Photodynamic therapy using Lu-Tex induces apoptosis in vitro, and its effect is potentiated by angiostatin in retinal capillary endothelial cells.

abstract：Purpose:Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Methods:Purified retinal gang...

journal_title：Investigative ophthalmology & visual science

authors： Galvao J,Iwao K,Apara A,Wang Y,Ashouri M,Shah TN,Blackmore M,Kunzevitzky NJ,Moore DL,Goldberg JL

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts. METHODS:The GJA8 gene was directly sequenced. Formation of functional channels was assessed by the two-microelectrode voltage-clamp METHOD:Connexin protein levels and distribu...

journal_title：Investigative ophthalmology & visual science

authors： Minogue PJ,Tong JJ,Arora A,Russell-Eggitt I,Hunt DM,Moore AT,Ebihara L,Beyer EC,Berthoud VM

更新日期：2009-12-01 00:00:00

abstract：Purpose:RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Method...

journal_title：Investigative ophthalmology & visual science

authors： Kumaran N,Ripamonti C,Kalitzeos A,Rubin GS,Bainbridge JWB,Michaelides M

更新日期：2018-01-01 00:00:00

abstract：:Reaching a consensus in terms of interchangeability and utility (i.e., disease detection/monitoring) of a medical device is the eventual aim of repeatability and agreement studies. The aim of the tolerance and relative utility indices described in this report is to provide a methodology to compare change in clinical m...

journal_title：Investigative ophthalmology & visual science

authors： Bergin C,Guber I,Hashemi K,Majo F

更新日期：2015-08-01 00:00:00

abstract：Purpose:To describe the pathology of AMD in eyes with geographic atrophy (GA) using confocal scanning laser ophthalmoscopy (SLO) blue light autofluorescence (BAF), and near-infrared (IR) AF and to correlate it with the histology and immunohistochemistry analysis at the margins of the GA lesion. Methods:Enucleated, fix...

journal_title：Investigative ophthalmology & visual science

authors： Bonilha VL,Bell BA,Hu J,Milliner C,Pauer GJ,Hagstrom SA,Radu RA,Hollyfield JG

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape. ME...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Chandrasekara K,Abbondandolo CJ,Coll TJ,Rutzen AR

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. METHODS:A well-characterized murine model of retinal NV was used to study the expression of specific MMPs (MMP-2, MMP-9, and MT1-MMP) and tissue inhibit...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire P,Colombo S,Das A

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on the photoreceptors, and whether it slows the rate of decrease of the electroretinogram (ERG) in rhodopsin P347L transgenic (Tg) rabbits. METHODS:Six-week-old Tg rabbits received TES through a contact lens electrode on...

journal_title：Investigative ophthalmology & visual science

authors： Morimoto T,Kanda H,Kondo M,Terasaki H,Nishida K,Fujikado T

更新日期：2012-06-28 00:00:00

abstract：PURPOSE:To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS:In an earlier study, it was shown that a model using vB-ICA-mm...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Boden C,Zhang Z,Pascual J,Lee TW,Zangwill LM,Weinreb RN,Crowston JG,Hoffmann EM,Medeiros FA,Sejnowski T,Goldbaum M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS:Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Eghrari AO,Al-Saif A,Davey L,Meadows DN,Katsanis N,Gottsch JD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:The possible role of protein kinase C (PKC) inhibitors in novel pressure-lowering drugs is currently under investigation. To gain further insight into regulation of contractility by PKC in trabecular meshwork (TM) and ciliary muscle (CM), the effects of various PKC inhibitors and activators were tested. METHOD...

journal_title：Investigative ophthalmology & visual science

authors： Thieme H,Nass JU,Nuskovski M,Bechrakis NE,Stumpff F,Strauss O,Wiederholt M

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:To examine the effects of oxidized low-density lipoproteins (oxLDL) on phagocytosis and processing of photoreceptor outer segments (OS) by retinal pigment epithelial (RPE) cells. METHODS:Confluent cultures of RPE-J cells were pretreated with oxLDL or LDL, and the effects of such treatment on the processing of ...

journal_title：Investigative ophthalmology & visual science

authors： Hoppe G,Marmorstein AD,Pennock EA,Hoff HF

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Sildenafil increases ocular blood flow. Thus, the authors investigated if it also increases anterior chamber (AC) refilling after paracentesis. METHODS:Corriedale sheep and albino rabbits were used as animal models. Intraocular pressure (IOP) was measured, paracentesis performed on one eye, and AC refilling fo...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Alvarez LJ,Candia OA

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:Autoimmune uveitis is a sight-threatening disease in which autoreactive T cells cross the blood-retinal barrier. Molecular mechanisms contributing to the loss of eye immune privilege in this autoimmune disease are not well understood. In this study, the authors investigated the changes in the matrix metalloprot...

