Impaired temporal, not just spatial, resolution in amblyopia.

abstract：PURPOSE:To evaluate the importance of lens epithelial cell death in age-related cataract. To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive lens epithelial cells previously reported in human capsulotomy specimens results from apopto...

journal_title：Investigative ophthalmology & visual science

authors： Harocopos GJ,Alvares KM,Kolker AE,Beebe DC

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To test the hypothesis that overexpression of genes coding for the anti-apoptotic proteins Bcl-2 or Bcl-XL in photoreceptor cells may prevent or delay photoreceptor degenerations. METHODS:Transgenic mice were generated in which the bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells under the tran...

journal_title：Investigative ophthalmology & visual science

authors： Joseph RM,Li T

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:Submucosal fibrosis due to excessive accumulation of collagens is an important histologic feature in the pathogenesis of ocular cicatricial pemphigoid (OCP). Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined ...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Foster CS,Ahmed AR

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To study the effect of pars plana vitrectomy (PPV) on vitreous oxygenation (pO2) using magnetic resonance imaging (MRI). METHODS:Patients due to undergo PPV for either macular hole or epiretinal membrane were recruited. MRI scanning was performed 1 week before and at least 3 months after PPV. MRI T1 mapping wa...

journal_title：Investigative ophthalmology & visual science

authors： Simpson AR,Dowell NG,Jackson TL,Tofts PS,Hughes EH

更新日期：2013-03-21 00:00:00

abstract：PURPOSE:Environmental tobacco smoke (ETS) is widely regarded as a major modifiable risk factor for age-related macular degeneration (AMD). Yet, precisely how it exerts its pathologic effects is poorly understood. Since early-stage AMD is characterized by choroidal capillary loss, this study examined the effect of sides...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Scott HA,Ardekani S,Williams M,Talbot P,Ghosh K

更新日期：2014-04-08 00:00:00

abstract：PURPOSE:To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS:DNA was prepared from whole blood of 126 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Wallace GR,Vaughan RW,Kondeatis E,Mathew R,Chen Y,Graham EM,Stanford MR

更新日期：2006-07-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：:In cell culture, azelaic acid (C9) has been shown to have an antiproliferative and cytotoxic effect on human and murine malignant cutaneous melanocytes. Normal melanocytes are unaffected, as are normal choroidal melanocytes. Here, effects on cell kinetics and ultrastructure of cells of a human choroidal melanoma line ...

journal_title：Investigative ophthalmology & visual science

authors： Breathnach AS,Robins EJ,Pätzold HC,Bhasin YP,Ethridge LB,Garner A,Nazzaro-Porro M

更新日期：1989-03-01 00:00:00

abstract：Purpose:To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods:Wide-field spectral-domain OCT scans, including the disc and mac...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Tsamis E,Bommakanti NK,Joiner DB,Al-Aswad LL,Blumberg DM,Cioffi GA,Liebmann JM,De Moraes CG

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Recent studies suggest that photoreceptor cells regulate local inflammation in the retina in diabetes. The purpose of this study was to determine if photoreceptor cells themselves produce inflammatory proteins in diabetes and if soluble factors released by photoreceptors in elevated glucose induce inflammatory ...

journal_title：Investigative ophthalmology & visual science

authors： Tonade D,Liu H,Kern TS

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：:Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized b...

journal_title：Investigative ophthalmology & visual science

authors： Iso T,Uda K,Yamauchi H,Nakajima N,Suda H

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To identify factors associated prospectively with increased cataract surgical rate (CSR) in rural Chinese hospitals. METHODS:Annual cataract surgical output was obtained at baseline and 24 months later from operating room records at 42 rural, county-level hospitals. Total local CSR (cases/million population/y)...

journal_title：Investigative ophthalmology & visual science

authors： Chen T,Jin L,Zhou Z,Huang Y,Yan X,Liu T,Ong EL,Liu B,Huang W,Iezzi B,He M,Friedman DS,Congdon NG

更新日期：2015-02-03 00:00:00

abstract：PURPOSE:Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice. METHODS:To ...

journal_title：Investigative ophthalmology & visual science

authors： Tang Y,Liu X,Zoltoski RK,Novak LA,Herrera RA,Richard I,Kuszak JR,Kumar NM

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To assess the mutation spectrum in the ABCR gene and clinical phenotypes in Italian families with autosomal recessive Stargardt disease (STGD1) and fundus flavimaculatus (FFM). METHODS:Eleven families from southern Italy, including 18 patients with diagnoses of STGD1, were clinically examined. Ophthalmologic e...

journal_title：Investigative ophthalmology & visual science

authors： Simonelli F,Testa F,de Crecchio G,Rinaldi E,Hutchinson A,Atkinson A,Dean M,D'Urso M,Allikmets R

