The role of cholesterol in chronic blepharitis.

abstract：:Using aqueous and vitreous fluorophotometry, the authors examined the blood-aqueous and blood-retinal barrier functions in three groups of pigmented rabbits. Epinephrine (1.25%) was applied topically five times daily and indomethacin (0.5% sesame oil suspension) was applied topically three times daily to one eye of ea...

journal_title：Investigative ophthalmology & visual science

authors： Miyake K,Kayazawa F,Manabe R,Miyake Y

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:To test whether eliprodil (SL 82.0715), a unique antagonist for the N-methyl-D-aspartate (NMDA) receptor, is protective in the glutamate-induced cytotoxicity model in cultured rat retinal ganglion cells (RGCs). METHODS:Two to four days after a fluorescent dye, Di-I, was injected near the superior colliculi, ne...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Wexler EM,Nawy S,DeSantis L,Kapin MA

更新日期：1999-05-01 00:00:00

abstract：:Dog corneas were studied by indirect immunofluorescence with antibodies specific for pemphigus and pemphigoid antigens, laminin, and type IV collagen. The distribution of these antigens was similar to that observed in other squamous epithelia and skin. This study provides further evidence for close immunochemical simi...

journal_title：Investigative ophthalmology & visual science

authors： Cowen SJ,Anhalt GJ,Wicha MS,Sugar A,Labib RS,Diaz LA

更新日期：1981-12-01 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Lens epithelial tissue does not normally express major histocompatibility complex (MHC) class I molecules. In addition, the mechanism of self-tolerance to intraocular antigens is unknown. To study the effect of class I expression in the lens, transgenic mice were produced that express an allo-MHC class I molecu...

journal_title：Investigative ophthalmology & visual science

authors： Martin WD,Egan RM,Stevens JL,Woodward JG

更新日期：1995-05-01 00:00:00

abstract：Purpose:To investigate diabetic optic neuropathy (DON) prevalence and risk factors in Chinese diabetic retinopathy (DR) patients. Methods:This retrospective study included 1067 eyes (550 patients) that underwent ocular imaging. The diabetes duration, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and high-dens...

journal_title：Investigative ophthalmology & visual science

authors： Hua R,Qu L,Ma B,Yang P,Sun H,Liu L

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS:Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-...

journal_title：Investigative ophthalmology & visual science

authors： Syed R,Sundquist SM,Ratnam K,Zayit-Soudry S,Zhang Y,Crawford JB,MacDonald IM,Godara P,Rha J,Carroll J,Roorda A,Stepien KE,Duncan JL

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Several nonsyndromic high-grade myopia loci have been mapped primarily by microsatellite markers and a limited number of pedigrees. In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites. METHODS:G...

journal_title：Investigative ophthalmology & visual science

authors： Li YJ,Guggenheim JA,Bulusu A,Metlapally R,Abbott D,Malecaze F,Calvas P,Rosenberg T,Paget S,Creer RC,Kirov G,Owen MJ,Zhao B,White T,Mackey DA,Young TL

更新日期：2009-07-01 00:00:00

abstract：:Alloantigens placed into the anterior chamber of the eye elicit antigen-specific suppression of systemic delayed-type hypersensitivity (DTH) responses and severe impairment of skin allograft rejection. This pattern of immunologic alteration has been termed anterior chamber-associated immune deviation (ACAID) and is th...

journal_title：Investigative ophthalmology & visual science

authors： Benson JL,Niederkorn JY

更新日期：1990-10-01 00:00:00

abstract：Purpose:To compare the changes in human tear proteome and clinical effects following topical cyclosporine A (CsA) 0.05% or diquafosol tetrasodium (DQS) 3% treatment of dry eye disease (DED), and to identify biomarkers for determining disease severity and treatment effectiveness in DED. Methods:A total of 18 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Ji YW,Kim HM,Ryu SY,Oh JW,Yeo A,Choi CY,Kim MJ,Song JS,Kim HS,Seo KY,Kim KP,Lee HK

更新日期：2019-12-02 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The prevalence of cataract increases with age. Conversely, the abundance of native α-crystallin diminishes with age and cataract development. We hypothesize replenishing lens α-crystallin may delay or prevent cataract. Herein we investigated the ability of cell penetration peptides (CPP) to enhance entry of α-c...

journal_title：Investigative ophthalmology & visual science

authors： Mueller NH,Ammar DA,Petrash JM

更新日期：2013-01-02 00:00:00

abstract：Purpose:Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods:We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-...

journal_title：Investigative ophthalmology & visual science

authors： Kogo T,Muraoka Y,Iida Y,Ooto S,Murakami T,Kadomoto S,Iida-Miwa Y,Numa S,Miyake M,Miyata M,Uji A,Tsujikawa A

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To examine the expression and localization of the neuroplastins (np), two synapse-enriched members of the immunoglobulin (Ig) superfamily of cell-adhesion molecules, in the developing and adult retina and optic nerve. METHODS:Expressions of the two isoforms np55 and np65 and carboxyl-terminal splice variants w...

journal_title：Investigative ophthalmology & visual science

authors： Kreutz MR,Langnaese K,Dieterich DC,Seidenbecher CI,Zuschratter W,Beesley PW,Gundelfinger ED

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To assess the repeatability, intersession and interobserver reproducibility, and agreement of central corneal thickness (CCT) measurements obtained by scanning-slit topography (SST) and noncontact specular microscopy (NCSM) after advanced surface ablation (ASA). METHODS:To analyze repeatability, one examiner m...

