Effects of Dorzolamide on Retinal and Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma.

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:The aim of this study was to deepen our knowledge on the basis of intrafamilial genetic heterogeneity of inherited retinal dystrophies (RD) to further discern the contribution of individual alleles to the pathology. METHODS:Families with intrafamilial locus and/or allelic heterogeneity were selected from a coh...

journal_title：Investigative ophthalmology & visual science

authors： Sánchez-Alcudia R,Cortón M,Ávila-Fernández A,Zurita O,Tatu SD,Pérez-Carro R,Fernandez-San Jose P,Lopez-Martinez MÁ,del Castillo FJ,Millan JM,Blanco-Kelly F,García-Sandoval B,Lopez-Molina MI,Riveiro-Alvarez R,Ayuso C

更新日期：2014-10-23 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of genetic deletion of NOS3 in CAV1-/- mice on aqueous humor outflow function using a mouse genetic double knockout model (DKO, NOS3-/- CAV1-/-). Methods:IOP was measured in DKO, NOS3 KO, CAV1 KO, and wild-type (WT) mice by rebound tonometry. Outflow faci...

journal_title：Investigative ophthalmology & visual science

authors： Song M,Wu J,Lei Y,Sun X

更新日期：2017-10-01 00:00:00

abstract：:The circulating renin-angiotensin system (RAS) is an important determinant in maintaining adequate systemic blood pressure, and it also may modify organ-specific blood flow. All recognized RAS components have been identified in the eye. In this study, angiotensinogen (ANG) was localized using an affinity-purified anti...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Tewksbury DA,Brandt CR,Poulsen GL

更新日期：1992-04-01 00:00:00

abstract：Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

journal_title：Investigative ophthalmology & visual science

authors： Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To determine whether retinal progenitor cells in the inner nuclear layer give rise to regenerated cones after laser ablation of photoreceptors in adult goldfish retina. METHODS:Using a technique developed previously in this laboratory, photoreceptors in the retina of adult goldfish were ablated with an argon l...

journal_title：Investigative ophthalmology & visual science

authors： Wu DM,Schneiderman T,Burgett J,Gokhale P,Barthel L,Raymond PA

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To characterize the features and possible mechanism of plus disease in the mouse oxygen-induced retinopathy (OIR) model for retinopathy of prematurity. METHODS:Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were exposed to 75% oxygen from postnatal day 7 to 12 (P7 to P12) (hyperoxia), t...

journal_title：Investigative ophthalmology & visual science

authors： Guaiquil VH,Hewing NJ,Chiang MF,Rosenblatt MI,Chan RV,Blobel CP

更新日期：2013-08-07 00:00:00

abstract：PURPOSE:To describe refractive status in children and young adults with cerebral palsy (CP) and relate refractive error to standardized measures of type and severity of CP impairment and to ocular dimensions. METHODS:A population-based sample of 118 participants aged 4 to 23 years with CP (mean 11.64 +/- 4.06) and an ...

journal_title：Investigative ophthalmology & visual science

authors： Saunders KJ,Little JA,McClelland JF,Jackson AJ

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Lens epithelial cells transdifferentiate to myofibroblasts during the formation of anterior subcapsular cataracts and secondary cataracts. One of the defining characteristics of myofibroblasts is the expression of alpha-smooth muscle actin (alpha-SMA). This study investigated some of the factors that influence ...

journal_title：Investigative ophthalmology & visual science

authors： Nagamoto T,Eguchi G,Beebe DC

更新日期：2000-04-01 00:00:00

abstract：Purpose:To determine the effects of narrowband light exposure on choroidal thickness and the pupil response in humans. Methods:Twenty subjects, ages 21 to 43 years, underwent 1 hour of exposure to broadband, short wavelength "blue," or long wavelength "red" light, or darkness. Choroidal thickness, imaged with spectral...

journal_title：Investigative ophthalmology & visual science

authors： Lou L,Ostrin LA

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To determine the relationship between optical coherence tomography (OCT) images of the retina and retinal substructure in vitro and in vivo. METHODS:In vitro, OCT images of human and bovine retina were acquired after sequential excimer laser ablation of the inner retinal layers. Measurements of bands in the OC...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan DS,Marshall J

更新日期：1999-09-01 00:00:00

abstract：:The retinal pigment epithelium (RPE)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using Ussing-type chambers. With zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with sub...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE

更新日期：1988-11-01 00:00:00

abstract：Purpose:To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant. Methods:This was a retrospective, observational study. The medical records of 53 RP ...

journal_title：Investigative ophthalmology & visual science

authors： Inooka D,Ueno S,Kominami T,Sayo A,Okado S,Ito Y,Terasaki H

更新日期：2018-01-01 00:00:00

abstract：:The scleral spur and trabecular mesh of the human eye contain approximately 5% elastic tissue. Elastic tissue forms less than 2% of the sclera. ...

journal_title：Investigative ophthalmology & visual science

authors： Moses RA,Grodzki WJ Jr,Starcher BC,Galione MJ

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:To develop a novel in vitro model to study the formation of Staphylococcus epidermidis biofilm on intraocular lenses (IOLs) from the primary-attachment phase to the biofilm-accumulation phase. The model was designed to replicate intraocular conditions especially by taking into account intraocular hydrodynamics....

