Vertical saccades in senescence.

abstract：:Healing of corneal alkali injuries remains a severe clinical challenge. The authors evaluated the effect of a new synthetic inhibitor of matrix metalloproteinases (GM6001 or N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-L-tryptophane methylamide) on preventing ulceration of rabbit corneas after alkali inju...

journal_title：Investigative ophthalmology & visual science

authors： Schultz GS,Strelow S,Stern GA,Chegini N,Grant MB,Galardy RE,Grobelny D,Rowsey JJ,Stonecipher K,Parmley V

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a leading cause of blindness, yet pertinent animal models are uncommon. The sand rat (Psammomys obesus), exhibiting diet-induced metabolic syndrome, might constitute a relevant model. METHODS:Adult P. obesus (n = 39) were maintained in captivity for 4 to 7 months and fed either veg...

journal_title：Investigative ophthalmology & visual science

authors： Saïdi T,Mbarek S,Omri S,Behar-Cohen F,Chaouacha-Chekir RB,Hicks D

更新日期：2011-11-21 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:There is uncertainty in the published literature as to whether physical activity should be advocated for age-related macular degeneration (AMD) prevention. We aimed to assess prospectively the association between physical activity and the 15-year incidence of AMD in older adults. METHODS:We assessed AMD from r...

journal_title：Investigative ophthalmology & visual science

authors： Gopinath B,Liew G,Burlutsky G,Mitchell P

更新日期：2014-11-11 00:00:00

abstract：PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...

journal_title：Investigative ophthalmology & visual science

authors： Kallinikos P,Berhanu M,O'Donnell C,Boulton AJ,Efron N,Malik RA

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:The goal of this study was to extend the results of previous immunoassay, immunocytochemistry, and in situ hybridization studies showing the presence of insulin-related peptide in the rat retina by confirming the expression of insulin genes in the rat eye. METHODS:Total and poly(A)+ RNA were isolated from whol...

journal_title：Investigative ophthalmology & visual science

authors： Budd GC,Pansky B,Glatzer L

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

journal_title：Investigative ophthalmology & visual science

authors： Wu YT,Zhu H,Willcox M,Stapleton F

更新日期：2010-12-01 00:00:00

abstract：Purpose:We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT). Methods:Diabetic participants underwent VA testing and AO...

journal_title：Investigative ophthalmology & visual science

authors： Lammer J,Karst SG,Lin MM,Cheney M,Silva PS,Burns SA,Aiello LP,Sun JK

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To evaluate the effects of 5-fluorouracil (5-FU) on ocular cells in vitro and the effects of degradable 5-FU-loaded poly(DL-lactide-co-glycolide; PDLGA) 50:50 implant in the rabbit eye in vivo. METHODS:Cytotoxicity was assessed with a tetrazolium salt WST-1 cell proliferation/viability test and a lactate dehyd...

journal_title：Investigative ophthalmology & visual science

authors： Huhtala A,Rönkkö S,Teräsvirta M,Puustjärvi T,Sihvola R,Vehanen K,Laukkanen A,Anttila J,Urtti A,Pohjonen T,Uusitalo H

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To determine whether anthocyanin-enriched bilberry extracts modulate pre- or posttranslational levels of oxidative stress defense enzymes heme-oxygenase (HO)-1 and glutathione S-transferase-pi (GST-pi) in cultured human retinal pigment epithelial (RPE) cells. METHODS:Confluent ARPE-19 cells were preincubated w...

journal_title：Investigative ophthalmology & visual science

authors： Milbury PE,Graf B,Curran-Celentano JM,Blumberg JB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:There is no consensus as how to calculate orbital soft tissue volume based on CT or MRI scans. The authors sought to validate their technique and to assess the intraobserver and interobserver variability of their calculations of bony orbital volume (OV), orbital fat volume (FV), and extraocular muscle volume (M...

journal_title：Investigative ophthalmology & visual science

authors： Regensburg NI,Kok PH,Zonneveld FW,Baldeschi L,Saeed P,Wiersinga WM,Mourits MP

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To demonstrate the presence of corneal stromal precursors that express neural markers in vitro. METHODS:To isolate sphere-forming cells, human corneal stromal cells were subjected to a reaggregation-free neurosphere assay in medium containing methylcellulose gel matrix. To promote differentiation, the isolated...

