Rat corneal allograft survival prolonged by the superantigen staphylococcal enterotoxin B.

abstract：:Diabetes mellitus has been shown to be a factor in the development of corneal epithelial abnormalities in stressed human eyes, but the biochemical basis for this is not known. To see if sorbitol pathway activation might be involved, ocular surface epithelial healing rates and metabolites of the glycolytic and sorbitol...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes TC,Thoft RA

更新日期：1981-08-01 00:00:00

abstract：PURPOSE:To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS:A total of 660 men and women born in Sheffield, United Kingdom, between 1922 and 1930 and whose size at birth was available were traced and invited to take part...

journal_title：Investigative ophthalmology & visual science

authors： Hall NF,Gale CR,Syddall H,Martyn CN,Phillips DI

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat. METHODS:EIU was induced in Long-Evans rats by a single footpad injection of lipopolysaccharide (LPS; 350 microg/kg) from Salmonella typhimurium. A single injec...

journal_title：Investigative ophthalmology & visual science

authors： Koizumi K,Poulaki V,Doehmen S,Welsandt G,Radetzky S,Lappas A,Kociok N,Kirchhof B,Joussen AM

更新日期：2003-05-01 00:00:00

abstract：Purpose:We previously reported that a specific treadmill running exercise regimen protects against light-induced retinal degeneration (LIRD) in mice. We hypothesized that this protective effect varies with running intensity. To test this, mice undergoing LIRD were run at different treadmill speeds and retinal function ...

journal_title：Investigative ophthalmology & visual science

authors： Mees LM,Coulter MM,Chrenek MA,Motz CT,Landis EG,Boatright JH,Pardue MT

更新日期：2019-04-01 00:00:00

abstract：Purpose:To investigate the difference in intraocular vascular endothelial growth factor (VEGF) concentration between pachychoroid neovasculopathy and neovascular age-related macular degeneration (nAMD) and its associations with responses to three monthly anti-VEGF injections as an initial treatment for the two conditio...

journal_title：Investigative ophthalmology & visual science

authors： Hata M,Yamashiro K,Ooto S,Oishi A,Tamura H,Miyata M,Ueda-Arakawa N,Takahashi A,Tsujikawa A,Yoshimura N

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:There is considerable variation in the degree of form-deprivation myopia (FDM) induced in chickens by a uniform treatment regimen. Sex and pretreatment eye size have been found to be predictive of the rate of FD-induced eye growth. Therefore, this study was undertaken to test whether the greater rate of myopic ...

journal_title：Investigative ophthalmology & visual science

authors： Chen YP,Prashar A,Hocking PM,Erichsen JT,To CH,Schaeffel F,Guggenheim JA

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:This was a prospective case-control study conducted to evaluate the effectiveness of the Tear Stability Analysis System (TSAS) for the assessment of patients with dry eye. METHODS:The TSAS can take 10 consecutive corneal topograms at one per second for 10 seconds. Examinations using the TSAS were conducted in ...

journal_title：Investigative ophthalmology & visual science

authors： Kojima T,Ishida R,Dogru M,Goto E,Takano Y,Matsumoto Y,Kaido M,Ohashi Y,Tsubota K

更新日期：2004-05-01 00:00:00

abstract：:The Early Treatment Diabetic Retinopathy Study (ETDRS) and other standardized classification schemes have laid a foundation for tremendous advances in the understanding and management of diabetic retinopathy (DR). However, technological advances in optics and image analysis, especially optical coherence tomography (OC...

journal_title：Investigative ophthalmology & visual science

authors： Abramoff MD,Fort PE,Han IC,Jayasundera KT,Sohn EH,Gardner TW

更新日期：2018-01-01 00:00:00

abstract：Purpose:To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods:Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected to unilateral injection of hypertonic saline into a limbal vein, causing sclerosis of the outflow pathway and su...

journal_title：Investigative ophthalmology & visual science

authors： Nettesheim A,Dixon A,Shim MS,Coyne A,Walsh M,Liton PB

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To isolate all constituent mucins from human conjunctival mucus. METHODS:Mucins were extracted from human conjunctiva in guanidine hydrochloride and protease inhibitors. The mucins were isolated by density gradient centrifugation, gel filtration, and ion exchange chromatography. Throughout purification, the mu...

journal_title：Investigative ophthalmology & visual science

authors： Berry M,Ellingham RB,Corfield AP

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To examine the expression of five prostaglandin (PG) receptors, EP(1), EP(2), EP(3), EP(4), and FP and their corresponding mRNA transcripts in human sclera and cultured human scleral fibroblasts (HSFs). METHODS:Primary cultures of HSFs were established from donor eyes. Also, sclera from human donor eyes was sn...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Aihara M,Weinreb RN

更新日期：2001-12-01 00:00:00

abstract：Purpose:Prospective treatments for age-related macular degeneration and inherited retinal degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before translation into clinical application. Historically, retinal thickness obtained through postmortem anatomic assessments has been a key outcome ...

journal_title：Investigative ophthalmology & visual science

authors： Ryals RC,Andrews MD,Datta S,Coyner AS,Fischer CM,Wen Y,Pennesi ME,McGill TJ

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. METHODS:Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes of TES, whereas SHAM (n = 15) received identical sham stimulation 2 hours before e...

journal_title：Investigative ophthalmology & visual science

authors： Schatz A,Arango-Gonzalez B,Fischer D,Enderle H,Bolz S,Röck T,Naycheva L,Grimm C,Messias A,Zrenner E,Bartz-Schmidt KU,Willmann G,Gekeler F

