Topical application of a cyclic GMP analog lowers IOP in normal and ocular hypertensive rabbits.

abstract：:We describe an instrument called a scanning ocular spectrofluorophotometer (SOSF) that measures fluorescence in a two-dimensional cross-section through the anterior chamber and cornea and provides the ability to change excitation and emission wavelengths rapidly. The output of a xenon arc lamp is filtered by a diffrac...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Injury to the adult optic nerve, caused mechanically or by diseases, is still not reparable because the retinal ganglion cells (RGCs) are not allowed to regrow their axons and die retrogradely, although they possess the intrinsic propensity to regenerate axons in experimental conditions. METHODS:In vitro propa...

journal_title：Investigative ophthalmology & visual science

authors： Charalambous P,Hurst LA,Thanos S

更新日期：2008-08-01 00:00:00

abstract：:The relative importance of the anterior ciliary arteries to blood flow to the anterior segment and the quadrant distribution of blood to the iris, ciliary body, and ciliary processes were determined in canines with the use of 15 +/- 3 mum 103Ru microspheres with the reference blood flow method. Recti muscles were isol...

journal_title：Investigative ophthalmology & visual science

authors： Keough EM,Wilcox LM,Connolly RJ,Hotte CE

更新日期：1980-11-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：:Freshly enucleated monkey, calf, and human eyes were quantitatively perfused with mock aqueous humor through the anterior chamber by a constant pressure technique. After baseline perfusion at 15 mm Hg, intraocular pressure was raised to 45 mm Hg and later reduced back to 15 mm Hg. Calf and human (both adult and infant...

journal_title：Investigative ophthalmology & visual science

authors： Hashimoto JM,Epstein DL

更新日期：1980-12-01 00:00:00

abstract：PURPOSE:Experiments in chickens have implicated the transcription factor ZENK (also known as Egr-1, NGFI-A, zif268, tis8, cef5, and Krox24) in the feedback mechanisms for visual control of axial eye growth and myopia development. ZENK is upregulated in retinal glucagon amacrine cells when axial eye growth is inhibited ...

journal_title：Investigative ophthalmology & visual science

authors： Schippert R,Burkhardt E,Feldkaemper M,Schaeffel F

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To determine the role of the small guanosine triphosphate (GTP)-binding protein Rho in the migration of corneal epithelial cells. METHODS:The presence of the Rho target proteins Rho-associated coiled coil-containing protein kinase (ROCK)-1 and ROCK-2 in rabbit cornea was examined by immunohistochemical analysi...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura M,Nagano T,Chikama T,Nishida T

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To demonstrate the application of multiphoton fluorescence (MF) and second harmonic generation (SHG) microscopy for ex vivo characterization of the structural alterations of human corneas due to keratoconus. METHODS:Buttons of keratoconic corneas derived from penetrating keratoplasty were sent for structural a...

journal_title：Investigative ophthalmology & visual science

authors： Tan HY,Sun Y,Lo W,Lin SJ,Hsiao CH,Chen YF,Huang SC,Lin WC,Jee SH,Yu HS,Dong CY

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Despite the high metabolic demands of the neural retina, its detachment from the retinal pigment epithelium does not lead to immediate death for most of the cells. This study was undertaken to test the hypothesis that intrinsic protective mechanisms are activated in the neural retina during early stages of reti...

journal_title：Investigative ophthalmology & visual science

authors： Zacks DN,Han Y,Zeng Y,Swaroop A

更新日期：2006-04-01 00:00:00

abstract：:The neutrophilic response in the alkali-injured rabbit cornea can be separated into two peaks: the first from 12-24 hr and the second at 21 days. In the experiments detailed here, alkali-injured rabbit eyes were treated for 0-7 days (early peak), 6-35 days (late peak), or 0-35 days (both peaks) with 6.5% or 10% topica...

journal_title：Investigative ophthalmology & visual science

authors： Haddox JL,Pfister RR,Yuille-Barr D

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a disparate array of functions in development (e.g., proliferation and apoptosis). Among three types of PACAP receptor (VPAC1, VPAC2, and PAC1), PAC1 is subject to alternative splicing that generates isoforms. Although the literature docu...

journal_title：Investigative ophthalmology & visual science

authors： Lakk M,Szabó B,Völgyi B,Gábriel R,Dénes V

更新日期：2012-11-27 00:00:00

abstract：PURPOSE:To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. METHODS:A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS)...

journal_title：Investigative ophthalmology & visual science

authors： Lim LS,Yang X,Gazzard G,Lin X,Sng C,Saw SM,Qiu A

更新日期：2011-11-17 00:00:00

abstract：:The visual field of normal infants was assessed using a perimeter with LED stimuli and a forced-choice observation procedure. Central fixation was elicited by four central, pulsing LEDs and maintained with the aid of auditory stimuli. Field extent was derived from the four-alternative, forced-choice judgments of an ad...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Cummings MF

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:Beta-adrenergic receptor (AR) antagonists are frequently prescribed ophthalmic drugs, yet previous investigations into how catecholamines affect corneal wound healing have yielded conflicting RESULTS:With the use of an integrated pharmacologic and genetic approach, the authors investigated how the beta-AR impa...

journal_title：Investigative ophthalmology & visual science

authors： Ghoghawala SY,Mannis MJ,Pullar CE,Rosenblatt MI,Isseroff RR

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...

