Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice.

abstract：PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

journal_title：Investigative ophthalmology & visual science

authors： Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To evaluate the utility of baseline Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) normative classification in the prediction of future visual field (VF) loss. METHODS:Eighty-eight eyes with suspected glaucoma with abnormal RNFL classification by Str...

journal_title：Investigative ophthalmology & visual science

authors： Sung KR,Kim S,Lee Y,Yun SC,Na JH

更新日期：2011-04-22 00:00:00

abstract：:Nonenzymatic glycated lens alpha-crystallin, isolated from human diabetic cataract lenses, does not differ in subunit size and secondary structure from nonglycated alpha-crystallin. The tertiary structure, however, has undergone a significant change as reflected in the changes of near-ultraviolet (UV) circular dichroi...

journal_title：Investigative ophthalmology & visual science

authors： Liang JN,Chylack LT Jr

更新日期：1987-05-01 00:00:00

abstract：:The authors' study of the viscosities of various concentrations of sodium hyaluronate, chondroitin sulfate, and methylcellulose revealed that sodium hyaluronate and methylcellulose are pseudoplastic fluids in contrast to chondroitin sulfate, which is a Newtonian fluid. Pseudoplastic fluids are ideal for maintaining th...

journal_title：Investigative ophthalmology & visual science

authors： Hammer ME,Burch TG

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:Cataract is the most common cause of blindness in the world today, and yet there is no generally accepted treatment other than surgical intervention. Studies in rodent models designed to increase understanding of the molecular basis of cataract have shown that transforming growth factor (TGF)-beta induces morph...

journal_title：Investigative ophthalmology & visual science

authors： Hales AM,Chamberlain CG,McAvoy JW

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:In Graves' orbitopathy (GO), inflammation and expansion of the retrobulbar tissue are the result of a pathophysiologic process in which orbital fibroblasts (GO-Fs) are considered the central cell type. However, in a previous study we observed that GO-Fs expressed some of the consensus surface markers described ...

journal_title：Investigative ophthalmology & visual science

authors： Brandau S,Bruderek K,Hestermann K,Görtz GE,Horstmann M,Mattheis S,Lang S,Eckstein A,Berchner-Pfannschmidt U

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To evaluate the glaucoma progression in patients with a history of refractive corneal surgery (RCS). METHODS:A total of 313 eyes of 313 glaucoma patients (RCS group, 34 eyes; non-RCS group, 279 eyes) with a mean follow-up period of 2.7 years were included. Glaucoma progression was determined either by experts'...

journal_title：Investigative ophthalmology & visual science

authors： Kim YJ,Yun SC,Na JH,Tchah HW,Jung JJ,Sung KR

更新日期：2012-07-03 00:00:00

abstract：Purpose:To characterize intraocular pressure (IOP) dynamics by identifying the sources of transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative IOP-related mechanical energy, and temporal distribution. Methods:IOP was monitored at 500 Hz for periods of 16 to 451 days in nine normal...

journal_title：Investigative ophthalmology & visual science

authors： Turner DC,Edmiston AM,Zohner YE,Byrne KJ,Seigfreid WP,Girkin CA,Morris JS,Downs JC

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS:Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tis...

journal_title：Investigative ophthalmology & visual science

authors： Kadkol SS,Lin AY,Barak V,Kalickman I,Leach L,Valyi-Nagy K,Majumdar D,Setty S,Maniotis AJ,Folberg R,Pe'er J

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP). METHODS:The two affected sisters, 17 (BR) and 13 (MR) years old, were examined clinically and with perimetry, color vis...

journal_title：Investigative ophthalmology & visual science

authors： Seeliger MW,Biesalski HK,Wissinger B,Gollnick H,Gielen S,Frank J,Beck S,Zrenner E

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:The expression of the lens fiber cell integral membrane proteins MP20, the alpha 3 gap junction protein (connexin 46), and MP26 (MIP) was determined both during development of the bovine fetal lens and in different animal species. METHODS:The relative levels of the mRNA species coding for these proteins was de...

journal_title：Investigative ophthalmology & visual science

authors： Jarvis LJ,Kumar NM,Louis CF

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese ...

journal_title：Investigative ophthalmology & visual science

authors： How AC,Aung T,Chew X,Yong VH,Lim MC,Lee KY,Toh JY,Li Y,Liu J,Vithana EN

更新日期：2007-05-01 00:00:00

abstract：Purpose:Neuroretinopathy is increasingly being recognized as an independent cause of vision loss in diabetes. Visual field loss, as detected by frequency doubling technology (FDT)-based visual perimetry, is a sign of neuroretinopathy and occurs in early stages of diabetic retinopathy (DR). Here, we hypothesized that FD...

journal_title：Investigative ophthalmology & visual science

authors： Bao YK,Yan Y,Gordon M,McGill JB,Kass M,Rajagopal R

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：:PURPOSE. To investigate morphologic photoreceptor layer abnormalities and their correlation with visual function in occult macular dystrophy (OMD), by using spectral-domain optical coherence tomography (SD-OCT). METHODS. This observational case series included 18 eyes of 9 patients with OMD. All patients underwent an ...

