Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: implication for protection against oxidative stress.

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：:Checkerboard reversal stimuli were used to evoke transient pattern electroretinograms (P-ERGs) from the eyes of 14 patients with amblyopia and 14 normal subjects. In the control group, and in normal eyes of patients, pattern electroretinograms were obtained with monocular central fixation. Amblyopic eyes were examined...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Welge-Lüssen L

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle cells in vitro and to determine whether MMP release is altered by exposure to prostaglandins (PGs). METHODS:Human ciliary smooth muscle cells were grown to confluence in monolayer cultures and treated with PGF2 alpha, 11-deoxy-PGE1,...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Kashiwagi K,Kashiwagi F,Tsukahara S,Lindsey JD

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H stat...

journal_title：Investigative ophthalmology & visual science

authors： Hakobyan S,Harris CL,Tortajada A,Goicochea de Jorge E,García-Layana A,Fernández-Robredo P,Rodríguez de Córdoba S,Morgan BP

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To describe the age-, gender-, and cause-specific 5-year incidence of bilateral visual impairment in participants in the Melbourne Visual Impairment Project, Victoria, Australia. METHODS:Participants aged 40 years and older were recruited from Melbourne, Victoria, Australia, by random cluster sampling. The mea...

journal_title：Investigative ophthalmology & visual science

authors： Dimitrov PN,Mukesh BN,McCarty CA,Taylor HR

更新日期：2003-12-01 00:00:00

abstract：:A recent hypothesis for the cellular mechanism of fluid secretion by lacrimal acini has been based, in part, on the results of subcellular fractionation analyses of lacrimal gland fragments which had been incubated for a brief period in vitro. An important assumption in those studies was that the ion transporters and ...

journal_title：Investigative ophthalmology & visual science

authors： Yiu SC,Wood RL,Mircheff AK

更新日期：1990-11-01 00:00:00

abstract：:Horseradish peroxidase has been injected into the dorsal lateral geniculate nucleus of macaque monkeys to label ganglion cells of the retina by retrograde axoplasmic transport. Displaced ganglion cells, with somata in the inner nuclear layer and dendrites in the inner plexiform layer, were detected by virtue of their ...

journal_title：Investigative ophthalmology & visual science

authors： Bunt AH,Minckler DS

更新日期：1977-01-01 00:00:00

abstract：Purpose:To analyze the anti-inflammatory and antioxidative effects of Camellia japonica (CJ) on human corneal epithelial (HCE) cells and its therapeutic effects in a mouse model of experimental dry eye (EDE). Methods:Camellia japonica extracts of varying concentrations (0.001%, 0.01%, and 0.1%) were used to treat HCE ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HS,Choi JH,Cui L,Li Y,Yang JM,Yun JJ,Jung JE,Choi W,Yoon KC

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To determine whether a novel peroxynitrite-based photosensitizer S-nitrosoglutathione (GSNO) can produce specific in vitro light-induced cell death of both standard animal lung and human Tenon's capsule (TC) fibroblasts and to compare this effect with that produced by the established photodynamic porphyrin prec...

journal_title：Investigative ophthalmology & visual science

authors： Tannous M,Hutnik CM,Tingey DP,Mutus B

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:Adaptive optics scanning laser ophthalmoscopy (AOSLO) under optimized wavefront correction allows for routine imaging of foveal cone photoreceptors. The intersubject variability of foveal cone density was measured and its relation to eye length evaluated. METHODS:AOSLO was used to image 18 healthy eyes with ax...

journal_title：Investigative ophthalmology & visual science

authors： Li KY,Tiruveedhula P,Roorda A

更新日期：2010-12-01 00:00:00

abstract：:We investigated the possibility that the spatial imprecision of amblyopic eyes can be accounted for by the relative insensitivity to contrast that has been documented for these eyes. Thresholds for the discrimination of spatial misalignment, a measure of spatial uncertainty, were determined for three amblyopes and one...

journal_title：Investigative ophthalmology & visual science

authors： Barbeito R,Bedell HE,Flom MC

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:This study evaluated the level of histamine in the interaction between the environment and the visual system during lifespan development, exploring potential sex differences. METHODS:Male and female Wistar rats, reared in standard laboratory or enriched-environment cages from birth to prepuberty or adulthood, ...

journal_title：Investigative ophthalmology & visual science

authors： Bessinis DP,Dalla C,Daifoti ZP,Tiligada E

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:To characterize the possible role of transducin Gtβγ-complex in modulating the signaling properties of photoactivated rhodopsin and its lifetime in rod disc membranes and intact rods. METHODS:Rhodopsin photolysis was studied using UV-visible spectroscopy and rapid scanning spectroscopy in the presence of hydro...

journal_title：Investigative ophthalmology & visual science

authors： Lomonosova E,Kolesnikov AV,Kefalov VJ,Kisselev OG

更新日期：2012-03-09 00:00:00

abstract：Purpose:Most of the inflammation in murine herpes simplex virus type 1 (HSV-1)-induced stromal keratitis (HSK) is due to exposure stress resulting from loss of corneal nerves and blink reflex. Corneal grafts often fail when placed on corneal beds with a history of HSK. We asked if corneal exposure contributes to the se...

