Retinal vessel diameters and their associations with age and blood pressure.

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：PURPOSE:The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism type 1, in the RPE during development and after birth. METHODS:Enzyme activi...

journal_title：Investigative ophthalmology & visual science

authors： Cortese K,Giordano F,Surace EM,Venturi C,Ballabio A,Tacchetti C,Marigo V

更新日期：2005-12-01 00:00:00

abstract：Purpose:Prospective treatments for age-related macular degeneration and inherited retinal degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before translation into clinical application. Historically, retinal thickness obtained through postmortem anatomic assessments has been a key outcome ...

journal_title：Investigative ophthalmology & visual science

authors： Ryals RC,Andrews MD,Datta S,Coyner AS,Fischer CM,Wen Y,Pennesi ME,McGill TJ

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To determine protective properties of recombinant TCR ligands (RTLs) as a new treatment for experimental autoimmune anterior uveitis (AU). RTLs comprise the rat RT1.B beta1alpha1 domains, linked either to the guinea pig MBP69-89 peptide (RTL201), to the corresponding rat MBP69-89 peptide (RTL200), or to the car...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Burrows GG,Vandenbark AA,Offner H

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae. METHODS:Femtosecond laser tech...

journal_title：Investigative ophthalmology & visual science

authors： Abahussin M,Hayes S,Knox Cartwright NE,Kamma-Lorger CS,Khan Y,Marshall J,Meek KM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To analyze cone and rod phototransduction parameters from ERG a-waves in patients with RP and to determine the relationships among these parameters, age, and mode of inheritance. METHODS:Sets of four white flashes (3.2-4.4 log scotopic troland [scot td-s]) were presented in the dark. The same stimuli were late...

journal_title：Investigative ophthalmology & visual science

authors： Tzekov RT,Locke KG,Hood DC,Birch DG

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloproteinases (MMPs) also involve insulin-like gr...

journal_title：Investigative ophthalmology & visual science

authors： Lorenc VE,Jaldín-Fincati JR,Luna JD,Chiabrando GA,Sánchez MC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Macrophages are thought to be the first line of defense in many infectious diseases and are present in high numbers in corneas with Acanthamoeba keratitis. Conjunctival macrophage depletion was performed in an animal model of Acanthamoeba infection to determine the importance of macrophages in this disease. ME...

journal_title：Investigative ophthalmology & visual science

authors： van Klink F,Taylor WM,Alizadeh H,Jager MJ,van Rooijen N,Niederkorn JY

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:Submucosal fibrosis due to excessive accumulation of collagens is an important histologic feature in the pathogenesis of ocular cicatricial pemphigoid (OCP). Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined ...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Foster CS,Ahmed AR

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to demonstrate the synthesis and cellular distribution of group II phospholipase A2 and lysozyme in the main and accessory lacrimal glands. METHODS:The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients wh...

journal_title：Investigative ophthalmology & visual science

authors： Aho HJ,Saari KM,Kallajoki M,Nevalainen TJ

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To describe the prevalence of AMD in an elderly urban Chinese population in China. METHODS:A population-based, cross-sectional study was conducted using a cluster random sample of residents aged 50 years or older living in the Jiangning Road Subdistrict, Jing'an District, Shanghai, China. All participants unde...

journal_title：Investigative ophthalmology & visual science

authors： Ye H,Zhang Q,Liu X,Cai X,Yu W,Yu S,Wang T,Lu W,Li X,Jin H,Hu Y,Kang X,Zhao P

更新日期：2014-09-04 00:00:00

abstract：PURPOSE:Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability. METHODS:(1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired. RESULTS:Compared with meibum fr...

journal_title：Investigative ophthalmology & visual science

authors： Borchman D,Foulks GN,Yappert MC,Milliner SE

更新日期：2012-01-31 00:00:00

abstract：PURPOSE:Anti-vascular endothelial growth factor (anti-VEGF) drugs have dramatically improved the treatment of neovascular AMD. In pivotal studies, almost 90% of patients maintain vision, with approximately 30% showing significant improvement. Despite these successes, 10% to 15% of patients continue to lose vision, even...

journal_title：Investigative ophthalmology & visual science

authors： Wickremasinghe SS,Xie J,Lim J,Chauhan DS,Robman L,Richardson AJ,Hageman G,Baird PN,Guymer R

更新日期：2011-06-08 00:00:00

abstract：PURPOSE:To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors. METHODS:The expression of short (S)- and medium (M)-wavelength cone opsins was analyzed by reverse transcription polymerase...

