当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Optical coherence tomography in the diagnosis of optic pathway gliomas.

Optical coherence tomography in the diagnosis of optic pathway gliomas.

Abstract：

PURPOSE:To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy, and retinal nerve fiber layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in pediatric patients (2-15 years old) affected by neurofibromatosis type 1. METHODS:Fifty-seven consecutive patients with neurofibromatosis type 1 with recent (<6 months) orbital/brain magnetic resonance images (MRI) were included. Patients underwent visual function assessment (Hyvarinen symbols chart and/or Snellen charts) and optic disc evaluation by indirect ophthalmoscopy performed by experienced, masked pediatric ophthalmologists. Spectral domain OCT was performed to assess retinal nerve fiber layer. RESULTS:Fifteen of 57 enrolled patients (26%) were affected by MRI-proven optic pathway gliomas. Visual function assessment, optic disc evaluation, and retinal nerve fiber layer analysis by OCT were feasible in 84%, 95%, and 88% of patients, respectively. Visual function assessment, retinal nerve fiber layer analysis, and optic disc evaluation results correlated with the presence of optic pathway gliomas (P = 0.007, P < 0.0001, and P = 0.03, respectively). Specificity and negative predictive value of each test were statistically significant in detecting optic pathway glioma (P < 0.0001), whereas only retinal nerve fiber layers analysis reached statistically significant sensitivity and positive predictive value (P = 0.0386). CONCLUSIONS:Retinal nerve fiber layer analysis assessment using spectral domain OCT is superior to visual function assessment and optic disc evaluation as a clinical screening tool for optic pathway gliomas.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Parrozzani R,Clementi M,Kotsafti O,Miglionico G,Trevisson E,Orlando G,Pilotto E,Midena E

doi

10.1167/iovs.13-13093

subject

Has Abstract

pub_date

2013-12-17 00:00:00

pages

8112-8

issue

13

eissn

0146-0404

issn

1552-5783

pii

iovs.13-13093

journal_volume

54

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Three-dimensional modeling of metabolic species transport in the cornea with a hydrogel intrastromal inlay.

    abstract：PURPOSE:Intrastromal inlays for refractive correction of presbyopia are being adopted into clinical practice. An important concern is the effect of the inlay on the long-term health of the cornea due to disturbances in the concentration profiles of metabolic species. A three-dimensional metabolic model for the cornea i...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-13844

    authors： Pinsky PM

    更新日期：2014-05-15 00:00:00

  • Partial rescue of retinal function in chronically hypoglycemic mice.

    abstract：PURPOSE:Mice rendered hypoglycemic by a null mutation in the glucagon receptor gene Gcgr display late-onset retinal degeneration and loss of retinal sensitivity. Acute hyperglycemia induced by dextrose ingestion does not restore their retinal function, which is consistent with irreversible loss of vision. The goal of t...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8787

    authors： Umino Y,Cuenca N,Everhart D,Fernandez-Sanchez L,Barlow RB,Solessio E

    更新日期：2012-02-21 00:00:00

  • The Stiles-Crawford effect in retinitis pigmentosa.

    abstract：:Stiles-Crawford functions were obtained from the maculas of 22 patients with different genetic types of retinitis pigmentosa and visual acuity of 20/40 or better. Reduced cone directional sensitivity was seen in the fovea with both focal cone electroretinographic testing and psychophysical testing. Functions from the ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Birch DG,Sandberg MA,Berson EL

    更新日期：1982-02-01 00:00:00

  • Is whole-body hydration an important consideration in dry eye?

    abstract：PURPOSE:To identify if whole-body hydration plays an important role in dry eye (DE). We hypothesized that individuals classified as DE have higher plasma osmolality (Posm), indicating suboptimal hydration, compared with those classified as non-DE. METHODS:Using a hospital-based observational cross-sectional design, as...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-10175

    authors： Walsh NP,Fortes MB,Raymond-Barker P,Bishop C,Owen J,Tye E,Esmaeelpour M,Purslow C,Elghenzai S

    更新日期：2012-09-25 00:00:00

  • Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults.

    abstract：Purpose:Growing evidence suggests the involvement of the macula even in early stages of glaucoma. However, little is known about the impact of glaucomatous macular damage on central pattern vision. Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.17-22621

    authors： Chien L,Liu R,Girkin C,Kwon M

    更新日期：2017-12-01 00:00:00

  • Atrial natriuretic peptide receptors on the corneal endothelium.

