Activin expression by cultured human retinal pigment epithelial cells.

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

journal_title：Investigative ophthalmology & visual science

authors： Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

更新日期：2010-02-01 00:00:00

abstract：Purpose:Conjunctival squamous cell carcinoma (SCC), a type of ocular surface neoplasia, is primarily treated by surgical resection and topical immuno- or chemotherapy. Metastatic disease may be treated with systemic chemo- or immunotherapy, albeit with variable response. The purpose of this study was to determine wheth...

journal_title：Investigative ophthalmology & visual science

authors： Nagarajan P,El-Hadad C,Gruschkus SK,Ning J,Hudgens CW,Sagiv O,Gross N,Tetzlaff MT,Esmaeli B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS:C57BL/6(B6), FasL (CD95L)-deficient B6-...

journal_title：Investigative ophthalmology & visual science

authors： Stuart PM,Pan F,Plambeck S,Ferguson TA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The prevalence of cataract increases with age. Conversely, the abundance of native α-crystallin diminishes with age and cataract development. We hypothesize replenishing lens α-crystallin may delay or prevent cataract. Herein we investigated the ability of cell penetration peptides (CPP) to enhance entry of α-c...

journal_title：Investigative ophthalmology & visual science

authors： Mueller NH,Ammar DA,Petrash JM

更新日期：2013-01-02 00:00:00

abstract：:Attempts to describe normal corneal shape and to represent corneal topography by an array of discrete points have limited usefulness. A quantitative photogrammetric method that produces indices to describe corneal shape was developed. Four indices depict the departure of keratographic rings from circularity, and two i...

journal_title：Investigative ophthalmology & visual science

authors： Cohen KL,Tripoli NK,Pellom AC,Kupper LL,Fryczkowski AW

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at differ...

journal_title：Investigative ophthalmology & visual science

authors： Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To assess the repeatability and reproducibility of central corneal thickness (CCT) measurements obtained by combined scanning-slit/Placido-disc topography (Orbscan II; Bausch & Lomb, Rochester, NY) after laser in situ keratomileusis (LASIK) and to compare the results with another noncontact method, specular mic...

journal_title：Investigative ophthalmology & visual science

authors： Maldonado MJ,López-Miguel A,Nieto JC,Cano-Parra J,Calvo B,Alió JL

更新日期：2009-09-01 00:00:00

abstract：Purpose:To validate widefield autofluorescence (AF) in vivo imaging of the retina in mice expressing green fluorescent protein (gfp) in microglia, and to monitor retinal microglia reconstitution in vivo after lethal irradiation and bone marrow transplantation. Methods:Transgenic Cx3cr1gfp/gfp and wildtype Balb/c mice ...

journal_title：Investigative ophthalmology & visual science

authors： Kokona D,Schneider N,Giannakaki-Zimmermann H,Jovanovic J,Ebneter A,Zinkernagel M

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:There are two human 15-lipoxygenases (LOX), 15-LOX-1 and -2, which convert arachidonic acid to 15S-hydroxyeicosatetraenoic acid (15S-HETE). The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium. METHODS:Human corneal epithelia from donor c...

journal_title：Investigative ophthalmology & visual science

authors： Chang MS,Schneider C,Roberts RL,Shappell SB,Haselton FR,Boeglin WE,Brash AR

更新日期：2005-03-01 00:00:00

abstract：:Sixteen patients with osteogenesis imperfecta (OI) have undergone a thorough eye examination. These patients had statistically significantly lower ocular rigidity measurements than a group of normal volunteers matched on age, sex, and refractive error. In addition, the corneal diameter and length of the eyeball was sm...

journal_title：Investigative ophthalmology & visual science

authors： Kaiser-Kupfer MI,McCain L,Shapiro JR,Podgor MJ,Kupfer C,Rowe D

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：:PURPOSE. To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). METHODS. OCT macular...

journal_title：Investigative ophthalmology & visual science

authors： Ho J,Castro DP,Castro LC,Chen Y,Liu J,Mattox C,Krishnan C,Fujimoto JG,Schuman JS,Duker JS

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：:Experiments were performed with a model of focal, thermal-induced ulceration to test the clinical impression that vascularization prevents ulceration of the corneal stroma. Slow-release polymers containing a vasoproliferase agent (tumor angiogenesis factor) were placed in corneal pockets 2 mm central to the limbus of ...

journal_title：Investigative ophthalmology & visual science

authors： Conn H,Berman M,Kenyon K,Langer R,Gage J

更新日期：1980-04-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To characterize the features and possible mechanism of plus disease in the mouse oxygen-induced retinopathy (OIR) model for retinopathy of prematurity. METHODS:Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were exposed to 75% oxygen from postnatal day 7 to 12 (P7 to P12) (hyperoxia), t...