journal_title：Investigative ophthalmology & visual science

authors： Yanagi Y,Takezawa S,Kato S

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

journal_title：Investigative ophthalmology & visual science

authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:To determine whether a new cyclic GMP analog, 2'-O-(4-benzoyl)benzoylguanosine 3',5' cyclic monophosphate (BB-cGMP), significantly reduces intraocular pressure in either normotensive or hypertensive eyes of rabbits. METHODS:Intraocular pressure of normal adult rabbits and/or rabbits with alpha-chymotrypsin-ind...

journal_title：Investigative ophthalmology & visual science

authors： Stein PJ,Clack JW

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To determine the effect of macrophage depletion on herpes simplex virus type (HAV)-1 replication in the eye and on the establishment of latency in trigeminal ganglia (TG) of immunized and ocularly infected mice. METHODS:BALB/c mice were immunized with five HSV-1 glycoprotein DNA genes or were sham immunized. T...

journal_title：Investigative ophthalmology & visual science

authors： Mott K,Brick DJ,van Rooijen N,Ghiasi H

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The Farnsworth-Munsell 100-Hue test (FM100) is a standardized measure of chromatic discrimination, based on colored cap-sorting, which has been widely used in both adults and children. Its dependence on seriation ability raises questions as to its universal suitability and accuracy in assessing purely sensory d...

journal_title：Investigative ophthalmology & visual science

authors： Cranwell MB,Pearce B,Loveridge C,Hurlbert AC

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Vitreous degeneration contributes to several age-related eye diseases, including retinal detachment, macular hole, macular traction syndrome, and nuclear cataracts. Remarkably little is understood about the molecular interactions responsible for maintaining vitreous structure. The purpose of this study was to m...

journal_title：Investigative ophthalmology & visual science

authors： Filas BA,Zhang Q,Okamoto RJ,Shui YB,Beebe DC

更新日期：2014-01-03 00:00:00

abstract：:In orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. The density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794...

journal_title：Investigative ophthalmology & visual science

authors： Allansmith MR,Baird RS,Kashima K,Bloch KJ

更新日期：1979-08-01 00:00:00

abstract：:Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infe...

journal_title：Investigative ophthalmology & visual science

authors： Cooper JA Jr,Daniels CA,Trofatter EF Jr

更新日期：1978-04-01 00:00:00

abstract：:PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantat...

journal_title：Investigative ophthalmology & visual science

authors： Choi HJ,Kim MK,Lee HJ,Ko JH,Jeong SH,Lee JI,Oh BC,Kang HJ,Wee WR

更新日期：2011-08-22 00:00:00

abstract：Purpose:Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments. Methods:Rabbit corneas e...

journal_title：Investigative ophthalmology & visual science

authors： Wertheimer CM,Elhardt C,Kaminsky SM,Pham L,Pei Q,Mendes B,Afshar S,Kochevar IE

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To determine whether resolvin E1 (RvE1), an endogenous oxygenation product of eicosapentaenoic acid (EPA), induces increases in migration in human corneal epithelial cells (HCECs) and to identify signal pathways mediating this response. METHODS:Migration was measured with the scratch wound assay. Western blot ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang F,Yang H,Pan Z,Wang Z,Wolosin JM,Gjorstrup P,Reinach PS

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro would thus be beneficial for transplantation in the retina. Howeve...

journal_title：Investigative ophthalmology & visual science

authors： Djojosubroto M,Bollotte F,Wirapati P,Radtke F,Stamenkovic I,Arsenijevic Y

更新日期：2009-12-01 00:00:00

abstract：Purpose:To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. Methods:C57BL/6JJcl mice were fed a diet containing RTU-1096, a specific inhibitor for VAP-1, or a control diet ad libitum...

journal_title：Investigative ophthalmology & visual science

authors： Matsuda T,Noda K,Murata M,Kawasaki A,Kanda A,Mashima Y,Ishida S

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:RPE65 has been shown to be essential for the production of 11-cis retinal by the retinal pigment epithelium. Mutations in RPE65 are known to be associated with severe forms of early-onset retinal dystrophy. This project was designed to determine the amount of regenerable opsin in Rpe65-/- mice during developmen...

journal_title：Investigative ophthalmology & visual science

authors： Rohrer B,Goletz P,Znoiko S,Ablonczy Z,Ma JX,Redmond TM,Crouch RK

更新日期：2003-01-01 00:00:00

abstract：Purpose:It has been suggested that arteriolar annuli localized in retinal arterioles regulate retinal blood flow acting as sphincters. Here, the morphology and protein expression profile of arteriolar annuli have been analyzed under physiologic conditions in the retina of wild-type, β-actin-Egfp, and Nestin-gfp transge...

journal_title：Investigative ophthalmology & visual science

authors： Ramos D,Catita J,López-Luppo M,Valença A,Bonet A,Carretero A,Navarro M,Nacher V,Mendez-Ferrer S,Meseguer A,Casellas A,Mendes-Jorge L,Ruberte J

更新日期：2019-02-01 00:00:00