journal_title：Investigative ophthalmology & visual science

authors： Hofmaier F,Hauck SM,Amann B,Degroote RL,Deeg CA

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:Migration of retinal pigment epithelial (RPE) cells can be triggered by disruption of the RPE monolayer or injury to the neural retina. Migrating cells may re-establish a confluent monolayer, or they may invade the neural retina and disrupt visual function. The purpose of this study was to examine the role of e...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DA,Fields C,Fallon A,Fitzgerald ME,Viar MJ,Johnson LR

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Endotoxin-induced uveitis (EIU) is a model that mimics human acute anterior uveitis. Cyclooxygenase (COX)-2 is an enzyme that initiates the conversion of arachidonic acid (AA) into prostaglandins (PGs), whereas 5-lipoxygenase (5-LO) generates leukotrienes (LT). The purpose of this study was to delineate the rol...

journal_title：Investigative ophthalmology & visual science

authors： Tuo J,Tuaillon N,Shen D,Chan CC

更新日期：2004-07-01 00:00:00

abstract：:Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Hansen RM

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor (VEGF) is a potent angiogenic factor expressed as multiple RNA transcripts due to alternative splicing. During an investigation of the expression of VEGF mRNA in human Müller cells cultured under hypoxic conditions, a cDNA species was isolated whose size was incompatible with ...

journal_title：Investigative ophthalmology & visual science

authors： Jingjing L,Xue Y,Agarwal N,Roque RS

更新日期：1999-03-01 00:00:00

abstract：Purpose:To determine the relationship between the sensitivity of the retina in the central 10° and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). Methods:Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayo A,Ueno S,Kominami T,Okado S,Inooka D,Komori S,Terasaki H

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. METHODS:Temporal, rather than spatial, resolution was investigated in pa...

journal_title：Investigative ophthalmology & visual science

authors： Spang K,Fahle M

更新日期：2009-11-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA). Methods:Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang YS,Lee HE,Kwan CC,Schwartz GW,Fawzi AA

更新日期：2020-04-09 00:00:00

abstract：PURPOSE:Amino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with minimal adverse tissue reaction. In this study, we exami...

journal_title：Investigative ophthalmology & visual science

authors： McAlvin JB,Zhan C,Dohlman JC,Kolovou PE,Salvador-Culla B,Kohane DS

更新日期：2015-06-01 00:00:00

abstract：:Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrop...

journal_title：Investigative ophthalmology & visual science

authors： D'Amico DJ,Libert J,Kenyon KR,Hanninen LA,Caspers-Velu L

更新日期：1984-05-01 00:00:00

abstract：UNLABELLED:PURPOSE. Test the hypothesis that the developmental increases in rod photoreceptor sensitivity and rod-mediated visual sensitivity at 10 degrees, 20 degrees , and 30 degrees eccentric are concurrent. It is known that maturation of the parafoveal (10 degrees eccentric) rod outer segments and visual sensitivit...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Hansen RM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:One of the critical difficulties in design of a high-resolution retinal implant is the proximity of stimulating electrodes to the target cells. This is a report of a phenomenon of retinal cellular migration into a perforated membrane that may help to address this problem. METHODS:Mylar membranes with an array ...

journal_title：Investigative ophthalmology & visual science

authors： Palanker D,Huie P,Vankov A,Aramant R,Seiler M,Fishman H,Marmor M,Blumenkranz M

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is an inherited retinal disease that causes early-onset severe visual impairment. To evaluate the mutation spectrum in the Chinese population, we performed a mutation screen in 145 Chinese LCA families. METHODS:First, we performed direct Sanger sequencing of 7 LCA disease genes...

journal_title：Investigative ophthalmology & visual science

authors： Wang H,Wang X,Zou X,Xu S,Li H,Soens ZT,Wang K,Li Y,Dong F,Chen R,Sui R

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the repeatability of manual measurements of choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using the enhanced depth imaging (EDI) technique. METHODS:Fifty consecutive, healthy, young, adult volunteers with no known e...

journal_title：Investigative ophthalmology & visual science

authors： Rahman W,Chen FK,Yeoh J,Patel P,Tufail A,Da Cruz L

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:We evaluated the relationship between cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 15 degrees. METHODS:Individual differences for healthy subjects in cone packing density and ONL thickness were examined in 8 younger and 8 older subjects, mean age 27.2 versus 56....

journal_title：Investigative ophthalmology & visual science

authors： Chui TY,Song H,Clark CA,Papay JA,Burns SA,Elsner AE

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...

journal_title：Investigative ophthalmology & visual science

authors： Mutti DO,Zadnik K,Murphy CJ

更新日期：1999-06-01 00:00:00