    abstract：PURPOSE:To ascertain whether the corneal endothelium exhibits specific receptors for atrial natriuretic peptide (ANP) and to characterize partially any binding activity. METHODS:Most experiments employed radioligand-binding techniques to characterize 125I-ANP binding activity. Guanylate cyclase and corneal deturgescen...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Walkenbach RJ,Ye GS,Korenfeld MS,Boney F

    更新日期：1993-07-01 00:00:00

  • Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema.

    abstract：PURPOSE:Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly d...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-9950

    authors： Framme C,Schweizer P,Imesch M,Wolf S,Wolf-Schnurrbusch U

    更新日期：2012-08-24 00:00:00

  • β-Zone parapapillary atrophy and the rate of retinal nerve fiber layer thinning in glaucoma.

    abstract：PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were obse...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-6818

    authors： Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DM

    更新日期：2011-06-22 00:00:00

  • TMS over the left posterior parietal cortex prolongs latency of contralateral saccades and convergence.

    abstract：PURPOSE:This study explored the role of the left posterior parietal cortex (PPC) in saccades, vergence, and combined saccade-vergence movements by means of transcranial magnetic stimulation (TMS) in humans. METHODS:TMS was applied over the left PPC for 80, 90, or 100 ms after target onset. In a control experiment, TMS...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.03-1291

    authors： Yang Q,Kapoula Z

    更新日期：2004-07-01 00:00:00

  • Muscarinic receptors and their regulation of cyclic GMP in corneal endothelial cells.

    abstract：:Particulate fractions from fresh bovine corneal endothelium exhibited high affinity, specific binding by a potent muscarinic cholinergic radioligand, [3H]QNB. Particulate fraction binding sites exhibited half maximal binding at approximately 0.3 nM [3H]QNB and reached a maximal binding capacity of 820 fmoles/mg of pro...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Walkenbach RJ,Ye GS

    更新日期：1990-04-01 00:00:00

  • Mutations in the gene coding for the pre-mRNA splicing factor, PRPF31, in patients with autosomal dominant retinitis pigmentosa.

    abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0963

    authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

    更新日期：2007-03-01 00:00:00

  • Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.

    abstract：PURPOSE:In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the sh1 alleles examined hav...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Libby RT,Steel KP

    更新日期：2001-03-01 00:00:00

  • The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.

    abstract：PURPOSE:Experimental autoimmune uveoretinitis (EAU) in mice is an important model for elucidating basic mechanisms in autoimmune eye disease. The need for pertussis toxin (PTX) as an additional adjuvant to elicit EAU has limited the usefulness of this model in some types of studies by introducing a pleiotropic factor w...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Silver PB,Chan CC,Wiggert B,Caspi RR

    更新日期：1999-11-01 00:00:00

  • Accommodative facility in eyes with and without myopia.

    abstract：PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,多中心研究

    doi：10.1167/iovs.05-1078

    authors： Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

    更新日期：2006-11-01 00:00:00

  • Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization.

    abstract：PURPOSE:Vascular endothelial growth factor (VEGF) is required for vascular development and for ischemia-related tumor, iris, and retinal neovascularization. The role of VEGF in inflammatory corneal neovascularization is unknown and was investigated in these studies. METHODS:A rat model was used in which removal of the...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Amano S,Rohan R,Kuroki M,Tolentino M,Adamis AP

    更新日期：1998-01-01 00:00:00

  • Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography.

    abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-9369

    authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

    更新日期：2012-06-20 00:00:00

  • Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions.

    abstract：:We have investigated the involvement of cell-mediated immune responses to Herpes simplex virus type 1 (HSV-1) in the pathogenesis of HSV-1 induced corneal stromal lesions in mice. Topical corneal (TC) HSV-1 infection induced a vigorous delayed hypersensitivity response, as well as lymphoproliferative and cytotoxic res...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Ksander BR,Hendricks RL

    更新日期：1987-12-01 00:00:00

  • Effect of Gravity Acceleration on Choroidal and Retinal Nerve Fiber Layer Thickness: A Swept-Source Optical Coherence Tomography Study.

    abstract：Purpose:The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods:Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight su...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.17-21994

    authors： Kim DY,Song J,Kim JY,Choi K,Hyung S,Chae JB

    更新日期：2017-12-01 00:00:00

  • Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation.

