A comparison of color and luminance discrimination in amblyopia.

abstract：:Attempts to describe normal corneal shape and to represent corneal topography by an array of discrete points have limited usefulness. A quantitative photogrammetric method that produces indices to describe corneal shape was developed. Four indices depict the departure of keratographic rings from circularity, and two i...

journal_title：Investigative ophthalmology & visual science

authors： Cohen KL,Tripoli NK,Pellom AC,Kupper LL,Fryczkowski AW

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS:Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conducta...

journal_title：Investigative ophthalmology & visual science

authors： Martinez-Wittinghan FJ,Sellitto C,White TW,Mathias RT,Paul D,Goodenough DA

更新日期：2004-10-01 00:00:00

abstract：:Moiré fringes generated by two equal gratings in contact, looked at in Maxwellian view, are well suited for the assessment of retinal visual acuity. High-contrast fringes practically free from spatial harmonics (higher Fourier components) are obtained if, instead of the zero diffraction order, one first-order diffract...

journal_title：Investigative ophthalmology & visual science

authors： Lotmar W

更新日期：1980-04-01 00:00:00

abstract：Purpose:The purpose of this study was to describe the cellular architecture of normal human peripapillary sclera (PPS) and evaluate surface topography's role in fibroblast behavior. Methods:PPS cryosections from nonglaucomatous eyes were labelled for nuclei, fibrillar actin (FA), and alpha smooth muscle actin (αSMA) a...

journal_title：Investigative ophthalmology & visual science

authors： Szeto J,Chow A,McCrea L,Mozzer A,Nguyen TD,Quigley HA,Pitha I

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:Familial exudative vitreoretinopathy (FEVR) is a rare hereditary disorder characterized by the failure of peripheral retinal vascularization. The genes FZD4, LRP5, and TSPAN12 are known to be associated with the autosomal inheritance form of FEVR. In this study, we performed mutation screening for FZD4, LRP5, a...

journal_title：Investigative ophthalmology & visual science

authors： Seo SH,Yu YS,Park SW,Kim JH,Kim HK,Cho SI,Park H,Lee SJ,Seong MW,Park SS,Kim JY

更新日期：2015-08-01 00:00:00

abstract：Purpose:ISG15, a di-ubiquitin-like protein, is critical for controlling certain viral and bacterial infections. We sought to determine if ISG15 plays a role in corneal innate immunity against Candida albicans (C. albicans) using a C57BL/6 (B6) mouse model of human fungal keratitis. Methods:Scarified corneas of adult B...

journal_title：Investigative ophthalmology & visual science

authors： Dong C,Gao N,Ross BX,Yu FX

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS:Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tis...

journal_title：Investigative ophthalmology & visual science

authors： Kadkol SS,Lin AY,Barak V,Kalickman I,Leach L,Valyi-Nagy K,Majumdar D,Setty S,Maniotis AJ,Folberg R,Pe'er J

更新日期：2006-03-01 00:00:00

abstract：Purpose:To investigate by optical coherence tomography angiography (OCT-A) the choroidal vascular response to experimentally increased blood pressure in patients with central serous chorioretinopathy (CSCR). Methods:For this multicenter, observational, case-control study, we enrolled 35 patients with an established di...

journal_title：Investigative ophthalmology & visual science

authors： Cardillo Piccolino F,Lupidi M,Cagini C,Fruttini D,Nicolò M,Eandi CM,Tito S

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pig...

journal_title：Investigative ophthalmology & visual science

authors： Repetto R,Pralits JO,Siggers JH,Soleri P

更新日期：2015-05-01 00:00:00

abstract：:The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated via a reduction in aqueous outflow through the conventional (trabecular meshwork and Schlemm's canal) outflow pathway. Current IOP lowering pharmacological strategies target the uveoscleral (nonconventional) outflow pathway or ...

journal_title：Investigative ophthalmology & visual science

authors： Cavet ME,Vittitow JL,Impagnatiello F,Ongini E,Bastia E

更新日期：2014-08-14 00:00:00

abstract：:Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit incr...

journal_title：Investigative ophthalmology & visual science

authors： Abramovsky-Kaplan I,Jones IS

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL...

journal_title：Investigative ophthalmology & visual science

authors： Hidalgo-de-Quintana J,Evans RJ,Cheetham ME,van der Spuy J

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To identify the differently expressed micro (mi) RNAs in pterygium compared with normal conjunctiva and investigate the potential role of miRNAs in the pathogenesis of pterygium. METHODS:With microRNA microarray and quantitative RT-PCR, we identified that microRNA-122 (miR-122) was significantly decreased in p...

journal_title：Investigative ophthalmology & visual science

authors： Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity of acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number of immunogenetic factors including IL2RA, miR-27a, miR-182, and FoxO1 are associated with Treg cell function. In this study, we investig...

journal_title：Investigative ophthalmology & visual science

authors： Yu H,Liu Y,Zhang L,Wu L,Zheng M,Cheng L,Luo L,Kijlstra A,Yang P

更新日期：2014-11-20 00:00:00

abstract：:The overall morphology of corneal fibroblasts in the rat was examined by scanning electron microscopy after removal of stromal connective tissue elements by tryptic digestion and HCl hydrolysis. Fibroblasts thus exposed were flattened and stellate cells with a diameter of about 10 micron and had a number of ramified c...

journal_title：Investigative ophthalmology & visual science

authors： Nishida T,Yasumoto K,Otori T,Desaki J

更新日期：1988-12-01 00:00:00

abstract：:Cell membranes from the human lens contain two major polypeptides with molecular weights near 26,000 and 22,000. These two species have been isolated in a highly purified state and purified by means of an antiserum against the 26,000 dalton membrane polypeptide from bovine lens. Immunochemical data are presented that ...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Horwitz J

