DNA repair synthesis in the rat retina following in vivo exposure to 300-nm radiation.

abstract：PURPOSE:Fibroblast growth factor-binding proteins (FGF-BPs) have been identified recently in blood and other biologic fluids and have been shown to be identical to a truncated form of the high-affinity cell surface FGF receptor. The authors examined the hypothesis that FGF-BPs also are present in human vitreous fluid. ...

journal_title：Investigative ophthalmology & visual science

authors： Hanneken A,Baird A

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To detect the expression of cell adhesion molecules (CAMs), including beta integrins, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1, leukocyte-endothelial cell adhesion molecule-2, E-cadherin, and CD44, in cultured lens epithelial cells (LECs) of human cataracts. To show that LEC...

journal_title：Investigative ophthalmology & visual science

authors： Nishi O,Nishi K,Akaishi T,Shirasawa E

更新日期：1997-03-01 00:00:00

abstract：Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

journal_title：Investigative ophthalmology & visual science

authors： Ono M,Takano Y,Haida M

更新日期：2018-09-04 00:00:00

abstract：:An arterial connection between the two internal ophthalmic arteries in the rabbit was confirmed. The consensual response to ocular injury and its relationship to this interconnecting artery was examined by transecting the interconnecting vessel and creating a monocular injury by anterior chamber paracentesis. In the r...

journal_title：Investigative ophthalmology & visual science

authors： Forster S,Mead A,Sears M

更新日期：1979-02-01 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To better understand the cellular contributions to the human multifocal ERG (mfERG), rhesus monkey and human mfERGs were recorded using the same stimulus conditions. The monkey mfERGs were recorded before and after injections of pharmacologic agents known to selectively block activity of particular cells and ci...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Frishman LJ,Saszik S,Viswanathan S

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS:We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), ...

journal_title：Investigative ophthalmology & visual science

authors： Akashi A,Kanamori A,Nakamura M,Fujihara M,Yamada Y,Negi A

更新日期：2013-07-10 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:To study the survival of adult retinal grafts prepared in a physiologically optimized way. METHODS:Twenty-three rabbits received an adult full-thickness rabbit retinal transplant positioned under the host retina, using a vitrectomy technique. The transplants were prepared using a procedure based on a previousl...

journal_title：Investigative ophthalmology & visual science

authors： Wassélius J,Ghosh F

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Müller glia play crucial roles in retinal homeostasis and function. Genetic modification of Müller cells by viral gene delivery would be valuable for studies of their normal physiology and roles in retinal disease states. However, stable and efficient transgene expression in Müller cells after delivery of gene ...

journal_title：Investigative ophthalmology & visual science

authors： Greenberg KP,Geller SF,Schaffer DV,Flannery JG

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Conventional time-domain optical coherence tomography (OCT) has been shown to provide reproducible retinal nerve fiber layer (RNFL) measurements. Recently, high-speed, high-resolution Fourier-domain 3D-OCT has been introduced to improve OCT quality. It can provide 6-mm(2) high-density scans to provide RNFL thic...

journal_title：Investigative ophthalmology & visual science

authors： Menke MN,Knecht P,Sturm V,Dabov S,Funk J

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic ...

journal_title：Investigative ophthalmology & visual science

authors： Hirano Y,Sakurai E,Matsubara A,Ogura Y

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS:The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two in...

journal_title：Investigative ophthalmology & visual science

authors： Van de Veire S,Germonpre P,Renier C,Stalmans I,Zeyen T

更新日期：2008-12-01 00:00:00

abstract：Purpose:Prospective treatments for age-related macular degeneration and inherited retinal degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before translation into clinical application. Historically, retinal thickness obtained through postmortem anatomic assessments has been a key outcome ...

journal_title：Investigative ophthalmology & visual science

authors： Ryals RC,Andrews MD,Datta S,Coyner AS,Fischer CM,Wen Y,Pennesi ME,McGill TJ

更新日期：2017-03-01 00:00:00

abstract：:Ocular ultraviolet radiation (UVR) exposure was assessed in three occupational groups: fisherman, landscape workers and construction workers. The ratio of ocular exposure to ambient exposure was determined by placing UV-sensitive film (295-320 nm) between the eyes of the subjects and in a nearby open field. The mean o...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal FS,Phoon C,Bakalian AE,Taylor HR

更新日期：1988-04-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The author...

journal_title：Investigative ophthalmology & visual science

authors： Sano Y,Ksander BR,Streilein JW

更新日期：1995-10-01 00:00:00

abstract：:Application of devices that degrade the retinal image has been reported to produce enlargement of the ocular globe in young domestic chicks. Two such device types (domes and arches) were applied to 3-day-old chicks. The domes affected the entire visual field whereas the arches affected only the lateral field. A third ...