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), which involves ocular, dental, and umbilical abnormalities. Identification of cis-regulatory elements of PITX2 is important to better understand the mechanisms of disease. METHODS:Conserved noncoding elements surrounding PITX2/pitx2 were id...

journal_title：Investigative ophthalmology & visual science

authors： Volkmann BA,Zinkevich NS,Mustonen A,Schilter KF,Bosenko DV,Reis LM,Broeckel U,Link BA,Semina EV

更新日期：2011-03-18 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal dominant retinitis pigmentosa in a Chinese Family. METHODS:Families were ascertained and patients underwent complete ophthalmic examinations. Blood samples were collected and DNA was extracted. A linkage scan of genomic regions containing known ...

journal_title：Investigative ophthalmology & visual science

authors： Li N,Mei H,MacDonald IM,Jiao X,Hejtmancik JF

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate genotypic and macular morphologic correlations in patients with RPE65-, CEP290-, GUCY2D-, or AIPL1-related Leber congenital amaurosis (LCA) using spectral-domain optical coherence tomography (SD-OCT). METHODS:SD-OCT macular scans were performed in 21 patients, including 10 with RPE65, 7 with CEP290...

journal_title：Investigative ophthalmology & visual science

authors： Pasadhika S,Fishman GA,Stone EM,Lindeman M,Zelkha R,Lopez I,Koenekoop RK,Shahidi M

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

journal_title：Investigative ophthalmology & visual science

authors： Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

更新日期：2015-09-01 00:00:00

abstract：:The expression of receptors for Fc portion (FcR) of immunoglobulin G (IgG) and for a C3b component of complement (C3bR) by herpes simplex virus (HSV) was studied in primary cultures of rabbit corneal cells. Monolayer cultures of epithelial, stromal and endothelial cells of the rabbit cornea were infected with three st...

journal_title：Investigative ophthalmology & visual science

authors： Hatano H,Oh JO,Ou KH,Minasi P

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:To characterize the interleukin (IL)-4 receptor (IL-4R) complex in human corneal fibroblasts. METHODS:The presence of IL-4R subunit mRNAs and proteins in cultured human corneal fibroblasts was examined by reverse transcription-polymerase chain reaction and flow cytometry, respectively. The interaction of 125I-...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Fujitsu Y,Kumagai N,Nishida T

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Hypoxia and growth factors are postulated to be involved in the development of retinal neovascularization through the regulation of extracellular proteinase production. It has been shown that matrix metalloproteinases (MMPs) are elevated in the retina during the neovascularization process. However, the factors ...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire PG,Das A

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To examine the expression of five prostaglandin (PG) receptors, EP(1), EP(2), EP(3), EP(4), and FP and their corresponding mRNA transcripts in human sclera and cultured human scleral fibroblasts (HSFs). METHODS:Primary cultures of HSFs were established from donor eyes. Also, sclera from human donor eyes was sn...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Aihara M,Weinreb RN

更新日期：2001-12-01 00:00:00

abstract：:Paired human donor corneas (age, 73 +/- 12 yr), preserved in organ culture medium, were used to evaluate the effect of human epidermal growth factor (hEGF) on endothelial wound closure rate (WCR), on morphometric parameters (cell size, shape, and density), and on cell division in the wound area. The endothelium of the...

journal_title：Investigative ophthalmology & visual science

authors： Hoppenreijs VP,Pels E,Vrensen GF,Oosting J,Treffers WF

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Two noninvasive delivery strategies for VEGF/PDGF receptor tyrosine kinase inhibitors (RTKI) were explored that exploited uveal retention as a means for establishing an ocular drug depot: a single oral "loading" dose and topical administration. METHODS:Melanin binding was confirmed by centrifugation and mass s...

journal_title：Investigative ophthalmology & visual science

authors： Robbie SJ,Lundh von Leithner P,Ju M,Lange CA,King AG,Adamson P,Lee D,Sychterz C,Coffey P,Ng YS,Bainbridge JW,Shima DT

更新日期：2013-02-27 00:00:00

abstract：Purpose:Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods:We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-...

journal_title：Investigative ophthalmology & visual science

authors： Kogo T,Muraoka Y,Iida Y,Ooto S,Murakami T,Kadomoto S,Iida-Miwa Y,Numa S,Miyake M,Miyata M,Uji A,Tsujikawa A

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:During fixation and saccades, human eye movements obey Listing's law, which specifies the torsional eye position for each combination of horizontal and vertical eye positions. To study the mechanisms that implement Listing's law, the authors measured whether the law was violated in peripheral and central unilat...

journal_title：Investigative ophthalmology & visual science

authors： Wong AM,Tweed D,Sharpe JA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of ocular growth. METHODS:To induce accelerated growth a...

journal_title：Investigative ophthalmology & visual science

authors： Ashby RS,Zeng G,Leotta AJ,Tse DY,McFadden SA

更新日期：2014-07-22 00:00:00