Metabolic influences on the absorption of serous subretinal fluid.

abstract：Purpose:Conjunctival squamous cell carcinoma (SCC), a type of ocular surface neoplasia, is primarily treated by surgical resection and topical immuno- or chemotherapy. Metastatic disease may be treated with systemic chemo- or immunotherapy, albeit with variable response. The purpose of this study was to determine wheth...

journal_title：Investigative ophthalmology & visual science

authors： Nagarajan P,El-Hadad C,Gruschkus SK,Ning J,Hudgens CW,Sagiv O,Gross N,Tetzlaff MT,Esmaeli B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To evaluate the influence of a control group on the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) in early glaucoma. METHODS:In a diagnostic, case-control study, 119 eyes of 60 normal subjects with no findings suspicious for glaucoma (control cohort 1); 76 eyes of 41 subjects ref...

journal_title：Investigative ophthalmology & visual science

authors： Rao HL,Kumbar T,Addepalli UK,Bharti N,Senthil S,Choudhari NS,Garudadri CS

更新日期：2012-02-29 00:00:00

abstract：PURPOSE:To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress. METHODS:ARPE-19 cells were treated with the chemical oxidant tert-butyl hydroperoxide (t-BOOH), and cell viability was ...

journal_title：Investigative ophthalmology & visual science

authors： Hutnik CM,Pocrnich CE,Liu H,Laird DW,Shao Q

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:To determine the cell-killing activity of varying doses of carboplatin, graded hyperthermia, and the combination of carboplatin and hyperthermia in the treatment of a transgenic murine retinoblastoma cell line. METHODS:Replicate cell wells (more than six wells per dose point) from an established transgenic mur...

journal_title：Investigative ophthalmology & visual science

authors： Murray TG,Cicciarelli N,McCabe CM,Ksander B,Feuer W,Schiffman J,Mieler WF,O'Brien JM

更新日期：1997-11-01 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:As part of a systematic elucidation of the pharmacology of prostaglandin's (PG) effects on intraocular pressure in the monkey, the prototypical selective prostanoid EP(4) receptor agonist (3,7-dithia PGE(1)) was examined. It was found to be highly efficacious in nonhuman primates, and its mechanism of ocular hy...

journal_title：Investigative ophthalmology & visual science

authors： Woodward DF,Nilsson SF,Toris CB,Kharlamb AB,Nieves AL,Krauss AH

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 during the eye-opening stage when the goblet cells first appear. METHODS:Laser microdissection (LMD) was used to collect conjunctival forniceal cells from postnatal (PN) day 9, PN14 and PN20 wild-type...

journal_title：Investigative ophthalmology & visual science

authors： Gupta D,Harvey SA,Kaminski N,Swamynathan SK

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug...

journal_title：Investigative ophthalmology & visual science

authors： Barbosa Saliba J,Vieira L,Fernandes-Cunha GM,Rodrigues Da Silva G,Ligório Fialho S,Silva-Cunha A,Bousquet E,Naud MC,Ayres E,Oréfice RL,Tekaya M,Kowalczuk L,Zhao M,Behar-Cohen F

更新日期：2016-04-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:To calculate the relative amount of hemoglobin (Hb) in sectors of the optic nerve head (ONH) from stereoscopic color fundus images using the Laguna ONhE method and compare the results with the visual field evaluation and optical coherence tomography (OCT). METHODS:Healthy eyes (n = 87) and glaucoma eyes (n = 7...

journal_title：Investigative ophthalmology & visual science

authors： Pena-Betancor C,Gonzalez-Hernandez M,Fumero-Batista F,Sigut J,Medina-Mesa E,Alayon S,Gonzalez de la Rosa M

更新日期：2015-02-10 00:00:00

abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

journal_title：Investigative ophthalmology & visual science

authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To evaluate the ability of various screening tests, both individually and in combination, to detect glaucoma in the general Latino population and high-risk subgroups. METHODS:The Los Angeles Latino Eye Study is a population-based study of eye disease in Latinos 40 years of age and older. Participants (n = 6082...

journal_title：Investigative ophthalmology & visual science

authors： Francis BA,Varma R,Vigen C,Lai MY,Winarko J,Nguyen B,Azen S,Los Angeles Latino Eye Study Group.

