The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility.

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：Purpose:We compare the choroidal vascular area between Bietti crystalline dystrophy (BCD) patients with CYP4V2 mutations, retinitis pigmentosa (RP) patients with EYS mutations, and normal controls, and investigate the correlation between choroidal vascular area and associated parameters. Methods:This prospective case-...

journal_title：Investigative ophthalmology & visual science

authors： Hirashima T,Miyata M,Ishihara K,Hasegawa T,Sugahara M,Ogino K,Yoshikawa M,Hata M,Kuroda Y,Muraoka Y,Ooto S,Yoshimura N

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To better understand the cellular contributions to the human multifocal ERG (mfERG), rhesus monkey and human mfERGs were recorded using the same stimulus conditions. The monkey mfERGs were recorded before and after injections of pharmacologic agents known to selectively block activity of particular cells and ci...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Frishman LJ,Saszik S,Viswanathan S

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the involvement of nerve growth factor (NGF) in the conjunctival inflammatory process and in corneal epithelium proliferation and differentiation. To verify the hypothesis that NGF could locally modulate the inflammatory and reparative processes, the authors evaluated the expressio...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Micera A,Rama P,Bonini S,Aloe L

更新日期：1998-06-01 00:00:00

abstract：:Flicker sensitivity was measured in groups of younger and older adult observers to assess its mean values and the test-retest variability both between sessions and in a single session. Test-retest sensitivities differed by less than 15% but tended to decrease slightly in a session and increase slightly between session...

journal_title：Investigative ophthalmology & visual science

authors： Tyler CW

更新日期：1991-08-01 00:00:00

abstract：Purpose:High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreore...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi M,Taguchi M,Sato T,Karasawa K,Sakurai Y,Harimoto K,Ito M

更新日期：2017-01-01 00:00:00

abstract：Purpose:The aim of the study was to investigate the signaling of growth hormone-releasing hormone receptor (GHRH-R) in the pathogenesis of pterygium and determine the apoptotic effect of GHRH-R antagonist on pterygium epithelial cells (PECs). Methods:Fourteen samples of primary pterygium of grade T3 with size of corne...

journal_title：Investigative ophthalmology & visual science

authors： Qin YJ,Chu WK,Huang L,Ng CHY,Chan TCY,Cao D,Yang C,Zhang L,Huang SP,Li J,Lin HL,Li WQ,Chen L,Schally AV,Chan SO,Zhang HY,Pang CP

更新日期：2018-10-01 00:00:00

abstract：:The retinas of six pigmented rabbits (12 eyes) were irradiated with a cw-Nd:YAG laser using two different pulse forms, in conjunction with a constant pulse duration of 200 msec and a retinal focus diameter of 200 microns. The first pulse form (a) was characterized by an initial transient, lasting 15-20 msec, with a pe...

journal_title：Investigative ophthalmology & visual science

authors： van der Zypen E,Fankhauser F,Kwasniewska S,England C

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:This study was designed to investigate the suppressive effects of antithrombin (AT)III on inflammatory reactions during endotoxin-induced uveitis (EIU) in rats by studying leukocyte-endothelium interactions. METHODS:EIU was induced in Lewis rats by footpad injection of lipopolysaccharide (LPS). ATIII was admin...

journal_title：Investigative ophthalmology & visual science

authors： Yamashiro K,Kiryu J,Tsujikawa A,Honjo M,Nonaka A,Miyamoto K,Honda Y,Tanihara H,Ogura Y

更新日期：2001-06-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:To determine factors affecting the disc-fovea angle (DFA), and to test the hypotheses that adjusting for DFA improves limits of retinal nerve fiber layer (RNFL) variability in normal subjects or enhances performance of RNFL measures for glaucoma detection. METHODS:Disc-fovea angle was measured on scanning lase...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Nowroozizadeh S,Cirineo N,Henry S,Chang T,Chou T,Coleman AL,Caprioli J,Nouri-Mahdavi K

更新日期：2014-10-09 00:00:00

abstract：PURPOSE:To address the consequences of visual deprivation paradigms in rat (dark rearing) and monkey (monocular deprivation) on extraocular muscle (EOM) development using genome-wide expression profiling. METHODS:Serial analysis of gene expression (SAGE) was used to determine alterations in the EOM transcriptome induc...

journal_title：Investigative ophthalmology & visual science

authors： Cheng G,Mustari MJ,Khanna S,Porter JD

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Retinal blood vessel diameter and arteriovenous ratio (AVR) are commonly used diagnostic parameters. Because vascular walls are typically not visible in funduscopy, clinical AVR estimation is based on the lumen rather than the entire vessel diameter. Here the authors used a transgenic mouse model to quantify AV...

journal_title：Investigative ophthalmology & visual science

authors： Fischer MD,Huber G,Feng Y,Tanimoto N,Mühlfriedel R,Beck SC,Tröger E,Kernstock C,Preising MN,Lorenz B,Hammes HP,Seeliger MW

更新日期：2010-10-01 00:00:00

abstract：Purpose:Aging affects a variety of visual functions. In this study, we aim to quantitatively investigate the temporal characteristics of visual processing in aging. Methods:Twelve younger (24.1 ± 1.6 years) and 12 older observers (58.4 ± 3.6 years) participated in the study. All participants had normal or corrected-to...

