IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes Müller Glial Cell Motility.

abstract：PURPOSE:This study describes the expression and distribution of arrestin, phosducin, and recoverin in the cone-dominant retina of the ground squirrel Spermophilus tridecemlineatus. METHODS:mRNA expression was studied by blot hybridization of ground squirrel retinal RNA, with human and murine RNA as controls. The distr...

journal_title：Investigative ophthalmology & visual science

authors： von Schantz M,Szél A,van Veen T,Farber DB

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To characterize the cellular expression patterns of antiangiogenic factors differentially regulated in the fetal human macula. METHODS:RNA was extracted from macular, nasal, and surround biopsies of three human fetal retinas at midgestation. Relative levels of expression of pigment epithelium-derived factor (P...

journal_title：Investigative ophthalmology & visual science

authors： Kozulin P,Natoli R,Bumsted O'Brien KM,Madigan MC,Provis JM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To assess the impact on visual function of community glaucoma screening in an African American population using spectral-domain optical coherence tomography (SD-OCT). METHODS:Using a Monte Carlo microsimulation model with a 10-year time horizon, we analyzed the efficacy of SD-OCT screening on visual field outc...

journal_title：Investigative ophthalmology & visual science

authors： Blumberg DM,Vaswani R,Nong E,Al-Aswad L,Cioffi GA

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Using transient ischemia followed by reperfusion (IR) to model ischemic retinal disease, this study compares the effects of ischemic preconditioning (IPC) and therapies targeting vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF)-α on retinal apoptosis, vascular permeability, and mRNA exp...

journal_title：Investigative ophthalmology & visual science

authors： Abcouwer SF,Lin CM,Wolpert EB,Shanmugam S,Schaefer EW,Freeman WM,Barber AJ,Antonetti DA

更新日期：2010-11-01 00:00:00

abstract：:Failure of corneal grafts is thought to involve the development and activation of specifically sensitized T-cells. One method which might be used to circumvent the development of such cells is the phenomenon of anterior chamber-associated immune deviation (ACAID). Injection of antigen into the anterior chamber of the ...

journal_title：Investigative ophthalmology & visual science

authors： She SC,Steahly LP,Moticka EJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress. METHODS:ARPE-19 cells were treated with the chemical oxidant tert-butyl hydroperoxide (t-BOOH), and cell viability was ...

journal_title：Investigative ophthalmology & visual science

authors： Hutnik CM,Pocrnich CE,Liu H,Laird DW,Shao Q

更新日期：2008-02-01 00:00:00

abstract：:The temporal modulation sensitivity function was studied in eight strabismic and/or anisometropic amblyopes and in two subjects with amblyopia resulting from monocular stimulus deprivation (cataract and ptosis). Half of the strabismic/anisometropic amblyopes showed a reduction in the sensitivity of the amblyopic eye. ...

journal_title：Investigative ophthalmology & visual science

authors： Manny RE,Levi DM

更新日期：1982-04-01 00:00:00

abstract：PURPOSE:To test whether the incidence of long-term drift to timolol can be reduced by a "pulsatile" treatment (6 months timolol-2 months dipivefrin). METHODS:In a randomized clinical trial, 100 consecutive subjects with ocular hypertension or high-tension primary open-angle glaucoma in at least one eye were randomly a...

journal_title：Investigative ophthalmology & visual science

authors： Gandolfi SA,Vecchi M

更新日期：1996-03-01 00:00:00

abstract：Purpose:Asymmetry in disease progression between left and right eyes can occur in Stargardt disease (STGD1), and this needs to be considered in novel therapeutic trials with a fellow-eye paired controlled design. This study investigated the inter-eye discordance of best-corrected visual acuity (BCVA) and progression of...

journal_title：Investigative ophthalmology & visual science

authors： Lambertus S,Bax NM,Groenewoud JM,Cremers FP,van der Wilt GJ,Klevering BJ,Theelen T,Hoyng CB

更新日期：2016-12-01 00:00:00

abstract：:The circulating renin-angiotensin system (RAS) is an important determinant in maintaining adequate systemic blood pressure, and it also may modify organ-specific blood flow. All recognized RAS components have been identified in the eye. In this study, angiotensinogen (ANG) was localized using an affinity-purified anti...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Tewksbury DA,Brandt CR,Poulsen GL

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cultures of human corneal epithelial, stromal fibroblast, and end...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Walker JW,Chwang EL,He YG

更新日期：1993-07-01 00:00:00

abstract：Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

journal_title：Investigative ophthalmology & visual science

authors： Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：Purpose:Structural retinal microvascular changes have been identified as risk markers of diabetic retinopathy (DR). In order to estimate the retinal response of neuroprotective eye drops, we aimed to evaluate the effect of topical retinal neuroprotection on retinal microvascular changes in early DR. Methods:Patients w...

journal_title：Investigative ophthalmology & visual science

authors： Grauslund J,Frydkjaer-Olsen U,Peto T,Fernández-Carneado J,Ponsati B,Hernández C,Cunha-Vaz J,Simó R,EUROCONDOR.

