The effect of vanadate on aqueous humor dynamics in cynomolgus monkeys.

abstract：PURPOSE:To make the first quantitative assessment of the rate of oxygen consumption in high oxygen-consuming layers of both the outer and inner retina of the rat in vivo. METHODS:Oxygen-sensitive microelectrodes were used to measure the oxygen tension as a function of depth through the retina in anesthetized rats. Ind...

journal_title：Investigative ophthalmology & visual science

authors： Cringle SJ,Yu DY,Yu PK,Su EN

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:We evaluated the relationship between cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 15 degrees. METHODS:Individual differences for healthy subjects in cone packing density and ONL thickness were examined in 8 younger and 8 older subjects, mean age 27.2 versus 56....

journal_title：Investigative ophthalmology & visual science

authors： Chui TY,Song H,Clark CA,Papay JA,Burns SA,Elsner AE

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor (TIMP). Laser trabeculoplasty appears to rely on this process to restore normal aqueous humor outflow facility. Thus, studies were conducted to determine whether the extracellular signal-reg...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Acott TS

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Evidence suggests oxidative stress plays a role in the disease. To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specifi...

journal_title：Investigative ophthalmology & visual science

authors： Hunter A,Spechler PA,Cwanger A,Song Y,Zhang Z,Ying GS,Hunter AK,Dezoeten E,Dunaief JL

更新日期：2012-04-24 00:00:00

abstract：PURPOSE:To ablate retina and vitreous membranes using the 193-nm argon fluoride excimer laser in a fluid medium. METHODS:A special delivery system for the 193-nm excimer laser was developed that enabled the delivery of the laser into high-absorption liquid environments. The system was tested on the retina in an in vit...

journal_title：Investigative ophthalmology & visual science

authors： Palanker D,Hemo I,Turovets I,Zauberman H,Fish G,Lewis A

更新日期：1994-10-01 00:00:00

abstract：:PURPOSE. To evaluate the shape of the posterior corneal surface in eyes with normal myopia or myopic astigmatism and the changes after LASIK and epi-LASIK. METHODS. A total of 152 eyes were included in the study. The posterior corneal elevation was measured with Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany)...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Wang Y

更新日期：2010-07-01 00:00:00

abstract：:The relationship between corneal edema and hydrogel lens oxygen transmissibility was examined for both daily and extended contact lens wear by measuring the corneal swelling response induced by a variety of contact lenses over a 36-hr wearing period. The relationships derived enable average edema levels that occur wit...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Mertz GW

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a disparate array of functions in development (e.g., proliferation and apoptosis). Among three types of PACAP receptor (VPAC1, VPAC2, and PAC1), PAC1 is subject to alternative splicing that generates isoforms. Although the literature docu...

journal_title：Investigative ophthalmology & visual science

authors： Lakk M,Szabó B,Völgyi B,Gábriel R,Dénes V

更新日期：2012-11-27 00:00:00

abstract：PURPOSE:To determine the effect of human recombinant TIGR/myocilin (MYOC) protein on outflow resistance in the human anterior segment. METHODS:A cDNA for MYOC was inserted into a bacterial expression system and purified with nickel ion affinity chromatography. The anterior segments of 12 pairs of human eyes were place...

journal_title：Investigative ophthalmology & visual science

authors： Fautsch MP,Bahler CK,Jewison DJ,Johnson DH

更新日期：2000-12-01 00:00:00

abstract：:Retinal leukocyte velocity and density were estimated using blue-field entoptic imaging techniques in a controlled double-masked study to determine the relative effects of oxygen and carbon dioxide on perimacular hemodynamics in single eyes of ten normal human subjects. Mild hypoxia (inspiration of 16% O2) did not sig...

journal_title：Investigative ophthalmology & visual science

authors： Sponsel WE,DePaul KL,Zetlan SR

更新日期：1992-05-01 00:00:00

abstract：Purpose:Effective intravitreal gene delivery to cells of the central retina (i.e., photoreceptors) would be of substantial benefit for treating patients with retinal diseases, such as achromatopsia, where retinal detachment from a subretinal may be harmful. Previous studies demonstrated that mutation of the recombinant...

journal_title：Investigative ophthalmology & visual science

authors： Reid CA,Ertel KJ,Lipinski DM

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Autoimmune uveitis is a sight-threatening disease in which autoreactive T cells cross the blood-retinal barrier. Molecular mechanisms contributing to the loss of eye immune privilege in this autoimmune disease are not well understood. In this study, the authors investigated the changes in the matrix metalloprot...

journal_title：Investigative ophthalmology & visual science

authors： Hofmaier F,Hauck SM,Amann B,Degroote RL,Deeg CA

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS:Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conducta...

