The inheritance of peripapillary atrophy.

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：:Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor fro...

journal_title：Investigative ophthalmology & visual science

authors： Shepherd VL,Tarnowski BI,McLaughlin BJ

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:To investigate the pharmacologic effect of tetramethylpyrazine (TMP) on human Tenon's fibroblasts (HTFs), the cells implicated in scarring after filtration surgery. METHODS:Transforming growth factor-β2 (TGF-β2) was used to stimulate a fibrotic phenotype in primary HTFs, and the influence of TMP on the fibroti...

journal_title：Investigative ophthalmology & visual science

authors： Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

更新日期：2016-09-01 00:00:00

abstract：Purpose:To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods:In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained tw...

journal_title：Investigative ophthalmology & visual science

authors： Tan R,Guymer RH,Luu CD

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitochondrial function. Th...

journal_title：Investigative ophthalmology & visual science

authors： Iacovelli J,Rowe GC,Khadka A,Diaz-Aguilar D,Spencer C,Arany Z,Saint-Geniez M

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Retinal injuries that affect the photoreceptors and/or the retinal pigment epithelium (RPE) may result in the leakage of retinal proteins into the systemic circulation. This study was designed to determine whether an immune response is elicited after an acute retinal injury resulting in circulating anti-retinal...

journal_title：Investigative ophthalmology & visual science

authors： Scott SE,Bouhenni RA,Chomyk AM,Dunmire JJ,Patil J,Nakamura H,Deepak P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To determine the impact of repetitive nonlethal oxidant injury with hydroquinone (HQ) on regulation of cell membrane blebbing and molecules, which are essential in extracellular matrix turnover (ECM) maintenance, especially matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-2, and type IV collagen...

journal_title：Investigative ophthalmology & visual science

authors： Marin-Castaño ME,Striker GE,Alcazar O,Catanuto P,Espinosa-Heidmann DG,Cousins SW

更新日期：2006-09-01 00:00:00

abstract：:The expression of receptors for Fc portion (FcR) of immunoglobulin G (IgG) and for a C3b component of complement (C3bR) by herpes simplex virus (HSV) was studied in primary cultures of rabbit corneal cells. Monolayer cultures of epithelial, stromal and endothelial cells of the rabbit cornea were infected with three st...

journal_title：Investigative ophthalmology & visual science

authors： Hatano H,Oh JO,Ou KH,Minasi P

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:There is considerable variation in the degree of form-deprivation myopia (FDM) induced in chickens by a uniform treatment regimen. Sex and pretreatment eye size have been found to be predictive of the rate of FD-induced eye growth. Therefore, this study was undertaken to test whether the greater rate of myopic ...

journal_title：Investigative ophthalmology & visual science

authors： Chen YP,Prashar A,Hocking PM,Erichsen JT,To CH,Schaeffel F,Guggenheim JA

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Activity in regions of the visual cortex corresponding to central scotomas in subjects with macular degeneration (MD) is considered evidence for functional reorganization in the brain. Three unresolved issues related to cortical activity in subjects with MD were addressed: Is the cortical response to stimuli pr...

journal_title：Investigative ophthalmology & visual science

authors： Liu T,Cheung SH,Schuchard RA,Glielmi CB,Hu X,He S,Legge GE

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Vitreous degeneration contributes to several age-related eye diseases, including retinal detachment, macular hole, macular traction syndrome, and nuclear cataracts. Remarkably little is understood about the molecular interactions responsible for maintaining vitreous structure. The purpose of this study was to m...

journal_title：Investigative ophthalmology & visual science

authors： Filas BA,Zhang Q,Okamoto RJ,Shui YB,Beebe DC

更新日期：2014-01-03 00:00:00

abstract：PURPOSE:This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes. METHODS:Control and streptozotocin (STZ)-diabetic rats were treated with or without the PARP inhibitors 1,5-isoquinolinediol (ISO; 3 mg kg(-1) d(-1) intraperitoneally) and 10-(4-...

journal_title：Investigative ophthalmology & visual science

authors： Drel VR,Xu W,Zhang J,Kador PF,Ali TK,Shin J,Julius U,Slusher B,El-Remessy AB,Obrosova IG

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:The temporal and spatial sequence of development of laminar vascular plexuses was determined qualitatively and quantitatively in monkey and human retina. METHODS:Histologic and cytochemical methods were used to study Macaca monkey eyes from fetal day 55 (F55d; birth = F168d) to 17 years, and human retina from ...

journal_title：Investigative ophthalmology & visual science

authors： Gariano RF,Iruela-Arispe ML,Hendrickson AE

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:A number of protocols have been published to induce retinal determination from human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Although all these studies have shown some degree of expression of markers of retinal cells, fewer than 30 markers are typically used to characterize the ES...

