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Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa.

Abstract：

Purpose:To determine the relationship between the sensitivity of the retina in the central 10° and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). Methods:Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and spectral-domain optical coherence tomography (SD-OCT). The thicknesses of the photoreceptor outer segment (OS), outer nuclear layer (ONL), inner nuclear layer (INL), and the retinal nerve fiber layer (RNFL) were measured at 1°, 3°, 5°, 7°, and 9° from the fovea. The same measurements were made on the SD-OCT images of 40 healthy subjects and used as controls. The relationships between the retinal sensitivities and retinal layer thicknesses were determined. Results:The thicknesses of the OS and ONL and their product were significantly and positively correlated with the retinal sensitivities. The thickness of the INL was significantly and negatively correlated with the sensitivity. The strongest correlation with the sensitivity was with the OS thickness (marginal R2 [mR2] = 0.525, P < 0.001), followed by the product of the OS and ONL thicknesses (mR2 = 0.420, P < 0.001), ONL thickness (mR2 = 0.416, P < 0.001), and the INL thickness (mR2 = 0.014, P = 0.044). The thickness of the RNFL was not correlated with the sensitivity (mR2 = 0.005, P = 0.331). Conclusions:In contrast to previous reports, the thickness of the OS reflected the retinal sensitivity better than the product of OS and ONL.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Sayo A,Ueno S,Kominami T,Okado S,Inooka D,Komori S,Terasaki H

doi

10.1167/iovs.18-24635

subject

Has Abstract

pub_date

2018-07-02 00:00:00

pages

3469-3475

issue

8

eissn

0146-0404

issn

1552-5783

pii

2688227

journal_volume

59

pub_type

杂志文章

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