更新日期：2012-08-15 00:00:00

abstract：PURPOSE:To determine whether messenger RNA coding for fibroblast growth factor receptor-1, interleukin-1 receptor, and glucocorticoid receptor messenger RNA are produced in human lacrimal tissue. METHODS:Total cellular RNA was isolated from three specimens of normal human lacrimal tissue and complementary DNA was synt...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Lloyd SA,Kennedy RH

更新日期：1993-05-01 00:00:00

abstract：:Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 +/- 0.8 to 7.1 +/- 1.4 mm Hg (P less than 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the ...

journal_title：Investigative ophthalmology & visual science

authors： Toris CB,Pederson JE

更新日期：1985-12-01 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:Lectin studies have shown that in the rabbit corneal epithelium, alpha-2,3 sialylation of O-linked glycans differentiates limbal and corneal epithelial cell phenotypes. Because sialic acid can be regulated at the level of the expression of sialyltransferases (STs), the purpose of the present study was to analyz...

journal_title：Investigative ophthalmology & visual science

authors： Matic M,Petrov I,Stegman Z,Buku A,Wolosin JM

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:The majority of patients with X chromosome-linked retinitis pigmentosa (XlRP) carry mutations in the RPGR gene. The authors studied whether patients with RPGR mutations show additional splice defects that may interfere with RPGR properties. METHODS:Patient-derived cell lines with RPGR mutations were raised in ...

journal_title：Investigative ophthalmology & visual science

authors： Schmid F,Glaus E,Cremers FP,Kloeckener-Gruissem B,Berger W,Neidhardt J

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To investigate the slow phase in latent/manifest latent nystagmus (LMLN) by producing long eye-drift intervals devoid of fast phases (extended slow phases [ESPs]) and to relate ESP metrics to clinical findings. METHODS:Ten patients with LMLN had eye movements recorded while attending to paired visual and audit...

journal_title：Investigative ophthalmology & visual science

authors： Gradstein L,Goldstein HP,Wizov SS,Reinecke RD

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Rabbits are commonly used for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The accuracy of intraocular pressure measurement is therefore critical in the analysis of data and subsequent extrapolation to humans. The purpose of this study was to establish the most reliable technique, fr...

journal_title：Investigative ophthalmology & visual science

authors： Lim KS,Wickremasinghe SS,Cordeiro MF,Bunce C,Khaw PT

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To test the validity of the color component subtraction method, a new objective technique of measuring nuclear cataract, and to correlate the tangent values of the different degrees of nuclear opacities to their corresponding subjective nuclear cataract grading using the Lens Opacities Classification System II ...

journal_title：Investigative ophthalmology & visual science

authors： Khu PM,Kashiwagi T

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To examine the expression pattern and roles of Sonic hedgehog (Shh) in healing corneal epithelium. METHODS:Immunofluorescent staining and Western blot analysis were used to detect Shh, patched 1 (Ptc 1) receptors, and Gli transcription factors in corneal epithelium of Wistar rats (n = 44) at various intervals ...

journal_title：Investigative ophthalmology & visual science

authors： Saika S,Muragaki Y,Okada Y,Miyamoto T,Ohnishi Y,Ooshima A,Kao WW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To assess the impact on visual function of community glaucoma screening in an African American population using spectral-domain optical coherence tomography (SD-OCT). METHODS:Using a Monte Carlo microsimulation model with a 10-year time horizon, we analyzed the efficacy of SD-OCT screening on visual field outc...

journal_title：Investigative ophthalmology & visual science

authors： Blumberg DM,Vaswani R,Nong E,Al-Aswad L,Cioffi GA

更新日期：2014-05-01 00:00:00

abstract：Purpose:To investigate the effect of short-wavelength light (SL) on guinea pigs with lens-induced myopia (LIM) and the possible retinoic acid (RA)-related mechanisms. Methods:Two-week-old guinea pigs (n = 60) with monocular -5D lenses were reared under white light (WL, 580 lux) or SL (440 nm, 500 lux). The left eyes w...

journal_title：Investigative ophthalmology & visual science

authors： Yu M,Liu W,Wang B,Dai J

更新日期：2021-01-04 00:00:00

abstract：Purpose:To improve the transparency of the acellular dermal matrix (ADM) and investigate the optical, mechanical and histologic properties and biocompatibility of transparent ADM (TADM) in lamellar keratoplasty. Methods:A stepwise sectioning strategy was applied to determine the transparency distribution of the ADM, a...

journal_title：Investigative ophthalmology & visual science

authors： Wang Y,Ma J,Jiang X,Liu Z,Yang J,Li X

更新日期：2020-01-23 00:00:00

abstract：Purpose:To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes. Methods:Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axia...

journal_title：Investigative ophthalmology & visual science

authors： Lee SH,Kim TW,Lee EJ,Girard MJ,Mari JM

更新日期：2017-02-01 00:00:00

abstract：Purpose:To investigate foveal avascular zone (FAZ) changes in the superficial (SCP) and deep (DCP) capillary plexuses in beta-thalassemia major (BTM) patients, as shown in optical coherence tomography angiography. Methods:Nonrandomized, comparative case series of 54 eyes of 27 BTM patients and 46 eyes of 23 healthy co...

journal_title：Investigative ophthalmology & visual science

authors： Georgalas I,Makris G,Papaconstantinou D,Petrou P,Chalkiadaki E,Droutsas K,Andreanos K,Kanakis M

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts. METHODS:The GJA8 gene was directly sequenced. Formation of functional channels was assessed by the two-microelectrode voltage-clamp METHOD:Connexin protein levels and distribu...

journal_title：Investigative ophthalmology & visual science

authors： Minogue PJ,Tong JJ,Arora A,Russell-Eggitt I,Hunt DM,Moore AT,Ebihara L,Beyer EC,Berthoud VM

更新日期：2009-12-01 00:00:00

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00