journal_title：Investigative ophthalmology & visual science

authors： Lamba DA,Reh TA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters. METHODS:Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocol...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Zarranz-Ventura J,Fung S,Powner MB,Platteau E,Bunce CV,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2013-03-28 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) die as a result of axonal injury in a variety of optic neuropathies, including glaucoma. Reactive oxygen species (ROS) act as intracellular signaling molecules and initiate apoptosis in nerve growth factor-deprived sympathetic neurons and axotomized RGCs. Determination of the role ...

journal_title：Investigative ophthalmology & visual science

authors： Schlieve CR,Lieven CJ,Levin LA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to show the usefulness of three methods for measuring IOP: Goldmann applanation tonometry, rebound tonometry, and Ultra-High-Speed Scheimpflug technology. METHODS:The examined group consisted of 96 patients (192 eyes), including 63 women and 33 men with a mean age of 59.3 ± 19.9 years...

journal_title：Investigative ophthalmology & visual science

authors： Smedowski A,Weglarz B,Tarnawska D,Kaarniranta K,Wylegala E

更新日期：2014-02-04 00:00:00

abstract：PURPOSE:To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS:A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly f...

journal_title：Investigative ophthalmology & visual science

authors： Galli-Resta L,Piccardi M,Ziccardi L,Fadda A,Minnella A,Marangoni D,Placidi G,Resta G,Falsini B

更新日期：2013-10-09 00:00:00

abstract：PURPOSE:To demonstrate the potential use of subpixel image processing methods to perform automated Hirschberg measurements of strabismic deviations using relatively inexpensive personal computer hardware; to determine if the method might allow screening for strabismus using full-face video images obtained from a distan...

journal_title：Investigative ophthalmology & visual science

authors： Miller JM,Mellinger M,Greivenkemp J,Simons K

更新日期：1993-10-01 00:00:00

abstract：:Various noninvasive test procedures were used to evaluate retinal function in a patient who had become night blind following vincristine chemotherapy. The results obtained were strikingly similar to those reported previously in subjects with recessively inherited stationary night blindness; the dark-adaptation curve w...

journal_title：Investigative ophthalmology & visual science

authors： Ripps H,Carr RE,Siegel IM,Greenstein VC

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：:The histological distribution of R-cognin in chick retinas was determined from embryonic day 8 through 13 wk post-hatching by indirect immunofluorescence using polyclonal anticognin. On embryonic day 8, at a developmental stage without distinct retina layers, most of the cells within the tissue exhibited fluorescence....

journal_title：Investigative ophthalmology & visual science

authors： Dobi ET,Troccoli NM,Hausman RE

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro would thus be beneficial for transplantation in the retina. Howeve...

journal_title：Investigative ophthalmology & visual science

authors： Djojosubroto M,Bollotte F,Wirapati P,Radtke F,Stamenkovic I,Arsenijevic Y

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye. METHODS:Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follow...

journal_title：Investigative ophthalmology & visual science

authors： Denis D,Burguière O,Burillon C

更新日期：1998-11-01 00:00:00

abstract：:Eight murine monoclonal antibodies to retinal S-antigen were found to recognize three antigenic clusters in competitive binding experiments. Variable patterns of immunohistochemical staining of retinal sections supported the competitive binding studies. Monoclonal antibodies to two of these three antigenic clusters on...

journal_title：Investigative ophthalmology & visual science

authors： Banga JP,LeRoy F,Suleyman S,Kasp E,Brown E,Dumonde D

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Cornea confocal microscopy is emerging as a clinical tool to evaluate the development and progression of diabetic neuropathy. The purpose of these studies was to characterize the early changes in corneal sensitivity and innervation in a rat model of type 1 diabetes in relation to standard peripheral neuropathy ...

journal_title：Investigative ophthalmology & visual science

authors： Davidson EP,Coppey LJ,Yorek MA

更新日期：2012-12-07 00:00:00

abstract：PURPOSE:To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS:Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess ...

journal_title：Investigative ophthalmology & visual science

authors： Tao A,Wang J,Chen Q,Shen M,Lu F,Dubovy SR,Shousha MA

更新日期：2011-06-01 00:00:00

abstract：:To investigate the role of cellular immunodeficiency in recurrent toxoplasmic retinochoroiditis, six Cynomolgus monkeys (Macaca fascicularis) with healed toxoplasmic lesions of the retina were immunosuppressed by total lymphoid irradiation. Three months prior to irradiation 30,000 Toxoplasma gondii organisms of the Be...

journal_title：Investigative ophthalmology & visual science

authors： Holland GN,O'Connor GR,Diaz RF,Minasi P,Wara WM

更新日期：1988-06-01 00:00:00