and in controlling choroidal neovascularization. The purpose of this study was to identify a factor or factors that would stimulate RPE cells to proliferate. METHODS:To isolate such a factor, 1...

journal_title：Investigative ophthalmology & visual science

authors： Tanaka Y,Utsumi J,Matsui M,Sudo T,Nakamura N,Mutoh M,Kajita A,Sone S,Kigasawa K,Shibuya M,Reddy VN,Zhang Q,Iwata T

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. METHODS:In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared refl...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Ayton LN,Makeyeva G,Guymer RH,Luu CD

更新日期：2015-03-03 00:00:00

abstract：PURPOSE:Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape. ME...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Chandrasekara K,Abbondandolo CJ,Coll TJ,Rutzen AR

更新日期：2008-08-01 00:00:00

abstract：:Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

journal_title：Investigative ophthalmology & visual science

authors： Polans AS,Burton MD

更新日期：1988-10-01 00:00:00