The sand rat, Psammomys obesus, develops type 2 diabetic retinopathy similar to humans.

abstract：PURPOSE:To evaluate the importance of lens epithelial cell death in age-related cataract. To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive lens epithelial cells previously reported in human capsulotomy specimens results from apopto...

journal_title：Investigative ophthalmology & visual science

authors： Harocopos GJ,Alvares KM,Kolker AE,Beebe DC

更新日期：1998-12-01 00:00:00

abstract：Purpose:Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). Methods:Expression of postulated s...

journal_title：Investigative ophthalmology & visual science

authors： Doherty RE,Sisley K,Hammond DW,Rennie IG,Cross NA

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts. METHODS:The GJA8 gene was directly sequenced. Formation of functional channels was assessed by the two-microelectrode voltage-clamp METHOD:Connexin protein levels and distribu...

journal_title：Investigative ophthalmology & visual science

authors： Minogue PJ,Tong JJ,Arora A,Russell-Eggitt I,Hunt DM,Moore AT,Ebihara L,Beyer EC,Berthoud VM

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

journal_title：Investigative ophthalmology & visual science

authors： Burroughs SL,Kaja S,Koulen P

更新日期：2011-06-01 00:00:00

abstract：:Using isochromatic luminance gratings and isoluminant red-green color gratings, examined luminance and color discrimination in amblyopia were examined. Complete color and luminance contrast sensitivity functions were measured monocularly from each eye of six normal and six amblyopic observers. Similar spatial frequenc...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Dahlman C,Switkes E,De Valois K

更新日期：1986-09-01 00:00:00

abstract：PURPOSE:To determine whether retinal progenitor cells in the inner nuclear layer give rise to regenerated cones after laser ablation of photoreceptors in adult goldfish retina. METHODS:Using a technique developed previously in this laboratory, photoreceptors in the retina of adult goldfish were ablated with an argon l...

journal_title：Investigative ophthalmology & visual science

authors： Wu DM,Schneiderman T,Burgett J,Gokhale P,Barthel L,Raymond PA

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To determine which components present in oxidized LDL are responsible for the cytotoxicity associated with its internalization by culture ARPE19 cells. METHODS:ARPE19 cells were grown in 24-well and 96-well plates. Cell viability was measured by MTT and/or adenosine triphosphate (ATP) content. LDL was oxidized...

journal_title：Investigative ophthalmology & visual science

authors： Rodriguez IR,Alam S,Lee JW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:To ascertain whether the corneal endothelium exhibits specific receptors for atrial natriuretic peptide (ANP) and to characterize partially any binding activity. METHODS:Most experiments employed radioligand-binding techniques to characterize 125I-ANP binding activity. Guanylate cyclase and corneal deturgescen...

journal_title：Investigative ophthalmology & visual science

authors： Walkenbach RJ,Ye GS,Korenfeld MS,Boney F

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:A preferential loss of ERG b-wave was detected in a substrain of C57BL/10 mice. Electroretinographic and histologic techniques were used to investigate this hitherto unknown retinopathy. METHODS:ERGs were obtained from normal and affected C57BL/10. C57BL/6 mice served also as controls. a-Wave and c-wave analys...

journal_title：Investigative ophthalmology & visual science

authors： Ruether K,Grosse J,Matthiessen E,Hoffmann K,Hartmann C

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in corneal epithelial cell proliferation by suppressing the Pax6 gene. The present study focused on further understanding the role of CTCF in mediating EGF-induced migration of immortalized human corneal epithelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Deng SX,Lu L

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...

journal_title：Investigative ophthalmology & visual science

authors： Price BA,Sandoval IM,Chan F,Simons DL,Wu SM,Wensel TG,Wilson JH

更新日期：2011-12-28 00:00:00

abstract：PURPOSE:To determine whether there is rod system dysfunction in the central retina of patients with age-related macular degeneration (AMD). METHODS:Dark-adapted sensitivity (500-nm stimulus) and light-adapted sensitivity (600 nm) were measured psychophysically at 52 loci in the central 38 degrees (diameter) of retina ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,Jackson GR,Cideciyan AV,Huang Y,Fine SL,Ho AC,Maguire MG,Lolley V,Jacobson SG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). METHODS:Paired explants were used as control versus VIP (10 nM)-treated before storage in corne...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Gloria D,Molloy J