journal_title：Investigative ophthalmology & visual science

authors： Guaiquil VH,Hewing NJ,Chiang MF,Rosenblatt MI,Chan RV,Blobel CP

更新日期：2013-08-07 00:00:00

abstract：PURPOSE:To determine whether nonglaucomatous optic disc cupping in children violates the ISNT rule (which states that for normal optic discs the neuroretinal rim width is greatest in the order inferior >or= superior >or= nasal >or= temporal). METHODS:Digital ocular fundus photographs from a random cohort of children w...

journal_title：Investigative ophthalmology & visual science

authors： Pogrebniak AE,Wehrung B,Pogrebniak KL,Shetty RK,Crawford P

更新日期：2010-02-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of genetic deletion of NOS3 in CAV1-/- mice on aqueous humor outflow function using a mouse genetic double knockout model (DKO, NOS3-/- CAV1-/-). Methods:IOP was measured in DKO, NOS3 KO, CAV1 KO, and wild-type (WT) mice by rebound tonometry. Outflow faci...

journal_title：Investigative ophthalmology & visual science

authors： Song M,Wu J,Lei Y,Sun X

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To investigate the specific role of myosin II, a critical biochemical determinant of cellular contraction, in modulation of aqueous humor outflow facility through the trabecular meshwork (TM) pathway. METHODS:Expression of the nonmuscle myosin II heavy chains (IIA, IIB, and IIC) in human TM and ciliary body (C...

journal_title：Investigative ophthalmology & visual science

authors： Zhang M,Rao PV

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate in rabbits the relationship between nitric oxide and the noncholinergic vasodilation caused by facial nerve stimulation in the eye and some extraocular tissues. METHODS:Uveal vascular resistance was determined by measuring simultaneously the flow from a cannulated vorte...

journal_title：Investigative ophthalmology & visual science

authors： Nilsson SF

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS:The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A total of 4822 subjects who at baseline were a...

journal_title：Investigative ophthalmology & visual science

authors： van Leeuwen R,Ikram MK,Vingerling JR,Witteman JC,Hofman A,de Jong PT

更新日期：2003-09-01 00:00:00

abstract：:The capacities of porcine choroidal fibroblasts, retinal glial cells, and retinal pigment epithelial cells to contract collagen gels in vitro were compared. Experiments with varied cell numbers indicated that glial cells are the most effective, followed by choroidal fibroblasts and retinal pigment epithelial cells. An...

journal_title：Investigative ophthalmology & visual science

authors： Guidry C,McFarland RJ,Morris R,Witherspoon CD,Hook M

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Retinal basement membranes (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Müller cells (MCs) on the inner limiting membrane (ILM), providing polarity cues to adherent cells. The beta2 and gamma3 chains of laminin are key components of retinal BMs throughout developm...

journal_title：Investigative ophthalmology & visual science

authors： Pinzón-Duarte G,Daly G,Li YN,Koch M,Brunken WJ

更新日期：2010-03-01 00:00:00

abstract：:The relationship between intraocular and systemic blood pressures was investigated in a prospective study of 572 middle-aged men. There was no consistent relationship between intraocular pressure at first visit and age. Subjects with an intraocular pressure greater than 20 mm Hg had a significantly higher systolic blo...

journal_title：Investigative ophthalmology & visual science

authors： McLeod SD,West SK,Quigley HA,Fozard JL

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Slow oscillatory eye movements (SOMs) occur simultaneously with tremor, drifts, and microsaccades during visual fixation. In a previous study, the amplitude of SOM was found to be affected by the visual characteristics of the stimuli. This indicates a perceptual influence on the control of the movement. However...

journal_title：Investigative ophthalmology & visual science

authors： Zhang B,Bolzani R,Öqvist Seimyr G,Ygge J,Pansell T

更新日期：2013-12-11 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：:Two distinct patterns of delayed-onset, cell-mediated hypersensitivity have been induced in the guinea pig eye with the same soluble protein antigen and two different methods of immunization. The predominant histologic feature of these reactions was the large number of eosinophils which infiltrated the uveal tract and...

journal_title：Investigative ophthalmology & visual science

authors： Friedlaender MH,Howes EL Jr,Hall JM,Krasnobrod H,Wormstead MA

更新日期：1978-04-01 00:00:00

abstract：Purpose:To develop deep learning (DL) models for the automatic detection of optical coherence tomography (OCT) measures of diabetic macular thickening (MT) from color fundus photographs (CFPs). Methods:Retrospective analysis on 17,997 CFPs and their associated OCT measurements from the phase 3 RIDE/RISE diabetic macul...

journal_title：Investigative ophthalmology & visual science

authors： Arcadu F,Benmansour F,Maunz A,Michon J,Haskova Z,McClintock D,Adamis AP,Willis JR,Prunotto M

更新日期：2019-03-01 00:00:00