A new photogrammetric method for quantifying corneal topography.

abstract：PURPOSE:Tenascin (TN) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has also been reported that TN is expressed in the embryonic cornea and during corneal wound healing. However, the role of TN in the cornea is not fully known. In this study, the role of TN...

journal_title：Investigative ophthalmology & visual science

authors： Matsuda A,Yoshiki A,Tagawa Y,Matsuda H,Kusakabe M

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To study the relationships between the refractive power of the crystalline lens, overall refractive error of the eye, and degree of nuclear cataract. METHODS:All phakic participants of the population-based Central India Eye and Medical Study with an age of 50+ years were included. Calculation of the refractive...

journal_title：Investigative ophthalmology & visual science

authors： Iribarren R,Morgan IG,Nangia V,Jonas JB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:Adhesion molecules play a critical role in leukocyte emigration to wound sites, but differences are evident in different vascular beds. In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated. METHODS:Re-epithelialization, neut...

journal_title：Investigative ophthalmology & visual science

authors： Li Z,Rumbaut RE,Burns AR,Smith CW

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk. METHODS:Relevant studies that reported the associations between H...

journal_title：Investigative ophthalmology & visual science

authors： Zeng J,Liu H,Liu X,Ding C

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To evaluate the intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV), the hydrolysis product of HDP-cyclic-CDV, a long-lasting intravitreal cidofovir prodrug for cytomegalovirus (CMV) retinitis. METHODS:HDP-cyclic-CDV was suspended in phosphate-buffered saline (PBS) at 37°C and for...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Chhablani J,Freeman WR,Beadle JR,Hostetler KY,Hartmann K,Conner L,Aldern KA,Pearson L,Cheng L

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To compare the developmental sequences of two basic measures of pattern vision, Vernier acuity and grating acuity, using steady state visual-evoked potentials (VEPs) and an analysis designed to isolate pattern-specific responses from those due to motion in the Vernier stimulus. METHODS:The authors recorded VEP...

journal_title：Investigative ophthalmology & visual science

authors： Skoczenski AM,Norcia AM

更新日期：1999-09-01 00:00:00

abstract：Purpose:To validate widefield autofluorescence (AF) in vivo imaging of the retina in mice expressing green fluorescent protein (gfp) in microglia, and to monitor retinal microglia reconstitution in vivo after lethal irradiation and bone marrow transplantation. Methods:Transgenic Cx3cr1gfp/gfp and wildtype Balb/c mice ...

journal_title：Investigative ophthalmology & visual science

authors： Kokona D,Schneider N,Giannakaki-Zimmermann H,Jovanovic J,Ebneter A,Zinkernagel M

更新日期：2017-04-01 00:00:00

abstract：:Albino rabbits were exposed to repeated microwave irradiations once daily for a month. Clinical examination was carried out for a period up to one year. No changes occurred below 300 mW./cm.2. At and above this level posterior subcapsular iridescence and posterior cortical cataracts were produced. The histologic findi...

journal_title：Investigative ophthalmology & visual science

authors： Hirsch SE,Appleton B,Fine BS,Brown PV

更新日期：1977-04-01 00:00:00

abstract：PURPOSE:This study describes the effects of the cyclic adenosine monophosphate (cAMP) pathway on the tight junctional barrier of the corneal endothelium, which plays a critical role in maintaining the corneal stroma in an underhydrated, transparent state. METHODS:Subcultured bovine corneal endothelial cells grown on f...

journal_title：Investigative ophthalmology & visual science

authors： Le Varlet B,Ducroc R,Dagonet FB,Pouliquen Y,Vandewalle A,Hirsch M

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:To test the hypothesis that acute topical dorzolamide (DZ) decreases intraocular pressure (IOP) and increases retinal and choroidal blood flow in the DBA/2J mouse model of glaucoma. METHODS:Retinal and choroidal blood flow were measured in 4- and 9-month-old DBA/2J mice, and 4-month C57BL/6 (control) mice unde...

journal_title：Investigative ophthalmology & visual science

authors： Chandra S,Muir ER,Deo K,Kiel JW,Duong TQ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To characterize the possible role of transducin Gtβγ-complex in modulating the signaling properties of photoactivated rhodopsin and its lifetime in rod disc membranes and intact rods. METHODS:Rhodopsin photolysis was studied using UV-visible spectroscopy and rapid scanning spectroscopy in the presence of hydro...

journal_title：Investigative ophthalmology & visual science

authors： Lomonosova E,Kolesnikov AV,Kefalov VJ,Kisselev OG

更新日期：2012-03-09 00:00:00

abstract：Purpose:To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. Methods:Enhanced-depth imaging-OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal-scle...

journal_title：Investigative ophthalmology & visual science

authors： Yiu G,Vuong VS,Oltjen S,Cunefare D,Farsiu S,Garzel L,Roberts J,Thomasy SM

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To investigate the relationship between ornithine-delta-aminotransferase (OAT) deficiency and ornithine accumulation and the specific degeneration of retinal pigment epithelial (RPE) cells in gyrate atrophy. METHODS:Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromet...

journal_title：Investigative ophthalmology & visual science

authors： Ueda M,Masu Y,Ando A,Maeda H,Del Monte MA,Uyama M,Ito S

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:To compare local functional measures, the multifocal electroretinogram (mfERG) and visual field sensitivity, with a local structural measure, spectral domain (SD) optical coherence tomography (OCT), of receptor damage in patients with retinitis pigmentosa (RP). METHODS:MfERGs, visual fields, and SD-OCT scans w...

journal_title：Investigative ophthalmology & visual science

authors： Wen Y,Klein M,Hood DC,Birch DG

更新日期：2012-02-21 00:00:00

abstract：:Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate. ...

