Isolation of non-pigmented epithelial cells from rabbit ciliary body.

abstract：PURPOSE:Beta-adrenergic receptor (AR) antagonists are frequently prescribed ophthalmic drugs, yet previous investigations into how catecholamines affect corneal wound healing have yielded conflicting RESULTS:With the use of an integrated pharmacologic and genetic approach, the authors investigated how the beta-AR impa...

journal_title：Investigative ophthalmology & visual science

authors： Ghoghawala SY,Mannis MJ,Pullar CE,Rosenblatt MI,Isseroff RR

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin, which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton of cultured bovine aortic endothelial cells (BAECs) and on outflow facility in living monkeys. METHODS:Latrunculin-A dose-time-response...

journal_title：Investigative ophthalmology & visual science

authors： Peterson JA,Tian B,Bershadsky AD,Volberg T,Gangnon RE,Spector I,Geiger B,Kaufman PL

更新日期：1999-04-01 00:00:00

abstract：:The earlier reports from this laboratory that the renewal of rat photoreceptor membranes was dependent on essential fatty acids have not been confirmed in more recent studies. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RE

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

journal_title：Investigative ophthalmology & visual science

authors： Phillips BE,Cancel L,Tarbell JM,Antonetti DA

更新日期：2008-06-01 00:00:00

abstract：Purpose:To examine the early glial reactivity and neuron damage in response to short-term cerebrospinal fluid pressure (CSFp) reduction, as compared with intraocular pressure (IOP) elevation. Methods:The experiment included 54 male Sprague-Dawley rats with elevated translaminar cribrosa pressure difference (TLPD), def...

journal_title：Investigative ophthalmology & visual science

authors： Li XX,Zhang Z,Zeng HY,Wu S,Liu L,Zhang JX,Liu Q,Yang DY,Wang NL

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:The outcome of glaucoma filtration surgery is affected by subconjunctival wound healing. The effects of the antiglaucoma drug latanoprost on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel were investigated. METHODS:HTFs were cultured in a type I collagen gel wi...

journal_title：Investigative ophthalmology & visual science

authors： Liu Y,Ko JA,Yanai R,Kimura K,Chikama T,Sagara T,Nishida T

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To determine the mechanism that leads to the UVA light-dependent loss of glutathione reductase (GR) activity in human lens (HL). METHODS:Both the HL water-soluble (WS) fraction and yeast GR were irradiated with UVA light (200 mW/(cm(2). h) for 1 hour at +20 degrees C, and the specific activity (SA) was observe...

journal_title：Investigative ophthalmology & visual science

authors： Linetsky M,Hill JM,Chemoganskiy VG,Hu F,Ortwerth BJ

更新日期：2003-09-01 00:00:00

abstract：Purpose:To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. Methods:We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at ba...

journal_title：Investigative ophthalmology & visual science

authors： Ng WY,Ting DS,Agrawal R,Khandelwal N,Htoon HM,Lee SY,Wong TY,Cheung GC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:Dietary supplementation with vitamin A is sometimes prescribed as a treatment for retinitis pigmentosa, a group of inherited retinal degenerations that cause progressive blindness. Loss-of-function mutations in the ABCA4 gene are responsible for a subset of recessive retinitis pigmentosa. Other mutant alleles o...

journal_title：Investigative ophthalmology & visual science

authors： Radu RA,Yuan Q,Hu J,Peng JH,Lloyd M,Nusinowitz S,Bok D,Travis GH

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug...

journal_title：Investigative ophthalmology & visual science

authors： Barbosa Saliba J,Vieira L,Fernandes-Cunha GM,Rodrigues Da Silva G,Ligório Fialho S,Silva-Cunha A,Bousquet E,Naud MC,Ayres E,Oréfice RL,Tekaya M,Kowalczuk L,Zhao M,Behar-Cohen F

更新日期：2016-04-01 00:00:00

abstract：Purpose:Retinal damage in ocular toxoplasmosis reflects Toxoplasma gondii-induced cell lysis and reactive inflammation. Human retinal histopathology demonstrates the presence of neutrophils, but activities of this leukocyte subset are unstudied. We conducted in vitro experiments to evaluate roles for neutrophils as ret...

journal_title：Investigative ophthalmology & visual science

authors： Ashander LM,Lie S,Ma Y,Rochet E,Washington JM,Furtado JM,Appukuttan B,Smith JR

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Neuronal and glial alterations precede the overt vascular change that characterizes diabetic retinopathy. Because retinal astrocytes modulate neuronal and vascular function, this study investigated the time course of astrocyte, Müller cell, and neuronal change during diabetes to determine whether astrocytes may...

journal_title：Investigative ophthalmology & visual science

authors： Ly A,Yee P,Vessey KA,Phipps JA,Jobling AI,Fletcher EL

更新日期：2011-12-02 00:00:00

abstract：PURPOSE:FGF-2 stimulates cell proliferation of rabbit corneal endothelial cells (rCECs) by degrading the cyclin-dependent kinase inhibitor p27(Kip1) (p27) through its phosphorylation mechanism. The authors investigated whether the cell proliferation of human CECs (hCECs) is also induced by FGF-2 stimulation through the...

journal_title：Investigative ophthalmology & visual science

authors： Lee JG,Song JS,Smith RE,Kay EP

更新日期：2011-10-17 00:00:00

abstract：PURPOSE:In an earlier study it was reported that thrombin significantly reduces the rate of Na,K-adenosine triphosphatase (ATPase)-mediated ion transport by porcine lens. Because thrombin stimulates the release of endogenous endothelin (ET)-1 stores from some tissues, and because ET-1 can cause Na,K-ATPase inhibition, ...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Mukhopadhyay P,Delamere NA

