The response of cultured human retinal pigment epithelium to hypoxia: a comparison to other cell types.

abstract：PURPOSE:To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS:In the reliability study, two independent examiners obtained repeated ORA measurements i...

journal_title：Investigative ophthalmology & visual science

authors： Moreno-Montañés J,Maldonado MJ,García N,Mendiluce L,García-Gómez PJ,Seguí-Gómez M

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To describe lacrimal gland involvement in a murine model of acute graft-versus-host disease (GVHD). METHODS:Histopathologic examination was performed on lacrimal glands of mice affected by GVHD at 1, 2, 4, and 6 weeks after allogeneic bone marrow transplantation (BMT). Histopathologic scoring, based on charact...

journal_title：Investigative ophthalmology & visual science

authors： Hassan AS,Clouthier SG,Ferrara JL,Stepan A,Mian SI,Ahmad AZ,Elner VM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00

abstract：Purpose:Epithelial to mesenchymal transition (EMT) is a cause of anterior and posterior subcapsular cataracts. Central to EMT is the formation of actin stress fibers. Selective targeting of actin stress fiber-associated tropomyosin (Tpm) in epithelial cells may be a means to prevent stress fiber formation and repress l...

journal_title：Investigative ophthalmology & visual science

authors： Parreno J,Amadeo MB,Kwon EH,Fowler VM

更新日期：2020-06-03 00:00:00

abstract：PURPOSE:Define a role for Fas-FasL in oxygen-induced retinopathy and explore the mechanism of pigment-epithelium-derived growth factor (PEDF) inhibition in this model. METHODS:Seven-day-old mice C57BL/6J (B6), FasL-defective (B6-gld), or Fas-defective (B6-lpr) mice were exposed to 75% oxygen for 5 days (postnatal day ...

journal_title：Investigative ophthalmology & visual science

authors： Barreiro R,Schadlu R,Herndon J,Kaplan HJ,Ferguson TA

更新日期：2003-03-01 00:00:00

abstract：:Sodium removal from the solution bathing the isolated rabbit corneal endothelium caused a reduction in both unidirectional and net flux of bicarbonate, whereas chloride withdrawal from the solution had no effect on the net bicarbonate flux but increased the unidirectional fluxes. These data correlate with previously p...

journal_title：Investigative ophthalmology & visual science

authors： Green K,Simon S,Kelly GM Jr,Bowman KA

更新日期：1981-10-01 00:00:00

abstract：:Autoregulation of the retinal circulation in response to an acute elevation of intraocular pressure was investigated in 17 subjects (23 eyes) with no ocular abnormalities, by means of the blue field entoptic phenomenon. This phenomenon allows a person to observe leukocytes flowing in his own macular capillaries. Subje...

journal_title：Investigative ophthalmology & visual science

authors： Riva CE,Sinclair SH,Grunwald JE

更新日期：1981-07-01 00:00:00

abstract：PURPOSE:We tested the hypotheses that the mismatch between the clinical disc margin (CDM) and Bruch's membrane opening (BMO) is a function of BMO area (BMOA) and is affected by the presence of glaucoma. METHODS:A total of 45 normal eyes (45 subjects) and 53 glaucomatous eyes (53 patients) were enrolled and underwent r...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Miraftabi A,Henry S,Chung N,Nowroozizadeh S,Caprioli J,Nouri-Mahdavi K

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Excitotoxicity has been proposed to play a pivotal role in retinal damage, but the mechanisms that underlie retinal damage are not clearly understood. In this study, the role of matrix metalloproteinases in excitotoxin-mediated retinal damage was investigated. METHODS:KA, CNQX (6-cyano-7-nitroquinoxaline-2,3,-...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Cheng M,Chintala SK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:An early injury response to retinal detachment is disruption of synaptic connectivity between photoreceptors and second-order neurons. Most dramatic is the retraction of rod cell axons and their terminals away from the outer synaptic layer and toward their cell bodies. This study tested whether axonal retractio...