更新日期：2019-05-01 00:00:00

abstract：:Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by th...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Alexander EL,Green WR

更新日期：1985-09-01 00:00:00

abstract：:The first heritable model of retinoblastoma was established by retina-specific expression of simian virus 40 T-antigen (SV40 T-ag) in transgenic mice. Bilateral, multifocal ocular tumors were observed in 100% of transgene-bearing mice. Central nervous system neoplasms occurred at a lower rate (27%) and represented the...

journal_title：Investigative ophthalmology & visual science

authors： Marcus DM,Carpenter JL,O'Brien JM,Kivela T,Brauner E,Tarkkanen A,Virtanen I,Albert DM

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:To evaluate the serum fatty acid changes in Chinese patients with Bietti crystalline dystrophy (BCD) in association with CYP4V2 mutation. METHODS:Sixteen Chinese patients with BCD confirmed with CYP4V2 mutation were recruited. Peripheral venous blood was obtained after fasting and serum fatty acid concentratio...

journal_title：Investigative ophthalmology & visual science

authors： Lai TY,Chu KO,Chan KP,Ng TK,Yam GH,Lam DS,Pang CP

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Adeno-associated viral (AAV) vectors have been used to express several different proteins in the eye. The purpose of this study was to determine whether AAV-mediated intraocular gene transfer of pigment epithelium-derived factor (PEDF) inhibits the development of choroidal neovascularization (CNV) in a murine m...

journal_title：Investigative ophthalmology & visual science

authors： Mori K,Gehlbach P,Yamamoto S,Duh E,Zack DJ,Li Q,Berns KI,Raisler BJ,Hauswirth WW,Campochiaro PA

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：:Protocols for light microscopy of frog lenses that result in good visibility of cell structure from the lens surface to its nucleus are presented. The lenses are fixed in 10% neutral formalin in 0.06 M phosphate buffer and are embedded in Epon 812. Following staining of the thick sections with selected Procion dyes, e...

journal_title：Investigative ophthalmology & visual science

authors： Rae JL,Truitt KD,Kuszak JR

更新日期：1983-09-01 00:00:00

abstract：PURPOSE:Vision restoration is a fast-approaching reality for some people with profound vision loss. In order to reliably determine treatment efficacy, accurate assessment of baseline residual visual function is critical. The purpose of this study was to compare residual function as detected on Goldman visual field (GVF...

journal_title：Investigative ophthalmology & visual science

authors： Ayton LN,Apollo NV,Varsamidis M,Dimitrov PN,Guymer RH,Luu CD

更新日期：2014-03-06 00:00:00

abstract：PURPOSE:Intraocular pressure (IOP) is dynamic and can be influenced by the use of tonometers. The authors developed a technique to implant a telemetric pressure transducer to measure IOP continuously in unrestrained rabbits. METHODS:A commercial telemetric pressure transducer was implanted subcutaneously on the dorsal...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF,FitzSimon JS

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:Cardiovascular risk factors such as smoking, hypertension, and atherosclerosis seem to play an important role in the development of choroidal neovascularization (CNV). Recent studies have also provided evidence suggesting that choroidal and retinal blood flow is decreased in patients with AMD. On the basis of t...

journal_title：Investigative ophthalmology & visual science

authors： Boltz A,Luksch A,Wimpissinger B,Maar N,Weigert G,Frantal S,Brannath W,Garhöfer G,Ergun E,Stur M,Schmetterer L

更新日期：2010-08-01 00:00:00

abstract：:To investigate the pathogenesis of ocular cytomegalovirus infections, 3-week-old BALB/c mice were inoculated with 10(4) plaque-forming units of murine cytomegalovirus (MCMV) by the right anterior chamber and studied sequentially with the use of virus assays and in situ nucleic acid hybridization methods. During acute ...

journal_title：Investigative ophthalmology & visual science

authors： Bale JF Jr,O'Neil ME,Lyon B,Perlman S

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. METHODS:A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS)...

journal_title：Investigative ophthalmology & visual science

authors： Lim LS,Yang X,Gazzard G,Lin X,Sng C,Saw SM,Qiu A

更新日期：2011-11-17 00:00:00

abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Wirtschafter JD

更新日期：1999-10-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00