Abstract:
PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide and were hybridized with silicone elastomer by spin coating. The stability of the hybrid between the two materials was flex and blister tested. The feasibility of the hybrid electrode was evaluated in the rabbit eye by reviewing optical coherence tomography (OCT) findings after suprachoroidal implantation. RESULTS:The flex test showed no dehiscence between the two materials for 24 hours of alternative flexion and extension from -45.0 degrees to +45.0 degrees . During the blister test, delamination was observed at 8.33 +/- 1.36 psi of pressure stress; however, this property was improved to 11.50 +/- 1.04 psi by oxygen plasma treatment before hybridization. OCT examination revealed that the implanted electrodes were safely located in the suprachoroidal space during the 4-week follow-up period. CONCLUSIONS:The silicone-polyimide hybrid microelectrode array showed moderate physical properties, which are suitable for in vivo application. Appropriate pretreatment before hybridization improved electrode stability. In vivo testing indicated that this electrode is suitable as a stimulation electrode in artificial retina.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJdoi
10.1167/iovs.08-2500subject
Has Abstractpub_date
2009-09-01 00:00:00pages
4337-41issue
9eissn
0146-0404issn
1552-5783pii
iovs.08-2500journal_volume
50pub_type
杂志文章abstract:PURPOSE:Looping patterns rich in laminin are present in tissue samples of primary aggressive human uveal melanomas and their metastases. Because these extravascular patterns connect to blood vessels and transmit fluid in vitro and in vivo, the three-dimensional configuration of these patterns has been the subject of co...
journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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更新日期:2015-07-01 00:00:00
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更新日期:2009-05-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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doi:
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更新日期:1985-04-01 00:00:00
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更新日期:2018-03-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:2002-05-01 00:00:00
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更新日期:2013-10-23 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:2001-08-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2011-08-22 00:00:00