Humoral and cell-mediated immune responses to epidermal growth factor in the rabbit.

abstract：:Intravitreal membranes from patients with proliferative vitreoretinopathy (PVR) consist partly of retinal glial (RG) and retinal pigment epithelial (RPE) cells surrounded by varying amounts of extracellular matrix (ECM). The contribution of the ECM to the growth of PVR membranes is unknown. This study was undertaken t...

journal_title：Investigative ophthalmology & visual science

authors： Williams DF,Burke JM

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:To examine the prognostic relevance of expression of the chemokine receptors CCR7 and CXCR4 and its ligand CXCL12 in uveal melanoma in nonmetastatic and metastatic patients with correlation to liver metastasis and overall survival. METHODS:Primary uveal melanoma specimens from 19 patients with correlating live...

journal_title：Investigative ophthalmology & visual science

authors： van den Bosch T,Koopmans AE,Vaarwater J,van den Berg M,de Klein A,Verdijk RM

更新日期：2013-11-08 00:00:00

abstract：:After viewing red vertical stripes and green horizontal stripes, the eye subsequently views white vertical stripes as greenish and white horizontal stripes as pinkish. It has been theorized that this phenomenon, known as the McCollough effect, is related to long-tern adaptation of cells tuned for both color and orient...

journal_title：Investigative ophthalmology & visual science

authors： Maguire WM,Meyer GE,Baizer JS

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. METHODS:Temporal, rather than spatial, resolution was investigated in pa...

journal_title：Investigative ophthalmology & visual science

authors： Spang K,Fahle M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Previous studies have shown that binocular coordination during saccadic eye movement is affected in humans with large strabismus. The purpose of this study was to examine the conjugacy of saccadic eye movements in monkeys with sensory strabismus. METHODS:The authors recorded binocular eye movements in four str...

journal_title：Investigative ophthalmology & visual science

authors： Fu L,Tusa RJ,Mustari MJ,Das VE

更新日期：2007-07-01 00:00:00

abstract：:Intact rod photoreceptors were dissociated from pronase-treated whole retinas of adult mice by repeated passage through a plastic pipette tip. Hemocytometer counts of the cell suspensions indicate that, during a series of ten dissociation steps, a total of about 1-2 million intact photoreceptor cells are dissociated f...

journal_title：Investigative ophthalmology & visual science

authors： Lolley RN,Lee RH,Chase DG,Racz E

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:To determine whether the human retinal oxygenation response (deltaPO2) to a hyperoxic provocation is abnormal in patients with type I diabetes. METHODS:Magnetic resonance imaging (MRI) was used to measure deltaPO2 during 100% oxygen breathing in patients with type I diabetes who had either no clinically detect...

journal_title：Investigative ophthalmology & visual science

authors： Trick GL,Edwards P,Desai U,Berkowitz BA

更新日期：2006-04-01 00:00:00

abstract：:Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Hansen RM

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To determine the metrics of vertical saccades in elderly subjects for comparison in neurologic disease. METHODS:Sixteen elderly subjects, ten middle-aged subjects, and thirteen young subjects were examined using a magnetic search coil technique. Saccades were measured to predictable vertical target steps and m...

journal_title：Investigative ophthalmology & visual science

authors： Huaman AG,Sharpe JA

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS:The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber l...

journal_title：Investigative ophthalmology & visual science

authors： Chen WW,Wang N,Cai S,Fang Z,Yu M,Wu Q,Tang L,Guo B,Feng Y,Jonas JB,Chen X,Liu X,Gong Q

更新日期：2013-01-17 00:00:00

abstract：PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

journal_title：Investigative ophthalmology & visual science

authors： Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the performance of optical coherence tomography angiography (OCTA) in visualizing laser-induced choroidal neovascularization (CNV) in the rodent retina. METHODS:Choroidal neovascularization was induced via laser photocoagulation in 2 male Brown Norway rats and 2 male C...

journal_title：Investigative ophthalmology & visual science

authors： Park JR,Choi W,Hong HK,Kim Y,Jun Park S,Hwang Y,Kim P,Joon Woo S,Hyung Park K,Oh WY

更新日期：2016-07-01 00:00:00

abstract：:We describe a new technique for the separation and isolation of nonpigmented ciliary body epithelial cells from rabbit. Excised ciliary body is incubated in a medium buffered with EGTA to a free-Ca2+ concentration of 10(-8) M, and the nonpigmented cell layer is separated from the pigmented layer by microdissection und...

journal_title：Investigative ophthalmology & visual science

authors： Fain GL,Cilluffo MC,Fain MJ,Lee DA

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the mutational incidence and spectrum of mitochondrial ND1 gene in subjects with Leber's hereditary optic neuropathy (LHON). METHODS:A cohort of 1281 Han Chinese probands and 478 control subjects underwent sequence analysis of mitochondrial (mt)DNA. Resultant varian...

journal_title：Investigative ophthalmology & visual science

authors： Ji Y,Liang M,Zhang J,Zhu L,Zhang Z,Fu R,Liu X,Zhang M,Fu Q,Zhao F,Tong Y,Sun Y,Jiang P,Guan MX