更新日期：2011-08-05 00:00:00

abstract：:Mucins, which play important roles on the ocular surface in wettability, lubrication, and barrier function, are classified into two categories: secreted mucins and membrane-associated mucins. The most important secreted mucin on the ocular surface is MUC5AC, which is secreted by the conjunctival goblet cells. In the h...

journal_title：Investigative ophthalmology & visual science

authors： Hori Y

更新日期：2018-11-01 00:00:00

abstract：Purpose:RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Method...

journal_title：Investigative ophthalmology & visual science

authors： Kumaran N,Ripamonti C,Kalitzeos A,Rubin GS,Bainbridge JWB,Michaelides M

更新日期：2018-01-01 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：Purpose:To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. Methods:We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at ba...

journal_title：Investigative ophthalmology & visual science

authors： Ng WY,Ting DS,Agrawal R,Khandelwal N,Htoon HM,Lee SY,Wong TY,Cheung GC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To determine if lens epithelial lines can be established from cryopreserved whole rabbit lenses and from cryopreserved capsule-epithelial preparations (CEPs). METHODS:Lenses or freshly isolated CEPs were cryopreserved and subsequently thawed. Thawed whole lenses were cultured for 48 hours in growth medium and ...

journal_title：Investigative ophthalmology & visual science

authors： Reddan JR,Misra IC,Dziedzic DC

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cycl...

journal_title：Investigative ophthalmology & visual science

authors： Dismuke WM,Sharif NA,Ellis DZ

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To describe a software program developed to provide an objective assessment of the amount of posterior capsular opacification (PCO) in high-resolution digital images of the posterior capsule after cataract surgery. METHODS:Images are analyzed by a set protocol of defining the area of the posterior capsule, rem...

journal_title：Investigative ophthalmology & visual science

authors： Barman SA,Hollick EJ,Boyce JF,Spalton DJ,Uyyanonvara B,Sanguinetti G,Meacock W

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS:IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps...

journal_title：Investigative ophthalmology & visual science

authors： Kong YX,Crowston JG,Vingrys AJ,Trounce IA,Bui VB

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina. Because gangliosides play an important role in neuronal cell differentiation and proliferation, this change in ganglioside profile may indicate retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Park EJ,Suh M,Clandinin MT

更新日期：2005-07-01 00:00:00

abstract：:The distribution and organization of type I and type V collagens were studied in the embryonic chicken cornea using anti-collagen, type specific, monoclonal antibodies and immunoelectron microscopy. These studies were performed on lathyritic 17-day corneas treated at 4 degrees C or 37 degrees C. At the lower temperatu...

journal_title：Investigative ophthalmology & visual science

authors： Birk DE,Fitch JM,Linsenmayer TF

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:To characterize the response of cultured human retinal pigment epithelial (RPE) cells to lowered environmental oxygen. METHODS:The response of cultured RPE cells to lowered oxygen environments was compared to that of cell types of presumed high (Madin-Darby canine kidney [MDCK] cells, an epithelial cell line) ...

journal_title：Investigative ophthalmology & visual science

authors： Nash RW,McKay BS,Burke JM

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy, and retinal nerve fiber layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in pediatric patients (2-15 years old) affected by neurofibromatosis type 1. METHODS:Fifty-seven conse...

journal_title：Investigative ophthalmology & visual science

authors： Parrozzani R,Clementi M,Kotsafti O,Miglionico G,Trevisson E,Orlando G,Pilotto E,Midena E

更新日期：2013-12-17 00:00:00

abstract：Purpose:The subbasal nerve plexus (SNP) is the densest and most recognizable component of the mammalian corneal innervation; however, the anatomical configuration of the SNP in most animal models remains incompletely described. The purpose of the current study is to describe in detail the SNP architecture in eight diff...

journal_title：Investigative ophthalmology & visual science

authors： Marfurt C,Anokwute MC,Fetcko K,Mahony-Perez E,Farooq H,Ross E,Baumanis MM,Weinberg RL,McCarron ME,Mankowski JL

更新日期：2019-12-02 00:00:00

abstract：Purpose:To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods:Thirty-three adults and 33 children (...

journal_title：Investigative ophthalmology & visual science

authors： Jones PR,Yasoubi N,Nardini M,Rubin GS

更新日期：2016-11-01 00:00:00

abstract：:The extracellular matrix of retinal pigment epithelial (RPE) cells is an important component of the fibroelastic membranes formed in proliferative vitreoretinopathy (PVR). These membranes consist of cells intermingled with fibrillar proteins, such as elastin and collagen. Because RPE cells may be exposed to vitreous a...

journal_title：Investigative ophthalmology & visual science

authors： Martini B,Pandey R,Ogden TE,Ryan SJ

更新日期：1992-03-01 00:00:00

abstract：Purpose:To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care. Methods:All patients had ≥5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma ...

journal_title：Investigative ophthalmology & visual science

authors： Ballae Ganeshrao S,Senthil S,Choudhari N,Sri Durgam S,Garudadri CS

更新日期：2019-03-01 00:00:00

abstract：Purpose:To determine the effects of narrowband light exposure on choroidal thickness and the pupil response in humans. Methods:Twenty subjects, ages 21 to 43 years, underwent 1 hour of exposure to broadband, short wavelength "blue," or long wavelength "red" light, or darkness. Choroidal thickness, imaged with spectral...

journal_title：Investigative ophthalmology & visual science

authors： Lou L,Ostrin LA

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a ...

journal_title：Investigative ophthalmology & visual science

authors： Kumar M,Hill JM,Clement C,Varnell ED,Thompson HW,Kaufman HE

更新日期：2009-12-01 00:00:00