Estimation of the short-term fluctuation from a single determination of the visual field.

abstract：PURPOSE:Lacritin is a tear glycoprotein with prosecretory, prosurvival, and mitogenic properties. We examined lacritin levels in the tears of Sjögren's syndrome (SS) patients and explored the therapeutic potential of topical lacritin for the treatment of keratoconjunctivitis sicca. METHODS:Tears from healthy controls ...

journal_title：Investigative ophthalmology & visual science

authors： Vijmasi T,Chen FY,Balasubbu S,Gallup M,McKown RL,Laurie GW,McNamara NA

更新日期：2014-07-17 00:00:00

abstract：Purpose:During development, the corneal epithelium (CE) and the conjunctiva are derived from the surface ectoderm. Here we have examined how, during development, the cells of these two issues become isolated from each other. Methods:Epithelia from the anterior eyes of chicken embryos were labeled with the fluorescent,...

journal_title：Investigative ophthalmology & visual science

authors： Kubilus JK,Zapater I Morales C,Linsenmayer TF

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS:Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Eghrari AO,Al-Saif A,Davey L,Meadows DN,Katsanis N,Gottsch JD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To determine global mRNA expression levels in corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS:cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide arra...

journal_title：Investigative ophthalmology & visual science

authors： Turner HC,Budak MT,Akinci MA,Wolosin JM

更新日期：2007-05-01 00:00:00

abstract：Purpose:The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP). Methods:Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior...

journal_title：Investigative ophthalmology & visual science

authors： Quigley H,Arora K,Idrees S,Solano F,Bedrood S,Lee C,Jefferys J,Nguyen TD

更新日期：2017-05-01 00:00:00

abstract：:Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by th...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Alexander EL,Green WR

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：:To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal ...

journal_title：Investigative ophthalmology & visual science

authors： Quigley HA,Sanchez RM,Dunkelberger GR,L'Hernault NL,Baginski TA

更新日期：1987-06-01 00:00:00

abstract：Purpose:To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods:Wide-field spectral-domain OCT scans, including the disc and mac...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Tsamis E,Bommakanti NK,Joiner DB,Al-Aswad LL,Blumberg DM,Cioffi GA,Liebmann JM,De Moraes CG

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To estimate the critical duration of temporal summation for achromatic Goldmann III stimuli under the conditions of standard automated perimetry (SAP) and quantify response variability for short-duration stimuli. METHODS:Contrast thresholds were gathered using the method of constant stimuli for seven circular ...

journal_title：Investigative ophthalmology & visual science

authors： Mulholland PJ,Redmond T,Garway-Heath DF,Zlatkova MB,Anderson RS

更新日期：2014-12-16 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:Cystinosis is caused by a deficiency in the lysosomal cystine transporter, cystinosin (CTNS gene), resulting in cystine crystal accumulation in tissues. In eyes, crystals accumulate in the cornea causing photophobia and eventually blindness. Hematopoietic stem progenitor cells (HSPCs) rescue the kidney in a mou...

journal_title：Investigative ophthalmology & visual science

authors： Rocca CJ,Kreymerman A,Ur SN,Frizzi KE,Naphade S,Lau A,Tran T,Calcutt NA,Goldberg JL,Cherqui S

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To investigate the effect of corneal trauma on gene expression in the lacrimal gland and to assess how many genes and what specific genes are regulated in response to corneal trauma. METHODS:A mouse model with acute corneal trauma was created with a chemical burn to the cornea with silver nitrate. Sixty-four f...

journal_title：Investigative ophthalmology & visual science

authors： Fang Y,Choi D,Searles RP,Mathers WD

更新日期：2005-02-01 00:00:00

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：:The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNA...

journal_title：Investigative ophthalmology & visual science

authors： Ambati J

更新日期：2011-04-06 00:00:00

abstract：PURPOSE:To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. METHODS:Hepc KO mice were given DFP in ...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Zhao L,Li Y,Hadziahmetovic M,Song Y,Connelly J,Spino M,Dunaief JL

更新日期：2014-06-26 00:00:00

abstract：:The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated ...

journal_title：Investigative ophthalmology & visual science

authors： Gilbard JP,Rossi SR,Gray KL

更新日期：1987-02-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:The goal of this study was to extend the results of previous immunoassay, immunocytochemistry, and in situ hybridization studies showing the presence of insulin-related peptide in the rat retina by confirming the expression of insulin genes in the rat eye. METHODS:Total and poly(A)+ RNA were isolated from whol...

