Synthesis of group II phospholipase A2 and lysozyme in lacrimal glands.

abstract：:Prostaglandins and other eicosanoids in the trabecular meshwork may play important physiological and pharmacological roles in the aqueous outflow pathway. In the present studies, we employed [14C]-arachidonic acid to explore potentially important pathways for the production of eicosanoids in cultured human trabecular ...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Polansky JR,Alvarado JA,Mitchell MD

更新日期：1988-11-01 00:00:00

abstract：Purpose:To validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset. Method:The training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital. The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG) da...

journal_title：Investigative ophthalmology & visual science

authors： Murata H,Zangwill LM,Fujino Y,Matsuura M,Miki A,Hirasawa K,Tanito M,Mizoue S,Mori K,Suzuki K,Yamashita T,Kashiwagi K,Shoji N,Asaoka R

更新日期：2018-04-01 00:00:00

abstract：:Intact rod photoreceptors were dissociated from pronase-treated whole retinas of adult mice by repeated passage through a plastic pipette tip. Hemocytometer counts of the cell suspensions indicate that, during a series of ten dissociation steps, a total of about 1-2 million intact photoreceptor cells are dissociated f...

journal_title：Investigative ophthalmology & visual science

authors： Lolley RN,Lee RH,Chase DG,Racz E

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Oxygen-induced retinopathy (OIR) is a model for human retinopathy of prematurity (ROP). In OIR mice, this study determined whether blockade of β-adrenergic receptors (β-ARs) with propranolol influences retinal levels of proangiogenic factors, retinal vascularization, and blood-retinal barrier (BRB) breakdown. ...

journal_title：Investigative ophthalmology & visual science

authors： Ristori C,Filippi L,Dal Monte M,Martini D,Cammalleri M,Fortunato P,la Marca G,Fiorini P,Bagnoli P

更新日期：2011-01-05 00:00:00

abstract：PURPOSE:Ca(2+) is a major regulator of cell function. In the retinal pigment epithelium (RPE), intracellular free Ca(2+) concentration ([Ca(2+)](i)) is essential for the maintenance of normal retinal function. Therefore, accurate control of [Ca(2+)](i) is vital in these cells. Because Ca(2+) is permanently extruded fro...

journal_title：Investigative ophthalmology & visual science

authors： Wimmers S,Strauss O

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:The purpose of this study was to elucidate the differentiated expression patterns and phagocytic activities of two subtypes of microglia. METHODS:A rat optic nerve crush model was used to identify the expression patterns of two subtypes of microglia. Primary microglia were isolated from rat mixed glial culture...

journal_title：Investigative ophthalmology & visual science

authors： Haga A,Takahashi E,Inomata Y,Kawahara K,Tanihara H

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To demonstrate the conjunctival alterations in patients with Sjögren's (SSDE) and non-Sjögren's syndrome dry eye (NSSDE) using a new generation confocal microscope (HRTII/ RCM; Heidelberg Engineering, Heidelberg, Germany), in a prospective controlled study. METHODS:Twenty-eight right eyes of 28 patients with S...

journal_title：Investigative ophthalmology & visual science

authors： Wakamatsu TH,Sato EA,Matsumoto Y,Ibrahim OM,Dogru M,Kaido M,Ishida R,Tsubota K

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Downregulation of melanoma-associated antigens (MAAs), against which natural cytolytic T lymphocytes (CTLs) exist in humans, is one of the mechanisms that aids in evasion of immune surveillance. In view of putative re-expression strategies for MAAs during immunotherapy, this study was conducted to investigate M...

journal_title：Investigative ophthalmology & visual science

authors： van Dinten LC,Pul N,van Nieuwpoort AF,Out CJ,Jager MJ,van den Elsen PJ

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns. METHODS:Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol usi...

journal_title：Investigative ophthalmology & visual science

authors： McGowan A,Silvestri G,Moore E,Silvestri V,Patterson CC,Maxwell AP,McKay GJ

更新日期：2014-12-18 00:00:00

abstract：PURPOSE:To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS:Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conducta...

journal_title：Investigative ophthalmology & visual science

authors： Martinez-Wittinghan FJ,Sellitto C,White TW,Mathias RT,Paul D,Goodenough DA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To compare directly the robustness of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), frequency-doubling perimetry (FDP), and grating-resolution perimetry (GRP) stimuli to different degrees of intraocular stray light induced by commercially available opacity-containing filters. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RS,Redmond T,McDowell DR,Breslin KM,Zlatkova MB

更新日期：2009-08-01 00:00:00

abstract：:Swollen rabbit corneas incubated in vitro with their posterior surfaces blocked with silicone oil maintained fairly constant thickness over an 11 hr. period. Increasing the simulated intraocular pressure from 10 to 30 mm. Hg did not produce stromal thinning. When theophylline was added to stimulate epithelial Cl secre...

journal_title：Investigative ophthalmology & visual science

authors： Klyce SD

更新日期：1977-10-01 00:00:00

abstract：PURPOSE:To identify the chromosomal location of the gene causing snowflake vitreoretinal degeneration (SVD), an autosomal dominant retinal degeneration characterized by small yellow-white dots in the retina, fibrillar anomaly of the vitreous humor, and retinal detachment. METHODS:Clinical data were collected on 31 fam...