journal_title：Investigative ophthalmology & visual science

authors： Martinez-Wittinghan FJ,Sellitto C,White TW,Mathias RT,Paul D,Goodenough DA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To determine whether human retinal pigment epithelial (hRPE) cells produce activin, a growth factor in the transforming growth factor beta family, and to characterize growth regulatory effects of activin on retinal pigment epithelium. METHODS:mRNA expression was examined using polymerase chain reaction with pr...

journal_title：Investigative ophthalmology & visual science

authors： Jaffe GJ,Harrison CE,Lui GM,Roberts WL,Goldsmith PC,Mesiano S,Jaffe RB

更新日期：1994-06-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:Subtle structural and functional neuroretinal changes have been described in human immunodeficiency virus (HIV)-infected adults without retinitis treated with combination antiretroviral therapy (cART). However, studies on this subject in HIV-infected children are scarce. This study aimed to assess the presence ...

journal_title：Investigative ophthalmology & visual science

authors： Demirkaya N,Cohen S,Wit FW,Abramoff MD,Schlingemann RO,Kuijpers TW,Reiss P,Pajkrt D,Verbraak FD

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The goal of this study was to determine the role of Src family kinases (SFKs) in the development of lens cataract. This question was particularly significant, because these tyrosine kinases mediate the stress pathways known to lead to cataract formation. The experiments were focused on whether the inhibition of...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Menko AS

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:The goal was to establish an accurate method for measuring intraocular pressure (IOP) in living adult zebrafish and to determine the average IOPs of genetically different strains and mutants. The overall purpose was to develop the zebrafish system for studies of IOP and glaucoma. Elevated IOP and anterior segme...

journal_title：Investigative ophthalmology & visual science

authors： Link BA,Gray MP,Smith RS,John SW

更新日期：2004-12-01 00:00:00

abstract：:The existence of wide-band, phase-specific channels in the human visual system has been suggested in recent investigations. We used a number of adapting gratings to test for phase-specific adaptation effects. Observers were asked to discriminate between a simple 3 cpd sine-wave grating, (3), and a complex grating comp...

journal_title：Investigative ophthalmology & visual science

authors： Sansbury RV,Distelhorst J,Moore S

更新日期：1978-05-01 00:00:00

abstract：:Isotonic, neutral buffered solutions of benzalkonium chloride or chlorhexidine digluconate were applied topically to one eye of rabbits or human subjects. Contralateral control eyes received phosphate buffered saline as placebo. One-half hour later, the tear film of both eyes was loaded with nonpreserved sodium fluore...

journal_title：Investigative ophthalmology & visual science

authors： Burstein NL

更新日期：1984-12-01 00:00:00

abstract：PURPOSE:Docosahexaenoic acid (DHA) was supplemented in a single-site, placebo-controlled, randomized clinical trial designed to slow vision loss associated with X-linked retinitis pigmentosa (XLRP); the DHAX Trial. We previously reported no significant differences between supplemented and placebo groups in intent-to-tr...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman DR,Hughbanks-Wheaton DK,Spencer R,Fish GE,Pearson NS,Wang YZ,Klein M,Takacs A,Locke KG,Birch DG

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To optimize fixation, sectioning, and immunolabeling protocols to map the morphology of the human lens with confocal microscopy. METHODS:Transparent human lenses were fixed in 0.75% paraformaldehyde for 24 hours, cut in half, and fixed for another 24 hours. Lenses were cryoprotected, sectioned, and labeled wit...

journal_title：Investigative ophthalmology & visual science

authors： Lim JC,Walker KL,Sherwin T,Schey KL,Donaldson PJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

journal_title：Investigative ophthalmology & visual science

authors： Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

更新日期：2006-11-01 00:00:00

abstract：:Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber in surgically virgin, aniridic, and ciliary muscle disinserted cynomolgus monkey eyes 6 to 13 times at 1- to 2-month intervals over periods of 8 to 24 months. Facility decreased approximately 15 to 20% between consec...

journal_title：Investigative ophthalmology & visual science

authors： Kaufman PL,Erickson KA,Bárány EH

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:This study examined the influence of stimulus chromaticity on simple reaction times (RTs) to determine the stage of chromatic processing that is most influential in their generation. METHODS:Simple RTs were measured in response to the cosinusoidally ramped onset of small, equiluminant, colored Gaussian spots. ...

journal_title：Investigative ophthalmology & visual science

authors： McKeefry DJ,Parry NR,Murray IJ

更新日期：2003-05-01 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Invasion of tumor cells into blood vessels is essential for metastasis of uveal melanoma. The occurrence of ingrowth of tumor cells in blood vessels in uveal melanoma was analyzed, and this parameter was compared with the survival of the patients. METHODS:Between 1972 and 2007, 643 eyes primarily enucleated fo...

journal_title：Investigative ophthalmology & visual science

authors： Ly LV,Odish OF,Wolff-Rouendaal Dd,Missotten GS,Luyten GP,Jager MJ

更新日期：2010-02-01 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00