journal_title：Investigative ophthalmology & visual science

authors： Baillif S,Casoli E,Marion K,Roques C,Pellon G,Hartmann DJ,Freney J,Burillon C,Kodjikian L

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To determine the role of the small guanosine triphosphate (GTP)-binding protein Rho in the migration of corneal epithelial cells. METHODS:The presence of the Rho target proteins Rho-associated coiled coil-containing protein kinase (ROCK)-1 and ROCK-2 in rabbit cornea was examined by immunohistochemical analysi...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura M,Nagano T,Chikama T,Nishida T

更新日期：2001-04-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and d-ala2-methionine enkephalinamide (DALA, a long-lasting enkephalin analogue) were used to investigate the peptidergic control of lacrimal gland function. To characterize the mechanism by which VIP stimulates and DALA inhibits lacrimal peroxidase secretion, the effect of these pe...

journal_title：Investigative ophthalmology & visual science

authors： Cripps MM,Bennett DJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00

abstract：PURPOSE:To identify objective criteria to quantify visual function in the rat for developing therapeutic strategies to protect neuronal cells after ischemia. The impact of ocular ischemia on luminance and frequency-modulated contrast vision was compared with the function of outer retinal cells and the number of intact ...

journal_title：Investigative ophthalmology & visual science

authors： Jehle T,Wingert K,Dimitriu C,Meschede W,Lasseck J,Bach M,Lagrèze WA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility. METHODS:A system capable of tracking common fundus features based on reflectance changes was integrated into a commercial O...

journal_title：Investigative ophthalmology & visual science

authors： Ishikawa H,Gabriele ML,Wollstein G,Ferguson RD,Hammer DX,Paunescu LA,Beaton SA,Schuman JS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine whether alteration in mucins could be detected in patients with dry eye symptoms by using the monoclonal antibody H185, which recognizes carbohydrate epitopes on mucin molecules. METHODS:Immunohistochemistry and immunoelectron microscopy was used to examine binding ...

journal_title：Investigative ophthalmology & visual science

authors： Danjo Y,Watanabe H,Tisdale AS,George M,Tsumura T,Abelson MB,Gipson IK

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with A...

journal_title：Investigative ophthalmology & visual science

authors： Guzman CP,Gong T,Nongpiur ME,Perera SA,How AC,Lee HK,Cheng L,He M,Baskaran M,Aung T

更新日期：2013-08-07 00:00:00

abstract：PURPOSE:To study transition zones from normal to abnormal retina in Usher syndrome IB (USH1B) caused by myosin 7A (MYO7A) mutations. METHODS:Optical coherence tomography (OCT) scattering layers in outer retina were segmented in patients (n = 16, ages 2-42; eight patients had serial data, average interval 4.5 years) to...

journal_title：Investigative ophthalmology & visual science

authors： Sumaroka A,Matsui R,Cideciyan AV,McGuigan DB 3rd,Sheplock R,Schwartz SB,Jacobson SG

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To assess whether tonometric measurements of the drop in intraocular pressure (IOP) induced by 0.005% latanoprost are modified after photorefractive keratectomy (PRK). METHODS:Data from 24 randomly selected eyes of 24 patients (12 men and 12 women, mean age +/- SD: 31.7 +/- 6.2 years) who were undergoing bilat...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Vaiano AS,Salgarello T,Caputo CG,Scullica L

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To determine whether vascular tone of isolated porcine retinal veins can be modulated by tissue-generated vasoactive factors such as endothelin-1 and adenosine. Such information may be useful in understanding the role of the retinal veins in regulating blood flow, and also provide a model for investigating new ...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Su EN,Cringle SJ,Morgan WH,McAllister IL,Yu PK

更新日期：2016-02-01 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:To determine the molecular mechanisms underlying the protective effects of zinc against oxidative stress in cultured retinal pigment epithelial (RPE) cells. METHODS:Cultured ARPE-19 cells were treated with different concentrations of zinc for various times. Cellular glutathione (GSH) and glutathione disulfide ...

journal_title：Investigative ophthalmology & visual science

authors： Ha KN,Chen Y,Cai J,Sternberg P Jr

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. METHODS:A series of birth, anthropometric, and 13 ocular biometric traits were ...

journal_title：Investigative ophthalmology & visual science

authors： Sanfilippo PG,Medland SE,Hewitt AW,Kearns LS,Ruddle JB,Sun C,Hammond CJ,Young TL,Martin NG,Mackey DA

更新日期：2011-07-29 00:00:00

abstract：Purpose:The purpose of this study was to clinically characterize patients with CNGA3-linked achromatopsia (CNGA3-ACHM) in preparation of a gene therapy trial. Methods:Thirty-six patients (age 7-56 years) with complete (cACHM) or incomplete (iACHM) CNGA3-ACHM were examined, including detailed psychophysical tests, exte...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Werner A,Stanzial F,Benedicenti F,Rudolph G,Kellner U,Hamel C,Andréasson S,Zobor G,Strasser T,Wissinger B,Kohl S,Zrenner E,RD-CURE Consortium.

更新日期：2017-02-01 00:00:00