journal_title：Investigative ophthalmology & visual science

authors： Jiao X,Ritter R 3rd,Hejtmancik JF,Edwards AO

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To examine the signal transduction pathways involved in the activation of orbital fibroblast effector functions relevant to the pathogenesis of Graves' ophthalmopathy (GO). To determine, using antisense technology, whether the c-myc protooncogene is involved in cell proliferation and glycosaminoglycan (GAG) syn...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Bahn RS

更新日期：1995-06-01 00:00:00

abstract：Purpose:This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods:Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Han X,Kunz E,Hartnett ME

更新日期：2016-10-01 00:00:00

abstract：Purpose:To compare blood pressure and urine albumin-creatinine ratio over time for participants receiving aflibercept, bevacizumab, or ranibizumab. Methods:Preplanned secondary analyses from a randomized trial comparing aflibercept, bevacizumab, and ranibizumab for diabetic macular edema (DME). The Diabetic Retinopath...

journal_title：Investigative ophthalmology & visual science

authors： Glassman AR,Liu D,Jampol LM,Sun JK,Diabetic Retinopathy Clinical Research Network.

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Nd:YAG laser photodisruption with nanosecond (ns) pulses in the millijoule range is an established tool for intraocular surgery. This study investigates tissue effects in cornea, lens, and retina to assess whether picosecond (ps) pulses with energies in the microjoule range can increase the surgical precision, ...

journal_title：Investigative ophthalmology & visual science

authors： Vogel A,Capon MR,Asiyo-Vogel MN,Birngruber R

更新日期：1994-06-01 00:00:00

abstract：Purpose:To investigate changes of β-zone parapapillary atrophy (PPA) during axial elongation. Methods:Change of β-zone PPA was evaluated by spectral-domain optical coherence tomography (SD-OCT) in myopic children for 2 years, prospectively. Using the infrared images acquired by a fixed scan circle in the glaucoma prog...

journal_title：Investigative ophthalmology & visual science

authors： Lee KM,Choung HK,Kim M,Oh S,Kim SH

更新日期：2018-08-01 00:00:00

abstract：:To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in se...

journal_title：Investigative ophthalmology & visual science

authors： Gottlieb MD,Fugate-Wentzek LA,Wallman J

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:To identify the localization of indoleamine 2,3-dioxygenase (IDO) in human corneal cells and to evaluate its functional ability as a local immunosuppressive factor. METHODS:The expression profile of IDO was identified in primary cultures of human corneal cells (fibroblasts, epithelial cells, endothelial cells)...

journal_title：Investigative ophthalmology & visual science

authors： Ryu YH,Kim JC

更新日期：2007-09-01 00:00:00

abstract：Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

journal_title：Investigative ophthalmology & visual science

authors： Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Conventional time-domain optical coherence tomography (OCT) has been shown to provide reproducible retinal nerve fiber layer (RNFL) measurements. Recently, high-speed, high-resolution Fourier-domain 3D-OCT has been introduced to improve OCT quality. It can provide 6-mm(2) high-density scans to provide RNFL thic...

journal_title：Investigative ophthalmology & visual science

authors： Menke MN,Knecht P,Sturm V,Dabov S,Funk J

更新日期：2008-12-01 00:00:00

abstract：:Iron is a potent generator of oxidative damage whose levels increase with age, potentially exacerbating age-related diseases. Several lines of evidence suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). AMD retinas have more iron within the photoreceptors, RPE, and drusen than do...

journal_title：Investigative ophthalmology & visual science

authors： Dunaief JL

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization. This study was undertaken to elucidate the mechanisms by which PDGF exerts its effects on corneal angiogenesis. METHODS:Corneal neovascularization ...

journal_title：Investigative ophthalmology & visual science

authors： Dell S,Peters S,Müther P,Kociok N,Joussen AM

更新日期：2006-05-01 00:00:00

abstract：Purpose:To investigate foveal avascular zone (FAZ) changes in the superficial (SCP) and deep (DCP) capillary plexuses in beta-thalassemia major (BTM) patients, as shown in optical coherence tomography angiography. Methods:Nonrandomized, comparative case series of 54 eyes of 27 BTM patients and 46 eyes of 23 healthy co...

journal_title：Investigative ophthalmology & visual science

authors： Georgalas I,Makris G,Papaconstantinou D,Petrou P,Chalkiadaki E,Droutsas K,Andreanos K,Kanakis M

更新日期：2019-09-03 00:00:00

abstract：:In orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. The density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794...

journal_title：Investigative ophthalmology & visual science

authors： Allansmith MR,Baird RS,Kashima K,Bloch KJ

更新日期：1979-08-01 00:00:00

abstract：:The adhesion complex of the corneal epithelium consists of the hemidesmosome and its associated structures, such as anchoring filaments, lamina densa of the basement membrane, and anchoring fibrils. It contributes to the adhesion of the corneal epithelium to Bowman's layer. To understand the adhesion complex better, a...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Kurpakus MA,Sambol B,Jones JC

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery. METHODS:A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After ...

journal_title：Investigative ophthalmology & visual science

authors： Jee JP,Choung HK,Kim CK,Hwang JM

更新日期：2006-06-01 00:00:00

abstract：Purpose:Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Methods:Purified retinal gang...

journal_title：Investigative ophthalmology & visual science

authors： Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL

更新日期：2018-06-01 00:00:00