更新日期：2011-07-29 00:00:00

abstract：:Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave im...

journal_title：Investigative ophthalmology & visual science

authors： Witzel DA,Smith EL,Wilson RD,Aguirre GD

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). METHODS:We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who underwent both fluorescein angiography (FA) and volu...

journal_title：Investigative ophthalmology & visual science

authors： Hariri A,Heussen FM,Nittala MG,Sadda SR

更新日期：2013-12-09 00:00:00

abstract：PURPOSE:It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can...

journal_title：Investigative ophthalmology & visual science

authors： Wang S,Lu B,Girman S,Holmes T,Bischoff N,Lund RD

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To examine the reliability and usefulness of a video-based Hirschberg test under clinical conditions. METHODS:The authors estimated ocular deviation in 87 patients with strabismus through automated analysis of corneal reflex displacement using a video refractor. The reproducibility of measurement, the comparis...

journal_title：Investigative ophthalmology & visual science

authors： Hasebe S,Ohtsuki H,Tadokoro Y,Okano M,Furuse T

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:To our knowledge, studies comparing binocular eye movements during reading task in strabismic children are scarce. The goal of our study was to examine binocular coordination of saccades during reading in strabismic children. METHODS:Binocular eye movements were recorded by an infrared system (mobile EBT) in 1...

journal_title：Investigative ophthalmology & visual science

authors： Lions C,Bui-Quoc E,Seassau M,Bucci MP

更新日期：2013-01-21 00:00:00

abstract：PURPOSE:To examine the temporal summation of a Goldmann III-sized stimulus under the conditions of standard automated perimetry in healthy participants of varying age. METHODS:Twenty-seven healthy individuals of varying age (24-80 years) were tested. Achromatic contrast thresholds were measured for seven 0.48° diamete...

journal_title：Investigative ophthalmology & visual science

authors： Mulholland PJ,Redmond T,Garway-Heath DF,Zlatkova MB,Anderson RS

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Currently, the test for useful field of view (UFOV) typically relies on subjective feedback for detecting peripheral targets while attending to a central target. Steady-state visual evoked potential (SSVEP) recorded from the occipital region of the brain has been frequently used as an objective alternative to r...

journal_title：Investigative ophthalmology & visual science

authors： Lin ST,Tey LK

更新日期：2016-06-01 00:00:00

abstract：Purpose:To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods:Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. ...

journal_title：Investigative ophthalmology & visual science

authors： Kimlin JA,Black AA,Wood JM

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Intramuscular innervation of horizontal rectus extraocular muscles (EOMs) is segregated into superior and inferior (transverse) compartments, while all EOMs are also divided into global (GL) and orbital (OL) layers with scleral and pulley insertions, respectively. We sought evidence of potential independent act...

journal_title：Investigative ophthalmology & visual science

authors： Shin A,Yoo L,Chaudhuri Z,Demer JL

更新日期：2012-12-19 00:00:00

abstract：PURPOSE:The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested. This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctiva...

journal_title：Investigative ophthalmology & visual science

authors： Garrett Q,Xu S,Simmons PA,Vehige J,Flanagan JL,Willcox MD

更新日期：2008-11-01 00:00:00

abstract：:Purpose. To establish a theoretical model to determine the relationship between retinal coverage and tamponade shape in relation to tamponade volume, for a variety of tamponades, and to test these relationships with a physical analogue of the human eye. Methods. The theoretical model was based on a static balance betw...

journal_title：Investigative ophthalmology & visual science

authors： Eames I,Angunawela RI,Aylward GW,Azarbadegan A

更新日期：2010-04-01 00:00:00

abstract：Purpose:To investigate the chromatic characteristics and intensity-response function of light-induced reflex lacrimation and its correlation with the melanopsin-driven postillumination pupil response (PIPR). Methods:Eleven visually normal participants completed the experiment. Lacrimation was measured in one eye by pl...

journal_title：Investigative ophthalmology & visual science

authors： Lei S,Goltz HC,Chen X,Zivcevska M,Wong AM

更新日期：2017-03-01 00:00:00