journal_title：Investigative ophthalmology & visual science

authors： Fontainhas AM,Townes-Anderson E

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To investigate the nature and reversibility of biochemical and functional changes in the retina encountered over a single generation of dietary n-3 polyunsaturated fatty acid deficiency in guinea pigs. METHODS:Dunkin-Hartley guinea pigs were fed for 16 weeks after weaning with diets supplemented with safflower...

journal_title：Investigative ophthalmology & visual science

authors： Weisinger HS,Vingrys AJ,Bui BV,Sinclair AJ

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a leading cause of blindness, yet pertinent animal models are uncommon. The sand rat (Psammomys obesus), exhibiting diet-induced metabolic syndrome, might constitute a relevant model. METHODS:Adult P. obesus (n = 39) were maintained in captivity for 4 to 7 months and fed either veg...

journal_title：Investigative ophthalmology & visual science

authors： Saïdi T,Mbarek S,Omri S,Behar-Cohen F,Chaouacha-Chekir RB,Hicks D

更新日期：2011-11-21 00:00:00

abstract：Purpose:Determine which posterior uveal melanoma (PUM) size classification with three categories has the best prognostic discrimination. Methods:Single-institution study of 424 consecutive patients with PUM. The tumor's largest basal diameter (LBD), smallest basal diameter (SBD), and thickness (TH) were estimated by f...

journal_title：Investigative ophthalmology & visual science

authors： Skinner CC,Augsburger JJ,Augsburger BD,Correa ZM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To identify major gangliosides - the sialated glycolipids - of corneal epithelium; to determine which specific gangliosides, if any, are synthesized in a higher amount or are downregulated during corneal epithelial cell migration; and to determine what role, if any, they play in the modulation of corneal epithe...

journal_title：Investigative ophthalmology & visual science

authors： Yang Z,Zhao Z,Panjwani N

更新日期：1996-03-01 00:00:00

abstract：:Steady-state visual evoked potentials were elicited by the appearance/disappearance of sinusoidal gratings of varying spatial frequency for both eyes of amblyopic subjects. The amblyopic eyes showed reduced responses and a phase shift relative to the nonamblyopic eyes across a wide range of spatial frequencies. Both t...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1978-06-01 00:00:00

abstract：PURPOSE:VEGF has been shown to be necessary, but not sufficient alone, for the development of subretinal pathologic angiogenesis. In the current study, the influence of placental growth factor (PlGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Rakic JM,Lambert V,Devy L,Luttun A,Carmeliet P,Claes C,Nguyen L,Foidart JM,Noël A,Munaut C

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：Purpose:To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods:The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The...

journal_title：Investigative ophthalmology & visual science

authors： Xiong S,Zhang B,Hong Y,He X,Zhu J,Zou H,Xu X

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To decipher the biological pathways involved in keratoconus pathophysiology by determining the patterns of differential gene expression between keratoconus and control corneas. METHODS:RNA was extracted from surgically removed corneas of 10 keratoconus patients and from normal corneas of 10 control patients wh...

journal_title：Investigative ophthalmology & visual science

authors： Macé M,Galiacy SD,Erraud A,Mejía JE,Etchevers H,Allouche M,Desjardins L,Calvas P,Malecaze F

更新日期：2011-08-03 00:00:00

abstract：PURPOSE:To determine whether there is rod system dysfunction in the central retina of patients with age-related macular degeneration (AMD). METHODS:Dark-adapted sensitivity (500-nm stimulus) and light-adapted sensitivity (600 nm) were measured psychophysically at 52 loci in the central 38 degrees (diameter) of retina ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,Jackson GR,Cideciyan AV,Huang Y,Fine SL,Ho AC,Maguire MG,Lolley V,Jacobson SG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia. METHODS:We performed a cross-sectional study on Norfolk Island and recruited individuals aged ≥ 15 years. Participants completed a sun-exposure questionnaire and un...