journal_title：Investigative ophthalmology & visual science

authors： He X,Shen M,Cui R,Zheng H,Ruan X,Lu ZL,Hou F

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00

abstract：PURPOSE:To isolate tissue-specific gene products that contribute to corneal integrity. METHODS:A cDNA library was constructed and differentially hybridized. Cornea-specific clones were purified and further characterized. RESULTS:In this study cornea-specific gene products were isolated by differential cDNA hybridizat...

journal_title：Investigative ophthalmology & visual science

authors： Peek R,van Gelderen BE,Bruinenberg M,Kijlstra A

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population. METHODS:In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide poly...

journal_title：Investigative ophthalmology & visual science

authors： Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:Macular corneal dystrophy (MCD) is a rare corneal dystrophy that is characterized by abnormal deposits in the corneal stroma, keratocytes, Descemet's membrane, and endothelium, accompanied by progressive clouding. It has been classified into three immunophenotypes--MCD types I, IA, and II--according to the seru...

journal_title：Investigative ophthalmology & visual science

authors： El-Ashry MF,Abd El-Aziz MM,Wilkins S,Cheetham ME,Wilkie SE,Hardcastle AJ,Halford S,Bayoumi AY,Ficker LA,Tuft S,Bhattacharya SS,Ebenezer ND

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Imaging studies suggest that the choroidal vasculature may be altered in central serous chorioretinopathy. Little is known, however, about the regulation of ocular blood flow in patients with central serous chorioretinopathy (CSC). The hypothesis for the present study was that choroidal blood flow changes durin...

journal_title：Investigative ophthalmology & visual science

authors： Tittl M,Maar N,Polska E,Weigert G,Stur M,Schmetterer L

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Severe ocular allergic diseases are characterized by pronounced conjunctival inflammation triggered by T helper 2 (Th2) cells and corneal epithelial damage induced by eosinophils. To examine the role of alarmins released by damaged corneal epithelial cells in tissue eosinophilia, we investigated the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Ishida W,Tanaka H,Harada Y,Matsuda A,Ebihara N,Fukushima A

更新日期：2013-08-27 00:00:00

abstract：:Ultrastructural morphometric techniques were used to quantify pericyte degeneration in retinal and uveal capillaries of streptozotocin-diabetic rats in order to assess the suitability of this small rodent model of diabetes for studies of the pathogenesis of microvascular eye disease in diabetic humans. Male, Sprague-D...

journal_title：Investigative ophthalmology & visual science

authors： Tilton RG,LaRose LS,Kilo C,Williamson JR

更新日期：1986-05-01 00:00:00

abstract：:Healing of corneal alkali injuries remains a severe clinical challenge. The authors evaluated the effect of a new synthetic inhibitor of matrix metalloproteinases (GM6001 or N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-L-tryptophane methylamide) on preventing ulceration of rabbit corneas after alkali inju...

journal_title：Investigative ophthalmology & visual science

authors： Schultz GS,Strelow S,Stern GA,Chegini N,Grant MB,Galardy RE,Grobelny D,Rowsey JJ,Stonecipher K,Parmley V

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS:The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patient...

journal_title：Investigative ophthalmology & visual science

authors： Nishiguchi KM,Sokal I,Yang L,Roychowdhury N,Palczewski K,Berson EL,Dryja TP,Baehr W

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS:Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. ...

journal_title：Investigative ophthalmology & visual science

authors： Kwong JM,Quan A,Kyung H,Piri N,Caprioli J

更新日期：2011-12-28 00:00:00

abstract：PURPOSE:To investigate the slow phase in latent/manifest latent nystagmus (LMLN) by producing long eye-drift intervals devoid of fast phases (extended slow phases [ESPs]) and to relate ESP metrics to clinical findings. METHODS:Ten patients with LMLN had eye movements recorded while attending to paired visual and audit...

journal_title：Investigative ophthalmology & visual science

authors： Gradstein L,Goldstein HP,Wizov SS,Reinecke RD

更新日期：2004-04-01 00:00:00

abstract：:The peroxidase-antiperoxidase method was used to study ten surgically obtained human optic nerve gliomas (pilocytic astrocytomas). All tissues were formalin fixed and paraffin embedded. Primary antisera included glial fibrillary acidic protein (GFAP), HNK-1 (type 1 astrocyte precursor marker), A2B5 (type 2 astrocyte p...

journal_title：Investigative ophthalmology & visual science

authors： Cutarelli PE,Roessmann UR,Miller RH,Specht CS,Grossniklaus HE

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:The structure of collagen lamellae in the anterior stroma of the human cornea is thought to be an important determinant of corneal rigidity. The three-dimensional structure of such collagen lamellae in normal human corneas was examined. METHODS:The anterior portion of 27 normal human corneas was obtained from ...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Takagi Y,Chikama T,Takahara A,Nishida T

更新日期：2011-02-16 00:00:00

abstract：PURPOSE:Gangliosides are normal components of cell membranes, contribute to structural rigidity and membrane function, and have been shown to protect against various insults to the brain. This study evaluates the effect of exogenously administered monosialoganglioside GM1 on retinal damage induced by transient retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Weber M,Mohand-Said S,Hicks D,Dreyfus H,Sahel JA

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00

abstract：PURPOSE:The endothelium produces nitric oxide and endothelin (ET). This study was designed to investigate the endothelium-dependent regulation of the porcine ophthalmic microcirculation. METHODS:Isolated porcine eyes were perfused with a modified Langendorff setup (Hugo Sachs Elektronik KG, Freiburg, Germany) at a per...

journal_title：Investigative ophthalmology & visual science

authors： Meyer P,Flammer J,Lüscher TF

更新日期：1993-12-01 00:00:00