journal_title：Investigative ophthalmology & visual science

authors： Uchida S,Yokoo S,Yanagi Y,Usui T,Yokota C,Mimura T,Araie M,Yamagami S,Amano S

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:meso-Zeaxanthin is a carotenoid that is rarely encountered in nature outside of the vertebrate eye. It is not a constituent of a normal human diet, yet this carotenoid comprises one-third of the primate macular pigment. In the current study, we undertook a systematic approach to biochemically characterize the p...

journal_title：Investigative ophthalmology & visual science

authors： Gorusupudi A,Shyam R,Li B,Vachali P,Subhani YK,Nelson K,Bernstein PS

更新日期：2016-04-01 00:00:00

abstract：Purpose:This study evaluates the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the PARL-ABCC5-HTR3D-HTR3C region with primary angle closure glaucoma (PACG), with a view to identify the responsible SNP in this region. Methods:Thirty SNPs from the PARL-ABCC5-HTR3D-HTR3C region were genotype...

journal_title：Investigative ophthalmology & visual science

authors： Tang FY,Ma L,Tam POS,Pang CP,Tham CC,Chen LJ

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. METHODS:A rat cornea micropocket assay was used to initiate IL-6- and VEGF-mediated angiogenesis. The ability of TA or neutralizing VE...

journal_title：Investigative ophthalmology & visual science

authors： Ebrahem Q,Minamoto A,Hoppe G,Anand-Apte B,Sears JE

更新日期：2006-11-01 00:00:00

abstract：Purpose:Patients with diabetes mellitus are reported to have ocular surface defects, impaired ocular surface barrier function, and a higher incidence of corneal and conjunctival infections. Tight junctions are critical for ocular surface barrier function. The present study was designed to investigate the effect of high...

journal_title：Investigative ophthalmology & visual science

authors： Alfuraih S,Barbarino A,Ross C,Shamloo K,Jhanji V,Zhang M,Sharma A

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:To determine the efficacy of a new formulation of topical dexamethasone 0.1%/povidone-iodine 0.4% (FST-100) in reducing clinical symptoms and infectious viral titers in a rabbit model of adenoviral keratoconjunctivitis. METHODS:Rabbit corneas were inoculated bilaterally with 2×10(6) plaque-forming-units (PFU) ...

journal_title：Investigative ophthalmology & visual science

authors： Clement C,Capriotti JA,Kumar M,Hobden JA,Foster TP,Bhattacharjee PS,Thompson HW,Mahmud R,Liang B,Hill JM

更新日期：2011-01-21 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Air puff systems have been presented recently to measure corneal biomechanical properties in vivo. In our study we tested the influence of several factors on corneal deformation to an air puff: IOP, corneal rigidity, dehydration, presence of sclera, and in vivo versus in vitro conditions. METHODS:We used 14 fr...

journal_title：Investigative ophthalmology & visual science

authors： Kling S,Marcos S

更新日期：2013-07-26 00:00:00

abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

journal_title：Investigative ophthalmology & visual science

authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

更新日期：2003-02-01 00:00:00

abstract：:The definition and diagnostic criteria of dry eye disease (DED) proposed by the Japan Dry Eye Society and other countries are reviewed. The first definition and criteria of DED in Japan were proposed in 1995. In that report, DED was considered a disease of tears, which subsequently damaged ocular epithelia. The presen...

journal_title：Investigative ophthalmology & visual science

authors： Shimazaki J

更新日期：2018-11-01 00:00:00

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. METHODS:Forty-five consecutive RR...

journal_title：Investigative ophthalmology & visual science

authors： Graham EC,You Y,Yiannikas C,Garrick R,Parratt J,Barnett MH,Klistorner A

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：PURPOSE:To estimate the heritability of the iridotrabecular angle width measured by anterior segment optical coherence tomography (ASOCT) in a classic twin study. METHODS:Twins aged 8 to 16 years were identified from the Guangzhou Twin Registry. ASOCT was used to obtain one horizontal scan, and the images were analyze...

journal_title：Investigative ophthalmology & visual science

authors： He M,Ge J,Wang D,Zhang J,Hewitt AW,Hur YM,Mackey DA,Foster PJ

更新日期：2008-04-01 00:00:00