Analysis of antigenic determinants of retinal S-antigen with monoclonal antibodies.

abstract：:Checkerboard reversal stimuli were used to evoke transient pattern electroretinograms (P-ERGs) from the eyes of 14 patients with amblyopia and 14 normal subjects. In the control group, and in normal eyes of patients, pattern electroretinograms were obtained with monocular central fixation. Amblyopic eyes were examined...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Welge-Lüssen L

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Strabismus is a common eye disorder with a prevalence of 1% to 4%. Comitant strabismus accounts for approximately 75% of all strabismus, yet more is known about the less common incomitant disorders. Comitant strabismus is at least partly inherited, but only one recessive genetic susceptibility locus, on chromos...

journal_title：Investigative ophthalmology & visual science

authors： Rice A,Nsengimana J,Simmons IG,Toomes C,Hoole J,Willoughby CE,Cassidy F,Williams GA,George ND,Sheridan E,Young TL,Hunter TI,Barrett BT,Elliott DB,Bishop DT,Inglehearn CF

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To investigate the alterations in gene expression when human retinal pigment epithelial (RPE) cells in culture are treated with vitreous as a model for the changes that occur in proliferative vitreoretinopathy. METHODS:Human RPE cells were cultured with or without human vitreous or collagen. RNA was extracted ...

journal_title：Investigative ophthalmology & visual science

authors： Parapuram SK,Ganti R,Hunt RC,Hunt DM

更新日期：2003-04-01 00:00:00

abstract：:Sixteen patients with osteogenesis imperfecta (OI) have undergone a thorough eye examination. These patients had statistically significantly lower ocular rigidity measurements than a group of normal volunteers matched on age, sex, and refractive error. In addition, the corneal diameter and length of the eyeball was sm...

journal_title：Investigative ophthalmology & visual science

authors： Kaiser-Kupfer MI,McCain L,Shapiro JR,Podgor MJ,Kupfer C,Rowe D

更新日期：1981-06-01 00:00:00

abstract：PURPOSE:Na,K-adenosine triphosphatase (ATPase) is essential for the regulation of cytoplasmic ion concentrations in lens cells. Earlier studies demonstrated that tyrosine phosphorylation by Lyn kinase, a Src-family member, inhibits Na,K-ATPase activity in porcine lens epithelium. In the present study, experiments were ...

journal_title：Investigative ophthalmology & visual science

authors： Bozulic LD,Dean WL,Delamere NA

更新日期：2005-02-01 00:00:00

abstract：Purpose:To ascertain cellular constituents within islands of preserved retina in choroideremia (CHM) by multimodal imaging. Methods:CHM probands (16) and female carriers (9) of CHM were studied. Near-infrared autofluorescence (NIR-AF; 787-nm excitation; emission, >830 nm), short-wavelength autofluorescence (SW-AF; 488...

journal_title：Investigative ophthalmology & visual science

authors： Paavo M,Carvalho JRL Jr,Lee W,Sengillo JD,Tsang SH,Sparrow JR

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：PURPOSE:To determine the concentration of group II phospholipase (PL) A(2), an antimicrobial molecule, in tears of normal subjects in different age and sex groups. METHODS:PLA(2) content of tears was measured in 122 healthy volunteers with ages ranging from 20 to 89 years (mean, 49.5 years) by a time-resolved fluoroim...

journal_title：Investigative ophthalmology & visual science

authors： Saari KM,Aho V,Paavilainen V,Nevalainen TJ

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. METHODS:In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared refl...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Ayton LN,Makeyeva G,Guymer RH,Luu CD

更新日期：2015-03-03 00:00:00

abstract：:Refractile inclusion bodies (approximately 0.80 micron in size) were found in the inner segments of cone photoreceptors in the aging human retina. They were easily resolved with the light microscope. They were never seen in rods, and occurred primarily in retinas from eye donors older than 40 years of age. The inciden...

journal_title：Investigative ophthalmology & visual science

authors： Tucker GS

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To investigate mechanical properties of the human posterior lens capsule. METHODS:Twenty-five human donor eyes were obtained from an eye bank. The age of the donors ranged from 1 to 94 years. Test specimens were prepared as tissue rings from posterior lens capsules by means of excimer laser. Capsular thickness...

journal_title：Investigative ophthalmology & visual science

authors： Krag S,Andreassen TT

更新日期：2003-02-01 00:00:00

abstract：:The microvascular permeability response of the guinea pig conjunctiva to sulfidopeptide leukotrienes (LTs) was quantified as extravasation of radiolabeled bovine serum albumin. The LTs were potent inducers of increased microvascular permeability, with relative potencies LTE4 greater than or equal to LTD4 greater than ...

journal_title：Investigative ophthalmology & visual science

authors： Gary RK Jr,Woodward DF,Nieves AL,Williams LS,Gleason JG,Wasserman MA

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate the expression pattern and function of survivin in the development of pterygium. METHODS:Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medi...

