The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells.

abstract：PURPOSE:The aim of this study was to use Raman spectra of tears to differentiate between infectious and noninfectious ulcerative keratitis. METHODS:Raman microspectroscopy was applied using the drop-coating deposition method on Ti/Au-coated glass slides to obtain sample spectra from different human tear groups, includ...

journal_title：Investigative ophthalmology & visual science

authors： Kuo MT,Lin CC,Liu HY,Yang MY,Chang HC

更新日期：2012-03-15 00:00:00

abstract：PURPOSE:Protein kinases C (PKCs) are key cell-signaling mediators in retinal physiology and pathophysiology. The cellular localization of PKC isoforms is important in defining their activity and specificity; the present study investigated the modulatory potential of the proinflammatory mediator platelet-activating fact...

journal_title：Investigative ophthalmology & visual science

authors： Faghiri Z,Bazan NG

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To examine the effect of combining angiostatin with photodynamic therapy (PDT) using Lutetium Texaphyrin (Lu-Tex; Alcon, Fort Worth, TX) as a photosensitizer in bovine retinal capillary endothelial (BRCE) and retinal pigment epithelial (RPE) cells and to determine the mode of PDT-induced cell death in these cel...

journal_title：Investigative ophthalmology & visual science

authors： Renno RZ,Delori FC,Holzer RA,Gragoudas ES,Miller JW

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To assess RNA stability after death in a porcine model to simulate current human eye bank techniques. METHODS:Eye bank time interval data were collected from 191 donor specimens: death to refrigeration, enucleation, and tissue processing. A control porcine eye was enucleated, retina and RPE isolated, and speci...

journal_title：Investigative ophthalmology & visual science

authors： Malik KJ,Chen CD,Olsen TW

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The ubiquitous pituitary adenylate cyclase-activating peptide (PACAP) has a disparate array of functions in development (e.g., proliferation and apoptosis). Among three types of PACAP receptor (VPAC1, VPAC2, and PAC1), PAC1 is subject to alternative splicing that generates isoforms. Although the literature docu...

journal_title：Investigative ophthalmology & visual science

authors： Lakk M,Szabó B,Völgyi B,Gábriel R,Dénes V

更新日期：2012-11-27 00:00:00

abstract：PURPOSE:To describe the age-, gender-, and cause-specific 5-year incidence of bilateral visual impairment in participants in the Melbourne Visual Impairment Project, Victoria, Australia. METHODS:Participants aged 40 years and older were recruited from Melbourne, Victoria, Australia, by random cluster sampling. The mea...

journal_title：Investigative ophthalmology & visual science

authors： Dimitrov PN,Mukesh BN,McCarty CA,Taylor HR

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:To determine using the multifocal ERG technique whether there are any regional differences in the increase in the amplitude of cone electroretinograms (ERGs) during light adaptation. METHODS:Multifocal ERGs were recorded with the Visual Evoked Response Imaging System from five normal subjects. Thirty-seven hex...

journal_title：Investigative ophthalmology & visual science

authors： Kondo M,Miyake Y,Piao CH,Tanikawa A,Horiguchi M,Terasaki H

更新日期：1999-10-01 00:00:00

abstract：Purpose:There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanic...

journal_title：Investigative ophthalmology & visual science

authors： Blackburn BJ,Gu S,Ford MR,de Stefano V,Jenkins MW,Dupps WJ Jr,Rollins AM

更新日期：2019-01-02 00:00:00

abstract：:The morphology of the apical surface of rabbit retinal pigment epithelium was studied by scanning electron microscopy from the first minute to several hours after making small nonrhegmatogenous retinal detachments (blebs). From 0 to 5 min, there were only slight changes in the homogeneous, dense mat of filamentous mic...

journal_title：Investigative ophthalmology & visual science

authors： Immel J,Negi A,Marmor MF

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that repairs DNA double strand breaks. This study investigates the putative i...

journal_title：Investigative ophthalmology & visual science

authors： Smith AJ,Ball SS,Manzar K,Bowater RP,Wormstone IM

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To design a contrast sensitivity perimetry (CSP) protocol that decreases variability in glaucomatous defects while maintaining good sensitivity to glaucomatous loss. METHODS:Twenty patients with glaucoma and 20 control subjects were tested with a CSP protocol implemented on a monitor-based testing station. In ...

journal_title：Investigative ophthalmology & visual science

authors： Hot A,Dul MW,Swanson WH

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major cause of visual handicap in the pediatric population. To date, this disorder is thought to stem from deficient retinal vascularization. Intriguingly, functional electrophysiological studies in patients with mild or moderate ROP and in the oxygen-induced retinopathy (O...

journal_title：Investigative ophthalmology & visual science

authors： Shao Z,Dorfman AL,Seshadri S,Djavari M,Kermorvant-Duchemin E,Sennlaub F,Blais M,Polosa A,Varma DR,Joyal JS,Lachapelle P,Hardy P,Sitaras N,Picard E,Mancini J,Sapieha P,Chemtob S

更新日期：2011-08-05 00:00:00

abstract：PURPOSE:To determine the role of the small guanosine triphosphate (GTP)-binding protein Rho in the migration of corneal epithelial cells. METHODS:The presence of the Rho target proteins Rho-associated coiled coil-containing protein kinase (ROCK)-1 and ROCK-2 in rabbit cornea was examined by immunohistochemical analysi...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura M,Nagano T,Chikama T,Nishida T