更新日期：2016-05-01 00:00:00

abstract：Purpose:Corneal endothelial cells (CECs) are critical in maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cell (PBMC)-originated, induced pluripotent stem cell (iPSC)-derived CECs. Methods:We isolated PBMCs and programmed the mononuclear cells to generate iPSCs, which...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Khan SY,Vasanth S,Ahmed MR,Chen R,Na CH,Thomson JJ,Qiu C,Gottsch JD,Riazuddin SA

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To evaluate the consequences of altering retinal sterol metabolism and composition on the development, histologic organization, and electrophysiological function of the retina, under conditions that mimic the biochemical hallmarks of the Smith-Lemli-Opitz (SLO) syndrome. METHODS:Pregnant Sprague-Dawley rats we...

journal_title：Investigative ophthalmology & visual science

authors： Fliesler SJ,Richards MJ,Miller C,Peachey NS

更新日期：1999-07-01 00:00:00

abstract：:An animal model has been developed to study the effects of various prophylaxis agents on acquisition of chlamydial conjunctivitis. When Hartley strain newborn guinea pigs received ocular inoculations of Chlamydia psittaci followed by the instillation of various agents, 1% AgNO3 significantly lowered the risk of develo...

journal_title：Investigative ophthalmology & visual science

authors： Sandstrom IK,Cummings M,Johnson P,Schachter J,Chandler JW

更新日期：1987-09-01 00:00:00

abstract：:Experimental detachments were made in Dutch rabbit eyes by injecting autologous serum or Hanks' solution into the subretinal space through a glass micropipette. The serum was resorbed at a rate of 0.064 +/- 0.023 microliter/mm2/hr, which is approximately half as fast as Hanks' solution. Both cyclic GMP and dibutyryl c...

journal_title：Investigative ophthalmology & visual science

authors： Kawano S,Marmor MF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Fundamental to the maintenance of ionic concentration gradients and transparency of the lens is the activity of Na+,K+-adenosine triphosphatase (ATPase) in the epithelial layer. Recent studies have identified endogenous digitalis-like compounds (DLCs) and 19-norbufalin and its peptide derivatives in human catar...

journal_title：Investigative ophthalmology & visual science

authors： Lichtstein D,Levy T,Deutsch J,Steinitz M,Zigler JS Jr,Russell P

更新日期：1999-02-01 00:00:00

abstract：Purpose:Pathologic myopia described as myopia accompanied by severe deformation of the eye besides excessive elongation of eye, is usually a genetic heterogeneous disorder characterized by extreme, familial, early-onset vision loss. However, the exact pathogenesis of pathologic myopia remains unclear. In this study, we...

journal_title：Investigative ophthalmology & visual science

authors： Wang B,Liu Y,Chen S,Wu Y,Lin S,Duan Y,Zheng K,Zhang L,Gu X,Hong W,Shao H,Zeng X,Sun B,Duan S

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:One of the difficulties in modeling visual field (VF) data is the sometimes large and correlated measurement errors in the point-wise sensitivity estimates. As these errors affect all locations of the same VF, we propose to model them as global visit effects (GVE). We evaluate this model and show the effect it ...

journal_title：Investigative ophthalmology & visual science

authors： Bryan SR,Eilers PH,Lesaffre EM,Lemij HG,Vermeer KA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mito...

journal_title：Investigative ophthalmology & visual science

authors： Joyce NC,Harris DL,Mello DM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Age-related nuclear cataracts involve denaturation and aggregation of intracellular proteins. We have documented age-dependent changes in membrane transport in the mouse lens to see what might initiate changes in the intracellular milieu. METHODS:Microelectrode-based intracellular impedance studies of intact l...

journal_title：Investigative ophthalmology & visual science

authors： Gao J,Wang H,Sun X,Varadaraj K,Li L,White TW,Mathias RT

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cycl...

journal_title：Investigative ophthalmology & visual science

authors： Dismuke WM,Sharif NA,Ellis DZ

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG...

journal_title：Investigative ophthalmology & visual science

authors： Dias AC,Módulo CM,Jorge AG,Braz AM,Jordão AA Jr,Filho RB,de Paula JS,Rocha EM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00

abstract：PURPOSE:The organization of scleral collagen helps to determine the eye's biomechanical response to intraocular pressure (IOP), and may therefore be important in glaucoma. This study provides a quantitative assessment of changes in scleral collagen fibril organization in bead-induced murine experimental glaucoma. METH...

journal_title：Investigative ophthalmology & visual science

authors： Pijanka JK,Kimball EC,Pease ME,Abass A,Sorensen T,Nguyen TD,Quigley HA,Boote C

更新日期：2014-09-16 00:00:00

abstract：:The retinas of six pigmented rabbits (12 eyes) were irradiated with a cw-Nd:YAG laser using two different pulse forms, in conjunction with a constant pulse duration of 200 msec and a retinal focus diameter of 200 microns. The first pulse form (a) was characterized by an initial transient, lasting 15-20 msec, with a pe...

journal_title：Investigative ophthalmology & visual science

authors： van der Zypen E,Fankhauser F,Kwasniewska S,England C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To investigate morphological characteristics of optic nerve head and peripapillary region with myopia and glaucoma. METHODS:Ten normal and 17 glaucomatous myopic participants were imaged with a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images were processed and segm...

journal_title：Investigative ophthalmology & visual science

authors： Lee S,Han SX,Young M,Beg MF,Sarunic MV,Mackenzie PJ

更新日期：2014-06-03 00:00:00