journal_title：Investigative ophthalmology & visual science

authors： López-Miguel A,Martínez-Almeida L,Mateo ME,Coco-Martín MB,Alió JL,Maldonado MJ

更新日期：2013-02-05 00:00:00

abstract：:In the tree shrew retina individual rod and cone photoreceptors can be readily identified and quantified because their perikarya are arranged in a single layer. This retina is therefore an ideal system for testing the specificity of photoreceptor-directed antibodies. Here we describe the staining properties of polyclo...

journal_title：Investigative ophthalmology & visual science

authors： Müller B,Peichl L,De Grip WJ,Gery I,Korf HW

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To investigate the molecular mechanism of Rho-associated kinase (ROCK) inhibitors Y-27632 and Y-39983 on corneal endothelial cell (CEC) proliferation and their wound-healing effect. METHODS:The expression of G1 proteins of the cell cycle and expression of phosphorylated Akt in monkey CECs (MCECs) treated with ...

journal_title：Investigative ophthalmology & visual science

authors： Okumura N,Nakano S,Kay EP,Numata R,Ota A,Sowa Y,Sakai T,Ueno M,Kinoshita S,Koizumi N

更新日期：2014-01-15 00:00:00

abstract：:The unscarified corneas of rabbits were inoculated with 50 microliter of 2-4 X 10(6) PFU/ml of herpes simplex virus, type 1 (HSV-1), McKrae strain in 10 separate experiments over a 12-month period. Sixty of 104 (57.7%) rabbits survived to postinoculation (PI) day 20. These sixty rabbits were swabbed with dacron-tipped...

journal_title：Investigative ophthalmology & visual science

authors： Berman EJ,Hill JM

更新日期：1985-04-01 00:00:00

abstract：Purpose:To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods:We extended a previously published numerical model of the ONH to include 24 factors representing tissue anato...

journal_title：Investigative ophthalmology & visual science

authors： Hua Y,Voorhees AP,Sigal IA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:Lacritin is a tear glycoprotein with prosecretory, prosurvival, and mitogenic properties. We examined lacritin levels in the tears of Sjögren's syndrome (SS) patients and explored the therapeutic potential of topical lacritin for the treatment of keratoconjunctivitis sicca. METHODS:Tears from healthy controls ...

journal_title：Investigative ophthalmology & visual science

authors： Vijmasi T,Chen FY,Balasubbu S,Gallup M,McKown RL,Laurie GW,McNamara NA

更新日期：2014-07-17 00:00:00

abstract：PURPOSE:To investigate phenotype characteristics of fellow eyes in patients with early onset of neovascular age-related macular degeneration (NVAMD). METHODS:Patients with new-onset unilateral NVAMD between 50 and 65 years (n = 57, early-onset choroidal neovascularization [CNV] group) or >80 years (n = 47, late-onset ...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Ersoy L,Hoyng CB,Kirchhof B,Liakopoulos S

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:To determine the morphologic changes in the retina in the macula and around the optic disc in patients with autosomal dominant optic atrophy (ADOA) associated with a mutation in the OPA1 gene. METHODS:Cross-sectional images of the macular area of the retina were obtained by optical coherence tomography (OCT) i...

journal_title：Investigative ophthalmology & visual science

authors： Ito Y,Nakamura M,Yamakoshi T,Lin J,Yatsuya H,Terasaki H

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To demonstrate the effectiveness of Hierarchical Bayesian (HB) approach in a modeling framework for association effects that accounts for SEs of vision-specific latent traits assessed using Rasch analysis. METHODS:A systematic literature review was conducted in four major ophthalmic journals to evaluate Rasch ...

journal_title：Investigative ophthalmology & visual science

authors： Wong WL,Li X,Li J,Wong TY,Cheng CY,Lamoureux EL

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:Endothelin (ET)-1 is known to inhibit active NaK transport by as much as 50% in kidney tubule and other tissues. The presence of low levels of ET-1 in aqueous humor combined with the potential for release of ET-1 from ciliary processes suggests that the lens could be exposed to ET-1 in vivo. In this study, expe...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Delamere NA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:CD40 antigen is a membrane receptor that plays a role in the regulation of immune reactions. The expressions of CD40 and CD40 ligand (CD40L) were investigated ex vivo and in vitro in conjunctival epithelial cells, in correlation with HLA DR class H antigen, previously shown to be upregulated in conjunctival inf...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,De Saint-Jean M,Brignole F,Goguel A,Baudouin C

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:To investigate the molecular basis of hereditary lattice corneal dystrophy (LCD) type IIIA associated with corneal amyloid deposits afflicting several members of a four-generation family. METHODS:Histologic, immunohistochemical and biochemical studies were performed on corneal tissue samples obtained after per...

journal_title：Investigative ophthalmology & visual science

authors： Stix B,Leber M,Bingemer P,Gross C,Rüschoff J,Fändrich M,Schorderet DF,Vorwerk CK,Zacharias M,Roessner A,Röcken C

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To investigate the responses of retinal ganglion cells (RGCs) to electrical stimulation, using electrodes comparable in size to those used in human studies investigating the feasibility of an electronic retinal prosthesis. METHODS:Rabbit retinas were stimulated in vitro with current pulses applied to the inner...

journal_title：Investigative ophthalmology & visual science

authors： Jensen RJ,Ziv OR,Rizzo JF 3rd

更新日期：2005-04-01 00:00:00