journal_title：Investigative ophthalmology & visual science

authors： Hodos W,Fitzke FW,Hayes BP,Holden AL

更新日期：1985-10-01 00:00:00

abstract：Purpose:The measurement of achromatic sensitivity has been an important tool for monitoring subtle changes in vision as the result of disease or response to therapy. In this study, we aimed to provide a normative data set for achromatic and chromatic contrast sensitivity functions within a common cone contrast space us...

journal_title：Investigative ophthalmology & visual science

authors： Kim YJ,Reynaud A,Hess RF,Mullen KT

更新日期：2017-07-01 00:00:00

abstract：Purpose:To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods:This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face and cross-sectional OCTA images w...

journal_title：Investigative ophthalmology & visual science

authors： Nesper PL,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To describe the cross-sectional relationship between retinal arteriolar and venular diameters with age and blood pressure. METHODS:A population-based study was conducted in Beaver Dam, Wisconsin (n=4926, age range, 43-84 years). Retinal photographs of right eyes taken at the baseline examination (1988-90) were...

journal_title：Investigative ophthalmology & visual science

authors： Wong TY,Klein R,Klein BE,Meuer SM,Hubbard LD

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:The association of age and blood pressure (BP) with retinal vessel change is widely reported, with inverse relationships between retinal arteriolar and venular diameter and increasing age and elevated BP. No previous studies have dissected the separate effects of age and BP on the diameter of retinal vessels. ...

journal_title：Investigative ophthalmology & visual science

authors： Kaushik S,Kifley A,Mitchell P,Wang JJ

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy commonly associated with elevated intraocular pressure (IOP), leading to optic nerve head (ONH) cupping, axon loss, and apoptosis of retinal ganglion cells (RGCs), which could ultimately result in blindness. Brn3b is a class-4 POU domain transcription factor that plays a key role...

journal_title：Investigative ophthalmology & visual science

authors： Stankowska DL,Minton AZ,Rutledge MA,Mueller BH 2nd,Phatak NR,He S,Ma HY,Forster MJ,Yorio T,Krishnamoorthy RR

更新日期：2015-01-13 00:00:00

abstract：PURPOSE:Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, and endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Exercise and posture changes can be used to manipulate blood pressure, ocular perfusion pressure (OPP), or both. It was hypothes...

journal_title：Investigative ophthalmology & visual science

authors： Khayi H,Pepin JL,Geiser MH,Tonini M,Tamisier R,Renard E,Baguet JP,Levy P,Romanet JP,Chiquet C

更新日期：2011-12-16 00:00:00

abstract：:Dog corneas were studied by indirect immunofluorescence with antibodies specific for pemphigus and pemphigoid antigens, laminin, and type IV collagen. The distribution of these antigens was similar to that observed in other squamous epithelia and skin. This study provides further evidence for close immunochemical simi...

journal_title：Investigative ophthalmology & visual science

authors： Cowen SJ,Anhalt GJ,Wicha MS,Sugar A,Labib RS,Diaz LA

更新日期：1981-12-01 00:00:00

abstract：:In order to determine whether a possible barrier exists to diffusion of tracer into the optic nerve during development and to provide a basis for later studies of retrograde axonal transport in embryonic nerves, we studied the diffusion of horseradish peroxidase (HRP) into the nerve after vitreal injections in chicks ...

journal_title：Investigative ophthalmology & visual science

authors： Kistler HB Jr,LaVail JH

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:Although primary congenital glaucoma (PCG)-associated CYP1B1 mutations in the heterozygous state have been evaluated for association with primary open-angle glaucoma (POAG) in several small studies, their contribution to the occurrence of POAG is still controversial. The present study was conducted to determine...

journal_title：Investigative ophthalmology & visual science

authors： Pasutto F,Chavarria-Soley G,Mardin CY,Michels-Rautenstrauss K,Ingelman-Sundberg M,Fernández-Martínez L,Weber BH,Rautenstrauss B,Reis A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To examine the possible presence of a major gene determining susceptibility to cortical cataract. METHODS:The percentage of the lens area involved with cortical opacity, summed over both eyes, was evaluated in 1275 individuals from the Beaver Dam Eye Study. After adjusting for the effects of age and sex, these...

journal_title：Investigative ophthalmology & visual science

authors： Heiba IM,Elston RC,Klein BE,Klein R

更新日期：1995-01-01 00:00:00