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：PURPOSE:To demonstrate the presence of corneal stromal precursors that express neural markers in vitro. METHODS:To isolate sphere-forming cells, human corneal stromal cells were subjected to a reaggregation-free neurosphere assay in medium containing methylcellulose gel matrix. To promote differentiation, the isolated...

journal_title：Investigative ophthalmology & visual science

authors： Uchida S,Yokoo S,Yanagi Y,Usui T,Yokota C,Mimura T,Araie M,Yamagami S,Amano S

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To compare the risk factors for bilateral and unilateral disease in normal-tension glaucoma (NTG). METHODS:The study analyzed data from consecutive NTG patients with either bilateral (n = 194) or unilateral (n = 193) disease. Multivariate regression models were used to evaluate the following potential risk fac...

journal_title：Investigative ophthalmology & visual science

authors： Kim C,Kim TW

更新日期：2009-03-01 00:00:00

abstract：:The relationship between intraocular and systemic blood pressures was investigated in a prospective study of 572 middle-aged men. There was no consistent relationship between intraocular pressure at first visit and age. Subjects with an intraocular pressure greater than 20 mm Hg had a significantly higher systolic blo...

journal_title：Investigative ophthalmology & visual science

authors： McLeod SD,West SK,Quigley HA,Fozard JL

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells. METHODS:Weri-Rb-1 retinoblastoma cells were cultured in the absence or p...

journal_title：Investigative ophthalmology & visual science

authors： Li A,Zhu X,Brown B,Craft CM

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To explore the correlation between optical coherence tomography (OCT) and stereoscopic fundus photographs (FP) for the assessment of retinal thickening (RT) in diabetic macular edema (DME) within a clinical trial. METHODS:OCT, FP, and best corrected visual acuity (VA) measurements were obtained in both eyes of...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Bressler SB,Aiello LP,Bressler NM,Browning DJ,Flaxel CJ,Fong DS,Foster WJ,Glassman AR,Hartnett ME,Kollman C,Li HK,Qin H,Scott IU,Diabetic Retinopathy Clinical Research Network Study Group.

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Slow oscillatory eye movements (SOMs) occur simultaneously with tremor, drifts, and microsaccades during visual fixation. In a previous study, the amplitude of SOM was found to be affected by the visual characteristics of the stimuli. This indicates a perceptual influence on the control of the movement. However...

journal_title：Investigative ophthalmology & visual science

authors： Zhang B,Bolzani R,Öqvist Seimyr G,Ygge J,Pansell T

更新日期：2013-12-11 00:00:00

abstract：Purpose:To investigate the role of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in ocular surface damage of dry eye. Methods:MK2 inhibition was performed in mice subjected to desiccating stress (DS) by topical application of MK2 inhibitor (MK2i) or vehicle eye drops. The total and phosphorylated M...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Bu J,Yang Y,Lin X,Cai X,Huang C,Zheng X,Ouyang W,Li W,Zhang X,Liu Z

更新日期：2017-09-01 00:00:00

abstract：:A method is presented for the rapid flow cytometric determination of epidermal growth factor (EGF) receptor densities on the surface of cultured ocular cells. The technique uses a biotinylated monoclonal antibody directed against the EGF receptor in conjunction with a streptavidin-bound fluorochrome and requires the s...

journal_title：Investigative ophthalmology & visual science

authors： Lopez JG,Chew SJ,Thompson HW,Malter JS,Insler MS,Beuerman RW

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. METHODS:A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS)...

journal_title：Investigative ophthalmology & visual science

authors： Lim LS,Yang X,Gazzard G,Lin X,Sng C,Saw SM,Qiu A

更新日期：2011-11-17 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation. METHODS:Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical ana...

journal_title：Investigative ophthalmology & visual science

authors： Ogawa Y,Kuwana M,Yamazaki K,Mashima Y,Yamada M,Mori T,Okamoto S,Oguchi Y,Kawakami Y

更新日期：2003-05-01 00:00:00

abstract：Purpose:To assess changes in Schlemm's canal (SC), intraocular pressure (IOP), and autonomic nervous system activity in healthy individuals after performing the water-drinking test (WDT). Methods:The SC area (SCAR), trabecular meshwork (TM) thickness, IOP, high frequency (HF) of heart rate variability (HRV), heart rat...

journal_title：Investigative ophthalmology & visual science

authors： Chen W,Chen L,Chen Z,Xiang Y,Liu S,Zhang H,Wang J

更新日期：2018-07-02 00:00:00

abstract：:Vascular luminal castings of rabbit eyes were microdissected and studied with the scanning electron microscope to delineate the anatomy of the ciliary body microvasculature. We found regional microvascular differences corresponding to well known gross topographical and ultrastructural differences that may indicate reg...

journal_title：Investigative ophthalmology & visual science

authors： Morrison JC,DeFrank MP,Van Buskirk EM

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:Identification of causative mutations for retinal blinding disorders is often limited by restricted understanding of gene expression and underlying molecular mechanisms that trigger degenerative processes. This study was conducted to develop a catalog of canine retina-expressed genes that would provide a unique...

journal_title：Investigative ophthalmology & visual science

authors： Zangerl B,Sun Q,Pillardy J,Johnson JL,Schweitzer PA,Hernandez AG,Liu L,Acland GM,Aguirre GD

更新日期：2006-06-01 00:00:00