Chronic glaucoma selectively damages large optic nerve fibers.

abstract：PURPOSE:To better understand the cellular contributions to the human multifocal ERG (mfERG), rhesus monkey and human mfERGs were recorded using the same stimulus conditions. The monkey mfERGs were recorded before and after injections of pharmacologic agents known to selectively block activity of particular cells and ci...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Frishman LJ,Saszik S,Viswanathan S

更新日期：2002-05-01 00:00:00

abstract：Purpose:Synthesis of keratan sulfate (KS) relies on coordinated action of multiple enzymes, including the N-acetylglucosamine-transferring enzyme, β-1,3-N-acetylglucosaminyltransferase-7 (β3GnT7). A mouse model deficient in β3GnT7 was developed to explore structural changes in KS and the extracellular matrix (ECM; i.e....

journal_title：Investigative ophthalmology & visual science

authors： Littlechild SL,Young RD,Caterson B,Yoshida H,Yamazaki M,Sakimura K,Quantock AJ,Akama TO

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To examine retinal function using the full-field electroretinogram (ERG) during and after acute intraocular pressure (IOP) elevation in wild-type mice. METHODS:IOP was elevated by anterior chamber cannulation in wild-type C57/BL6 mice. The pressure-function relationship was determined by IOP elevation in steps...

journal_title：Investigative ophthalmology & visual science

authors： Kong YX,Crowston JG,Vingrys AJ,Trounce IA,Bui VB

更新日期：2009-12-01 00:00:00

abstract：:Purpose. Experimental autoimmune uveoretinitis (EAU), a Th1/Th17 cell-mediated autoimmune disease induced in mice, serves as a model of human endogenous uveitis. In this model, proinflammatory cytokines and various stimuli activate the transcriptional factor, nuclear factor-kappaB (NF-kappaB), in the retina. The thera...

journal_title：Investigative ophthalmology & visual science

authors： Iwata D,Kitaichi N,Miyazaki A,Iwabuchi K,Yoshida K,Namba K,Ozaki M,Ohno S,Umezawa K,Yamashita K,Todo S,Ishida S,Onoé K

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of the tissue origin of stromal fibroblasts and epithelial cells on reconstructed corneas in vitro. METHODS:Four types of constructs were produced by the self-assembly approach using the following combinations of human cells: corneal fibroblasts/corneal epithelial cells, corneal fibro...

journal_title：Investigative ophthalmology & visual science

authors： Carrier P,Deschambeault A,Audet C,Talbot M,Gauvin R,Giasson CJ,Auger FA,Guérin SL,Germain L

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：:Eight murine monoclonal antibodies to retinal S-antigen were found to recognize three antigenic clusters in competitive binding experiments. Variable patterns of immunohistochemical staining of retinal sections supported the competitive binding studies. Monoclonal antibodies to two of these three antigenic clusters on...

journal_title：Investigative ophthalmology & visual science

authors： Banga JP,LeRoy F,Suleyman S,Kasp E,Brown E,Dumonde D

更新日期：1988-01-01 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To further understand alpha2 receptor signaling in the retina and the mechanisms that mediate ocular beneficial effects of brimonidine (an alpha2 agonist) and nimodipine (an L-type Ca(2+) channel blocker). METHODS:The authors used in situ retinal ganglion cells (RGCs) in the isolated rat retina to characterize...

journal_title：Investigative ophthalmology & visual science

authors： Dong CJ,Guo Y,Agey P,Wheeler L,Hare WA

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Cardiovascular risk factors such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV). Recent studies have also provided evidence suggesting that choroidal and retinal blood flow is decreased in patients with AMD. On the basis of t...

journal_title：Investigative ophthalmology & visual science

authors： Boltz A,Luksch A,Wimpissinger B,Maar N,Weigert G,Frantal S,Brannath W,Garhöfer G,Ergun E,Stur M,Schmetterer L

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To systematically assess the changes in retinal morphology during the healing of retinal photocoagulation lesions of various clinical grades. METHODS:Rabbits were irradiated with a 532-nm Nd:YAG laser with a beam diameter of 330 microm at the retinal surface, a power of 175 mW, and pulse durations between 5 an...

journal_title：Investigative ophthalmology & visual science

authors： Paulus YM,Jain A,Gariano RF,Stanzel BV,Marmor M,Blumenkranz MS,Palanker D

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To determine whether cultured retinal pigment epithelial (RPE) cells implanted in the subconjunctival space induce an immune response against autoantigens and whether an active downregulation is achieved by RPE grafts placed in the anterior chamber and within the subretinal space. METHODS:Cultured RPE cells fr...

journal_title：Investigative ophthalmology & visual science

authors： Grisanti S,Ishioka M,Kosiewicz M,Jiang LQ

更新日期：1997-07-01 00:00:00

abstract：:Immune complexes from retinoblastoma sera were characterized with molecular sieve chromatography, affinity chromatography, and polyacrylamide gel electrophoresis (PAGE). Retinoblastoma patients' sera had two well-defined peaks of immune complex activity after molecular sieve chromatography. These protein fractions had...