更新日期：1981-07-01 00:00:00

abstract：:Class II (DR or Ia) alloantigens are potent inducers of cell-mediated immune responses. However, the expression of Class II alloantigens on corneal cells, except for Langerhans cells within the limbal epithelium, has not previously been described. We have induced Ia expression on cultured rabbit corneal endothelial ce...

journal_title：Investigative ophthalmology & visual science

authors： Donnelly JJ,Li WY,Rockey JH,Prendergast RA

更新日期：1985-04-01 00:00:00

abstract：Purpose:Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (B...

journal_title：Investigative ophthalmology & visual science

authors： Jolly JK,Xue K,Edwards TL,Groppe M,MacLaren RE

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The stratified squamous epithelial covering of the cornea provides one of the first physical and immunological lines of defense. A breach in its integrity results in a wound healing response that resolves quickly. However, under certain conditions-for example, when migrating cells are unable to adhere to the ba...

journal_title：Investigative ophthalmology & visual science

authors： Chow S,Di Girolamo N

更新日期：2014-09-18 00:00:00

abstract：PURPOSE:To determine the fate of donor epithelial, stromal, and endothelial cells after corneal transplantation in humans. METHODS:Fifty-two transplanted corneal buttons were explanted over a 2-year period from patients who required regrafting and had received corneas from donors of opposite sex. Fluorescence in situ ...

journal_title：Investigative ophthalmology & visual science

authors： Lagali N,Stenevi U,Claesson M,Fagerholm P,Hanson C,Weijdegård B,Swedish Society of Corneal Surgeons.

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration. The authors characterized the consequences of genetically reduced retinal transferrin production on retinal structure and function. METHODS:Hypotransferrinemic (HPX⁻/⁻) mice tre...

journal_title：Investigative ophthalmology & visual science

authors： Lederman M,Obolensky A,Grunin M,Banin E,Chowers I

更新日期：2012-02-02 00:00:00

abstract：Purpose:The purpose of this study was to evaluate macular preganglionic function and to verify its relationship with retinal and choroidal morphology in patients with intermediate age-related macular degeneration (iAMD) patients. Methods:All included patients performed multifocal electroretinogram (mfERG) for investig...

journal_title：Investigative ophthalmology & visual science

authors： Parisi V,Ziccardi L,Costanzo E,Tedeschi M,Barbano L,Manca D,Di Renzo A,Giorno P,Varano M,Parravano M

更新日期：2020-05-11 00:00:00

abstract：:We have investigated alterations of the metabolic state in vitamin A-deficient (A-) corneas using phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopy. Comparing to the control, A- corneas showed a prominent rise of phosphocreatine (PCr) as well as a total loss of glycerophosphorylcholine (GPC). Further, ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi K,Cheng HM,Xiong J,Xiong H,Kenyon KR

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:To investigate the distribution of inflammatory mediators such as interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha and angiogenic cytokines such as vascular endothelial growth factor (VEGF) and to identify their cellular source in surgically excised choroidal neovascular membranes (CNVMs) of various...

journal_title：Investigative ophthalmology & visual science

authors： Oh H,Takagi H,Takagi C,Suzuma K,Otani A,Ishida K,Matsumura M,Ogura Y,Honda Y

更新日期：1999-08-01 00:00:00

abstract：:An arterial connection between the two internal ophthalmic arteries in the rabbit was confirmed. The consensual response to ocular injury and its relationship to this interconnecting artery was examined by transecting the interconnecting vessel and creating a monocular injury by anterior chamber paracentesis. In the r...

journal_title：Investigative ophthalmology & visual science

authors： Forster S,Mead A,Sears M

更新日期：1979-02-01 00:00:00

abstract：PURPOSE:To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS:Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of ste...

journal_title：Investigative ophthalmology & visual science

authors： Healey PR,Mitchell P,Gilbert CE,Lee AJ,Ge D,Snieder H,Spector TD,Hammond CJ

更新日期：2007-06-01 00:00:00

abstract：:Sodium removal from the solution bathing the isolated rabbit corneal endothelium caused a reduction in both unidirectional and net flux of bicarbonate, whereas chloride withdrawal from the solution had no effect on the net bicarbonate flux but increased the unidirectional fluxes. These data correlate with previously p...

journal_title：Investigative ophthalmology & visual science

authors： Green K,Simon S,Kelly GM Jr,Bowman KA

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:Organized conjunctiva-associated lymphoid tissue (O-CALT) is constantly exposed to environmental antigens and plays a central role in the common mucosal immune system. This study was undertaken to investigate whether O-CALT in rabbit lymphoid tissue, as in other lymphoid tissue in other mammals, changes with ag...

journal_title：Investigative ophthalmology & visual science

authors： Cain C,Phillips TE

更新日期：2008-02-01 00:00:00

abstract：Purpose:Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis...

journal_title：Investigative ophthalmology & visual science

authors： Denniston AK,Keane PA,Srivastava SK

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To determine the sensitivity to change and specificity achieved when published test-retest variability (TRV) data are used to determine whether measured changes in ETDRS logarithm of the minimum angle of resolution (logMAR) visual acuity reflect true clinical change or are attributable to measurement error alon...

journal_title：Investigative ophthalmology & visual science

authors： Rosser DA,Cousens SN,Murdoch IE,Fitzke FW,Laidlaw DA

更新日期：2003-08-01 00:00:00