journal_title：Investigative ophthalmology & visual science

authors： Podos SM,Lee PY,Severin C,Mittag T

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:To examine gain, speed, and temporal characteristics of initial and closed-loop components of vergence eye movements in young and elderly subjects. METHODS:Vergence eye movements in 13 elderly and 10 young adults were examined. A table with light-emitting diodes was used to elicit vergence starting from near (...

journal_title：Investigative ophthalmology & visual science

authors： Yang Q,Le TT,Kapoula Z

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To identify cell types and extracellular matrix components in Molteno implant capsules. METHODS:Histologic features including cytology, distribution of apoptotic cells, cytoantigens, collagens, basement membranes, elastic fibers, and glycoproteins were examined by light microscopy. Findings were correlated wit...

journal_title：Investigative ophthalmology & visual science

authors： Molteno AC,Thompson AM,Bevin TH,Dempster AG

更新日期：2009-03-01 00:00:00

abstract：Purpose:To identify potentially pathogenic variants (PPVs) in Chinese familial exudative vitreoretinopathy (FEVR) patients in FZD4, LRP5, NDP, TSPAN12, ZNF408, and KIF11 genes. Methods:Blood samples were collected from probands and their parent(s). Genomic DNA was analyzed by next-generation sequencing, and the sequen...

journal_title：Investigative ophthalmology & visual science

authors： Li JK,Li Y,Zhang X,Chen CL,Rao YQ,Fei P,Zhang Q,Zhao P,Li J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Changes in gene expression were investigated after treatment of cultured human retinal pigment epithelial (RPE) cells with vitreous. This may have implications for proliferative diseases such as proliferative vitreoretinopathy. METHODS:Cells were cultured in the presence or absence of human vitreous, and gene ...

journal_title：Investigative ophthalmology & visual science

authors： Hunt DM,Chen WH,Hunt RC

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To evaluate the effect of chemical chaperones on the trafficking of secretion-incompetent primary open-angle glaucoma-associated mutant myocilin and the possibility to rescue cells coexpressing mutant and wild-type myocilin from endoplasmic reticulum (ER) stress and apoptosis. METHODS:CHO-K1, HEK293 and human ...

journal_title：Investigative ophthalmology & visual science

authors： Yam GH,Gaplovska-Kysela K,Zuber C,Roth J

更新日期：2007-04-01 00:00:00

abstract：:A group of 32 patients with low vision who were considered clinically appropriate candidates for visual rehabilitation with telescopic spectacles were prospectively studied before the first attempted use of these visual aids. Laboratory measurements were made of: (1) rotational head stability in pitch and yaw during q...

journal_title：Investigative ophthalmology & visual science

authors： Demer JL,Goldberg J,Porter FI,Schmidt K

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate expression of methyl-CpG-binding protein 2 (MeCP2) in epiretinal membranes from patients with proliferative vitreoretinopathy (PVR) and to investigate effects of inhibition of MeCP2 and DNA methylation on transforming growth factor (TGF)-β-induced retinal pigment epithe...

journal_title：Investigative ophthalmology & visual science

authors： He S,Barron E,Ishikawa K,Nazari Khanamiri H,Spee C,Zhou P,Kase S,Wang Z,Dustin LD,Hinton DR

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Fractal dimension of retinal vasculature is a global summary measure of retinal vascular network pattern and geometry. This study was conducted to examine the effect of variations in image color, brightness, focus, contrast, and format on the measurement of retinal vascular fractal dimension. METHODS:A set of ...

journal_title：Investigative ophthalmology & visual science

authors： Wainwright A,Liew G,Burlutsky G,Rochtchina E,Zhang YP,Hsu W,Lee JM,Wong TY,Mitchell P,Wang JJ

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To assess the mutation spectrum in the ABCR gene and clinical phenotypes in Italian families with autosomal recessive Stargardt disease (STGD1) and fundus flavimaculatus (FFM). METHODS:Eleven families from southern Italy, including 18 patients with diagnoses of STGD1, were clinically examined. Ophthalmologic e...

journal_title：Investigative ophthalmology & visual science

authors： Simonelli F,Testa F,de Crecchio G,Rinaldi E,Hutchinson A,Atkinson A,Dean M,D'Urso M,Allikmets R

更新日期：2000-03-01 00:00:00

abstract：:Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor fro...

journal_title：Investigative ophthalmology & visual science

authors： Shepherd VL,Tarnowski BI,McLaughlin BJ

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:Videokeratography of early keratoconus may be difficult to distinguish from contact lens-induced corneal warpage, even by experienced examiners. Furthermore, topographic irregularity may be judged inconsistently if quantitative standards are not applied. Quantitative measures based on videokeratographic data we...

journal_title：Investigative ophthalmology & visual science

authors： Smolek MK,Klyce SD,Maeda N

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To describe and evaluate a new experimental reference plane for measuring rim area in scanning laser tomography. METHODS:The experimental reference plane was positioned so that (1) it always lay entirely below the margin of the optic nerve head (ONH), (2) it remained at a set z-axis distance below the ONH in i...

journal_title：Investigative ophthalmology & visual science

authors： Tan JC,Hitchings RA

更新日期：2003-03-01 00:00:00

abstract：Purpose:We investigated the accumulation of amyloid β (Aβ1-40, Aβ1-42, Aβ1-43) in the lens epithelium of patients with opacification of five different types (cortical cataract [COR]; nuclear cataract [NUC]; posterior subcapsular cataract [PSC]; retrodots [RD]; and water clefts [WC]). Methods:Samples were collected fro...

journal_title：Investigative ophthalmology & visual science

authors： Nagai N,Mano Y,Otake H,Shibata T,Kubo E,Sasaki H

更新日期：2017-06-01 00:00:00