journal_title：Investigative ophthalmology & visual science

authors： Sherwin JC,Hewitt AW,Coroneo MT,Kearns LS,Griffiths LR,Mackey DA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To determine the size variation of the X-chromosomal human red and green visual pigment gene array in the general population using pulsed field gel electrophoresis and Southern blotting. METHODS:Peripheral blood lymphocytes were prepared from 67 anonymous males. The cells were embedded in agarose and the genom...

journal_title：Investigative ophthalmology & visual science

authors： Macke JP,Nathans J

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:The authors' previous study showed that the expression of a Rho-associated serine/threonine kinase (ROCK) is regulated during cell cycle progression in corneal epithelial cells. The present study was conducted to determine whether and how Rho/ROCK signaling regulates cell cycle progression. METHODS:Rabbit corn...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Guerriero E,Lathrop K,SundarRaj N

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To determine whether the human retinal oxygenation response (deltaPO2) to a hyperoxic provocation is abnormal in patients with type I diabetes. METHODS:Magnetic resonance imaging (MRI) was used to measure deltaPO2 during 100% oxygen breathing in patients with type I diabetes who had either no clinically detect...

journal_title：Investigative ophthalmology & visual science

authors： Trick GL,Edwards P,Desai U,Berkowitz BA

更新日期：2006-04-01 00:00:00

abstract：:A simple clinical method for measurement of light backscatter from defined regions of the lens in vivo is described. Light scattering was quantitated in 168 lenses of 85 "normal" subjects spanning 8 decades of life. The results indicate that light scatter from the anterior capsule does not change with age. The light s...

journal_title：Investigative ophthalmology & visual science

authors： Ben-Sira I,Weinberger D,Bodenheimer J,Yassur Y

更新日期：1980-04-01 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are members of a large group of homologous peptides identified as the VEGF family. Although VEGF-A is known to act as a potent angiogenic peptide in the retina, the vasoactive function of PlGF in this tissue is less well defined. Thi...

journal_title：Investigative ophthalmology & visual science

authors： Feeney SA,Simpson DA,Gardiner TA,Boyle C,Jamison P,Stitt AW

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:Recent evidence suggests that platelets play a major role in ischemia-reperfusion injury, not only through thrombus formation but also through participation in inflammatory reactions with leukocytes. This study was designed to investigate the contribution of platelets in leukocyte recruitment to inflamed region...

journal_title：Investigative ophthalmology & visual science

authors： Nishijima K,Kiryu J,Tsujikawa A,Miyamoto K,Honjo M,Tanihara H,Nonaka A,Yamashiro K,Katsuta H,Miyahara S,Honda Y,Ogura Y

更新日期：2004-03-01 00:00:00

abstract：Purpose:Individuals with developmental dyslexia suffer not only from reading problems as more general motor deficits can also be observed in this patient group. Both psychometric clinical tests and objective eyetracking methods suggest that unstable binocular fixation may contribute to reading problems. Because binocul...

journal_title：Investigative ophthalmology & visual science

authors： Przekoracka-Krawczyk A,Brenk-Krakowska A,Nawrot P,Rusiak P,Naskrecki R

更新日期：2017-12-01 00:00:00

abstract：:Cone electroretinograms were elicited with a full-field red flash after-45 min of dark adaptation from 16 patients with retinitis pigmentosa and from 17 normal subjects. The average latency and implicit time of the cone a-waves recorded from the patients were each significantly delayed (p less than 0.005) compared wit...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Sullivan PL,Berson EL

更新日期：1981-11-01 00:00:00

abstract：Purpose:Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods:We evaluated the effects of ov...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto M,Fujihara K,Ishizawa M,Osawa T,Kaneko M,Ishiguro H,Matsubayashi Y,Seida H,Yamanaka N,Tanaka S,Kodama S,Hasebe H,Sone H

更新日期：2019-06-03 00:00:00