    abstract：PURPOSE:To determine whether resolvin E1 (RvE1), an endogenous oxygenation product of eicosapentaenoic acid (EPA), induces increases in migration in human corneal epithelial cells (HCECs) and to identify signal pathways mediating this response. METHODS:Migration was measured with the scratch wound assay. Western blot ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.09-4468

    authors： Zhang F,Yang H,Pan Z,Wang Z,Wolosin JM,Gjorstrup P,Reinach PS

    更新日期：2010-11-01 00:00:00

  • Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.

    abstract：Purpose:To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods:Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RT...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.18-25864

    authors： Lin Y,Jiang H,Liu Y,Rosa Gameiro G,Gregori G,Dong C,Rundek T,Wang J

    更新日期：2019-02-01 00:00:00

  • Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea.

    abstract：PURPOSE:The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cultures of human corneal epithelial, stromal fibroblast, and end...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Wilson SE,Walker JW,Chwang EL,He YG

    更新日期：1993-07-01 00:00:00

  • Glaucoma Diagnostic Ability of the New Circumpapillary Retinal Nerve Fiber Layer Thickness Analysis Based on Bruch's Membrane Opening.

    abstract：PURPOSE:To compare the diagnostic ability of the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch's membrane opening (BMO), with the conventional circumpapillary RNFL thickness measurement centered on the optic...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-19578

    authors： Lee EJ,Lee KM,Kim H,Kim TW

    更新日期：2016-08-01 00:00:00

  • Feasibility of Macular Integrity Assessment (MAIA) Microperimetry in Children: Sensitivity, Reliability, and Fixation Stability in Healthy Observers.

    abstract：Purpose:To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods:Thirty-three adults and 33 children (...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-20037

    authors： Jones PR,Yasoubi N,Nardini M,Rubin GS

    更新日期：2016-11-01 00:00:00

  • Leakage of aquaporin 5 in the tear of dacryoadenitis mice.

    abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Hirai S,Ishida N,Watanabe K,Mita S

    更新日期：2000-08-01 00:00:00

  • Multiphoton fluorescence and second harmonic generation imaging of the structural alterations in keratoconus ex vivo.

    abstract：PURPOSE:To demonstrate the application of multiphoton fluorescence (MF) and second harmonic generation (SHG) microscopy for ex vivo characterization of the structural alterations of human corneas due to keratoconus. METHODS:Buttons of keratoconic corneas derived from penetrating keratoplasty were sent for structural a...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0386

    authors： Tan HY,Sun Y,Lo W,Lin SJ,Hsiao CH,Chen YF,Huang SC,Lin WC,Jee SH,Yu HS,Dong CY

    更新日期：2006-12-01 00:00:00

  • Optic disc swelling in Vogt-Koyanagi-Harada disease.

    abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8984

    authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

    更新日期：2012-04-18 00:00:00

  • Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells.

    abstract：PURPOSE:To investigate the intracellular mechanisms that induce amyloid beta (Abeta) accumulation and angiogenesis in the human retinal pigment epithelial cell line ARPE19. METHODS:The authors used two endoplasmic reticulum (ER) stress-inducing reagents, thapsigargin (TG), which inhibits the sarcoplasmic/endoplasmic c...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1067

    authors： Koyama Y,Matsuzaki S,Gomi F,Yamada K,Katayama T,Sato K,Kumada T,Fukuda A,Matsuda S,Tano Y,Tohyama M

    更新日期：2008-06-01 00:00:00

  • Analysis of macrophage phenotype in rejected corneal allografts.

    abstract：PURPOSE:We investigated the phenotype of macrophages infiltrating rejected corneal allografts. METHODS:We performed allogeneic or syngeneic corneal transplantation in mice, and humanely killed animals at day 28 during allograft rejection when 60% of corneal allografts were rejected. We divided allografts into two grou...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-12650

    authors： Oh JY,Lee HJ,Ko AY,Ko JH,Kim MK,Wee WR

    更新日期：2013-11-21 00:00:00

  • MRP8/14 enhances corneal susceptibility to Pseudomonas aeruginosa Infection by amplifying inflammatory responses.

    abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-10172

    authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

    更新日期：2013-02-01 00:00:00

  • Apoptotic retinal cell death induced by antirecoverin autoantibodies of cancer-associated retinopathy.

    abstract：PURPOSE:Recoverin has been identified as a target autoantigen for antirecoverin antibodies found in the sera of some patients with cancer-associated retinopathy. The aim of this study was to investigate the role of antirecoverin antibodies in cancer-associated retinopathy. METHODS:Human, rat, and rabbit antirecoverin ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Adamus G,Machnicki M,Seigel GM

    更新日期：1997-02-01 00:00:00