journal_title：Investigative ophthalmology & visual science

authors： Park SJ,Woo SJ,Park KH,Hwang JM,Chung H

更新日期：2010-07-01 00:00:00

abstract：Purpose:To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods:One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18.1 repeat length (CTG18.1L) was determined via short tandem repeat as...

journal_title：Investigative ophthalmology & visual science

authors： Xu TT,Li YJ,Afshari NA,Aleff RA,Rinkoski TA,Patel SV,Maguire LJ,Edwards AO,Brown WL,Fautsch MP,Wieben ED,Baratz KH

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS:Binocular eye movements were recorded by an infrared system (mobile EBT) in 1...

journal_title：Investigative ophthalmology & visual science

authors： Lions C,Bui-Quoc E,Seassau M,Bucci MP

更新日期：2013-01-21 00:00:00

abstract：:The entoptic phenomenon by which one can observe leukocytes flowing in one's own parafoveal capillaries has been used to study the effect of changes in perfusion pressure on blood flow. Our measurements in humans with normal ocular fundi indicate that the retinal circulation of the parafovea is autoregulated in relati...

journal_title：Investigative ophthalmology & visual science

authors： Riva CE,Loebl M

更新日期：1977-06-01 00:00:00

abstract：PURPOSE:To examine the effects of modification of immune effector cells, including macrophages, in the pathogenesis of herpes simplex virus retinitis in BALB/c mice. METHODS:Two intravitreal injections (2 microliters each) of anti-CD11b monoclonal antibody (mAb) [13 micrograms/microliters] were administered to the con...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Rodriguez A,Heiligenhaus A,Pazos B,Van Rooijen N,Foster CS

更新日期：1994-06-01 00:00:00

abstract：:Ocular ultraviolet radiation (UVR) exposure was assessed in three occupational groups: fisherman, landscape workers and construction workers. The ratio of ocular exposure to ambient exposure was determined by placing UV-sensitive film (295-320 nm) between the eyes of the subjects and in a nearby open field. The mean o...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal FS,Phoon C,Bakalian AE,Taylor HR

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:To develop a sensitive and reproducible technique for measuring the adherence of blood lymphocytes to vessel walls exposed in sections of human retina and for examining the role of lymphocyte and vascular adhesion molecules in these events. METHODS:Cryostat sections of human retina were overlaid with blood lym...

journal_title：Investigative ophthalmology & visual science

authors： Hill TA,Stanford MR,Graham EM,Dumonde DC,Brown KA

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Corneal crystallins are lost from resident cells of the corneal stroma during wound repair, and this is associated with a loss of cell transparency. The goal of this study was to identify factors inducing loss of the corneal crystallin transketolase (TKT). METHODS:A cell culture model of freshly isolated rabbi...

journal_title：Investigative ophthalmology & visual science

authors： Stramer BM,Fini ME

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Abnormalities in the distribution of long-chain polyunsaturated fatty acids (LCPUFA) have been documented in plasma of patients with X-linked retinitis pigmentosa (XLRP). In this study, fatty acid profiles of red blood cells (RBC) were used as an index for LCPUFA metabolism in patients with XLRP because RBC lip...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman DR,Birch DG

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00

abstract：:A method for assessing the inward permeability of the blood-retinal barrier by fluorophotometry is presented. The permeability value is calculated with the fluorophotometer computer from fluorophotometric scan values in vitreous and non-protein-bound fluorescein concentration values in plasma. No diffusion coefficient...

journal_title：Investigative ophthalmology & visual science

authors： Kappelhof JP,van Best JA,van Valenberg PL,Oosterhuis JA

更新日期：1987-04-01 00:00:00

abstract：:Ocular sympathetic nerves were stimulated chronically in awake rabbits using electrodes unilaterally implanted on the cervical sympathetic trunk. IOP was measured by pneumatonometry and aqueous inflow was measured by fluorophotometry. In each animal, continuous trains of 1 msec pulses were delivered by means of a port...

journal_title：Investigative ophthalmology & visual science

authors： Belmonte C,Bartels SP,Liu JH,Neufeld AH

更新日期：1987-10-01 00:00:00

abstract：PURPOSE:To evaluate how aging alters 24-hour measurements of intraocular pressure (IOP) in the sitting and supine body positions. METHODS:Fifteen older volunteers with healthy eyes (ages, 53-71 years) were each housed for 1 day in a sleep laboratory. An 8-hour accustomed sleep period was assigned to each subject. Ever...

journal_title：Investigative ophthalmology & visual science

authors： Mansouri K,Weinreb RN,Liu JH

更新日期：2012-01-10 00:00:00

abstract：PURPOSE:Identification of novel proteins involved in retinal neovascularization may facilitate new and more effective molecular-based treatments for proliferative retinopathy. Tubedown-1 (Tbdn-1) is a novel protein that shows homology to the yeast acetyltransferase subunit NAT1 and copurifies with an acetyltransferase ...

journal_title：Investigative ophthalmology & visual science

authors： Wall DS,Gendron RL,Good WV,Miskiewicz E,Woodland M,Leblanc K,Paradis H

更新日期：2004-10-01 00:00:00

abstract：:Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light p...

journal_title：Investigative ophthalmology & visual science

authors： Dawis SM,Niemeyer G

更新日期：1986-03-01 00:00:00