Volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes.

Abstract:

:The retinal pigment epithelium (RPE)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using Ussing-type chambers. With zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with subacute retinal detachments (1-2 weeks). In eyes with chronic retinal detachment (8-20 months), the flow was 7.3 microliter/hr/cm2. Volume flow was not affected by the elimination of ambient bicarbonate. Transepithelial potential difference and resistance were 8.9 mV, retinal side positive, and 339 ohm-cm2, respectively, in chronic retinal detachments. It is concluded that there is a posteriorly directed flow of fluid across the RPE in cynomolgus monkey eyes with chronic retinal detachments.

authors

Tsuboi S,Pederson JE

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

1652-5

issue

11

eissn

0146-0404

issn

1552-5783

journal_volume

29

pub_type

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