journal_title：Investigative ophthalmology & visual science

authors： Budd GC,Pansky B,Glatzer L

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:We tested the hypothesis that retinal blood flow has a postocclusive reactive hyperemia response modulated by occlusion duration and metabolic activity, and that choroidal blood flow does not. METHODS:Anesthetized and paralyzed rats (n = 34) were studied. Retinal and choroidal blood flow was measured by laser ...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Kiel JW,Cardenas DP,De La Garza BH,Duong TQ

更新日期：2013-07-30 00:00:00

abstract：Purpose:Previous studies have reported a possible link between low bone mineral density and AMD. The aim of the present study was to investigate the association between osteoporosis and AMD in a South Korean cohort. Methods:This cross-sectional, nationwide study included 3496 women and 2789 men who had participated in...

journal_title：Investigative ophthalmology & visual science

authors： Yoo TK,Kim SH,Kwak J,Kim HK,Rim TH

更新日期：2018-03-20 00:00:00

abstract：PURPOSE:Connexin50 (Cx50) is absolutely essential for normal postnatal lens growth. Deletion of Cx50 or replacement with Cx46 by knockin resulted in smaller lenses containing fewer cells. To determine why Cx50-deficient lenses fail to grow normally, cell proliferation was assayed during the period of growth failure. M...

journal_title：Investigative ophthalmology & visual science

authors： Sellitto C,Li L,White TW

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To assess the prevalence, distribution, and demographic associations of refractive error in an urban population in southern India. METHODS:Two thousand five hundred twenty-two subjects of all ages, representative of the Hyderabad population, were examined in the population-based Andhra Pradesh Eye Disease Stud...

journal_title：Investigative ophthalmology & visual science

authors： Dandona R,Dandona L,Naduvilath TJ,Srinivas M,McCarty CA,Rao GN

更新日期：1999-11-01 00:00:00

abstract：Purpose:We assess if α retinal ganglion cells (αRGCs) and intrinsically photosensitive retinal ganglion cells (ipRGCs) survive in mouse models of glaucoma. Methods:Two microliters of N-methyl-D-aspartate (NMDA; 1 mM) or PBS were injected intraocularly 7 days before sacrifice. Immunohistochemical analyses of the retina...

journal_title：Investigative ophthalmology & visual science

authors： Honda S,Namekata K,Kimura A,Guo X,Harada C,Murakami A,Matsuda A,Harada T

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To identify genes and molecular mechanisms associated with photoreceptor degeneration in a canine model of XLRP caused by an RPGR exon ORF15 microdeletion. Methods. Expression profiles of mutant and normal retinas were compared by using canine retinal custom cDNA microarrays. qRT-PCR, Western blot analysis, and...

journal_title：Investigative ophthalmology & visual science

authors： Genini S,Zangerl B,Slavik J,Acland GM,Beltran WA,Aguirre GD

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：Purpose:To investigate diabetic optic neuropathy (DON) prevalence and risk factors in Chinese diabetic retinopathy (DR) patients. Methods:This retrospective study included 1067 eyes (550 patients) that underwent ocular imaging. The diabetes duration, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and high-dens...

journal_title：Investigative ophthalmology & visual science

authors： Hua R,Qu L,Ma B,Yang P,Sun H,Liu L

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To make the first quantitative assessment of the rate of oxygen consumption in high oxygen-consuming layers of both the outer and inner retina of the rat in vivo. METHODS:Oxygen-sensitive microelectrodes were used to measure the oxygen tension as a function of depth through the retina in anesthetized rats. Ind...

journal_title：Investigative ophthalmology & visual science

authors： Cringle SJ,Yu DY,Yu PK,Su EN

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Keratoconus is characterized by thinning and scarring of the central region of the cornea. Previous research showed that, in corneas obtained from patients with keratoconus, lysosomal enzyme activities are elevated, whereas levels of protease inhibitors such as alpha1-proteinase inhibitor are reduced. This stud...

journal_title：Investigative ophthalmology & visual science

authors： Zhou L,Sawaguchi S,Twining SS,Sugar J,Feder RS,Yue BY

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:To determine if cataract surgery on eyes with AMD confers as much functional visual improvement as surgery on eyes without retinal pathology. METHODS:This is a retrospective analysis of 4924 cataract surgeries from the Veterans Healthcare Administration Ophthalmic Surgical Outcomes Data Project (OSOD). We incl...

journal_title：Investigative ophthalmology & visual science

authors： Stock MV,Vollman DE,Baze EF,Chomsky AS,Daly MK,Lawrence MG

更新日期：2015-04-01 00:00:00