journal_title：Investigative ophthalmology & visual science

authors： Xu YX,Zhang LY,Zou DL,Liu ZS,Shang XM,Wu HP,Zhou Y,He H,Liu ZG

更新日期：2014-12-02 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the optimal conditions for prolonging corneal allograft survival by inducing anergy with the superantigen staphylococcal enterotoxin B (SEB). METHODS:A rat model of penetrating keratoplasty, whereby Fisher344 donor corneas are implanted into Lewis recipients, was used...

journal_title：Investigative ophthalmology & visual science

authors： Pan Z,Chen Y,Zhang W,Jie Y,Li N,Wu Y

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

journal_title：Investigative ophthalmology & visual science

authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

更新日期：2004-01-01 00:00:00

abstract：:The authors have put quantitation of human lens fluorescence on a rational basis by using the accompanying Raman signal from lens protein as a normalization factor. The intensity ratio, Fluorescence/Raman (F/R), may be used to compare lenses of different ages when the exciting wavelength is long enough to give a measu...

journal_title：Investigative ophthalmology & visual science

authors： Yu NT,Bando M,Kuck JF Jr

更新日期：1985-01-01 00:00:00

abstract：Purpose:To evaluate the nature and extent of functional abnormality in X-linked retinoschisis (XLRS) by comparing three dark-adapted, full-field measures: the electroretinogram (ERG), pupillary light reflex (PLR), and luminance threshold. Methods:ERGs, PLRs (pupil constriction due to light stimulation), and luminance ...

journal_title：Investigative ophthalmology & visual science

authors： McAnany JJ,Park JC,Fishman GA,Collison FT

更新日期：2020-06-03 00:00:00

abstract：Purpose:Global motion and global form perception have been found to be abnormal in the presence of amblyopia. How such deficits manifest in visual function reliant on the interactions between these two visual processing mechanisms has not been adequately explored. In the current study, we use dynamic Glass patterns (dG...

journal_title：Investigative ophthalmology & visual science

authors： Joshi MR,Simmers AJ,Jeon ST

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that repairs DNA double strand breaks. This study investigates the putative i...

journal_title：Investigative ophthalmology & visual science

authors： Smith AJ,Ball SS,Manzar K,Bowater RP,Wormstone IM

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide a...

journal_title：Investigative ophthalmology & visual science

authors： Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJ

更新日期：2009-09-01 00:00:00

abstract：:Steady-state visual evoked potentials were elicited by the appearance/disappearance of sinusoidal gratings of varying spatial frequency for both eyes of amblyopic subjects. The amblyopic eyes showed reduced responses and a phase shift relative to the nonamblyopic eyes across a wide range of spatial frequencies. Both t...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1978-06-01 00:00:00

abstract：PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

journal_title：Investigative ophthalmology & visual science

authors： Gray LS,Winn B,Gilmartin B,Eadie AS

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...

journal_title：Investigative ophthalmology & visual science

authors： Mutti DO,Zadnik K,Murphy CJ

更新日期：1999-06-01 00:00:00

abstract：:The visual field of normal infants was assessed using a perimeter with LED stimuli and a forced-choice observation procedure. Central fixation was elicited by four central, pulsing LEDs and maintained with the aid of auditory stimuli. Field extent was derived from the four-alternative, forced-choice judgments of an ad...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Cummings MF

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:TGF-betas regulate cell proliferation and differentiation, and they play important roles in maintenance of corneal epithelium. However, the precise function of TGF-betas in the corneal epithelium remains unclear. In this study, cDNA expression array technology was used to demonstrate the effect of TGF-beta1 on ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashida-Hibino S,Watanabe H,Nishida K,Tsujikawa M,Tanaka T,Hori Y,Saishin Y,Tano Y

更新日期：2001-07-01 00:00:00

abstract：Purpose:Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments. Methods:Rabbit corneas e...

journal_title：Investigative ophthalmology & visual science

authors： Wertheimer CM,Elhardt C,Kaminsky SM,Pham L,Pei Q,Mendes B,Afshar S,Kochevar IE

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Mutations in the genes that control cell proliferation in cutaneous melanoma are generally uncommon in uveal melanoma. Despite the absence of known activating mutations, the RAF-MEK-ERK, or mitogen-activated protein kinase (MAPK), pathway is usually activated in uveal melanoma. An assay with increased potential...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Kilic E,Luyten GP,de Klein A,Jager MJ,Gruis NA,Van der Velden PA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Many types of chronic blepharitis have been believed to be primarily microbial in origin; however, it was proposed that differences and changes in lipid composition of meibomian secretion may be the initiating factor in some of these. It was recently reported that there are two subgroups of normals, those whose...

journal_title：Investigative ophthalmology & visual science

authors： Shine WE,Silvany R,McCulley JP

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:The authors investigated the effect of brain-derived neurotrophic factor (BDNF) administration on the expression of Ca(2+)-binding proteins in the developing bdnf(-/-) mouse retina. METHODS:Intraocular injections of BDNF (0.5 microg) were applied on postnatal day (P) 11 bdnf(-/-) mice, and their effects were e...

journal_title：Investigative ophthalmology & visual science

authors： Arango-González B,Cellerino A,Kohler K

更新日期：2009-03-01 00:00:00