journal_title：Investigative ophthalmology & visual science

authors： Rowe AM,Yun H,Hendricks RL

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To compare adult discrimination performance on nine pediatric visual acuity tests to determine the consistency of optotype design. METHODS:After their binocular acuity was measured with each test, eight adult observers (mean age, 27 years ± 6.3 SD; three emmetropes and five corrected myopes) were shown isolate...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Mishoulam SR,Nosofsky RM,Dobson V

更新日期：2011-06-16 00:00:00

abstract：:Three methods of corneal epithelial preparation for subsequent analysis of epithelial glycogen and DNA content were compared: scraping, lamellar stripping, and in situ freezing. All three methods gave good recovery of these substances. However, there was incomplete recovery of the sample using the in situ freezing met...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes T,Kinoshita S

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：:Electroretinograms (ERGs) were elicited by hemicircular (half-disc) stimuli to the upper, lower, temporal and nasal maculas of 26 normal subjects, and the amplitudes and implicit times of the ERGs from opposing macular regions were compared. The amplitudes of a-wave, b-wave and oscillatory potentials (OPs) were signif...

journal_title：Investigative ophthalmology & visual science

authors： Miyake Y,Shiroyama N,Horiguchi M,Ota I

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to deepen our knowledge on the basis of intrafamilial genetic heterogeneity of inherited retinal dystrophies (RD) to further discern the contribution of individual alleles to the pathology. METHODS:Families with intrafamilial locus and/or allelic heterogeneity were selected from a coh...

journal_title：Investigative ophthalmology & visual science

authors： Sánchez-Alcudia R,Cortón M,Ávila-Fernández A,Zurita O,Tatu SD,Pérez-Carro R,Fernandez-San Jose P,Lopez-Martinez MÁ,del Castillo FJ,Millan JM,Blanco-Kelly F,García-Sandoval B,Lopez-Molina MI,Riveiro-Alvarez R,Ayuso C

更新日期：2014-10-23 00:00:00

abstract：Purpose:Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells u...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Zhong Y,Demetriades AM,Shen J,Sui A,Yao Y,Gao Y,Zhu Y,Shen X,Xie B

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To investigate corneal sensitivity to selective mechanical, chemical, heat, and cold stimulation in patients with fibromyalgia (FM). METHODS:Twenty patients with FM (18 women, 2 men; 51.9 +/- 2.3 years old) and 18 control subjects (16 women, 2 men; 51.7 +/- 2.4 years) participated voluntarily in the study. Sub...

journal_title：Investigative ophthalmology & visual science

authors： Gallar J,Morales C,Freire V,Acosta MC,Belmonte C,Duran JA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The selective muscarinic antagonist pirenzepine inhibits experimentally induced myopia in avian and mammalian species, including nonhuman primates and adolescent humans. Transient positive lens defocus has a potent inhibitory effect on negative-lens-induced myopia in avian and mammalian models. The purpose of t...

journal_title：Investigative ophthalmology & visual science

authors： Metlapally S,McBrien NA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To investigate both the effect of diabetic macular edema (DME) on measured peripapillary retinal nerve fiber layer (RNFL) thickness and the effect of intravitreal bevacizumab injection on RNFL thickness using spectral-domain optical coherence tomography (SD-OCT) in patients with diabetic retinopathy. METHODS:W...

journal_title：Investigative ophthalmology & visual science

authors： Hwang DJ,Lee EJ,Lee SY,Park KH,Woo SJ

更新日期：2014-05-15 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Endocannabinoids are important modulators of synaptic transmission and plasticity throughout the central nervous system. The cannabinoid receptor type 1 (CB1R) is extensively expressed in the adult retina of rodents, while CB2R mRNA and protein expression have been only recently demonstrated in retinal tissue. ...

journal_title：Investigative ophthalmology & visual science

authors： Cécyre B,Zabouri N,Huppé-Gourgues F,Bouchard JF,Casanova C

更新日期：2013-12-11 00:00:00

abstract：PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at differ...

journal_title：Investigative ophthalmology & visual science

authors： Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To better understand ocular hypertension-induced early molecular alterations that may determine the initiation of neurodegeneration in human glaucoma, this study analyzed retinal proteomic alterations in the ocular hypertensive human retina. METHODS:Retina samples were obtained from six human donors with ocula...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Hondur G,Li M,Cai J,Klein JB,Kuehn MH,Tezel G

更新日期：2015-09-01 00:00:00

abstract：Purpose:To investigate changes of β-zone parapapillary atrophy (PPA) during axial elongation. Methods:Change of β-zone PPA was evaluated by spectral-domain optical coherence tomography (SD-OCT) in myopic children for 2 years, prospectively. Using the infrared images acquired by a fixed scan circle in the glaucoma prog...

journal_title：Investigative ophthalmology & visual science

authors： Lee KM,Choung HK,Kim M,Oh S,Kim SH

更新日期：2018-08-01 00:00:00