Vitronectin: a migration and wound healing factor for human corneal epithelial cells.

abstract：PURPOSE:Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin coh...

journal_title：Investigative ophthalmology & visual science

authors： Schäche M,Richardson AJ,Pertile KK,Dirani M,Scurrah K,Baird PN

更新日期：2007-11-01 00:00:00

abstract：:In orbital exenteration specimens from 14 rats, 93% of the mast cells were found in the lids, the limbus, and the conjunctiva, 5% in the orbital tissues, and less than 1% in the globe. The density of mast cells was highest in lid (2843/mm3), limbus (2822/mm3), and orbit (2184/mm3) and lowest in bulbar conjunctiva (794...

journal_title：Investigative ophthalmology & visual science

authors： Allansmith MR,Baird RS,Kashima K,Bloch KJ

更新日期：1979-08-01 00:00:00

abstract：PURPOSE:Angiotensin II (AII) has been shown to play a role in many vascular diseases. In the study described, the effect of AII on vascular endothelial growth factor (VEGF) expression and related intracellular signaling mechanism was investigated in bovine retinal microcapillary pericytes. METHODS:Cultured bovine reti...

journal_title：Investigative ophthalmology & visual science

authors： Otani A,Takagi H,Oh H,Suzuma K,Matsumura M,Ikeda E,Honda Y

更新日期：2000-04-01 00:00:00

abstract：:The elastic fiber consists of several components: a central core of alpha-elastin and a microfibrillar sheath containing three components: fibrillin, microfibril-associated glycoprotein, and a 35-kD protein with amine oxidase activity. Elastin is a major component of the elastic fibers of the extracellular matrix (ECM...

journal_title：Investigative ophthalmology & visual science

authors： Hernandez MR

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：Purpose:To determine if variation in anterior lamina cribrosa surface depth (ALCSD) differs between glaucoma patients of African (AD) and European descent (ED). Methods:A total of 178 eyes from 123 glaucoma patients in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma St...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Bowd C,Medeiros FA,Weinreb RN,Liebmann JM,Proudfoot J,Zangwill LM,Belghith A

更新日期：2019-10-01 00:00:00

abstract：:Sections of the ciliary epithelium of adult sharks (Squalus acanthias) were mounted in Ussing-type chambers (area 0.2 cm2) for measurements of transepithelial potential difference (PD), short circuit current (SCC) and calculation of transepithelial resistance (R). In 15 preparations PD was aqueous side negative (-0.51...

journal_title：Investigative ophthalmology & visual science

authors： Wiederholt M,Zadunaisky JA

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:The Farnsworth-Munsell 100-Hue test (FM100) is a standardized measure of chromatic discrimination, based on colored cap-sorting, which has been widely used in both adults and children. Its dependence on seriation ability raises questions as to its universal suitability and accuracy in assessing purely sensory d...

journal_title：Investigative ophthalmology & visual science

authors： Cranwell MB,Pearce B,Loveridge C,Hurlbert AC

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:We investigated the effects of semaphorin 3E (Sema3E)/PlexinD1 signaling in the development of choroidal neovascularization (CNV) and explored the therapeutic potential of the pathway. METHODS:We used a laser-induced CNV model in the mouse. The expression of Sema3E and PlexinD1 was evaluated with immunohistoch...

journal_title：Investigative ophthalmology & visual science

authors： Suda K,Guo C,Oishi A,Ikeda S,Uemura A,Yoshimura N

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To evaluate by vector analysis the corneal astigmatic changes occurring in keratoconic corneas during a 3-year follow-up and to determine the relationship between these changes and other clinical changes. METHODS:Keratoconic eyes (n = 114) of 75 patients ranging in age from 14 to 70 years were retrospectively ...

journal_title：Investigative ophthalmology & visual science

authors： Piñero DP,Alio JL,Tomás J,Maldonado MJ,Teus MA,Barraquer RI

更新日期：2011-06-08 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：:Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. ...

journal_title：Investigative ophthalmology & visual science

authors： Lee DA,Lee TC,Cortes AE,Kitada S

更新日期：1990-10-01 00:00:00

abstract：Purpose:To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. Methods:We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at ba...

journal_title：Investigative ophthalmology & visual science

authors： Ng WY,Ting DS,Agrawal R,Khandelwal N,Htoon HM,Lee SY,Wong TY,Cheung GC

更新日期：2016-09-01 00:00:00

abstract：:Lenses from young rhesus monkeys were incubated in the presence of H2O2 or oxygen radical generating systems to determine their suitability as a model for investigating lenticular oxidative stress. Additionally, direct comparisons were made between the effects found with the monkey lenses and those observed with cultu...