journal_title：Investigative ophthalmology & visual science

authors： Zhou X,Robinson CM,Rajaiya J,Dehghan S,Seto D,Jones MS,Dyer DW,Chodosh J

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:P1 is the major positive component of pattern-reversal visual evoked potentials (PR-VEPs). The rapid decrease of its latency correlates with the progressive myelination in the developing infant brain, which affects signal transmission in the visual system. An age-dependent phase shift, analogous to P1 peak late...

journal_title：Investigative ophthalmology & visual science

authors： Mikó-Baráth E,Markó K,Budai A,Török B,Kovacs I,Jandó G

更新日期：2014-04-21 00:00:00

abstract：PURPOSE:To identify stem cells in the chamber angle of the monkey eye by detection of 5-bromo-2'-deoxyuridine (BrdU) long-term retention. METHODS:Four cynomolgus monkeys were treated with BrdU via subcutaneous pumps for 4 weeks. The eyes of two animals were processed immediately thereafter (group 1) while in the other...

journal_title：Investigative ophthalmology & visual science

authors： Braunger BM,Ademoglu B,Koschade SE,Fuchshofer R,Gabelt BT,Kiland JA,Hennes-Beann EA,Brunner KG,Kaufman PL,Tamm ER

更新日期：2014-10-16 00:00:00

abstract：PURPOSE:To test the effect of stimulators of activator protein (AP)-1, on expression of stromelysin (MMP-3) in human TM cells and on aqueous outflow in perfused human anterior segments. METHODS:Change in MMP-3 expression was determined by immunoassay of proMMP-3 levels in the media of cultured human TM cells. Anterior...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Fleenor DL,Hellberg PE,Stropki K,McCartney MD,Clark AF

更新日期：2003-08-01 00:00:00

abstract：Purpose:To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. Methods:Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared s...

journal_title：Investigative ophthalmology & visual science

authors： Kruijt CC,de Wit GC,Talsma HE,Schalij-Delfos NE,van Genderen MM

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To test the hypothesis that retinal hypoxia is present during vascular development in normal rat pups and in a newborn rat model of retinopathy of prematurity (ROP). METHODS:Preretinal vitreous PO(2) measurements were made during room air breathing using (19)F magnetic resonance spectroscopy (MRS) and a perflu...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Ito Y,Berlin E,Roberts R,Berkowitz BA

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To identify the differently expressed micro (mi) RNAs in pterygium compared with normal conjunctiva and investigate the potential role of miRNAs in the pathogenesis of pterygium. METHODS:With microRNA microarray and quantitative RT-PCR, we identified that microRNA-122 (miR-122) was significantly decreased in p...

journal_title：Investigative ophthalmology & visual science

authors： Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

更新日期：2016-07-01 00:00:00

abstract：:Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably accor...

journal_title：Investigative ophthalmology & visual science

authors： Sirigu P,Shen RL,Pinto da Silva P

更新日期：1992-06-01 00:00:00

abstract：:A group of 32 patients with low vision who were considered clinically appropriate candidates for visual rehabilitation with telescopic spectacles were prospectively studied before the first attempted use of these visual aids. Laboratory measurements were made of: (1) rotational head stability in pitch and yaw during q...

journal_title：Investigative ophthalmology & visual science

authors： Demer JL,Goldberg J,Porter FI,Schmidt K

更新日期：1991-09-01 00:00:00

abstract：:An automated Minigel electrophoresis system (PhastSystem, Pharmacia, Uppsala, Sweden) was tested for human tear protein analysis. Tear samples were treated under nonreducing or reducing conditions before sodium dodecyl sulphate polyacryl amide gel electrophoresis (SDS-PAGE). Micro-amounts of tears (2 microliters) were...

journal_title：Investigative ophthalmology & visual science

authors： Kuizenga A,van Haeringen NJ,Kijlstra A

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:Compensatory eye movements (CEM) maintain a stable image on the retina by minimizing retinal slip. The optokinetic reflex (OKR) and vestibulo-ocular reflex (VOR) compensate for low and high velocity stimuli, respectively. The OKR system is known to be highly nonlinear. The VOR is generally modeled as a linear s...

journal_title：Investigative ophthalmology & visual science

authors： Sibindi TM,Holland PJ,van der Geest JN,Donchin O,Frens MA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：Purpose:Despite the potential for adaptive optics scanning light ophthalmoscopy (AOSLO) to quantify retinal disease progression at the cellular level, there remain few longitudinal studies investigating changes in cone density as a measure of disease progression. Here, we undertook a prospective, longitudinal study to ...

journal_title：Investigative ophthalmology & visual science

authors： Jackson K,Vergilio GK,Cooper RF,Ying GS,Morgan JIW

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

journal_title：Investigative ophthalmology & visual science

authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

更新日期：2006-06-01 00:00:00

abstract：:Epidermal growth factor (EGF), which has been shown to stimulate epidermal proliferation and keratinization and to induce regeneration of rabbit corneal epithelium, was studied for its immunogenic potential in rabbits. Mouse-derived EGF was administered topically, subconjunctivally, intrastromally, and systemically. S...

journal_title：Investigative ophthalmology & visual science

authors： Meyers-Elliott RH,Elliott JH,Chitjian PA,Ho PC

更新日期：1981-01-01 00:00:00