journal_title：Investigative ophthalmology & visual science

authors： Stein PC,Christensen M,Char DH

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:To analyze the patterns of expression of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putative blue-light receptors with nonvisual photoreceptor localization. METHODS:CRY1 and CRY2 mRNA expression was analyzed in 4-mm diameter punches of macula and midperipheral hu...

journal_title：Investigative ophthalmology & visual science

authors： Thompson CL,Bowes Rickman C,Shaw SJ,Ebright JN,Kelly U,Sancar A,Rickman DW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To determine whether microtubule- and actin-altering drugs, which have been shown to increase aqueous humor outflow, cause cellular contraction in human trabecular meshwork (HTM) cells. METHODS:HTM cells were plated in culture dishes containing a polymerized deformable silicone substrate. After 48 hours, the d...

journal_title：Investigative ophthalmology & visual science

authors： Gills JP,Roberts BC,Epstein DL

更新日期：1998-03-01 00:00:00

abstract：Purpose:To determine the relationship between the sensitivity of the retina in the central 10° and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). Methods:Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayo A,Ueno S,Kominami T,Okado S,Inooka D,Komori S,Terasaki H

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To evaluate the rate and location of visual field (VF) progression before and after detection of disc hemorrhage (DH). METHODS:Disc photographs of consecutive patients with glaucoma with >or=5 SITA-Standard 24-2 VF in either eye were evaluated for the presence and location of DH. Exclusion criteria included di...

journal_title：Investigative ophthalmology & visual science

authors： De Moraes CG,Prata TS,Liebmann CA,Tello C,Ritch R,Liebmann JM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To assess the impact of vitamin A supplementation at 4-month intervals on the prevalence and incidence of xerophthalmia among preschool-age children. METHODS:A stratified, random sample of 40 wards with 4766 children in Sarlahi district of Nepal was selected to participate in a randomized, controlled, communit...

journal_title：Investigative ophthalmology & visual science

authors： Katz J,West KP Jr,Khatry SK,Thapa MD,LeClerq SC,Pradhan EK,Pokhrel RP,Sommer A

更新日期：1995-12-01 00:00:00

abstract：:Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate. ...

journal_title：Investigative ophthalmology & visual science

authors： Podos SM,Lee PY,Severin C,Mittag T

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:The selective muscarinic antagonist pirenzepine inhibits experimentally induced myopia in avian and mammalian species, including nonhuman primates and adolescent humans. Transient positive lens defocus has a potent inhibitory effect on negative-lens-induced myopia in avian and mammalian models. The purpose of t...

journal_title：Investigative ophthalmology & visual science

authors： Metlapally S,McBrien NA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:To determine whether caspase or cathepsin pathways are activated in human retinal pigment epithelial cells (ARPE-19) after exposure to 7-ketocholesterol (7kCh). METHODS:ARPE-19 cells were exposed to 7kCh with or without z-VAD-fmk, a pan-caspase inhibitor. Caspase-3, -8, and -9 activities were measured by a flu...

journal_title：Investigative ophthalmology & visual science

authors： Luthra S,Fardin B,Dong J,Hertzog D,Kamjoo S,Gebremariam S,Butani V,Narayanan R,Mungcal JK,Kuppermann BD,Kenney MC

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To identify objective criteria to quantify visual function in the rat for developing therapeutic strategies to protect neuronal cells after ischemia. The impact of ocular ischemia on luminance and frequency-modulated contrast vision was compared with the function of outer retinal cells and the number of intact ...

journal_title：Investigative ophthalmology & visual science

authors： Jehle T,Wingert K,Dimitriu C,Meschede W,Lasseck J,Bach M,Lagrèze WA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To determine the toxicity of various doses of intravitreal amphotericin B deoxycholate, amphotericin B lipid complex (ABLC), and liposomal amphotericin B (L-AmB). METHODS:Fifty-two rabbits were divided into two treatment groups (groups A and B). Thirteen treatments were administered intravitreally to the 104 r...

journal_title：Investigative ophthalmology & visual science

authors： Cannon JP,Fiscella R,Pattharachayakul S,Garey KW,De Alba F,Piscitelli S,Edward DP,Danziger LH

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:Visual field defects after vitrectomy can be seen after any surgery involving fluid-air exchange. To elucidate the effect during surgery of the infused air on the retina, the present study investigated the changes in the morphology of the rabbit retina induced by air infusion and the changes resulting from vary...

journal_title：Investigative ophthalmology & visual science

authors： Hasumura T,Yonemura N,Hirata A,Murata Y,Negi A

更新日期：2000-12-01 00:00:00

abstract：:The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Müller cells, offering conclusive evidence that in the mammalian retina, the protein is confine...

journal_title：Investigative ophthalmology & visual science

authors： Cocchia D,Polak JM,Terenghi G,Battaglia F,Stolfi V,Gangitano C,Michetti F

更新日期：1983-07-01 00:00:00

abstract：PURPOSE:To investigate regional differences in Ca(2+) mobilization kinetics in the intact human lens produced by exposure to agonists of tyrosine-kinase and G-protein-coupled receptors and to characterize the major receptor subtypes involved in Ca(2+) signaling in the different regions. METHODS:Whole human lenses were...

journal_title：Investigative ophthalmology & visual science

authors： Collison DJ,Duncan G

更新日期：2001-09-01 00:00:00