journal_title：Investigative ophthalmology & visual science

authors： Zigler JS Jr,Lucas VA,Du XY

更新日期：1989-10-01 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To gain better understanding of the relationship between abnormalities detected by the multifocal VEP (mfVEP) compared with those detected by static achromatic, automated perimetry in patients with glaucoma. METHODS:Fifty patients were studied who had open-angle glaucoma that met the following criteria: (1) a ...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Thienprasiddhi P,Greenstein VC,Winn BJ,Ohri N,Liebmann JM,Ritch R

更新日期：2004-02-01 00:00:00

abstract：Purpose:To investigate the association of microRNA (miRNA) copy number variants (CNVs) with acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) and to assess underlying disease mechanisms. Methods:This study included 768 patients with AAU+AS+ or AAU+AS- and 660 controls from a Chinese Han populati...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Du L,Yue Y,Huang Y,Zhou Q,Cao S,Qi J,Liang L,Wu L,Wang C,Ye Z,Tian Y,Kijlstra A,Hou S,Yang P

更新日期：2017-04-01 00:00:00

abstract：:The effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. Intravitreal injection of Shigella endotoxin and topical and/or intravitreal administr...

journal_title：Investigative ophthalmology & visual science

authors： Stetz DE,Bito LZ

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:To determine the role of polyphosphate kinase 1 (PPK1) in the ocular virulence of Pseudomonas aeruginosa. METHODS:Using a mouse model of infection, P. aeruginosa strains PAO1, PAOM5 (an isogenic mutant of PAO1 deficient in PPK1), and PAOM5+PPK1 (the mutant complemented with PPK1 on plasmid pHEPAK11) were compa...

journal_title：Investigative ophthalmology & visual science

authors： Parks QM,Hobden JA

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To investigate the prevalence and characteristics of primary angle-closure suspect (PACS), primary angle closure (PAC), and primary angle-closure glaucoma (PACG) in a rural population in China. METHODS:In all, 6716 Han Chinese 30 years of age and older (5480 subjects 40 years of age and older) from 13 villages...

journal_title：Investigative ophthalmology & visual science

authors： Liang Y,Friedman DS,Zhou Q,Yang XH,Sun LP,Guo L,Chang DS,Lian L,Wang NL,Handan Eye Study Group.

更新日期：2011-11-07 00:00:00

abstract：PURPOSE:To determine whether nonglaucomatous optic disc cupping in children violates the ISNT rule (which states that for normal optic discs the neuroretinal rim width is greatest in the order inferior >or= superior >or= nasal >or= temporal). METHODS:Digital ocular fundus photographs from a random cohort of children w...

journal_title：Investigative ophthalmology & visual science

authors： Pogrebniak AE,Wehrung B,Pogrebniak KL,Shetty RK,Crawford P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To determine whether the uniform field and pattern ERGs that are reduced in macaque eyes with experimental glaucoma have the same inner-retinal origins. METHODS:ERGs were recorded from 14 anesthetized adult macaques using DTL electrodes. Six monkeys had laser-induced experimental glaucoma, and two others recei...

journal_title：Investigative ophthalmology & visual science

authors： Viswanathan S,Frishman LJ,Robson JG

更新日期：2000-08-01 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

journal_title：Investigative ophthalmology & visual science

authors： Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To evaluate the absolute blood flow rate in a single choroidal vessel using Doppler optical coherence tomography (OCT). METHODS:Three choroidal vessels were selected in the right eye of three normal subjects, and were measured with Doppler OCT at a 1020-nm probe wavelength. The pulsatile change of the blood fl...

journal_title：Investigative ophthalmology & visual science

authors： Miura M,Makita S,Iwasaki T,Yasuno Y

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) c...

journal_title：Investigative ophthalmology & visual science

authors： Stamer WD,Bok D,Hu J,Jaffe GJ,McKay BS

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:There is considerable variation in the degree of form-deprivation myopia (FDM) induced in chickens by a uniform treatment regimen. Sex and pretreatment eye size have been found to be predictive of the rate of FD-induced eye growth. Therefore, this study was undertaken to test whether the greater rate of myopic ...

journal_title：Investigative ophthalmology & visual science

authors： Chen YP,Prashar A,Hocking PM,Erichsen JT,To CH,Schaeffel F,Guggenheim JA

更新日期：2010-02-01 00:00:00

abstract：:The authors compared cytoskeletal elements of the in situ human trabecular-meshwork cell with in situ human corneal cells using indirect immunofluorescence staining for tubulin and intermediate filaments (vimentin, cytokeratin, and desmin) and NBD-phallacidin staining for f-actin using both fixed frozen and unfixed fr...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Ryder MI

更新日期：1990-09-01 00:00:00