更新日期：2002-03-01 00:00:00

abstract：Purpose:Our goal was to generate and characterize a new mouse model in which only angiogenesis- and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla (MGP) gene is highly expressed in vascular smooth muscle cells (VSMC) and trabecular meshwork (TM). We sought to direct our Mgp-Cre.KI mouse recomb...

journal_title：Investigative ophthalmology & visual science

authors： Asokan P,Mitra RN,Periasamy R,Han Z,Borrás T

更新日期：2018-02-01 00:00:00

abstract：Purpose:Retinal nonperfusion and hypoxia are important factors in human diabetic retinopathy, and these presumably inhibit energy production and lead to cell death. The purpose of this study was to elucidate the effect of diabetes on inner retinal oxygen delivery and metabolism in a mouse model of diabetes. Methods:Ph...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Wanek J,Felder AE,Brewer KC,Joslin CE,Shahidi M

更新日期：2016-11-01 00:00:00

abstract：Purpose:ISG15, a di-ubiquitin-like protein, is critical for controlling certain viral and bacterial infections. We sought to determine if ISG15 plays a role in corneal innate immunity against Candida albicans (C. albicans) using a C57BL/6 (B6) mouse model of human fungal keratitis. Methods:Scarified corneas of adult B...

journal_title：Investigative ophthalmology & visual science

authors： Dong C,Gao N,Ross BX,Yu FX

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To compare psychophysical Naka-Rushton parameters in retinitis pigmentosa (RP) patients and healthy controls using a flash-on-flash increment threshold paradigm, and to measure changes of these parameters with RP progression. METHODS:Sixty-six RP patients and 10 normal subjects were tested, and their maximum r...

journal_title：Investigative ophthalmology & visual science

authors： Dagnelie G,Massof RW

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To reevaluate the validity of the light scatter factor (LSF) formula of Paulsson and Sjöstrand, LSF = L/E (M2/M1-1), where L is the target luminance, E is the illuminance of the glare source at the eye, and M2 and M1 are modulation contrast thresholds measured with and without the glare source, respectively. Th...

journal_title：Investigative ophthalmology & visual science

authors： Whitaker D,Elliott DB,Steen R

更新日期：1994-01-01 00:00:00

abstract：Purpose:To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods:Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedi...

journal_title：Investigative ophthalmology & visual science

authors： Tan NYQ,Leong YY,Lang SS,Htoon ZM,Young SM,Sundar G

更新日期：2017-05-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the role of optic disc torsion on the rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with myopic open-angle glaucoma. Methods:We included 102 patients with myopic open-angle glaucoma accompanied by glaucomatous damage confined to a single ...

journal_title：Investigative ophthalmology & visual science

authors： Na KI,Lee WJ,Kim YK,Park KH,Jeoung JW

更新日期：2017-12-01 00:00:00

abstract：:We present results from 64 glaucoma patients and glaucoma suspects followed up for a median period of 7.4 yr who had a median of seven examinations using Program 31 on the Octopus perimeter. The patients also had manual visual fields recorded on either the Tübinger or Goldmann perimeter during the same period. By exam...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

journal_title：Investigative ophthalmology & visual science

authors： Lei Y,Stamer WD,Wu J,Sun X

更新日期：2014-11-06 00:00:00

abstract：PURPOSE:To investigate the residual stereo function of a group of 15 patients with strabismic amblyopia, by using motion-in-depth stimuli that allow discrimination of contributions from local disparity as opposed to those from local velocity mechanisms as a function of the rate of depth change. METHODS:The stereo perf...

journal_title：Investigative ophthalmology & visual science

authors： Hess RF,Mansouri B,Thompson B,Gheorghiu E

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:In the Gbeta5(-/-) mouse, the electroretinogram (ERG) b-wave is absent, and the R7 subfamily of regulators of G protein signaling (RGS), which includes RGS6, -7, -9, and -11, is downregulated. Mutant mouse strains deficient in RGS7 or -11 were characterized, and the SG711 strain which is deficient in both prote...

journal_title：Investigative ophthalmology & visual science

authors： Chen FS,Shim H,Morhardt D,Dallman R,Krahn E,McWhinney L,Rao A,Gold SJ,Chen CK

更新日期：2010-02-01 00:00:00

abstract：:A monoclonal antibody, 4G10.3, was developed that preferentially binds limbal basal cells in adult rat, rabbit, and human corneas. These cells were hypothesized to be the stem cells for the corneal epithelium. The antibody 4G10.3 was localized by immunofluorescence microscopy in rats 1 d and 1, 1.5, 2, 3, 4, and 6 wk ...

journal_title：Investigative ophthalmology & visual science

authors： Chung EH,Bukusoglu G,Zieske JD

更新日期：1992-06-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis and also has a direct antiproliferative effect on human retinal endothelial cells. The purpose o...

journal_title：Investigative ophthalmology & visual science

authors： Lambooij AC,Kuijpers RW,van Lichtenauer-Kaligis EG,Kliffen M,Baarsma GS,van Hagen PM,Mooy CM

更新日期：2000-07-01 00:00:00

abstract：:Chinese hamster ovarian (CHO) cells in culture were used to evaluate the relative antiproliferative potential of drugs. These agents have been used to improve the clinical response after glaucoma filtering surgery. The following drugs were evaluated: 5-fluorouracil (5-FU) as the benchmark, 5-fluorouridine (FUR), 5-flu...

journal_title：Investigative ophthalmology & visual science

authors： Senderoff RI,Weber PA,Smith DR,Sokoloski TD

更新日期：1990-12-01 00:00:00